Bus Milan to Karlsruhe: Compare prices and save money

Compare all timetables for the bus from Milan to Karlsruhe

Here is a selection of the cheapest bus trips from the schedule from Milan to Karlsruhe from various bus operators like FlixBus or BlaBlaCar Bus for the next days.

today

$38

tomorrow

$38

Wednesday

$47

Thursday

$56

Friday

$47

Saturday

$40

Sunday

$49

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
BlaBlaCar Bus	11h 45m	3:20 PM	Milan	Lampugnano Bus Station	3:05 AM	Karlsruhe	Central Station	Economy	$38	A Bus from BlaBlaCar Bus goes from Lampugnano Bus Station, Milan (Italy) at 4/27/2026 3:20:00 PM to Central Station, Karlsruhe (Germany) arriving at 4/28/2026 3:05:00 AM. 50 Economy ticket for $38 per person are available. Travel duration is 11h 45m
FlixBus	7h 20m	8:25 PM	Milan	Lampugnano Bus Station	3:45 AM	Karlsruhe	Central Station	Economy	$47	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 4/27/2026 8:25:00 PM to Central Station, Karlsruhe (Germany) arriving at 4/28/2026 3:45:00 AM. 50 Economy ticket for $47 per person are available. Travel duration is 7h 20m
FlixBus	8h 35m	11:45 PM	Milan	Lampugnano Bus Station	8:20 AM	Karlsruhe	Central Station	Economy	$48	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 4/27/2026 11:45:00 PM to Central Station, Karlsruhe (Germany) arriving at 4/28/2026 8:20:00 AM. 50 Economy ticket for $48 per person are available. Travel duration is 8h 35m
FlixBus	9h 55m	1:15 AM	Milan	Lampugnano Bus Station	11:10 AM	Karlsruhe	Central Station	Economy	$49	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 4/27/2026 1:15:00 AM to Central Station, Karlsruhe (Germany) arriving at 4/27/2026 11:10:00 AM. 50 Economy ticket for $49 per person are available. Travel duration is 9h 55m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
BlaBlaCar Bus	11h 45m	3:20 PM	Milan	Lampugnano Bus Station	3:05 AM	Karlsruhe	Central Station	Economy	$38	A Bus from BlaBlaCar Bus goes from Lampugnano Bus Station, Milan (Italy) at 4/28/2026 3:20:00 PM to Central Station, Karlsruhe (Germany) arriving at 4/29/2026 3:05:00 AM. 50 Economy ticket for $38 per person are available. Travel duration is 11h 45m
FlixBus	8h 10m	7:00 PM	Milan	Lampugnano Bus Station	3:10 AM	Karlsruhe	Central Station	Economy	$46	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 4/28/2026 7:00:00 PM to Central Station, Karlsruhe (Germany) arriving at 4/29/2026 3:10:00 AM. 50 Economy ticket for $46 per person are available. Travel duration is 8h 10m
FlixBus	7h 20m	8:25 PM	Milan	Lampugnano Bus Station	3:45 AM	Karlsruhe	Central Station	Economy	$46	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 4/28/2026 8:25:00 PM to Central Station, Karlsruhe (Germany) arriving at 4/29/2026 3:45:00 AM. 50 Economy ticket for $46 per person are available. Travel duration is 7h 20m
FlixBus	8h 35m	11:45 PM	Milan	Lampugnano Bus Station	8:20 AM	Karlsruhe	Central Station	Economy	$47	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 4/28/2026 11:45:00 PM to Central Station, Karlsruhe (Germany) arriving at 4/29/2026 8:20:00 AM. 50 Economy ticket for $47 per person are available. Travel duration is 8h 35m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	7h 20m	8:25 PM	Milan	Lampugnano Bus Station	3:45 AM	Karlsruhe	Central Station	Economy	$47	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 4/29/2026 8:25:00 PM to Central Station, Karlsruhe (Germany) arriving at 4/30/2026 3:45:00 AM. 50 Economy ticket for $47 per person are available. Travel duration is 7h 20m
FlixBus	8h 20m	9:50 PM	Milan	Lampugnano Bus Station	6:10 AM	Karlsruhe	Central Station	Economy	$48	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 4/29/2026 9:50:00 PM to Central Station, Karlsruhe (Germany) arriving at 4/30/2026 6:10:00 AM. 50 Economy ticket for $48 per person are available. Travel duration is 8h 20m
FlixBus	9h 55m	1:15 AM	Milan	Lampugnano Bus Station	11:10 AM	Karlsruhe	Central Station	Economy	$49	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 4/29/2026 1:15:00 AM to Central Station, Karlsruhe (Germany) arriving at 4/29/2026 11:10:00 AM. 50 Economy ticket for $49 per person are available. Travel duration is 9h 55m
BlaBlaCar Bus	17h 50m	5:00 PM	Milan	Lampugnano Bus Station	10:50 AM	Karlsruhe	Central Station	Economy	$56	A Bus from BlaBlaCar Bus goes from Lampugnano Bus Station, Milan (Italy) at 4/29/2026 5:00:00 PM to Central Station, Karlsruhe (Germany) arriving at 4/30/2026 10:50:00 AM. 50 Economy ticket for $56 per person are available. Travel duration is 17h 50m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	8h 20m	7:15 AM	Milan	Lampugnano Bus Station	3:35 PM	Karlsruhe	Central Station	Economy	$56	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 4/30/2026 7:15:00 AM to Central Station, Karlsruhe (Germany) arriving at 4/30/2026 3:35:00 PM. 50 Economy ticket for $56 per person are available. Travel duration is 8h 20m
FlixBus	7h 20m	8:25 PM	Milan	Lampugnano Bus Station	3:45 AM	Karlsruhe	Central Station	Economy	$56	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 4/30/2026 8:25:00 PM to Central Station, Karlsruhe (Germany) arriving at 5/1/2026 3:45:00 AM. 50 Economy ticket for $56 per person are available. Travel duration is 7h 20m
FlixBus	8h 20m	9:50 PM	Milan	Lampugnano Bus Station	6:10 AM	Karlsruhe	Central Station	Economy	$57	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 4/30/2026 9:50:00 PM to Central Station, Karlsruhe (Germany) arriving at 5/1/2026 6:10:00 AM. 50 Economy ticket for $57 per person are available. Travel duration is 8h 20m
FlixBus	9h 55m	1:15 AM	Milan	Lampugnano Bus Station	11:10 AM	Karlsruhe	Central Station	Economy	$60	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 4/30/2026 1:15:00 AM to Central Station, Karlsruhe (Germany) arriving at 4/30/2026 11:10:00 AM. 50 Economy ticket for $60 per person are available. Travel duration is 9h 55m
FlixBus	8h 10m	7:00 PM	Milan	Lampugnano Bus Station	3:10 AM	Karlsruhe	Central Station	Economy	$60	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 4/30/2026 7:00:00 PM to Central Station, Karlsruhe (Germany) arriving at 5/1/2026 3:10:00 AM. 50 Economy ticket for $60 per person are available. Travel duration is 8h 10m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
BlaBlaCar Bus	11h 45m	3:20 PM	Milan	Lampugnano Bus Station	3:05 AM	Karlsruhe	Central Station	Economy	$47	A Bus from BlaBlaCar Bus goes from Lampugnano Bus Station, Milan (Italy) at 5/1/2026 3:20:00 PM to Central Station, Karlsruhe (Germany) arriving at 5/2/2026 3:05:00 AM. 50 Economy ticket for $47 per person are available. Travel duration is 11h 45m
FlixBus	7h 20m	8:25 PM	Milan	Lampugnano Bus Station	3:45 AM	Karlsruhe	Central Station	Economy	$49	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 5/1/2026 8:25:00 PM to Central Station, Karlsruhe (Germany) arriving at 5/2/2026 3:45:00 AM. 50 Economy ticket for $49 per person are available. Travel duration is 7h 20m
FlixBus	8h 10m	7:00 PM	Milan	Lampugnano Bus Station	3:10 AM	Karlsruhe	Central Station	Economy	$52	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 5/1/2026 7:00:00 PM to Central Station, Karlsruhe (Germany) arriving at 5/2/2026 3:10:00 AM. 50 Economy ticket for $52 per person are available. Travel duration is 8h 10m
FlixBus	8h 20m	9:50 PM	Milan	Lampugnano Bus Station	6:10 AM	Karlsruhe	Central Station	Economy	$52	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 5/1/2026 9:50:00 PM to Central Station, Karlsruhe (Germany) arriving at 5/2/2026 6:10:00 AM. 50 Economy ticket for $52 per person are available. Travel duration is 8h 20m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
BlaBlaCar Bus	11h 45m	3:20 PM	Milan	Lampugnano Bus Station	3:05 AM	Karlsruhe	Central Station	Economy	$40	A Bus from BlaBlaCar Bus goes from Lampugnano Bus Station, Milan (Italy) at 5/2/2026 3:20:00 PM to Central Station, Karlsruhe (Germany) arriving at 5/3/2026 3:05:00 AM. 50 Economy ticket for $40 per person are available. Travel duration is 11h 45m
FlixBus	8h 20m	7:15 AM	Milan	Lampugnano Bus Station	3:35 PM	Karlsruhe	Central Station	Economy	$54	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 5/2/2026 7:15:00 AM to Central Station, Karlsruhe (Germany) arriving at 5/2/2026 3:35:00 PM. 50 Economy ticket for $54 per person are available. Travel duration is 8h 20m
FlixBus	7h 20m	8:25 PM	Milan	Lampugnano Bus Station	3:45 AM	Karlsruhe	Central Station	Economy	$54	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 5/2/2026 8:25:00 PM to Central Station, Karlsruhe (Germany) arriving at 5/3/2026 3:45:00 AM. 50 Economy ticket for $54 per person are available. Travel duration is 7h 20m
FlixBus	8h 20m	9:50 PM	Milan	Lampugnano Bus Station	6:10 AM	Karlsruhe	Central Station	Economy	$54	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 5/2/2026 9:50:00 PM to Central Station, Karlsruhe (Germany) arriving at 5/3/2026 6:10:00 AM. 50 Economy ticket for $54 per person are available. Travel duration is 8h 20m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	7h 20m	8:25 PM	Milan	Lampugnano Bus Station	3:45 AM	Karlsruhe	Central Station	Economy	$49	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 5/3/2026 8:25:00 PM to Central Station, Karlsruhe (Germany) arriving at 5/4/2026 3:45:00 AM. 50 Economy ticket for $49 per person are available. Travel duration is 7h 20m
BlaBlaCar Bus	11h 45m	3:20 PM	Milan	Lampugnano Bus Station	3:05 AM	Karlsruhe	Central Station	Economy	$50	A Bus from BlaBlaCar Bus goes from Lampugnano Bus Station, Milan (Italy) at 5/3/2026 3:20:00 PM to Central Station, Karlsruhe (Germany) arriving at 5/4/2026 3:05:00 AM. 50 Economy ticket for $50 per person are available. Travel duration is 11h 45m
FlixBus	9h 55m	1:15 AM	Milan	Lampugnano Bus Station	11:10 AM	Karlsruhe	Central Station	Economy	$52	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 5/3/2026 1:15:00 AM to Central Station, Karlsruhe (Germany) arriving at 5/3/2026 11:10:00 AM. 50 Economy ticket for $52 per person are available. Travel duration is 9h 55m
FlixBus	8h 20m	9:50 PM	Milan	Lampugnano Bus Station	6:10 AM	Karlsruhe	Central Station	Economy	$52	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 5/3/2026 9:50:00 PM to Central Station, Karlsruhe (Germany) arriving at 5/4/2026 6:10:00 AM. 50 Economy ticket for $52 per person are available. Travel duration is 8h 20m

Best Price Offer: The price for the cheapest bus from Milan to Karlsruhe is $34 on 5/12/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Milan and Karlsruhe

See here how frequent the connections between Milan and Karlsruhe are, during different times and days of the week.

Sunday is the busiest day, with more than 8 daily buses from Milan to Karlsruhe. Tuesday has instead the fewest connections, with only 5 daily coaches between Milan and Karlsruhe.

The busiest time of the day is the Evening, with 26 buses from Milan to Karlsruhe, while Afternoon sees the fewest connections between Milan and Karlsruhe, with 6 offers.

Facts about the bus from Milan to Karlsruhe

Compare all providers like FlixBus and BlaBlaCar Bus that travel 7 times every day by bus from Milan to Karlsruhe in one click! Book your bus ticket from Milan to Karlsruhe starting from $34!

Cheapest Bus	$34
Fastest Bus	7h 20m
Earliest Bus	1:15 AM
Latest Bus	11:45 PM
Daily Bus Routes	7 Ø
Distance	247.5 miles
Bus Companies	FlixBus and BlaBlaCar Bus

Cheapest bus connections from Milan to Karlsruhe

Every day, 7 buses from 2 bus companies leave Milan for Karlsruhe: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 04/27/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 04/26

Monday 04/27

$47

Tuesday 04/28

$46

Wednesday 04/29

$47

Thursday 04/30

$56

Friday 05/01

$49

Saturday 05/02

$49

Sunday 05/03

$49

Monday 05/04

$42

Tuesday 05/05

$36

Wednesday 05/06

$35

Thursday 05/07

$36

Friday 05/08

$37

Saturday 05/09

$37

Sunday 05/10

$41

Monday 05/11

$36

Tuesday 05/12

$34

Wednesday 05/13

$36

Thursday 05/14

$35

Friday 05/15

$40

Saturday 05/16

$40

Sunday 05/17

$57

Monday 05/18

$36

Tuesday 05/19

$37

Wednesday 05/20

$52

Thursday 05/21

$39

Friday 05/22

$45

Saturday 05/23

The cheapest time to travel from Milan to Karlsruhe

See here on which day and which time of the day you can find the cheapest bus ticket from Milan to Karlsruhe, for the next 30 days.

With a price starting from $34, Tuesday is the cheapest day for a bus from Milan to Karlsruhe. Sunday instead is the most expensive day with prices starting from $41.

Night is the cheapest day time for bus tickets from Milan to Karlsruhe, with $34. Morning is the most expensive time of the day with prices starting from $53.

How to save money travelling from Milan to Karlsruhe

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Milan to Karlsruhe in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Milan to Karlsruhe, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Milan to Karlsruhe are also emptier.

All bus stations and stops in Milan and Karlsruhe

In the map below, you can see where to find all bus stations in Milan and Karlsruhe.

Lampugnano Bus Station

Via Giulio Natta Lampugnano

Rogoredo Bus Station

Via Cassinis Giovanni Battista 76

San Donato Bus Station

Via Giuseppe Impastato 25

Duomo Bus Stop

Piazza del Duomo

Central Bus Station

Central Station

Hinterm Hauptbahnhof 6

Durlach Train Station

Knielingen Train Station

Durlach Auer Str./Dr.Willmar Schwabe Bus Stop

Service and Comfort on the bus from Milan to Karlsruhe

Want to know which seat classes are available on the buses from Milan to Karlsruhe? Or which bus companies serve the route Milan to Karlsruhe? Below you will find answers to your questions.

FAQs about the Milan to Karlsruhe bus

How much does a Milan Karlsruhe bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $34 and takes 11h 45m to reach Karlsruhe. Compare offers to save money!

How much could I save by comparing buses from Milan to Karlsruhe?

This route is offered by 2 companies with a range of ticket prices between $34 and $102. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Karlsruhe.

On average, how many connections are available from Milan to Karlsruhe each day?

Every day, the Milan to Karlsruhe bus route is served by approximately 7 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Milan to Karlsruhe take?

The fastest bus from Milan to Karlsruhe is offered by FlixBus and takes 7h 20m. Bus tickets for this connection cost $47. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Milan to Karlsruhe?

The earliest bus arriving in Karlsruhe from Milan starts at 1:15 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Milan to Karlsruhe?

The latest bus trip departing from Milan for Karlsruhe starts at 11:45 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Milan Karlsruhe route?

When traveling by bus from Milan to Karlsruhe, passengers can travel with FlixBus and BlaBlaCar Bus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Milan and Karlsruhe?

You can check all the direct connections between Milan and Karlsruhe by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and BlaBlaCar Bus.

What can I take with me on the Milan to Karlsruhe bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Milan Karlsruhe bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Milan Karlsruhe bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Milan to Karlsruhe on your planned travel date.

How does CheckMyBus find the best bus deals from Milan to Karlsruhe?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 7 daily trips between Milan and Karlsruhe. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Milan to Karlsruhe?

Prices and availability for 7 trips between Milan and Karlsruhe change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Milan to Karlsruhe

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Milan and to Karlsruhe

Here’s an overview of the most popular bus routes to Milan and to Karlsruhe. Simply click on the connection of your choice, and you will find all the details about your bus route!