Which bus from Chicago to Santiago de Queretaro is the cheapest?

Compare all bus companies and find the best price: Bus tickets from $221
The Best Deals Save up to 70%
The Most Choices Millions of routes worldwide
Easy and Transparent Compare offers with 1 click

Compare all timetables for the bus from Chicago to Santiago de Queretaro

Here is a selection of the cheapest bus trips from the schedule from Chicago to Santiago de Queretaro from various bus operators like Greyhound US or FlixBus for the next days.

today
$223
tomorrow
Wednesday
Thursday
Friday
Saturday
$221
Sunday

Cheapest bus trips today

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 45h 30m 10:30 PM Chicago Downtown Bus Station 8:00 PM Santiago de Queretaro Centro Comercial Galeria  Economy $223
Greyhound US 56h 40m 10:00 AM Chicago Union Station 6:40 PM Santiago de Queretaro Centro Comercial Galeria  Economy $223
Greyhound US 67h 30m 11:10 PM Chicago Union Station 6:40 PM Santiago de Queretaro Centro Comercial Galeria  Economy $223
FlixBus 56h 55m 9:45 AM Chicago Downtown Bus Station 6:40 PM Santiago de Queretaro Centro Comercial Galeria  Economy $225

Cheapest bus trips Saturday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 45h 30m 10:30 PM Chicago Downtown Bus Station 8:00 PM Santiago de Queretaro Centro Comercial Galeria  Economy $221
FlixBus 47h 45m 9:45 AM Chicago Downtown Bus Station 9:30 AM Santiago de Queretaro Centro Comercial Galeria  Economy $224
Greyhound US 58h 20m 11:10 PM Chicago Union Station 9:30 AM Santiago de Queretaro Centro Comercial Galeria  Economy $225
Greyhound US 56h 40m 10:00 AM Chicago Union Station 6:40 PM Santiago de Queretaro Centro Comercial Galeria  Economy $229

Best Price Offer: The price for the cheapest bus from Chicago to Santiago de Queretaro is $221 on 1/24/2026. Flexible travelers save on ticket prices.


Frequency of bus connections between Chicago and Santiago de Queretaro

See here how frequent the connections between Chicago and Santiago de Queretaro are, during different times and days of the week.
Monday is the busiest day, with more than 4 daily buses from Chicago to Santiago de Queretaro. Monday has instead the fewest connections, with only 4 daily coaches between Chicago and Santiago de Queretaro.
The busiest time of the day is the Morning, with 4 buses from Chicago to Santiago de Queretaro, while Morning sees the fewest connections between Chicago and Santiago de Queretaro, with 4 offers.

Facts about the bus from Chicago to Santiago de Queretaro

Compare all providers like Greyhound US and FlixBus that travel 4 times every day by bus from Chicago to Santiago de Queretaro in one click! Book your bus ticket from Chicago to Santiago de Queretaro starting from $221!

Cheapest Bus $221
Fastest Bus 45h 30m
Earliest Bus 9:45 AM
Latest Bus 11:10 PM
Daily Bus Routes 4 Ø
Distance 1,648.5 miles
Bus Companies Greyhound US and FlixBus

Cheapest bus connections from Chicago to Santiago de Queretaro

Every day, 4 buses from 2 bus companies leave Chicago for Santiago de Queretaro: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 01/19/2026 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 01/18
Monday 01/19
$223
Tuesday 01/20
Wednesday 01/21
Thursday 01/22
Friday 01/23
Saturday 01/24
$221
Sunday 01/25
Monday 01/26
$221
Tuesday 01/27
Wednesday 01/28
Thursday 01/29
Friday 01/30
Saturday 01/31
Sunday 02/01
Monday 02/02
Tuesday 02/03
Wednesday 02/04
Thursday 02/05
Friday 02/06
Saturday 02/07
Sunday 02/08
Monday 02/09
Tuesday 02/10
Wednesday 02/11
Thursday 02/12
Friday 02/13
Saturday 02/14

The cheapest time to travel from Chicago to Santiago de Queretaro

See here on which day and which time of the day you can find the cheapest bus ticket from Chicago to Santiago de Queretaro, for the next 30 days.
With a price starting from $221, Monday is the cheapest day for a bus from Chicago to Santiago de Queretaro. Monday instead is the most expensive day with prices starting from $221.
Evening is the cheapest day time for bus tickets from Chicago to Santiago de Queretaro, with $221. Morning is the most expensive time of the day with prices starting from $223.

How to save money travelling from Chicago to Santiago de Queretaro

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Chicago to Santiago de Queretaro in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Chicago to Santiago de Queretaro, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Chicago to Santiago de Queretaro are also emptier.

Beloved bus companies from Chicago to Santiago de Queretaro

These are the most booked bus companies between Chicago to Santiago de Queretaro from our users.

FlixBus from Chicago to Santiago de Queretaro

FlixBus

Here you will find the key facts about the FlixBus bus route Chicago to Santiago de Queretaro:

Cheapest Price $224
Fastest Bus 47h 45m
Earliest Bus 9:45 AM
Last Bus 9:45 AM
Daily Connections 1 Ø
Found on 1/16/2026

All bus stations and stops in Chicago and Santiago de Queretaro

In the map below, you can see where to find all bus stations in Chicago and Santiago de Queretaro.

Service and Comfort on the bus from Chicago to Santiago de Queretaro

Want to know which seat classes are available on the buses from Chicago to Santiago de Queretaro? Or which bus companies serve the route Chicago to Santiago de Queretaro? Below you will find answers to your questions.

FAQs about the Chicago to Santiago de Queretaro bus

How much does a Chicago Santiago de Queretaro bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $221 and takes 45h 30m to reach Santiago de Queretaro. Compare offers to save money!

How much could I save by comparing buses from Chicago to Santiago de Queretaro?

This route is offered by 2 companies with a range of ticket prices between $221 and $229. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Santiago de Queretaro.

On average, how many connections are available from Chicago to Santiago de Queretaro each day?

Every day, the Chicago to Santiago de Queretaro bus route is served by approximately 4 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Chicago to Santiago de Queretaro take?

The fastest bus from Chicago to Santiago de Queretaro is offered by Greyhound US and takes 45h 30m. Bus tickets for this connection cost $223. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Chicago to Santiago de Queretaro?

The earliest bus arriving in Santiago de Queretaro from Chicago starts at 9:45 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Chicago to Santiago de Queretaro?

The latest bus trip departing from Chicago for Santiago de Queretaro starts at 11:10 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Chicago Santiago de Queretaro route?

When traveling by bus from Chicago to Santiago de Queretaro, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Chicago and Santiago de Queretaro?

You can check all the direct connections between Chicago and Santiago de Queretaro by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the Chicago to Santiago de Queretaro bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Chicago Santiago de Queretaro bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Chicago Santiago de Queretaro bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Chicago to Santiago de Queretaro on your planned travel date.

How does CheckMyBus find the best bus deals from Chicago to Santiago de Queretaro?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 4 daily trips between Chicago and Santiago de Queretaro. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Chicago to Santiago de Queretaro?

Prices and availability for 4 trips between Chicago and Santiago de Queretaro change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Chicago to Santiago de Queretaro

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Chicago and to Santiago de Queretaro

Here’s an overview of the most popular bus routes to Chicago and to Santiago de Queretaro. Simply click on the connection of your choice, and you will find all the details about your bus route!
Bus from New York to Chicago Bus from New York to Chicago
From Madison, WI to Chicago bus From Madison, WI to Chicago bus
Buses Milwaukee to Chicago Buses Milwaukee to Chicago
From Detroit to Chicago bus From Detroit to Chicago bus
Buses Guadalajara, JC - Santiago de Queretaro Buses Guadalajara, JC - Santiago de Queretaro
Buses San Luis Potosí - Santiago de Queretaro Buses San Luis Potosí - Santiago de Queretaro
Bus to Santiago de Queretaro from Morelia Bus to Santiago de Queretaro from Morelia
San Antonio, TX to Santiago de Queretaro bus San Antonio, TX to Santiago de Queretaro bus
Popular Airport Shuttles to Chicago and to Santiago de Queretaro
CheckMyBus › Buses in USA › Bus to Chicago › Bus to Santiago de Queretaro

The CheckMyBus App

Free Download

App Store
CheckMyBus App
Close
GPDR CheckMyBus shield

We value your privacy!

To

show

you

the

best

bus

offers,

we

and

our

partners

use

technical,

analytical,

and

marketing

cookies

to

personalize

the

ads.

We

remember

your

anonymized

details

to

provide

a

personalized

experience.