Bus from São Paulo to Santa Cruz de la Sierra from $190

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Compare all timetables for the bus from São Paulo to Santa Cruz de la Sierra

Here is a selection of the cheapest bus trips from the schedule from São Paulo to Santa Cruz de la Sierra from various bus operators like La Preferida Bus for the next days.

today
tomorrow
$299
Sunday
$299
Monday
Tuesday
$190
Wednesday
Thursday
$234

Cheapest bus trips tomorrow

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
La Preferida Bus 38h 30m 1:00 PM São Paulo Barra Funda Bus Station 3:30 AM Santa Cruz de la Sierra Terminal Bimodal  First Class $299
  • Did you know that if you travel from São Paulo to Santa Cruz de la Sierra via Puerto Quijarro, you can save more than $106? You can find the corresponding connections below.
    • Tickets Bolivia
      55h 30m
      0
      1:00 PM
      São Paulo
      Barra Funda Bus Station
      6:30 AM
      Puerto Quijarro
      Bus Station
      0
      Tickets Bolivia
      First Class
      $161
      • Waiting Time 28h 30m
    • Tickets Bolivia
      9h 30m
      0
      11:00 AM
      Puerto Quijarro
      Bus Station
      8:30 PM
      Santa Cruz de la Sierra
      Terminal Bimodal
      0
      Tickets Bolivia
      First Class
      $32
    Travel time is 17h 0m longer, but you will save $106

Cheapest bus trips Sunday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
La Preferida Bus 38h 30m 1:00 PM São Paulo Barra Funda Bus Station 3:30 AM Santa Cruz de la Sierra Terminal Bimodal  First Class $299
  • Did you know that if you travel from São Paulo to Santa Cruz de la Sierra via Puerto Quijarro, you can save more than $106? You can find the corresponding connections below.
    • Tickets Bolivia
      31h 30m
      0
      1:00 PM
      São Paulo
      Barra Funda Bus Station
      6:30 AM
      Puerto Quijarro
      Bus Station
      0
      Tickets Bolivia
      First Class
      $161
      • Waiting Time 4h 30m
    • Tickets Bolivia
      9h 30m
      0
      11:00 AM
      Puerto Quijarro
      Bus Station
      8:30 PM
      Santa Cruz de la Sierra
      Terminal Bimodal
      0
      Tickets Bolivia
      First Class
      $32
    Travel Time is 7h 0m shorter, and you will save $106

Cheapest bus trips Tuesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
La Preferida Bus 38h 30m 1:00 PM São Paulo Barra Funda Bus Station 3:30 AM Santa Cruz de la Sierra Terminal Bimodal  First Class $190

Cheapest bus trips Thursday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
La Preferida Bus 38h 30m 1:00 PM São Paulo Barra Funda Bus Station 3:30 AM Santa Cruz de la Sierra Terminal Bimodal  First Class $234
  • Did you know that if you travel from São Paulo to Santa Cruz de la Sierra via Puerto Quijarro, you can save more than $41? You can find the corresponding connections below.
    • Tickets Bolivia
      31h 30m
      0
      1:00 PM
      São Paulo
      Barra Funda Bus Station
      6:30 AM
      Puerto Quijarro
      Bus Station
      0
      Tickets Bolivia
      First Class
      $161
      • Waiting Time 4h 30m
    • Tickets Bolivia
      9h 30m
      0
      11:00 AM
      Puerto Quijarro
      Bus Station
      8:30 PM
      Santa Cruz de la Sierra
      Terminal Bimodal
      0
      Tickets Bolivia
      First Class
      $32
    Travel Time is 7h 0m shorter, and you will save $41

Best Price Offer: The price for the cheapest bus from São Paulo to Santa Cruz de la Sierra is $190 on 2/10/2026. Flexible travelers save on ticket prices.


Facts about the bus from São Paulo to Santa Cruz de la Sierra

Compare all providers like La Preferida Bus that travel 1 times every day by bus from São Paulo to Santa Cruz de la Sierra in one click! Book your bus ticket from São Paulo to Santa Cruz de la Sierra starting from $190!

Cheapest Bus $190
Fastest Bus 38h 30m
Earliest Bus 1:00 PM
Latest Bus 1:00 PM
Daily Bus Routes 1 Ø
Distance 1,140.8 miles
Bus Companies La Preferida Bus

Cheapest bus connections from São Paulo to Santa Cruz de la Sierra

Every day, 1 buses from 1 bus companies leave São Paulo for Santa Cruz de la Sierra: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 02/06/2026 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 02/01
Monday 02/02
Tuesday 02/03
Wednesday 02/04
Thursday 02/05
Friday 02/06
Saturday 02/07
$299
Sunday 02/08
$299
Monday 02/09
Tuesday 02/10
$190
Wednesday 02/11
Thursday 02/12
$234
Friday 02/13
$234
Saturday 02/14
Sunday 02/15
$299
Monday 02/16
Tuesday 02/17
$299
Wednesday 02/18
Thursday 02/19
$299
Friday 02/20
Saturday 02/21
$299
Sunday 02/22
$299
Monday 02/23
Tuesday 02/24
$299
Wednesday 02/25
Thursday 02/26
$299
Friday 02/27
Saturday 02/28

How to save money travelling from São Paulo to Santa Cruz de la Sierra

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from São Paulo to Santa Cruz de la Sierra in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from São Paulo to Santa Cruz de la Sierra, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from São Paulo to Santa Cruz de la Sierra are also emptier.

Beloved bus companies from São Paulo to Santa Cruz de la Sierra

These are the most booked bus companies between São Paulo to Santa Cruz de la Sierra from our users.

La Preferida Bus from São Paulo to Santa Cruz de la Sierra

La Preferida Bus

Here you will find the key facts about the La Preferida Bus bus route São Paulo to Santa Cruz de la Sierra:

Cheapest Price $190
Fastest Bus 38h 30m
Earliest Bus 1:00 PM
Last Bus 1:00 PM
Daily Connections 1 Ø
Found on 2/3/2026

All bus stations and stops in São Paulo and Santa Cruz de la Sierra

In the map below, you can see where to find all bus stations in São Paulo and Santa Cruz de la Sierra.

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from São Paulo to Santa Cruz de la Sierra? Compare all modes of transports from São Paulo to Santa Cruz de la Sierra.

Service and Comfort on the bus from São Paulo to Santa Cruz de la Sierra

Want to know which seat classes are available on the buses from São Paulo to Santa Cruz de la Sierra? Or which bus companies serve the route São Paulo to Santa Cruz de la Sierra? Below you will find answers to your questions.

FAQs about the São Paulo to Santa Cruz de la Sierra bus

How much does a São Paulo Santa Cruz de la Sierra bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $190 and takes 38h 30m to reach Santa Cruz de la Sierra. Compare offers to save money!

How much could I save by comparing buses from São Paulo to Santa Cruz de la Sierra?

This route is offered by 1 companies with a range of ticket prices between $190 and $299. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Santa Cruz de la Sierra.

On average, how many connections are available from São Paulo to Santa Cruz de la Sierra each day?

Every day, the São Paulo to Santa Cruz de la Sierra bus route is served by approximately 1 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from São Paulo to Santa Cruz de la Sierra take?

The fastest bus from São Paulo to Santa Cruz de la Sierra is offered by La Preferida Bus and takes 38h 30m. Bus tickets for this connection cost $299. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from São Paulo to Santa Cruz de la Sierra?

The earliest bus arriving in Santa Cruz de la Sierra from São Paulo starts at 1:00 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from São Paulo to Santa Cruz de la Sierra?

The latest bus trip departing from São Paulo for Santa Cruz de la Sierra starts at 1:00 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the São Paulo Santa Cruz de la Sierra route?

When traveling by bus from São Paulo to Santa Cruz de la Sierra, passengers can travel with La Preferida Bus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between São Paulo and Santa Cruz de la Sierra?

You can check all the direct connections between São Paulo and Santa Cruz de la Sierra by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: La Preferida Bus.

What can I take with me on the São Paulo to Santa Cruz de la Sierra bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the São Paulo Santa Cruz de la Sierra bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the São Paulo Santa Cruz de la Sierra bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from São Paulo to Santa Cruz de la Sierra on your planned travel date.

How does CheckMyBus find the best bus deals from São Paulo to Santa Cruz de la Sierra?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 1 daily trips between São Paulo and Santa Cruz de la Sierra. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from São Paulo to Santa Cruz de la Sierra?

Prices and availability for 1 trips between São Paulo and Santa Cruz de la Sierra change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route São Paulo to Santa Cruz de la Sierra

First Class
First

Best of the best: you will find the most comfortable accommodation to work or relax during your travel.

More bus routes to São Paulo and to Santa Cruz de la Sierra

Here’s an overview of the most popular bus routes to São Paulo and to Santa Cruz de la Sierra. Simply click on the connection of your choice, and you will find all the details about your bus route!
Buses Itamaraju to São Paulo Buses Itamaraju to São Paulo
Bus from Passos, MG to São Paulo Bus from Passos, MG to São Paulo
Buses from São João Evangelista, MG to São Paulo Buses from São João Evangelista, MG to São Paulo
Bus from Bom Jesus da Lapa, BA to São Paulo Bus from Bom Jesus da Lapa, BA to São Paulo
From Iquique to Santa Cruz de la Sierra bus From Iquique to Santa Cruz de la Sierra bus
From Villazón to Santa Cruz de la Sierra bus From Villazón to Santa Cruz de la Sierra bus
Buses from Tarija to Santa Cruz de la Sierra Buses from Tarija to Santa Cruz de la Sierra
Buses Uyuni - Santa Cruz de la Sierra Buses Uyuni - Santa Cruz de la Sierra
Popular Airport Shuttles to São Paulo and to Santa Cruz de la Sierra
CheckMyBus › Buses in Brazil › Bus to São Paulo › Bus to Santa Cruz de la Sierra

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