Bus Madrid to Santander - Compare all Companies

Compare all timetables for the bus from Madrid to Santander

Here is a selection of the cheapest bus trips from the schedule from Madrid to Santander from various bus operators like ALSA or FlixBus for the next days.

today

$46

tomorrow

$42

Sunday

$42

Monday

$45

Tuesday

$42

Wednesday

$42

Thursday

$42

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
ALSA	5h 45m	10:30 AM	Madrid	Avenida de América Bus Station	4:15 PM	Santander	Bus Station	Economy	$46	A Bus from ALSA goes from Avenida de América Bus Station, Madrid (Spain) at 12/5/2025 10:30:00 AM to Bus Station, Santander (Spain) arriving at 12/5/2025 4:15:00 PM. 50 Economy ticket for $46 per person are available. Travel duration is 5h 45m
ALSA	5h 30m	1:00 PM	Madrid	Avenida de América Bus Station	6:30 PM	Santander	Bus Station	Economy	$46	A Bus from ALSA goes from Avenida de América Bus Station, Madrid (Spain) at 12/5/2025 1:00:00 PM to Bus Station, Santander (Spain) arriving at 12/5/2025 6:30:00 PM. 50 Economy ticket for $46 per person are available. Travel duration is 5h 30m
ALSA	5h 45m	4:30 PM	Madrid	Avenida de América Bus Station	10:15 PM	Santander	Bus Station	Economy	$46	A Bus from ALSA goes from Avenida de América Bus Station, Madrid (Spain) at 12/5/2025 4:30:00 PM to Bus Station, Santander (Spain) arriving at 12/5/2025 10:15:00 PM. 50 Economy ticket for $46 per person are available. Travel duration is 5h 45m
ALSA	5h 30m	6:30 PM	Madrid	Avenida de América Bus Station	12:00 AM	Santander	Bus Station	Economy	$46	A Bus from ALSA goes from Avenida de América Bus Station, Madrid (Spain) at 12/5/2025 6:30:00 PM to Bus Station, Santander (Spain) arriving at 12/6/2025 12:00:00 AM. 50 Economy ticket for $46 per person are available. Travel duration is 5h 30m
ALSA	5h 50m	8:00 AM	Madrid	Avenida de Aragon	1:50 PM	Santander	Bus Station	Basic	$49	A Bus from ALSA goes from Avenida de Aragon, Madrid (Spain) at 12/5/2025 8:00:00 AM to Bus Station, Santander (Spain) arriving at 12/5/2025 1:50:00 PM. 50 Basic ticket for $49 per person are available. Travel duration is 5h 50m

Did you know that if you travel from Madrid to Santander via Burgos, you can save more than $5? You can find the corresponding connections below.
- Busbud
  
  5h 50m
  
  0
  
  8:00 AM
  
  Madrid
  Avenida de América Bus Station
  
  10:45 AM
  
  Burgos
  Bus Station
  
  0
  
  Economy
  
  $23
  
  A Bus from Busbud goes from Avenida de América Bus Station, Madrid (Spain) at 12/7/2025 8:00:00 AM to Bus Station, Burgos (Spain) arriving at 12/7/2025 10:45:00 AM. 50 Economy ticket for $23 per person are available. Travel duration is 2h 45m
- Busbud
  
  2h 50m
  
  0
  
  11:00 AM
  
  Burgos
  Bus Station
  
  1:50 PM
  
  Santander
  Bus Station
  
  0
  
  Economy
  
  $18
  
  A Bus from Busbud goes from Bus Station, Burgos (Spain) at 12/7/2025 11:00:00 AM to Bus Station, Santander (Spain) arriving at 12/7/2025 1:50:00 PM. 50 Economy ticket for $18 per person are available. Travel duration is 2h 50m
Travel time is 0h 20m longer, but you will save $5

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
ALSA	5h 45m	4:30 PM	Madrid	Avenida de América Bus Station	10:15 PM	Santander	Bus Station	Economy	$42	A Bus from ALSA goes from Avenida de América Bus Station, Madrid (Spain) at 12/6/2025 4:30:00 PM to Bus Station, Santander (Spain) arriving at 12/6/2025 10:15:00 PM. 50 Economy ticket for $42 per person are available. Travel duration is 5h 45m
ALSA	5h 30m	6:30 PM	Madrid	Avenida de América Bus Station	12:00 AM	Santander	Bus Station	Economy	$42	A Bus from ALSA goes from Avenida de América Bus Station, Madrid (Spain) at 12/6/2025 6:30:00 PM to Bus Station, Santander (Spain) arriving at 12/7/2025 12:00:00 AM. 50 Economy ticket for $42 per person are available. Travel duration is 5h 30m
ALSA	5h 50m	8:00 AM	Madrid	Avenida de América Bus Station	1:50 PM	Santander	Bus Station	Economy	$45	A Bus from ALSA goes from Avenida de América Bus Station, Madrid (Spain) at 12/6/2025 8:00:00 AM to Bus Station, Santander (Spain) arriving at 12/6/2025 1:50:00 PM. 50 Economy ticket for $45 per person are available. Travel duration is 5h 50m
FlixBus	16h 40m	4:40 PM	Madrid	Sur Bus Station	9:20 AM	Santander	Bus Station	Economy	$75	A Bus from FlixBus goes from Sur Bus Station, Madrid (Spain) at 12/6/2025 4:40:00 PM to Bus Station, Santander (Spain) arriving at 12/7/2025 9:20:00 AM. 50 Economy ticket for $75 per person are available. Travel duration is 16h 40m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
ALSA	5h 30m	6:30 PM	Madrid	Avenida de América Bus Station	12:00 AM	Santander	Bus Station	Economy	$42	A Bus from ALSA goes from Avenida de América Bus Station, Madrid (Spain) at 12/7/2025 6:30:00 PM to Bus Station, Santander (Spain) arriving at 12/8/2025 12:00:00 AM. 50 Economy ticket for $42 per person are available. Travel duration is 5h 30m
ALSA	5h 30m	3:00 PM	Madrid	Avenida de América Bus Station	8:30 PM	Santander	Bus Station	Economy	$43	A Bus from ALSA goes from Avenida de América Bus Station, Madrid (Spain) at 12/7/2025 3:00:00 PM to Bus Station, Santander (Spain) arriving at 12/7/2025 8:30:00 PM. 50 Economy ticket for $43 per person are available. Travel duration is 5h 30m
ALSA	5h 50m	8:00 AM	Madrid	Avenida de América Bus Station	1:50 PM	Santander	Bus Station	Economy	$45	A Bus from ALSA goes from Avenida de América Bus Station, Madrid (Spain) at 12/7/2025 8:00:00 AM to Bus Station, Santander (Spain) arriving at 12/7/2025 1:50:00 PM. 50 Economy ticket for $45 per person are available. Travel duration is 5h 50m
ALSA	5h 45m	10:30 AM	Madrid	Avenida de América Bus Station	4:15 PM	Santander	Bus Station	Economy	$46	A Bus from ALSA goes from Avenida de América Bus Station, Madrid (Spain) at 12/7/2025 10:30:00 AM to Bus Station, Santander (Spain) arriving at 12/7/2025 4:15:00 PM. 50 Economy ticket for $46 per person are available. Travel duration is 5h 45m
ALSA	5h 30m	1:00 PM	Madrid	Avenida de América Bus Station	6:30 PM	Santander	Bus Station	Economy	$46	A Bus from ALSA goes from Avenida de América Bus Station, Madrid (Spain) at 12/7/2025 1:00:00 PM to Bus Station, Santander (Spain) arriving at 12/7/2025 6:30:00 PM. 50 Economy ticket for $46 per person are available. Travel duration is 5h 30m

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
ALSA	5h 50m	8:00 AM	Madrid	Avenida de América Bus Station	1:50 PM	Santander	Bus Station	Economy	$45	A Bus from ALSA goes from Avenida de América Bus Station, Madrid (Spain) at 12/8/2025 8:00:00 AM to Bus Station, Santander (Spain) arriving at 12/8/2025 1:50:00 PM. 50 Economy ticket for $45 per person are available. Travel duration is 5h 50m
ALSA	5h 45m	10:30 AM	Madrid	Avenida de América Bus Station	4:15 PM	Santander	Bus Station	Economy	$46	A Bus from ALSA goes from Avenida de América Bus Station, Madrid (Spain) at 12/8/2025 10:30:00 AM to Bus Station, Santander (Spain) arriving at 12/8/2025 4:15:00 PM. 50 Economy ticket for $46 per person are available. Travel duration is 5h 45m
ALSA	5h 30m	1:00 PM	Madrid	Avenida de América Bus Station	6:30 PM	Santander	Bus Station	Economy	$46	A Bus from ALSA goes from Avenida de América Bus Station, Madrid (Spain) at 12/8/2025 1:00:00 PM to Bus Station, Santander (Spain) arriving at 12/8/2025 6:30:00 PM. 50 Economy ticket for $46 per person are available. Travel duration is 5h 30m
FlixBus	16h 40m	4:40 PM	Madrid	Sur Bus Station	9:20 AM	Santander	Bus Station	Economy	$85	A Bus from FlixBus goes from Sur Bus Station, Madrid (Spain) at 12/8/2025 4:40:00 PM to Bus Station, Santander (Spain) arriving at 12/9/2025 9:20:00 AM. 50 Economy ticket for $85 per person are available. Travel duration is 16h 40m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
ALSA	5h 45m	10:30 AM	Madrid	Avenida de América Bus Station	4:15 PM	Santander	Bus Station	Economy	$42	A Bus from ALSA goes from Avenida de América Bus Station, Madrid (Spain) at 12/9/2025 10:30:00 AM to Bus Station, Santander (Spain) arriving at 12/9/2025 4:15:00 PM. 50 Economy ticket for $42 per person are available. Travel duration is 5h 45m
ALSA	5h 45m	4:30 PM	Madrid	Avenida de América Bus Station	10:15 PM	Santander	Bus Station	Economy	$42	A Bus from ALSA goes from Avenida de América Bus Station, Madrid (Spain) at 12/9/2025 4:30:00 PM to Bus Station, Santander (Spain) arriving at 12/9/2025 10:15:00 PM. 50 Economy ticket for $42 per person are available. Travel duration is 5h 45m
ALSA	5h 30m	6:30 PM	Madrid	Avenida de América Bus Station	12:00 AM	Santander	Bus Station	Economy	$42	A Bus from ALSA goes from Avenida de América Bus Station, Madrid (Spain) at 12/9/2025 6:30:00 PM to Bus Station, Santander (Spain) arriving at 12/10/2025 12:00:00 AM. 50 Economy ticket for $42 per person are available. Travel duration is 5h 30m
FlixBus	16h 40m	4:40 PM	Madrid	Sur Bus Station	9:20 AM	Santander	Bus Station	Economy	$100	A Bus from FlixBus goes from Sur Bus Station, Madrid (Spain) at 12/9/2025 4:40:00 PM to Bus Station, Santander (Spain) arriving at 12/10/2025 9:20:00 AM. 50 Economy ticket for $100 per person are available. Travel duration is 16h 40m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
ALSA	5h 50m	8:00 AM	Madrid	Avenida de América Bus Station	1:50 PM	Santander	Bus Station	Economy	$42	A Bus from ALSA goes from Avenida de América Bus Station, Madrid (Spain) at 12/10/2025 8:00:00 AM to Bus Station, Santander (Spain) arriving at 12/10/2025 1:50:00 PM. 50 Economy ticket for $42 per person are available. Travel duration is 5h 50m
ALSA	5h 45m	10:30 AM	Madrid	Avenida de América Bus Station	4:15 PM	Santander	Bus Station	Economy	$42	A Bus from ALSA goes from Avenida de América Bus Station, Madrid (Spain) at 12/10/2025 10:30:00 AM to Bus Station, Santander (Spain) arriving at 12/10/2025 4:15:00 PM. 50 Economy ticket for $42 per person are available. Travel duration is 5h 45m
ALSA	5h 30m	1:00 PM	Madrid	Avenida de América Bus Station	6:30 PM	Santander	Bus Station	Economy	$42	A Bus from ALSA goes from Avenida de América Bus Station, Madrid (Spain) at 12/10/2025 1:00:00 PM to Bus Station, Santander (Spain) arriving at 12/10/2025 6:30:00 PM. 50 Economy ticket for $42 per person are available. Travel duration is 5h 30m
ALSA	5h 45m	4:30 PM	Madrid	Avenida de América Bus Station	10:15 PM	Santander	Bus Station	Economy	$42	A Bus from ALSA goes from Avenida de América Bus Station, Madrid (Spain) at 12/10/2025 4:30:00 PM to Bus Station, Santander (Spain) arriving at 12/10/2025 10:15:00 PM. 50 Economy ticket for $42 per person are available. Travel duration is 5h 45m
ALSA	5h 30m	6:30 PM	Madrid	Avenida de América Bus Station	12:00 AM	Santander	Bus Station	Economy	$42	A Bus from ALSA goes from Avenida de América Bus Station, Madrid (Spain) at 12/10/2025 6:30:00 PM to Bus Station, Santander (Spain) arriving at 12/11/2025 12:00:00 AM. 50 Economy ticket for $42 per person are available. Travel duration is 5h 30m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
ALSA	5h 45m	10:30 AM	Madrid	Avenida de América Bus Station	4:15 PM	Santander	Bus Station	Economy	$42	A Bus from ALSA goes from Avenida de América Bus Station, Madrid (Spain) at 12/11/2025 10:30:00 AM to Bus Station, Santander (Spain) arriving at 12/11/2025 4:15:00 PM. 50 Economy ticket for $42 per person are available. Travel duration is 5h 45m
ALSA	5h 45m	4:30 PM	Madrid	Avenida de América Bus Station	10:15 PM	Santander	Bus Station	Economy	$42	A Bus from ALSA goes from Avenida de América Bus Station, Madrid (Spain) at 12/11/2025 4:30:00 PM to Bus Station, Santander (Spain) arriving at 12/11/2025 10:15:00 PM. 50 Economy ticket for $42 per person are available. Travel duration is 5h 45m
ALSA	5h 30m	3:00 PM	Madrid	Avenida de América Bus Station	8:30 PM	Santander	Bus Station	Economy	$43	A Bus from ALSA goes from Avenida de América Bus Station, Madrid (Spain) at 12/11/2025 3:00:00 PM to Bus Station, Santander (Spain) arriving at 12/11/2025 8:30:00 PM. 50 Economy ticket for $43 per person are available. Travel duration is 5h 30m
FlixBus	16h 40m	4:40 PM	Madrid	Sur Bus Station	9:20 AM	Santander	Bus Station	Economy	$75	A Bus from FlixBus goes from Sur Bus Station, Madrid (Spain) at 12/11/2025 4:40:00 PM to Bus Station, Santander (Spain) arriving at 12/12/2025 9:20:00 AM. 50 Economy ticket for $75 per person are available. Travel duration is 16h 40m

Best Price Offer: The price for the cheapest bus from Madrid to Santander is $38 on 12/10/2025. Flexible travelers save on ticket prices.

Frequency of bus connections between Madrid and Santander

See here how frequent the connections between Madrid and Santander are, during different times and days of the week.

Monday is the busiest day, with more than 29 daily buses from Madrid to Santander. Sunday has instead the fewest connections, with only 13 daily coaches between Madrid and Santander.

The busiest time of the day is the Afternoon, with 59 buses from Madrid to Santander, while Night sees the fewest connections between Madrid and Santander, with 18 offers.

Facts about the bus from Madrid to Santander

Compare all providers like ALSA and FlixBus that travel 20 times every day by bus from Madrid to Santander in one click! Book your bus ticket from Madrid to Santander starting from $38!

Cheapest Bus	$38
Fastest Bus	5h 30m
Earliest Bus	12:30 AM
Latest Bus	6:30 PM
Daily Bus Routes	20 Ø
Distance	210.6 miles
Bus Companies	ALSA and FlixBus

Cheapest bus connections from Madrid to Santander

Every day, 20 buses from 2 bus companies leave Madrid for Santander: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/05/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 11/30

Monday 12/01

Tuesday 12/02

Wednesday 12/03

Thursday 12/04

Friday 12/05

$46

Saturday 12/06

$42

Sunday 12/07

$42

Monday 12/08

$49

Tuesday 12/09

$42

Wednesday 12/10

$38

Thursday 12/11

$42

Friday 12/12

$45

Saturday 12/13

$43

Sunday 12/14

$49

Monday 12/15

$42

Tuesday 12/16

$42

Wednesday 12/17

$79

Thursday 12/18

$42

Friday 12/19

$45

Saturday 12/20

$49

Sunday 12/21

$49

Monday 12/22

$72

Tuesday 12/23

$45

Wednesday 12/24

$46

Thursday 12/25

$46

Friday 12/26

$45

Saturday 12/27

The cheapest time to travel from Madrid to Santander

See here on which day and which time of the day you can find the cheapest bus ticket from Madrid to Santander, for the next 30 days.

With a price starting from $38, Wednesday is the cheapest day for a bus from Madrid to Santander. Friday instead is the most expensive day with prices starting from $45.

Night is the cheapest day time for bus tickets from Madrid to Santander, with $38. Morning is the most expensive time of the day with prices starting from $42.

How to save money travelling from Madrid to Santander

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Madrid to Santander in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Madrid to Santander, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Madrid to Santander are also emptier.

All bus stations and stops in Madrid and Santander

In the map below, you can see where to find all bus stations in Madrid and Santander.

Avenida de América Bus Station

Avenida de América 13

Bus Stop

Calle de Tiziano 40

Intercambiador de Moncloa

Calle de la Princesa 89n

Plaza de Castilla

Sur Bus Station

Calle de Méndez Álvaro 83

Bus Station

Plaza Las Estaciones

Bus Stop

Peñacastillo

Calle Camarreal-Ojaiz 65

Sardinero

Calle Real Racing Club

UIMP Bus Stop

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from Madrid to Santander? Compare all modes of transports from Madrid to Santander.

Service and Comfort on the bus from Madrid to Santander

Want to know which seat classes are available on the buses from Madrid to Santander? Or which bus companies serve the route Madrid to Santander? Below you will find answers to your questions.

FAQs about the Madrid to Santander bus

How much does a Madrid Santander bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $38 and takes 5h 45m to reach Santander. Compare offers to save money!

How much could I save by comparing buses from Madrid to Santander?

This route is offered by 2 companies with a range of ticket prices between $38 and $118. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Santander.

On average, how many connections are available from Madrid to Santander each day?

Every day, the Madrid to Santander bus route is served by approximately 20 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Madrid to Santander take?

The fastest bus from Madrid to Santander is offered by ALSA and takes 5h 30m. Bus tickets for this connection cost $51. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Madrid to Santander?

The earliest bus arriving in Santander from Madrid starts at 12:30 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Madrid to Santander?

The latest bus trip departing from Madrid for Santander starts at 6:30 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Madrid Santander route?

When traveling by bus from Madrid to Santander, passengers can travel with ALSA and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Madrid and Santander?

You can check all the direct connections between Madrid and Santander by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: ALSA and FlixBus.

What can I take with me on the Madrid to Santander bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Madrid Santander bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Madrid Santander bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Madrid to Santander on your planned travel date.

Available seat classes which are offered on the bus route Madrid to Santander

Basic

Name referring to the typical seat you will find with companies that don’t distinguish between different classes.

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Madrid and to Santander

Here’s an overview of the most popular bus routes to Madrid and to Santander. Simply click on the connection of your choice, and you will find all the details about your bus route!