Bus from São Paulo to Santa Cruz de la Sierra from $190

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Compare all timetables for the bus from São Paulo to Santa Cruz de la Sierra

Here is a selection of the cheapest bus trips from the schedule from São Paulo to Santa Cruz de la Sierra from various bus operators like La Preferida Bus for the next days.

today
$199
tomorrow
Thursday
Friday
$190
Saturday
$190
Sunday
$190
Monday
$190

Cheapest bus trips today

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
La Preferida Bus 39h 30m 1:00 PM São Paulo Barra Funda Bus Station 3:30 AM Santa Cruz de la Sierra Terminal Bimodal  First Class $199

Cheapest bus trips Friday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
La Preferida Bus 38h 30m 1:00 PM São Paulo Barra Funda Bus Station 3:30 AM Santa Cruz de la Sierra Terminal Bimodal  First Class $190
  • Did you know that if you travel from São Paulo to Santa Cruz de la Sierra via Asunción, PY, you can save more than $21? You can find the corresponding connections below.
    • Expreso Paraguay S.A.
      50h 0m
      0
      3:00 PM
      São Paulo
      Tietê Bus Station
      12:26 PM
      Asunción, PY
      Bus Station Assunção
      0
      Expreso Paraguay S.A.
      Business
      $81
      • Waiting Time 7h 34m
    • Stel Turismo SRL
      21h 0m
      0
      8:00 PM
      Asunción, PY
      Bus Station Assunção
      4:00 PM
      Santa Cruz de la Sierra
      Terminal Bimodal
      0
      Stel Turismo SRL
      Premium Economy
      $88
    Travel time is 11h 30m longer, but you will save $21

Cheapest bus trips Saturday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
La Preferida Bus 38h 30m 1:00 PM São Paulo Barra Funda Bus Station 3:30 AM Santa Cruz de la Sierra Terminal Bimodal  First Class $190
  • Did you know that if you travel from São Paulo to Santa Cruz de la Sierra via Asunción, PY, you can save more than $21? You can find the corresponding connections below.
    • Expreso Paraguay S.A.
      50h 0m
      0
      3:00 PM
      São Paulo
      Tietê Bus Station
      12:26 PM
      Asunción, PY
      Bus Station Assunção
      0
      Expreso Paraguay S.A.
      Business
      $81
      • Waiting Time 7h 34m
    • Stel Turismo SRL
      21h 0m
      0
      8:00 PM
      Asunción, PY
      Bus Station Assunção
      4:00 PM
      Santa Cruz de la Sierra
      Terminal Bimodal
      0
      Stel Turismo SRL
      Premium Economy
      $88
    Travel time is 11h 30m longer, but you will save $21

Cheapest bus trips Sunday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
La Preferida Bus 38h 30m 1:00 PM São Paulo Barra Funda Bus Station 3:30 AM Santa Cruz de la Sierra Terminal Bimodal  First Class $190
  • Did you know that if you travel from São Paulo to Santa Cruz de la Sierra via Asunción, PY, you can save more than $21? You can find the corresponding connections below.
    • Expreso Paraguay S.A.
      50h 0m
      0
      3:00 PM
      São Paulo
      Tietê Bus Station
      12:26 PM
      Asunción, PY
      Bus Station Assunção
      0
      Expreso Paraguay S.A.
      Business
      $81
      • Waiting Time 7h 34m
    • Stel Turismo SRL
      21h 0m
      0
      8:00 PM
      Asunción, PY
      Bus Station Assunção
      4:00 PM
      Santa Cruz de la Sierra
      Terminal Bimodal
      0
      Stel Turismo SRL
      Premium Economy
      $88
    Travel time is 11h 30m longer, but you will save $21

Cheapest bus trips Monday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
La Preferida Bus 38h 30m 1:00 PM São Paulo Barra Funda Bus Station 3:30 AM Santa Cruz de la Sierra Terminal Bimodal  First Class $190
  • Did you know that if you travel from São Paulo to Santa Cruz de la Sierra via Asunción, PY, you can save more than $21? You can find the corresponding connections below.
    • Expreso Paraguay S.A.
      50h 0m
      0
      3:00 PM
      São Paulo
      Tietê Bus Station
      12:26 PM
      Asunción, PY
      Bus Station Assunção
      0
      Expreso Paraguay S.A.
      Business
      $81
      • Waiting Time 7h 34m
    • Stel Turismo SRL
      21h 0m
      0
      8:00 PM
      Asunción, PY
      Bus Station Assunção
      4:00 PM
      Santa Cruz de la Sierra
      Terminal Bimodal
      0
      Stel Turismo SRL
      Premium Economy
      $88
    Travel time is 11h 30m longer, but you will save $21

Best Price Offer: The price for the cheapest bus from São Paulo to Santa Cruz de la Sierra is $190 on 5/3/2026. Flexible travelers save on ticket prices.


Facts about the bus from São Paulo to Santa Cruz de la Sierra

Compare all providers like La Preferida Bus that travel 1 times every day by bus from São Paulo to Santa Cruz de la Sierra in one click! Book your bus ticket from São Paulo to Santa Cruz de la Sierra starting from $190!

Cheapest Bus $190
Fastest Bus 38h 30m
Earliest Bus 1:00 PM
Latest Bus 1:00 PM
Daily Bus Routes 1 Ø
Distance 1,140.8 miles
Bus Companies La Preferida Bus

Cheapest bus connections from São Paulo to Santa Cruz de la Sierra

Every day, 1 buses from 1 bus companies leave São Paulo for Santa Cruz de la Sierra: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 05/05/2026 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 05/03
Monday 05/04
Tuesday 05/05
$199
Wednesday 05/06
Thursday 05/07
Friday 05/08
$190
Saturday 05/09
$190
Sunday 05/10
$190
Monday 05/11
$199
Tuesday 05/12
$199
Wednesday 05/13
$190
Thursday 05/14
$190
Friday 05/15
$199
Saturday 05/16
$199
Sunday 05/17
$199
Monday 05/18
$190
Tuesday 05/19
$190
Wednesday 05/20
$199
Thursday 05/21
$190
Friday 05/22
$190
Saturday 05/23
$190
Sunday 05/24
$190
Monday 05/25
$199
Tuesday 05/26
$199
Wednesday 05/27
$190
Thursday 05/28
$190
Friday 05/29
$190
Saturday 05/30

How to save money travelling from São Paulo to Santa Cruz de la Sierra

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from São Paulo to Santa Cruz de la Sierra in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from São Paulo to Santa Cruz de la Sierra, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from São Paulo to Santa Cruz de la Sierra are also emptier.

Beloved bus companies from São Paulo to Santa Cruz de la Sierra

These are the most booked bus companies between São Paulo to Santa Cruz de la Sierra from our users.

La Preferida Bus from São Paulo to Santa Cruz de la Sierra

La Preferida Bus

Here you will find the key facts about the La Preferida Bus bus route São Paulo to Santa Cruz de la Sierra:

Cheapest Price $190
Fastest Bus 38h 30m
Earliest Bus 1:00 PM
Last Bus 1:00 PM
Daily Connections 1 Ø
Found on 4/11/2026

All bus stations and stops in São Paulo and Santa Cruz de la Sierra

In the map below, you can see where to find all bus stations in São Paulo and Santa Cruz de la Sierra.

Service and Comfort on the bus from São Paulo to Santa Cruz de la Sierra

Want to know which seat classes are available on the buses from São Paulo to Santa Cruz de la Sierra? Or which bus companies serve the route São Paulo to Santa Cruz de la Sierra? Below you will find answers to your questions.

FAQs about the São Paulo to Santa Cruz de la Sierra bus

How much does a São Paulo Santa Cruz de la Sierra bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $190 and takes 38h 30m to reach Santa Cruz de la Sierra. Compare offers to save money!

How much could I save by comparing buses from São Paulo to Santa Cruz de la Sierra?

This route is offered by 1 companies with a range of ticket prices between $190 and $199. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Santa Cruz de la Sierra.

On average, how many connections are available from São Paulo to Santa Cruz de la Sierra each day?

Every day, the São Paulo to Santa Cruz de la Sierra bus route is served by approximately 1 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from São Paulo to Santa Cruz de la Sierra take?

The fastest bus from São Paulo to Santa Cruz de la Sierra is offered by La Preferida Bus and takes 38h 30m. Bus tickets for this connection cost $199. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from São Paulo to Santa Cruz de la Sierra?

The earliest bus arriving in Santa Cruz de la Sierra from São Paulo starts at 1:00 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from São Paulo to Santa Cruz de la Sierra?

The latest bus trip departing from São Paulo for Santa Cruz de la Sierra starts at 1:00 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the São Paulo Santa Cruz de la Sierra route?

When traveling by bus from São Paulo to Santa Cruz de la Sierra, passengers can travel with La Preferida Bus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between São Paulo and Santa Cruz de la Sierra?

You can check all the direct connections between São Paulo and Santa Cruz de la Sierra by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: La Preferida Bus.

What can I take with me on the São Paulo to Santa Cruz de la Sierra bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the São Paulo Santa Cruz de la Sierra bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the São Paulo Santa Cruz de la Sierra bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from São Paulo to Santa Cruz de la Sierra on your planned travel date.

How does CheckMyBus find the best bus deals from São Paulo to Santa Cruz de la Sierra?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 1 daily trips between São Paulo and Santa Cruz de la Sierra. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from São Paulo to Santa Cruz de la Sierra?

Prices and availability for 1 trips between São Paulo and Santa Cruz de la Sierra change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route São Paulo to Santa Cruz de la Sierra

First Class
First

Best of the best: you will find the most comfortable accommodation to work or relax during your travel.

More bus routes to São Paulo and to Santa Cruz de la Sierra

Here’s an overview of the most popular bus routes to São Paulo and to Santa Cruz de la Sierra. Simply click on the connection of your choice, and you will find all the details about your bus route!
Palmeira dos Índios, AL to São Paulo bus Palmeira dos Índios, AL to São Paulo bus
Buses to São Paulo from Marabá, PA Buses to São Paulo from Marabá, PA
Buses São Vicente, SP to São Paulo Buses São Vicente, SP to São Paulo
Paulo Afonso, BA to São Paulo bus Paulo Afonso, BA to São Paulo bus
From Iquique to Santa Cruz de la Sierra bus From Iquique to Santa Cruz de la Sierra bus
From Villazón to Santa Cruz de la Sierra bus From Villazón to Santa Cruz de la Sierra bus
Buses from Tarija to Santa Cruz de la Sierra Buses from Tarija to Santa Cruz de la Sierra
Buses Uyuni - Santa Cruz de la Sierra Buses Uyuni - Santa Cruz de la Sierra
Popular Airport Shuttles to São Paulo and to Santa Cruz de la Sierra
CheckMyBus › Buses in Brazil › Bus to São Paulo › Bus to Santa Cruz de la Sierra

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