Bus Talca, ML to La Serena: Compare prices and save money

Compare all timetables for the bus from Talca, ML to La Serena

Here is a selection of the cheapest bus trips from the schedule from Talca, ML to La Serena from various bus operators like FlixBus or Turbus for the next days.

today

$16

tomorrow

$31

Saturday

$25

Sunday

$26

Monday

$18

Tuesday

Wednesday

$16

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	11h 0m	8:40 AM	Talca, ML	Cruce Varoli	7:40 PM	La Serena	Central Bus Station	Economy	$16	A Bus from FlixBus goes from Cruce Varoli, Talca, ML (Chile) at 11/6/2025 8:40:00 AM to Central Bus Station, La Serena (Chile) arriving at 11/6/2025 7:40:00 PM. 50 Economy ticket for $16 per person are available. Travel duration is 11h 0m
FlixBus	10h 45m	1:40 PM	Talca, ML	Cruce Varoli	12:25 AM	La Serena	Central Bus Station	Economy	$18	A Bus from FlixBus goes from Cruce Varoli, Talca, ML (Chile) at 11/6/2025 1:40:00 PM to Central Bus Station, La Serena (Chile) arriving at 11/7/2025 12:25:00 AM. 50 Economy ticket for $18 per person are available. Travel duration is 10h 45m
FlixBus	12h 25m	6:40 AM	Talca, ML	Cruce Varoli	7:05 PM	La Serena	Central Bus Station	Economy	$20	A Bus from FlixBus goes from Cruce Varoli, Talca, ML (Chile) at 11/6/2025 6:40:00 AM to Central Bus Station, La Serena (Chile) arriving at 11/6/2025 7:05:00 PM. 50 Economy ticket for $20 per person are available. Travel duration is 12h 25m
FlixBus	11h 5m	5:40 PM	Talca, ML	Cruce Varoli	4:45 AM	La Serena	Central Bus Station	Economy	$25	A Bus from FlixBus goes from Cruce Varoli, Talca, ML (Chile) at 11/6/2025 5:40:00 PM to Central Bus Station, La Serena (Chile) arriving at 11/7/2025 4:45:00 AM. 50 Economy ticket for $25 per person are available. Travel duration is 11h 5m

Cheapest bus trips tomorrow
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Turbus	10h 0m	12:10 PM	Talca, ML	Central Bus Station	10:10 PM	La Serena	Avda. Fco de Aguirre Station		Premium Economy	$31	A Bus from Turbus goes from Central Bus Station, Talca, ML (Chile) at 11/7/2025 12:10:00 PM to Avda. Fco de Aguirre Station, La Serena (Chile) arriving at 11/7/2025 10:10:00 PM. 50 Premium Economy ticket for $31 per person are available. Travel duration is 10h 0m

Did you know that if you travel from Talca, ML to La Serena via Viña del Mar, you can save more than $7? You can find the corresponding connections below.
- kupos.cl
  
  13h 40m
  
  0
  
  7:10 AM
  
  Talca, ML
  Central Bus Station
  
  12:05 PM
  
  Viña del Mar
  Libertad Bus Station
  
  0
  
  Premium Economy
  
  $16
  
  A Bus from kupos.cl goes from Central Bus Station, Talca, ML (Chile) at 11/8/2025 7:10:00 AM to Libertad Bus Station, Viña del Mar (Chile) arriving at 11/8/2025 12:05:00 PM. 50 Premium Economy ticket for $16 per person are available. Travel duration is 4h 55m
- kupos.cl
  
  6h 20m
  
  0
  
  2:30 PM
  
  Viña del Mar
  Libertad Bus Station
  
  8:50 PM
  
  La Serena
  Avda. Fco de Aguirre Station
  
  0
  
  Premium Economy
  
  $8
  
  A Bus from kupos.cl goes from Libertad Bus Station, Viña del Mar (Chile) at 11/8/2025 2:30:00 PM to Avda. Fco de Aguirre Station, La Serena (Chile) arriving at 11/8/2025 8:50:00 PM. 50 Premium Economy ticket for $8 per person are available. Travel duration is 6h 20m
Travel time is 3h 40m longer, but you will save $7

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	11h 0m	8:40 AM	Talca, ML	Cruce Varoli	7:40 PM	La Serena	Central Bus Station	Economy	$25	A Bus from FlixBus goes from Cruce Varoli, Talca, ML (Chile) at 11/8/2025 8:40:00 AM to Central Bus Station, La Serena (Chile) arriving at 11/8/2025 7:40:00 PM. 50 Economy ticket for $25 per person are available. Travel duration is 11h 0m
FlixBus	10h 45m	1:40 PM	Talca, ML	Cruce Varoli	12:25 AM	La Serena	Central Bus Station	Economy	$25	A Bus from FlixBus goes from Cruce Varoli, Talca, ML (Chile) at 11/8/2025 1:40:00 PM to Central Bus Station, La Serena (Chile) arriving at 11/9/2025 12:25:00 AM. 50 Economy ticket for $25 per person are available. Travel duration is 10h 45m
FlixBus	10h 20m	6:40 AM	Talca, ML	Cruce Varoli	5:00 PM	La Serena	Central Bus Station	Economy	$26	A Bus from FlixBus goes from Cruce Varoli, Talca, ML (Chile) at 11/8/2025 6:40:00 AM to Central Bus Station, La Serena (Chile) arriving at 11/8/2025 5:00:00 PM. 50 Economy ticket for $26 per person are available. Travel duration is 10h 20m
FlixBus	10h 20m	5:40 PM	Talca, ML	Cruce Varoli	4:00 AM	La Serena	Central Bus Station	Economy	$31	A Bus from FlixBus goes from Cruce Varoli, Talca, ML (Chile) at 11/8/2025 5:40:00 PM to Central Bus Station, La Serena (Chile) arriving at 11/9/2025 4:00:00 AM. 50 Economy ticket for $31 per person are available. Travel duration is 10h 20m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	10h 20m	6:40 AM	Talca, ML	Cruce Varoli	5:00 PM	La Serena	Central Bus Station	Economy	$26	A Bus from FlixBus goes from Cruce Varoli, Talca, ML (Chile) at 11/9/2025 6:40:00 AM to Central Bus Station, La Serena (Chile) arriving at 11/9/2025 5:00:00 PM. 50 Economy ticket for $26 per person are available. Travel duration is 10h 20m
FlixBus	11h 0m	8:40 AM	Talca, ML	Cruce Varoli	7:40 PM	La Serena	Central Bus Station	Economy	$26	A Bus from FlixBus goes from Cruce Varoli, Talca, ML (Chile) at 11/9/2025 8:40:00 AM to Central Bus Station, La Serena (Chile) arriving at 11/9/2025 7:40:00 PM. 50 Economy ticket for $26 per person are available. Travel duration is 11h 0m
FlixBus	10h 45m	10:40 AM	Talca, ML	Cruce Varoli	9:25 PM	La Serena	Central Bus Station	Economy	$26	A Bus from FlixBus goes from Cruce Varoli, Talca, ML (Chile) at 11/9/2025 10:40:00 AM to Central Bus Station, La Serena (Chile) arriving at 11/9/2025 9:25:00 PM. 50 Economy ticket for $26 per person are available. Travel duration is 10h 45m
Turbus	10h 0m	12:10 PM	Talca, ML	Central Bus Station	10:10 PM	La Serena	Avda. Fco de Aguirre Station	Premium Economy	$31	A Bus from Turbus goes from Central Bus Station, Talca, ML (Chile) at 11/9/2025 12:10:00 PM to Avda. Fco de Aguirre Station, La Serena (Chile) arriving at 11/9/2025 10:10:00 PM. 50 Premium Economy ticket for $31 per person are available. Travel duration is 10h 0m

Did you know that if you travel from Coquimbo to Talca, ML via La Serena, you can save more than $22? You will find the corresponding connections below.
- Save more than 85%
  
  0h 35m
  
  0 mi
  
  1:30 PM
  
  Coquimbo
  Bus Station
  
  2:05 PM
  
  La Serena
  El Sto, 1060
  
  378 mi
  
  Talca, ML
  
  Premium Economy
  
  $4
  
  A Bus from goes from Bus Station, Coquimbo (Chile) at 11/9/2025 1:30:00 PM to El Sto, 1060, La Serena (Chile) arriving at 11/9/2025 2:05:00 PM. 50 Premium Economy ticket for $4 per person are available. Travel duration is 0h 35m
Did you know that if you travel from Talca, ML to La Serena via Coquimbo, you can save more than $3? You can find the corresponding connections below.
- FlixBus
  
  11h 55m
  
  0
  
  8:40 AM
  
  Talca, ML
  Cruce Varoli
  
  7:15 PM
  
  Coquimbo
  Bus Station
  
  0
  
  Economy
  
  $18
  
  A Bus from FlixBus goes from Cruce Varoli, Talca, ML (Chile) at 11/10/2025 8:40:00 AM to Bus Station, Coquimbo (Chile) arriving at 11/10/2025 7:15:00 PM. 50 Economy ticket for $18 per person are available. Travel duration is 10h 35m
- kupos.cl
  
  0h 20m
  
  0
  
  8:15 PM
  
  Coquimbo
  Bus Station
  
  8:35 PM
  
  La Serena
  El Sto, 1060
  
  0
  
  First Class
  
  $6
  
  A Bus from kupos.cl goes from Bus Station, Coquimbo (Chile) at 11/10/2025 8:15:00 PM to El Sto, 1060, La Serena (Chile) arriving at 11/10/2025 8:35:00 PM. 50 First Class ticket for $6 per person are available. Travel duration is 0h 20m
Travel time is 1h 55m longer, but you will save $3

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	11h 0m	8:40 AM	Talca, ML	Cruce Varoli	7:40 PM	La Serena	Central Bus Station	Economy	$18	A Bus from FlixBus goes from Cruce Varoli, Talca, ML (Chile) at 11/10/2025 8:40:00 AM to Central Bus Station, La Serena (Chile) arriving at 11/10/2025 7:40:00 PM. 50 Economy ticket for $18 per person are available. Travel duration is 11h 0m
FlixBus	10h 45m	1:40 PM	Talca, ML	Cruce Varoli	12:25 AM	La Serena	Central Bus Station	Economy	$18	A Bus from FlixBus goes from Cruce Varoli, Talca, ML (Chile) at 11/10/2025 1:40:00 PM to Central Bus Station, La Serena (Chile) arriving at 11/11/2025 12:25:00 AM. 50 Economy ticket for $18 per person are available. Travel duration is 10h 45m
FlixBus	12h 25m	6:40 AM	Talca, ML	Cruce Varoli	7:05 PM	La Serena	Central Bus Station	Economy	$20	A Bus from FlixBus goes from Cruce Varoli, Talca, ML (Chile) at 11/10/2025 6:40:00 AM to Central Bus Station, La Serena (Chile) arriving at 11/10/2025 7:05:00 PM. 50 Economy ticket for $20 per person are available. Travel duration is 12h 25m
FlixBus	11h 5m	5:40 PM	Talca, ML	Cruce Varoli	4:45 AM	La Serena	Central Bus Station	Economy	$25	A Bus from FlixBus goes from Cruce Varoli, Talca, ML (Chile) at 11/10/2025 5:40:00 PM to Central Bus Station, La Serena (Chile) arriving at 11/11/2025 4:45:00 AM. 50 Economy ticket for $25 per person are available. Travel duration is 11h 5m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	11h 0m	8:40 AM	Talca, ML	Cruce Varoli	7:40 PM	La Serena	Central Bus Station	Economy	$16	A Bus from FlixBus goes from Cruce Varoli, Talca, ML (Chile) at 11/12/2025 8:40:00 AM to Central Bus Station, La Serena (Chile) arriving at 11/12/2025 7:40:00 PM. 50 Economy ticket for $16 per person are available. Travel duration is 11h 0m
FlixBus	10h 45m	1:40 PM	Talca, ML	Cruce Varoli	12:25 AM	La Serena	Central Bus Station	Economy	$18	A Bus from FlixBus goes from Cruce Varoli, Talca, ML (Chile) at 11/12/2025 1:40:00 PM to Central Bus Station, La Serena (Chile) arriving at 11/13/2025 12:25:00 AM. 50 Economy ticket for $18 per person are available. Travel duration is 10h 45m
FlixBus	12h 25m	6:40 AM	Talca, ML	Cruce Varoli	7:05 PM	La Serena	Central Bus Station	Economy	$20	A Bus from FlixBus goes from Cruce Varoli, Talca, ML (Chile) at 11/12/2025 6:40:00 AM to Central Bus Station, La Serena (Chile) arriving at 11/12/2025 7:05:00 PM. 50 Economy ticket for $20 per person are available. Travel duration is 12h 25m
FlixBus	11h 5m	5:40 PM	Talca, ML	Cruce Varoli	4:45 AM	La Serena	Central Bus Station	Economy	$25	A Bus from FlixBus goes from Cruce Varoli, Talca, ML (Chile) at 11/12/2025 5:40:00 PM to Central Bus Station, La Serena (Chile) arriving at 11/13/2025 4:45:00 AM. 50 Economy ticket for $25 per person are available. Travel duration is 11h 5m

Best Price Offer: The price for the cheapest bus from Talca, ML to La Serena is $16 on 11/4/2025. Flexible travelers save on ticket prices.

Frequency of bus connections between Talca, ML and La Serena

See here how frequent the connections between Talca, ML and La Serena are, during different times and days of the week.

Sunday is the busiest day, with more than 6 daily buses from Talca, ML to La Serena. Friday has instead the fewest connections, with only 1 daily coaches between Talca, ML and La Serena.

The busiest time of the day is the Afternoon, with 12 buses from Talca, ML to La Serena, while Morning sees the fewest connections between Talca, ML and La Serena, with 11 offers.

Facts about the bus from Talca, ML to La Serena

Compare all providers like FlixBus and Turbus that travel 3 times every day by bus from Talca, ML to La Serena in one click! Book your bus ticket from Talca, ML to La Serena starting from $16!

Cheapest Bus	$16
Fastest Bus	10h 0m
Earliest Bus	6:40 AM
Latest Bus	5:40 PM
Daily Bus Routes	3 Ø
Distance	382.3 miles
Bus Companies	FlixBus and Turbus

Cheapest bus connections from Talca, ML to La Serena

Every day, 3 buses from 2 bus companies leave Talca, ML for La Serena: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 11/06/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 11/02

Monday 11/03

Tuesday 11/04

Wednesday 11/05

Thursday 11/06

$16

Friday 11/07

$31

Saturday 11/08

$25

Sunday 11/09

$31

Monday 11/10

$18

Tuesday 11/11

Wednesday 11/12

$16

Thursday 11/13

Friday 11/14

Saturday 11/15

Sunday 11/16

Monday 11/17

Tuesday 11/18

Wednesday 11/19

Thursday 11/20

Friday 11/21

Saturday 11/22

Sunday 11/23

Monday 11/24

Tuesday 11/25

Wednesday 11/26

Thursday 11/27

$20

Friday 11/28

Saturday 11/29

The cheapest time to travel from Talca, ML to La Serena

See here on which day and which time of the day you can find the cheapest bus ticket from Talca, ML to La Serena, for the next 30 days.

With a price starting from $16, Wednesday is the cheapest day for a bus from Talca, ML to La Serena. Friday instead is the most expensive day with prices starting from $31.

Morning is the cheapest day time for bus tickets from Talca, ML to La Serena, with $16. Afternoon is the most expensive time of the day with prices starting from $18.

How to save money travelling from Talca, ML to La Serena

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Talca, ML to La Serena in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Talca, ML to La Serena, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Talca, ML to La Serena are also emptier.

All bus stations and stops in Talca, ML and La Serena

In the map below, you can see where to find all bus stations in Talca, ML and La Serena.

Central Bus Station

Dos Sur 1932

Cruce Varoli

Calle 1 Norte / 18 ote

Terminal

Cruce Ruta 5

Avda. Fco de Aguirre Station

Avenida Francisco de Aguirre 410

Central Bus Station

Avenida El Santo 1475

terminal de buses covalle bus

Cienfuegos

Corsario

Service and Comfort on the bus from Talca, ML to La Serena

Want to know which seat classes are available on the buses from Talca, ML to La Serena? Or which bus companies serve the route Talca, ML to La Serena? Below you will find answers to your questions.

FAQs about the Talca, ML to La Serena bus

How much does a Talca, ML La Serena bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $16 and takes 11h 0m to reach La Serena. Compare offers to save money!

How much could I save by comparing buses from Talca, ML to La Serena?

This route is offered by 2 companies with a range of ticket prices between $16 and $31. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to La Serena.

On average, how many connections are available from Talca, ML to La Serena each day?

Every day, the Talca, ML to La Serena bus route is served by approximately 3 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Talca, ML to La Serena take?

The fastest bus from Talca, ML to La Serena is offered by Turbus and takes 10h 0m. Bus tickets for this connection cost $31. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Talca, ML to La Serena?

The earliest bus arriving in La Serena from Talca, ML starts at 6:40 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Talca, ML to La Serena?

The latest bus trip departing from Talca, ML for La Serena starts at 5:40 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Talca, ML La Serena route?

When traveling by bus from Talca, ML to La Serena, passengers can travel with FlixBus and Turbus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Talca, ML and La Serena?

You can check all the direct connections between Talca, ML and La Serena by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Turbus.

What can I take with me on the Talca, ML to La Serena bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Talca, ML La Serena bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Talca, ML La Serena bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Talca, ML to La Serena on your planned travel date.

Available seat classes which are offered on the bus route Talca, ML to La Serena

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

Premium Economy

A mix between Economy and Business, it offers extra legroom, WI-FI and possible snacks.

More bus routes to Talca, ML and to La Serena

Here’s an overview of the most popular bus routes to Talca, ML and to La Serena. Simply click on the connection of your choice, and you will find all the details about your bus route!