Bus Florence, SC to Philadelphia - Compare all Companies

Compare all timetables for the bus from Florence, SC to Philadelphia

Here is a selection of the cheapest bus trips from the schedule from Florence, SC to Philadelphia from various bus operators like Greyhound US or FlixBus for the next days.

today

$75

tomorrow

$70

Saturday

$75

Sunday

$70

Monday

$66

Tuesday

Wednesday

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	14h 15m	4:30 PM	Florence, SC	Bus Station	6:45 AM	Philadelphia	Convention Center	Economy	$75	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 4/30/2026 4:30:00 PM to Convention Center, Philadelphia (USA) arriving at 5/1/2026 6:45:00 AM. 50 Economy ticket for $75 per person are available. Travel duration is 14h 15m
Greyhound US	16h 15m	4:30 PM	Florence, SC	Bus Station	8:45 AM	Philadelphia	Spring Garden St Station	Economy	$75	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 4/30/2026 4:30:00 PM to Spring Garden St Station, Philadelphia (USA) arriving at 5/1/2026 8:45:00 AM. 50 Economy ticket for $75 per person are available. Travel duration is 16h 15m
Greyhound US	18h 30m	4:30 PM	Florence, SC	Bus Station	11:00 AM	Philadelphia	Schuylkill Ave and Walnut Street	Economy	$78	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 4/30/2026 4:30:00 PM to Schuylkill Ave and Walnut Street, Philadelphia (USA) arriving at 5/1/2026 11:00:00 AM. 50 Economy ticket for $78 per person are available. Travel duration is 18h 30m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	14h 15m	4:30 PM	Florence, SC	Bus Station	6:45 AM	Philadelphia	Convention Center	Economy	$70	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 5/1/2026 4:30:00 PM to Convention Center, Philadelphia (USA) arriving at 5/2/2026 6:45:00 AM. 50 Economy ticket for $70 per person are available. Travel duration is 14h 15m
Greyhound US	16h 15m	4:30 PM	Florence, SC	Bus Station	8:45 AM	Philadelphia	Spring Garden St Station	Economy	$70	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 5/1/2026 4:30:00 PM to Spring Garden St Station, Philadelphia (USA) arriving at 5/2/2026 8:45:00 AM. 50 Economy ticket for $70 per person are available. Travel duration is 16h 15m
Greyhound US	18h 30m	4:30 PM	Florence, SC	Bus Station	11:00 AM	Philadelphia	Schuylkill Ave and Walnut Street	Economy	$73	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 5/1/2026 4:30:00 PM to Schuylkill Ave and Walnut Street, Philadelphia (USA) arriving at 5/2/2026 11:00:00 AM. 50 Economy ticket for $73 per person are available. Travel duration is 18h 30m
FlixBus	15h 0m	12:05 AM	Florence, SC	TA Travel Center	3:05 PM	Philadelphia	Spring Garden St Station	Economy	$74	A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 5/1/2026 12:05:00 AM to Spring Garden St Station, Philadelphia (USA) arriving at 5/1/2026 3:05:00 PM. 50 Economy ticket for $74 per person are available. Travel duration is 15h 0m
FlixBus	11h 40m	12:05 AM	Florence, SC	TA Travel Center	11:45 AM	Philadelphia	Spring Garden St Station	Economy	$74	A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 5/1/2026 12:05:00 AM to Spring Garden St Station, Philadelphia (USA) arriving at 5/1/2026 11:45:00 AM. 50 Economy ticket for $74 per person are available. Travel duration is 11h 40m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	14h 15m	4:30 PM	Florence, SC	Bus Station	6:45 AM	Philadelphia	Convention Center	Economy	$75	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 5/2/2026 4:30:00 PM to Convention Center, Philadelphia (USA) arriving at 5/3/2026 6:45:00 AM. 50 Economy ticket for $75 per person are available. Travel duration is 14h 15m
Greyhound US	16h 15m	4:30 PM	Florence, SC	Bus Station	8:45 AM	Philadelphia	Spring Garden St Station	Economy	$76	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 5/2/2026 4:30:00 PM to Spring Garden St Station, Philadelphia (USA) arriving at 5/3/2026 8:45:00 AM. 50 Economy ticket for $76 per person are available. Travel duration is 16h 15m
Greyhound US	18h 30m	4:30 PM	Florence, SC	Bus Station	11:00 AM	Philadelphia	Schuylkill Ave and Walnut Street	Economy	$78	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 5/2/2026 4:30:00 PM to Schuylkill Ave and Walnut Street, Philadelphia (USA) arriving at 5/3/2026 11:00:00 AM. 50 Economy ticket for $78 per person are available. Travel duration is 18h 30m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	14h 15m	4:30 PM	Florence, SC	Bus Station	6:45 AM	Philadelphia	Convention Center	Economy	$70	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 5/3/2026 4:30:00 PM to Convention Center, Philadelphia (USA) arriving at 5/4/2026 6:45:00 AM. 50 Economy ticket for $70 per person are available. Travel duration is 14h 15m
Greyhound US	16h 15m	4:30 PM	Florence, SC	Bus Station	8:45 AM	Philadelphia	Spring Garden St Station	Economy	$70	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 5/3/2026 4:30:00 PM to Spring Garden St Station, Philadelphia (USA) arriving at 5/4/2026 8:45:00 AM. 50 Economy ticket for $70 per person are available. Travel duration is 16h 15m
Greyhound US	19h 0m	4:30 PM	Florence, SC	Bus Station	11:30 AM	Philadelphia	Schuylkill Ave and Walnut Street	Economy	$73	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 5/3/2026 4:30:00 PM to Schuylkill Ave and Walnut Street, Philadelphia (USA) arriving at 5/4/2026 11:30:00 AM. 50 Economy ticket for $73 per person are available. Travel duration is 19h 0m

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	14h 15m	4:30 PM	Florence, SC	Bus Station	6:45 AM	Philadelphia	Convention Center	Economy	$66	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 5/4/2026 4:30:00 PM to Convention Center, Philadelphia (USA) arriving at 5/5/2026 6:45:00 AM. 50 Economy ticket for $66 per person are available. Travel duration is 14h 15m
Greyhound US	16h 15m	4:30 PM	Florence, SC	Bus Station	8:45 AM	Philadelphia	Spring Garden St Station	Economy	$66	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 5/4/2026 4:30:00 PM to Spring Garden St Station, Philadelphia (USA) arriving at 5/5/2026 8:45:00 AM. 50 Economy ticket for $66 per person are available. Travel duration is 16h 15m
Greyhound US	16h 45m	4:30 PM	Florence, SC	Bus Station	9:15 AM	Philadelphia	Schuylkill Ave and Walnut Street	Economy	$66	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 5/4/2026 4:30:00 PM to Schuylkill Ave and Walnut Street, Philadelphia (USA) arriving at 5/5/2026 9:15:00 AM. 50 Economy ticket for $66 per person are available. Travel duration is 16h 45m
FlixBus	16h 20m	12:05 AM	Florence, SC	TA Travel Center	4:25 PM	Philadelphia	IRS Building	Economy	$70	A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 5/4/2026 12:05:00 AM to IRS Building, Philadelphia (USA) arriving at 5/4/2026 4:25:00 PM. 50 Economy ticket for $70 per person are available. Travel duration is 16h 20m
FlixBus	15h 0m	12:05 AM	Florence, SC	TA Travel Center	3:05 PM	Philadelphia	Spring Garden St Station	Economy	$71	A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 5/4/2026 12:05:00 AM to Spring Garden St Station, Philadelphia (USA) arriving at 5/4/2026 3:05:00 PM. 50 Economy ticket for $71 per person are available. Travel duration is 15h 0m

Best Price Offer: The price for the cheapest bus from Florence, SC to Philadelphia is $66 on 5/4/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Florence, SC and Philadelphia

See here how frequent the connections between Florence, SC and Philadelphia are, during different times and days of the week.

Monday is the busiest day, with more than 9 daily buses from Florence, SC to Philadelphia. Sunday has instead the fewest connections, with only 3 daily coaches between Florence, SC and Philadelphia.

The busiest time of the day is the Afternoon, with 21 buses from Florence, SC to Philadelphia, while Night sees the fewest connections between Florence, SC and Philadelphia, with 6 offers.

Facts about the bus from Florence, SC to Philadelphia

Compare all providers like Greyhound US and FlixBus that travel 5 times every day by bus from Florence, SC to Philadelphia in one click! Book your bus ticket from Florence, SC to Philadelphia starting from $66!

Cheapest Bus	$66
Fastest Bus	11h 40m
Earliest Bus	4:30 PM
Latest Bus	4:30 PM
Daily Bus Routes	5 Ø
Distance	471.3 miles
Bus Companies	Greyhound US and FlixBus

Cheapest bus connections from Florence, SC to Philadelphia

Every day, 5 buses from 2 bus companies leave Florence, SC for Philadelphia: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 04/30/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 04/26

Monday 04/27

Tuesday 04/28

Wednesday 04/29

Thursday 04/30

$75

Friday 05/01

$74

Saturday 05/02

$75

Sunday 05/03

$70

Monday 05/04

$70

Tuesday 05/05

Wednesday 05/06

Thursday 05/07

Friday 05/08

$77

Saturday 05/09

$86

Sunday 05/10

$81

Monday 05/11

$83

Tuesday 05/12

$85

Wednesday 05/13

$81

Thursday 05/14

$78

Friday 05/15

$79

Saturday 05/16

$77

Sunday 05/17

$83

Monday 05/18

$76

Tuesday 05/19

$81

Wednesday 05/20

$73

Thursday 05/21

$75

Friday 05/22

Saturday 05/23

The cheapest time to travel from Florence, SC to Philadelphia

See here on which day and which time of the day you can find the cheapest bus ticket from Florence, SC to Philadelphia, for the next 30 days.

With a price starting from $66, Monday is the cheapest day for a bus from Florence, SC to Philadelphia. Saturday instead is the most expensive day with prices starting from $75.

Afternoon is the cheapest day time for bus tickets from Florence, SC to Philadelphia, with $66. Night is the most expensive time of the day with prices starting from $70.

How to save money travelling from Florence, SC to Philadelphia

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Florence, SC to Philadelphia in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Florence, SC to Philadelphia, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Florence, SC to Philadelphia are also emptier.

All bus stations and stops in Florence, SC and Philadelphia

In the map below, you can see where to find all bus stations in Florence, SC and Philadelphia.

Bus Station

S Irby St 611

TA Travel Center

W Lucas St 2301

Exxon Gas Station

W Lucas Street 1901

McDonalds

W. Lucas St. 1908

Shell Gas Station

W Lucas Street 1832

Central Bus Station

Filbert St 1001

Market St

Spring Garden St Station

Spring Garden St & 2nd St

30th Street Station

Market St 2955

Philadelphia, PA

Service and Comfort on the bus from Florence, SC to Philadelphia

Want to know which seat classes are available on the buses from Florence, SC to Philadelphia? Or which bus companies serve the route Florence, SC to Philadelphia? Below you will find answers to your questions.

FAQs about the Florence, SC to Philadelphia bus

How much does a Florence, SC Philadelphia bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $66 and takes 14h 15m to reach Philadelphia. Compare offers to save money!

How much could I save by comparing buses from Florence, SC to Philadelphia?

This route is offered by 2 companies with a range of ticket prices between $66 and $78. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Philadelphia.

On average, how many connections are available from Florence, SC to Philadelphia each day?

Every day, the Florence, SC to Philadelphia bus route is served by approximately 5 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Florence, SC to Philadelphia take?

The fastest bus from Florence, SC to Philadelphia is offered by FlixBus and takes 11h 40m. Bus tickets for this connection cost $74. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Florence, SC to Philadelphia?

The earliest bus arriving in Philadelphia from Florence, SC starts at 4:30 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Florence, SC to Philadelphia?

The latest bus trip departing from Florence, SC for Philadelphia starts at 4:30 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Florence, SC Philadelphia route?

When traveling by bus from Florence, SC to Philadelphia, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Florence, SC and Philadelphia?

You can check all the direct connections between Florence, SC and Philadelphia by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the Florence, SC to Philadelphia bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Florence, SC Philadelphia bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Florence, SC Philadelphia bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Florence, SC to Philadelphia on your planned travel date.

How does CheckMyBus find the best bus deals from Florence, SC to Philadelphia?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 5 daily trips between Florence, SC and Philadelphia. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Florence, SC to Philadelphia?

Prices and availability for 5 trips between Florence, SC and Philadelphia change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Florence, SC to Philadelphia

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Florence, SC and to Philadelphia

Here’s an overview of the most popular bus routes to Florence, SC and to Philadelphia. Simply click on the connection of your choice, and you will find all the details about your bus route!