Bus Greenville, SC to Gainesville, FL: Compare prices and save money

Compare all timetables for the bus from Greenville, SC to Gainesville, FL

Here is a selection of the cheapest bus trips from the schedule from Greenville, SC to Gainesville, FL from various bus operators like FlixBus or Greyhound US for the next days.

today

tomorrow

$121

Wednesday

Thursday

Friday

$107

Saturday

Sunday

$121

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	10h 0m	11:15 AM	Greenville, SC	Woodruff Rd	9:15 PM	Gainesville, FL	Rosa Parks Transfer station	Economy	$121	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 12/23/2025 11:15:00 AM to Rosa Parks Transfer station, Gainesville, FL (USA) arriving at 12/23/2025 9:15:00 PM. 50 Economy ticket for $121 per person are available. Travel duration is 10h 0m
Greyhound US	12h 55m	2:45 PM	Greenville, SC	Woodruff Rd	3:40 AM	Gainesville, FL	Rosa Parks Transfer station	Economy	$121	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 12/23/2025 2:45:00 PM to Rosa Parks Transfer station, Gainesville, FL (USA) arriving at 12/24/2025 3:40:00 AM. 50 Economy ticket for $121 per person are available. Travel duration is 12h 55m
FlixBus	10h 40m	7:45 PM	Greenville, SC	Woodruff Rd	6:25 AM	Gainesville, FL	Greyhound Bus Station	Economy	$126	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 12/23/2025 7:45:00 PM to Greyhound Bus Station, Gainesville, FL (USA) arriving at 12/24/2025 6:25:00 AM. 50 Economy ticket for $126 per person are available. Travel duration is 10h 40m
FlixBus	16h 15m	7:45 PM	Greenville, SC	Woodruff Rd	12:00 PM	Gainesville, FL	Rosa Parks Transfer station	Economy	$137	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 12/23/2025 7:45:00 PM to Rosa Parks Transfer station, Gainesville, FL (USA) arriving at 12/24/2025 12:00:00 PM. 50 Economy ticket for $137 per person are available. Travel duration is 16h 15m
FlixBus	9h 15m	1:20 PM	Greenville, SC	Woodruff Rd	10:35 PM	Gainesville, FL	Rosa Parks Transfer station	Economy	$138	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 12/23/2025 1:20:00 PM to Rosa Parks Transfer station, Gainesville, FL (USA) arriving at 12/23/2025 10:35:00 PM. 50 Economy ticket for $138 per person are available. Travel duration is 9h 15m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	9h 15m	1:20 PM	Greenville, SC	Woodruff Rd	10:35 PM	Gainesville, FL	Rosa Parks Transfer station	Economy	$107	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 12/26/2025 1:20:00 PM to Rosa Parks Transfer station, Gainesville, FL (USA) arriving at 12/26/2025 10:35:00 PM. 50 Economy ticket for $107 per person are available. Travel duration is 9h 15m
FlixBus	16h 55m	10:00 PM	Greenville, SC	Woodruff Rd	2:55 PM	Gainesville, FL	Rosa Parks Transfer station	Economy	$109	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 12/26/2025 10:00:00 PM to Rosa Parks Transfer station, Gainesville, FL (USA) arriving at 12/27/2025 2:55:00 PM. 50 Economy ticket for $109 per person are available. Travel duration is 16h 55m
FlixBus	15h 15m	10:00 PM	Greenville, SC	Woodruff Rd	1:15 PM	Gainesville, FL	Greyhound Bus Station	Economy	$112	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 12/26/2025 10:00:00 PM to Greyhound Bus Station, Gainesville, FL (USA) arriving at 12/27/2025 1:15:00 PM. 50 Economy ticket for $112 per person are available. Travel duration is 15h 15m
Greyhound US	12h 55m	2:45 PM	Greenville, SC	Woodruff Rd	3:40 AM	Gainesville, FL	Rosa Parks Transfer station	Economy	$113	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 12/26/2025 2:45:00 PM to Rosa Parks Transfer station, Gainesville, FL (USA) arriving at 12/27/2025 3:40:00 AM. 50 Economy ticket for $113 per person are available. Travel duration is 12h 55m
Greyhound US	10h 0m	11:15 AM	Greenville, SC	Woodruff Rd	9:15 PM	Gainesville, FL	Rosa Parks Transfer station	Economy	$122	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 12/26/2025 11:15:00 AM to Rosa Parks Transfer station, Gainesville, FL (USA) arriving at 12/26/2025 9:15:00 PM. 50 Economy ticket for $122 per person are available. Travel duration is 10h 0m

Did you know that if you travel from Greenville, SC to Gainesville, FL via Atlanta, GA, you can save more than $25? You can find the corresponding connections below.
- Busbud
  
  10h 40m
  
  0
  
  7:45 PM
  
  Greenville, SC
  Woodruff Rd
  
  10:15 PM
  
  Atlanta, GA
  Garnett Transit Station
  
  0
  
  Economy
  
  $29
  
  A Bus from Busbud goes from Woodruff Rd, Greenville, SC (USA) at 12/26/2025 7:45:00 PM to Garnett Transit Station, Atlanta, GA (USA) arriving at 12/26/2025 10:15:00 PM. 50 Economy ticket for $29 per person are available. Travel duration is 2h 30m
- Busbud
  
  5h 35m
  
  0
  
  12:50 AM
  
  Atlanta, GA
  Garnett Transit Station
  
  6:25 AM
  
  Gainesville, FL
  North Walmart Supercenter Bus Stop
  
  0
  
  Economy
  
  $53
  
  A Bus from Busbud goes from Garnett Transit Station, Atlanta, GA (USA) at 12/27/2025 12:50:00 AM to North Walmart Supercenter Bus Stop, Gainesville, FL (USA) arriving at 12/27/2025 6:25:00 AM. 50 Economy ticket for $53 per person are available. Travel duration is 5h 35m
Travel time is 1h 25m longer, but you will save $25

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	10h 0m	11:15 AM	Greenville, SC	Woodruff Rd	9:15 PM	Gainesville, FL	Rosa Parks Transfer station	Economy	$121	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 12/28/2025 11:15:00 AM to Rosa Parks Transfer station, Gainesville, FL (USA) arriving at 12/28/2025 9:15:00 PM. 50 Economy ticket for $121 per person are available. Travel duration is 10h 0m
Greyhound US	12h 55m	2:45 PM	Greenville, SC	Woodruff Rd	3:40 AM	Gainesville, FL	Rosa Parks Transfer station	Economy	$121	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 12/28/2025 2:45:00 PM to Rosa Parks Transfer station, Gainesville, FL (USA) arriving at 12/29/2025 3:40:00 AM. 50 Economy ticket for $121 per person are available. Travel duration is 12h 55m
FlixBus	9h 15m	1:20 PM	Greenville, SC	Woodruff Rd	10:35 PM	Gainesville, FL	Rosa Parks Transfer station	Economy	$121	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 12/28/2025 1:20:00 PM to Rosa Parks Transfer station, Gainesville, FL (USA) arriving at 12/28/2025 10:35:00 PM. 50 Economy ticket for $121 per person are available. Travel duration is 9h 15m
FlixBus	10h 40m	7:45 PM	Greenville, SC	Woodruff Rd	6:25 AM	Gainesville, FL	Greyhound Bus Station	Economy	$123	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 12/28/2025 7:45:00 PM to Greyhound Bus Station, Gainesville, FL (USA) arriving at 12/29/2025 6:25:00 AM. 50 Economy ticket for $123 per person are available. Travel duration is 10h 40m
FlixBus	16h 55m	10:00 PM	Greenville, SC	Woodruff Rd	2:55 PM	Gainesville, FL	Rosa Parks Transfer station	Economy	$135	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 12/28/2025 10:00:00 PM to Rosa Parks Transfer station, Gainesville, FL (USA) arriving at 12/29/2025 2:55:00 PM. 50 Economy ticket for $135 per person are available. Travel duration is 16h 55m

Did you know that if you travel from Greenville, SC to Gainesville, FL via Atlanta, GA, you can save more than $39? You can find the corresponding connections below.
- Busbud
  
  10h 40m
  
  0
  
  7:45 PM
  
  Greenville, SC
  Woodruff Rd
  
  10:15 PM
  
  Atlanta, GA
  Garnett Transit Station
  
  0
  
  Economy
  
  $29
  
  A Bus from Busbud goes from Woodruff Rd, Greenville, SC (USA) at 12/26/2025 7:45:00 PM to Garnett Transit Station, Atlanta, GA (USA) arriving at 12/26/2025 10:15:00 PM. 50 Economy ticket for $29 per person are available. Travel duration is 2h 30m
- Busbud
  
  5h 35m
  
  0
  
  12:50 AM
  
  Atlanta, GA
  Garnett Transit Station
  
  6:25 AM
  
  Gainesville, FL
  North Walmart Supercenter Bus Stop
  
  0
  
  Economy
  
  $53
  
  A Bus from Busbud goes from Garnett Transit Station, Atlanta, GA (USA) at 12/27/2025 12:50:00 AM to North Walmart Supercenter Bus Stop, Gainesville, FL (USA) arriving at 12/27/2025 6:25:00 AM. 50 Economy ticket for $53 per person are available. Travel duration is 5h 35m
Travel time is 1h 25m longer, but you will save $39

Best Price Offer: The price for the cheapest bus from Greenville, SC to Gainesville, FL is $107 on 12/26/2025. Flexible travelers save on ticket prices.

Frequency of bus connections between Greenville, SC and Gainesville, FL

See here how frequent the connections between Greenville, SC and Gainesville, FL are, during different times and days of the week.

Sunday is the busiest day, with more than 7 daily buses from Greenville, SC to Gainesville, FL. Tuesday has instead the fewest connections, with only 5 daily coaches between Greenville, SC and Gainesville, FL.

The busiest time of the day is the Evening, with 10 buses from Greenville, SC to Gainesville, FL, while Morning sees the fewest connections between Greenville, SC and Gainesville, FL, with 3 offers.

Facts about the bus from Greenville, SC to Gainesville, FL

Compare all providers like FlixBus and Greyhound US that travel 6 times every day by bus from Greenville, SC to Gainesville, FL in one click! Book your bus ticket from Greenville, SC to Gainesville, FL starting from $107!

Cheapest Bus	$107
Fastest Bus	9h 15m
Earliest Bus	11:15 AM
Latest Bus	10:00 PM
Daily Bus Routes	6 Ø
Distance	359.9 miles
Bus Companies	FlixBus and Greyhound US

Cheapest bus connections from Greenville, SC to Gainesville, FL

Every day, 6 buses from 2 bus companies leave Greenville, SC for Gainesville, FL: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/22/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 12/21

Monday 12/22

Tuesday 12/23

$121

Wednesday 12/24

Thursday 12/25

Friday 12/26

$107

Saturday 12/27

Sunday 12/28

$121

Monday 12/29

Tuesday 12/30

Wednesday 12/31

Thursday 01/01

Friday 01/02

Saturday 01/03

Sunday 01/04

Monday 01/05

Tuesday 01/06

Wednesday 01/07

Thursday 01/08

Friday 01/09

Saturday 01/10

Sunday 01/11

Monday 01/12

Tuesday 01/13

Wednesday 01/14

Thursday 01/15

Friday 01/16

Saturday 01/17

The cheapest time to travel from Greenville, SC to Gainesville, FL

See here on which day and which time of the day you can find the cheapest bus ticket from Greenville, SC to Gainesville, FL, for the next 30 days.

With a price starting from $107, Friday is the cheapest day for a bus from Greenville, SC to Gainesville, FL. Sunday instead is the most expensive day with prices starting from $121.

Afternoon is the cheapest day time for bus tickets from Greenville, SC to Gainesville, FL, with $107. Morning is the most expensive time of the day with prices starting from $121.

How to save money travelling from Greenville, SC to Gainesville, FL

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Greenville, SC to Gainesville, FL in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Greenville, SC to Gainesville, FL, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Greenville, SC to Gainesville, FL are also emptier.

All bus stations and stops in Greenville, SC and Gainesville, FL

In the map below, you can see where to find all bus stations in Greenville, SC and Gainesville, FL.

McDonald's

Woodruff Rd 1111

Woodruff Rd

Woodruff Rd 1116

Guadalajara Supermarket

White Horse Rd 2803

Greyhound Bus Station

Hendrix Dr 9

N Church St

Rosa Parks Transfer station

SE 3rd St 700

Greyhound Bus Station

Northeast 23rd Avenue 101

North Walmart Supercenter Bus Stop

Westgate Plaza Bus Stop

Central Bus Station

Service and Comfort on the bus from Greenville, SC to Gainesville, FL

Want to know which seat classes are available on the buses from Greenville, SC to Gainesville, FL? Or which bus companies serve the route Greenville, SC to Gainesville, FL? Below you will find answers to your questions.

FAQs about the Greenville, SC to Gainesville, FL bus

How much does a Greenville, SC Gainesville, FL bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $107 and takes 9h 15m to reach Gainesville, FL. Compare offers to save money!

How much could I save by comparing buses from Greenville, SC to Gainesville, FL?

This route is offered by 2 companies with a range of ticket prices between $107 and $192. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Gainesville, FL.

On average, how many connections are available from Greenville, SC to Gainesville, FL each day?

Every day, the Greenville, SC to Gainesville, FL bus route is served by approximately 6 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Greenville, SC to Gainesville, FL take?

The fastest bus from Greenville, SC to Gainesville, FL is offered by FlixBus and takes 9h 15m. Bus tickets for this connection cost $138. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Greenville, SC to Gainesville, FL?

The earliest bus arriving in Gainesville, FL from Greenville, SC starts at 11:15 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Greenville, SC to Gainesville, FL?

The latest bus trip departing from Greenville, SC for Gainesville, FL starts at 10:00 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Greenville, SC Gainesville, FL route?

When traveling by bus from Greenville, SC to Gainesville, FL, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Greenville, SC and Gainesville, FL?

You can check all the direct connections between Greenville, SC and Gainesville, FL by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the Greenville, SC to Gainesville, FL bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Greenville, SC Gainesville, FL bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Greenville, SC Gainesville, FL bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Greenville, SC to Gainesville, FL on your planned travel date.

How does CheckMyBus find the best bus deals from Greenville, SC to Gainesville, FL?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 6 daily trips between Greenville, SC and Gainesville, FL. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Greenville, SC to Gainesville, FL?

Prices and availability for 6 trips between Greenville, SC and Gainesville, FL change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Greenville, SC to Gainesville, FL

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Greenville, SC and to Gainesville, FL

Here’s an overview of the most popular bus routes to Greenville, SC and to Gainesville, FL. Simply click on the connection of your choice, and you will find all the details about your bus route!