Bus Chicago to Santiago de Queretaro

Compare all timetables for the bus from Chicago to Santiago de Queretaro

Here is a selection of the cheapest bus trips from the schedule from Chicago to Santiago de Queretaro from various bus operators like Greyhound US or FlixBus for the next days.

today

tomorrow

$147

Tuesday

$147

Wednesday

$134

Thursday

$134

Friday

Saturday

$140

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	51h 0m	9:45 AM	Chicago	Downtown Bus Station	12:45 PM	Santiago de Queretaro	Prol Zaragoza Y City Club Las Plazas Bus Stop	Economy	$147	A Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 11/2/2026 9:45:00 AM to Prol Zaragoza Y City Club Las Plazas Bus Stop, Santiago de Queretaro (Mexico) arriving at 11/4/2026 12:45:00 PM. 50 Economy ticket for $147 per person are available. Travel duration is 51h 0m
Greyhound US	56h 45m	9:55 AM	Chicago	Downtown Bus Station	6:40 PM	Santiago de Queretaro	Prol Zaragoza Y City Club Las Plazas Bus Stop	Economy	$148	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 11/2/2026 9:55:00 AM to Prol Zaragoza Y City Club Las Plazas Bus Stop, Santiago de Queretaro (Mexico) arriving at 11/4/2026 6:40:00 PM. 50 Economy ticket for $148 per person are available. Travel duration is 56h 45m
Greyhound US	56h 25m	10:15 AM	Chicago	Canal & Van Buren	6:40 PM	Santiago de Queretaro	Prol Zaragoza Y City Club Las Plazas Bus Stop	Economy	$148	A Bus from Greyhound US goes from Canal & Van Buren, Chicago (USA) at 11/2/2026 10:15:00 AM to Prol Zaragoza Y City Club Las Plazas Bus Stop, Santiago de Queretaro (Mexico) arriving at 11/4/2026 6:40:00 PM. 50 Economy ticket for $148 per person are available. Travel duration is 56h 25m
Greyhound US	46h 0m	10:30 PM	Chicago	Downtown Bus Station	8:30 PM	Santiago de Queretaro	Prol Zaragoza Y City Club Las Plazas Bus Stop	Economy	$150	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 11/2/2026 10:30:00 PM to Prol Zaragoza Y City Club Las Plazas Bus Stop, Santiago de Queretaro (Mexico) arriving at 11/4/2026 8:30:00 PM. 50 Economy ticket for $150 per person are available. Travel duration is 46h 0m
FlixBus	55h 0m	5:45 AM	Chicago	95th Red Line Station	12:45 PM	Santiago de Queretaro	Prol Zaragoza Y City Club Las Plazas Bus Stop	Economy	$211	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 11/2/2026 5:45:00 AM to Prol Zaragoza Y City Club Las Plazas Bus Stop, Santiago de Queretaro (Mexico) arriving at 11/4/2026 12:45:00 PM. 50 Economy ticket for $211 per person are available. Travel duration is 55h 0m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	56h 45m	9:55 AM	Chicago	Downtown Bus Station	6:40 PM	Santiago de Queretaro	Prol Zaragoza Y City Club Las Plazas Bus Stop	Economy	$147	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 11/3/2026 9:55:00 AM to Prol Zaragoza Y City Club Las Plazas Bus Stop, Santiago de Queretaro (Mexico) arriving at 11/5/2026 6:40:00 PM. 50 Economy ticket for $147 per person are available. Travel duration is 56h 45m
Greyhound US	51h 40m	10:30 PM	Chicago	Downtown Bus Station	2:10 AM	Santiago de Queretaro	Prol Zaragoza Y City Club Las Plazas Bus Stop	Economy	$147	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 11/3/2026 10:30:00 PM to Prol Zaragoza Y City Club Las Plazas Bus Stop, Santiago de Queretaro (Mexico) arriving at 11/6/2026 2:10:00 AM. 50 Economy ticket for $147 per person are available. Travel duration is 51h 40m
Greyhound US	56h 25m	10:15 AM	Chicago	Canal & Van Buren	6:40 PM	Santiago de Queretaro	Prol Zaragoza Y City Club Las Plazas Bus Stop	Economy	$147	A Bus from Greyhound US goes from Canal & Van Buren, Chicago (USA) at 11/3/2026 10:15:00 AM to Prol Zaragoza Y City Club Las Plazas Bus Stop, Santiago de Queretaro (Mexico) arriving at 11/5/2026 6:40:00 PM. 50 Economy ticket for $147 per person are available. Travel duration is 56h 25m
FlixBus	60h 55m	5:45 AM	Chicago	95th Red Line Station	6:40 PM	Santiago de Queretaro	Prol Zaragoza Y City Club Las Plazas Bus Stop	Economy	$213	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 11/3/2026 5:45:00 AM to Prol Zaragoza Y City Club Las Plazas Bus Stop, Santiago de Queretaro (Mexico) arriving at 11/5/2026 6:40:00 PM. 50 Economy ticket for $213 per person are available. Travel duration is 60h 55m
FlixBus	57h 35m	4:35 PM	Chicago	95th Red Line Station	2:10 AM	Santiago de Queretaro	Prol Zaragoza Y City Club Las Plazas Bus Stop	Economy	$213	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 11/3/2026 4:35:00 PM to Prol Zaragoza Y City Club Las Plazas Bus Stop, Santiago de Queretaro (Mexico) arriving at 11/6/2026 2:10:00 AM. 50 Economy ticket for $213 per person are available. Travel duration is 57h 35m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	46h 0m	10:30 PM	Chicago	Downtown Bus Station	8:30 PM	Santiago de Queretaro	Prol Zaragoza Y City Club Las Plazas Bus Stop	Economy	$134	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 11/4/2026 10:30:00 PM to Prol Zaragoza Y City Club Las Plazas Bus Stop, Santiago de Queretaro (Mexico) arriving at 11/6/2026 8:30:00 PM. 50 Economy ticket for $134 per person are available. Travel duration is 46h 0m
Greyhound US	56h 45m	9:55 AM	Chicago	Downtown Bus Station	6:40 PM	Santiago de Queretaro	Prol Zaragoza Y City Club Las Plazas Bus Stop	Economy	$135	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 11/4/2026 9:55:00 AM to Prol Zaragoza Y City Club Las Plazas Bus Stop, Santiago de Queretaro (Mexico) arriving at 11/6/2026 6:40:00 PM. 50 Economy ticket for $135 per person are available. Travel duration is 56h 45m
Greyhound US	56h 25m	10:15 AM	Chicago	Canal & Van Buren	6:40 PM	Santiago de Queretaro	Prol Zaragoza Y City Club Las Plazas Bus Stop	Economy	$135	A Bus from Greyhound US goes from Canal & Van Buren, Chicago (USA) at 11/4/2026 10:15:00 AM to Prol Zaragoza Y City Club Las Plazas Bus Stop, Santiago de Queretaro (Mexico) arriving at 11/6/2026 6:40:00 PM. 50 Economy ticket for $135 per person are available. Travel duration is 56h 25m
FlixBus	51h 55m	4:35 PM	Chicago	95th Red Line Station	8:30 PM	Santiago de Queretaro	Prol Zaragoza Y City Club Las Plazas Bus Stop	Economy	$211	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 11/4/2026 4:35:00 PM to Prol Zaragoza Y City Club Las Plazas Bus Stop, Santiago de Queretaro (Mexico) arriving at 11/6/2026 8:30:00 PM. 50 Economy ticket for $211 per person are available. Travel duration is 51h 55m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	46h 0m	10:30 PM	Chicago	Downtown Bus Station	8:30 PM	Santiago de Queretaro	Prol Zaragoza Y City Club Las Plazas Bus Stop	Economy	$134	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 11/5/2026 10:30:00 PM to Prol Zaragoza Y City Club Las Plazas Bus Stop, Santiago de Queretaro (Mexico) arriving at 11/7/2026 8:30:00 PM. 50 Economy ticket for $134 per person are available. Travel duration is 46h 0m
FlixBus	48h 20m	9:45 AM	Chicago	Downtown Bus Station	10:05 AM	Santiago de Queretaro	Prol Zaragoza Y City Club Las Plazas Bus Stop	Economy	$135	A Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 11/5/2026 9:45:00 AM to Prol Zaragoza Y City Club Las Plazas Bus Stop, Santiago de Queretaro (Mexico) arriving at 11/7/2026 10:05:00 AM. 50 Economy ticket for $135 per person are available. Travel duration is 48h 20m
Greyhound US	56h 45m	9:55 AM	Chicago	Downtown Bus Station	6:40 PM	Santiago de Queretaro	Prol Zaragoza Y City Club Las Plazas Bus Stop	Economy	$135	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 11/5/2026 9:55:00 AM to Prol Zaragoza Y City Club Las Plazas Bus Stop, Santiago de Queretaro (Mexico) arriving at 11/7/2026 6:40:00 PM. 50 Economy ticket for $135 per person are available. Travel duration is 56h 45m
Greyhound US	56h 25m	10:15 AM	Chicago	Canal & Van Buren	6:40 PM	Santiago de Queretaro	Prol Zaragoza Y City Club Las Plazas Bus Stop	Economy	$135	A Bus from Greyhound US goes from Canal & Van Buren, Chicago (USA) at 11/5/2026 10:15:00 AM to Prol Zaragoza Y City Club Las Plazas Bus Stop, Santiago de Queretaro (Mexico) arriving at 11/7/2026 6:40:00 PM. 50 Economy ticket for $135 per person are available. Travel duration is 56h 25m
FlixBus	51h 55m	4:35 PM	Chicago	95th Red Line Station	8:30 PM	Santiago de Queretaro	Prol Zaragoza Y City Club Las Plazas Bus Stop	Economy	$211	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 11/5/2026 4:35:00 PM to Prol Zaragoza Y City Club Las Plazas Bus Stop, Santiago de Queretaro (Mexico) arriving at 11/7/2026 8:30:00 PM. 50 Economy ticket for $211 per person are available. Travel duration is 51h 55m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	46h 0m	10:30 PM	Chicago	Downtown Bus Station	8:30 PM	Santiago de Queretaro	Prol Zaragoza Y City Club Las Plazas Bus Stop	Economy	$140	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 11/7/2026 10:30:00 PM to Prol Zaragoza Y City Club Las Plazas Bus Stop, Santiago de Queretaro (Mexico) arriving at 11/9/2026 8:30:00 PM. 50 Economy ticket for $140 per person are available. Travel duration is 46h 0m
FlixBus	48h 20m	9:45 AM	Chicago	Downtown Bus Station	10:05 AM	Santiago de Queretaro	Prol Zaragoza Y City Club Las Plazas Bus Stop	Economy	$142	A Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 11/7/2026 9:45:00 AM to Prol Zaragoza Y City Club Las Plazas Bus Stop, Santiago de Queretaro (Mexico) arriving at 11/9/2026 10:05:00 AM. 50 Economy ticket for $142 per person are available. Travel duration is 48h 20m
Greyhound US	56h 45m	9:55 AM	Chicago	Downtown Bus Station	6:40 PM	Santiago de Queretaro	Prol Zaragoza Y City Club Las Plazas Bus Stop	Economy	$149	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 11/7/2026 9:55:00 AM to Prol Zaragoza Y City Club Las Plazas Bus Stop, Santiago de Queretaro (Mexico) arriving at 11/9/2026 6:40:00 PM. 50 Economy ticket for $149 per person are available. Travel duration is 56h 45m
Greyhound US	56h 25m	10:15 AM	Chicago	Canal & Van Buren	6:40 PM	Santiago de Queretaro	Prol Zaragoza Y City Club Las Plazas Bus Stop	Economy	$149	A Bus from Greyhound US goes from Canal & Van Buren, Chicago (USA) at 11/7/2026 10:15:00 AM to Prol Zaragoza Y City Club Las Plazas Bus Stop, Santiago de Queretaro (Mexico) arriving at 11/9/2026 6:40:00 PM. 50 Economy ticket for $149 per person are available. Travel duration is 56h 25m
FlixBus	51h 55m	4:35 PM	Chicago	95th Red Line Station	8:30 PM	Santiago de Queretaro	Prol Zaragoza Y City Club Las Plazas Bus Stop	Economy	$208	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 11/7/2026 4:35:00 PM to Prol Zaragoza Y City Club Las Plazas Bus Stop, Santiago de Queretaro (Mexico) arriving at 11/9/2026 8:30:00 PM. 50 Economy ticket for $208 per person are available. Travel duration is 51h 55m

Best Price Offer: The price for the cheapest bus from Chicago to Santiago de Queretaro is $129 on 11/9/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Chicago and Santiago de Queretaro

See here how frequent the connections between Chicago and Santiago de Queretaro are, during different times and days of the week.

Saturday is the busiest day, with more than 10 daily buses from Chicago to Santiago de Queretaro. Tuesday has instead the fewest connections, with only 6 daily coaches between Chicago and Santiago de Queretaro.

The busiest time of the day is the Morning, with 17 buses from Chicago to Santiago de Queretaro, while Night sees the fewest connections between Chicago and Santiago de Queretaro, with 4 offers.

Facts about the bus from Chicago to Santiago de Queretaro

Compare all providers like Greyhound US and FlixBus that travel 8 times every day by bus from Chicago to Santiago de Queretaro in one click! Book your bus ticket from Chicago to Santiago de Queretaro starting from $129!

Cheapest Bus	$129
Fastest Bus	46h 0m
Earliest Bus	5:45 AM
Latest Bus	11:55 PM
Daily Bus Routes	8 Ø
Distance	1,648.5 miles
Bus Companies	Greyhound US and FlixBus

Cheapest bus connections from Chicago to Santiago de Queretaro

Every day, 8 buses from 2 bus companies leave Chicago for Santiago de Queretaro: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 11/01/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 11/01

Monday 11/02

$147

Tuesday 11/03

$147

Wednesday 11/04

$134

Thursday 11/05

$134

Friday 11/06

Saturday 11/07

$140

Sunday 11/08

Monday 11/09

$129

Tuesday 11/10

$139

Wednesday 11/11

$164

Thursday 11/12

Friday 11/13

Saturday 11/14

$143

Sunday 11/15

$149

Monday 11/16

Tuesday 11/17

$145

Wednesday 11/18

Thursday 11/19

$179

Friday 11/20

$149

Saturday 11/21

$178

Sunday 11/22

Monday 11/23

$199

Tuesday 11/24

$190

Wednesday 11/25

$202

Thursday 11/26

$177

Friday 11/27

$188

Saturday 11/28

The cheapest time to travel from Chicago to Santiago de Queretaro

See here on which day and which time of the day you can find the cheapest bus ticket from Chicago to Santiago de Queretaro, for the next 30 days.

With a price starting from $129, Monday is the cheapest day for a bus from Chicago to Santiago de Queretaro. Saturday instead is the most expensive day with prices starting from $140.

Night is the cheapest day time for bus tickets from Chicago to Santiago de Queretaro, with $129. Afternoon is the most expensive time of the day with prices starting from $208.

How to save money travelling from Chicago to Santiago de Queretaro

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Chicago to Santiago de Queretaro in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Chicago to Santiago de Queretaro, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Chicago to Santiago de Queretaro are also emptier.

Beloved bus companies from Chicago to Santiago de Queretaro

These are the most booked bus companies between Chicago to Santiago de Queretaro from our users.

FlixBus from Chicago to Santiago de Queretaro

Here you will find the key facts about the FlixBus bus route Chicago to Santiago de Queretaro:

Cheapest Price	$135
Fastest Bus	48h 20m
Earliest Bus	5:45 AM
Last Bus	11:55 PM
Daily Connections	2 Ø
Found on	10/8/2026

All bus stations and stops in Chicago and Santiago de Queretaro

In the map below, you can see where to find all bus stations in Chicago and Santiago de Queretaro.

95th Red Line Station

W. 95th St 14

Downtown Bus Station

West Harrison Street 630-670

Union Station

S Canal St 225

Cumberland CTA

N Cumberland Ave 5800

Canal & Van Buren

S Canal St 310-320

Bus Station

Terminal de Autobuses

Centro Comercial Galeria

Prolongación Avenida Zaragoza 61

Terminal Norte

Av. 5 de Febrero 1400

Walmart Juriquilla

El Colorado

Service and Comfort on the bus from Chicago to Santiago de Queretaro

Want to know which seat classes are available on the buses from Chicago to Santiago de Queretaro? Or which bus companies serve the route Chicago to Santiago de Queretaro? Below you will find answers to your questions.

FAQs about the Chicago to Santiago de Queretaro bus

How much does a Chicago Santiago de Queretaro bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $129 and takes 46h 0m to reach Santiago de Queretaro. Compare offers to save money!

How much could I save by comparing buses from Chicago to Santiago de Queretaro?

This route is offered by 2 companies with a range of ticket prices between $129 and $231. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Santiago de Queretaro.

On average, how many connections are available from Chicago to Santiago de Queretaro each day?

Every day, the Chicago to Santiago de Queretaro bus route is served by approximately 8 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Chicago to Santiago de Queretaro take?

The fastest bus from Chicago to Santiago de Queretaro is offered by Greyhound US and takes 46h 0m. Bus tickets for this connection cost $150. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Chicago to Santiago de Queretaro?

The earliest bus arriving in Santiago de Queretaro from Chicago starts at 5:45 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Chicago to Santiago de Queretaro?

The latest bus trip departing from Chicago for Santiago de Queretaro starts at 11:55 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Chicago Santiago de Queretaro route?

When traveling by bus from Chicago to Santiago de Queretaro, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Chicago and Santiago de Queretaro?

You can check all the direct connections between Chicago and Santiago de Queretaro by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the Chicago to Santiago de Queretaro bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Chicago Santiago de Queretaro bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Chicago Santiago de Queretaro bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Chicago to Santiago de Queretaro on your planned travel date.

How does CheckMyBus find the best bus deals from Chicago to Santiago de Queretaro?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 8 daily trips between Chicago and Santiago de Queretaro. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Chicago to Santiago de Queretaro?

Prices and availability for 8 trips between Chicago and Santiago de Queretaro change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Chicago to Santiago de Queretaro

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Chicago and to Santiago de Queretaro

Here’s an overview of the most popular bus routes to Chicago and to Santiago de Queretaro. Simply click on the connection of your choice, and you will find all the details about your bus route!