Bus Santiago, RM to Antofagasta: Compare prices and save money

Compare all timetables for the bus from Santiago, RM to Antofagasta

Here is a selection of the cheapest bus trips from the schedule from Santiago, RM to Antofagasta from various bus operators like Pullman San Andres, Pluss Chile or Pullman Bus for the next days.

today

$36

tomorrow

$36

Tuesday

$32

Wednesday

$35

Thursday

$31

Friday

$31

Saturday

$33

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Cormar Bus	18h 40m	12:00 PM	Santiago, RM	Terminal San Borja	6:40 AM	Antofagasta	Camus Bus Station	Premium Economy	$36	A Bus from Cormar Bus goes from Terminal San Borja, Santiago, RM (Chile) at 3/22/2026 12:00:00 PM to Camus Bus Station, Antofagasta (Chile) arriving at 3/23/2026 6:40:00 AM. 50 Premium Economy ticket for $36 per person are available. Travel duration is 18h 40m
Cikbus Elité	19h 5m	1:30 PM	Santiago, RM	Sur Bus Station	8:35 AM	Antofagasta	Carlos Oviedo Cavada Bus Station	Premium Economy	$38	A Bus from Cikbus Elité goes from Sur Bus Station, Santiago, RM (Chile) at 3/22/2026 1:30:00 PM to Carlos Oviedo Cavada Bus Station, Antofagasta (Chile) arriving at 3/23/2026 8:35:00 AM. 50 Premium Economy ticket for $38 per person are available. Travel duration is 19h 5m
Pullman San Andres	18h 40m	3:30 PM	Santiago, RM	Terminal San Borja	10:10 AM	Antofagasta	Carlos Oviedo Cavada Bus Station	Premium Economy	$38	A Bus from Pullman San Andres goes from Terminal San Borja, Santiago, RM (Chile) at 3/22/2026 3:30:00 PM to Carlos Oviedo Cavada Bus Station, Antofagasta (Chile) arriving at 3/23/2026 10:10:00 AM. 50 Premium Economy ticket for $38 per person are available. Travel duration is 18h 40m
Gentour	16h 30m	6:30 PM	Santiago, RM	Terminal San Borja	11:00 AM	Antofagasta	Maipú	Premium Economy	$38	A Bus from Gentour goes from Terminal San Borja, Santiago, RM (Chile) at 3/22/2026 6:30:00 PM to Maipú, Antofagasta (Chile) arriving at 3/23/2026 11:00:00 AM. 50 Premium Economy ticket for $38 per person are available. Travel duration is 16h 30m
Chile Bus	19h 0m	2:00 PM	Santiago, RM	Terminal San Borja	9:00 AM	Antofagasta	Carlos Oviedo Cavada Bus Station	First Class	$38	A Bus from Chile Bus goes from Terminal San Borja, Santiago, RM (Chile) at 3/22/2026 2:00:00 PM to Carlos Oviedo Cavada Bus Station, Antofagasta (Chile) arriving at 3/23/2026 9:00:00 AM. 50 First Class ticket for $38 per person are available. Travel duration is 19h 0m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Cormar Bus	18h 40m	12:00 PM	Santiago, RM	Terminal San Borja	6:40 AM	Antofagasta	Camus Bus Station	Premium Economy	$36	A Bus from Cormar Bus goes from Terminal San Borja, Santiago, RM (Chile) at 3/23/2026 12:00:00 PM to Camus Bus Station, Antofagasta (Chile) arriving at 3/24/2026 6:40:00 AM. 50 Premium Economy ticket for $36 per person are available. Travel duration is 18h 40m
Pullman San Andres	18h 40m	3:30 PM	Santiago, RM	Terminal San Borja	10:10 AM	Antofagasta	Carlos Oviedo Cavada Bus Station	Premium Economy	$38	A Bus from Pullman San Andres goes from Terminal San Borja, Santiago, RM (Chile) at 3/23/2026 3:30:00 PM to Carlos Oviedo Cavada Bus Station, Antofagasta (Chile) arriving at 3/24/2026 10:10:00 AM. 50 Premium Economy ticket for $38 per person are available. Travel duration is 18h 40m
Chile Bus	19h 10m	2:00 PM	Santiago, RM	Terminal San Borja	9:10 AM	Antofagasta	Carlos Oviedo Cavada Bus Station	First Class	$38	A Bus from Chile Bus goes from Terminal San Borja, Santiago, RM (Chile) at 3/23/2026 2:00:00 PM to Carlos Oviedo Cavada Bus Station, Antofagasta (Chile) arriving at 3/24/2026 9:10:00 AM. 50 First Class ticket for $38 per person are available. Travel duration is 19h 10m
FlixBus	18h 35m	9:00 AM	Santiago, RM	Terminal San Borja	3:35 AM	Antofagasta	Carlos Oviedo Cavada Bus Station	Economy	$38	A Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 3/23/2026 9:00:00 AM to Carlos Oviedo Cavada Bus Station, Antofagasta (Chile) arriving at 3/24/2026 3:35:00 AM. 50 Economy ticket for $38 per person are available. Travel duration is 18h 35m
Cikbus Elité	19h 0m	7:30 AM	Santiago, RM	Sur Bus Station	2:30 AM	Antofagasta	Carlos Oviedo Cavada Bus Station	Premium Economy	$38	A Bus from Cikbus Elité goes from Sur Bus Station, Santiago, RM (Chile) at 3/23/2026 7:30:00 AM to Carlos Oviedo Cavada Bus Station, Antofagasta (Chile) arriving at 3/24/2026 2:30:00 AM. 50 Premium Economy ticket for $38 per person are available. Travel duration is 19h 0m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Nueva Andimar Vip	17h 45m	11:00 AM	Santiago, RM	Terminal San Borja	4:45 AM	Antofagasta	Carlos Oviedo Cavada Bus Station	Economy	$32	A Bus from Nueva Andimar Vip goes from Terminal San Borja, Santiago, RM (Chile) at 3/24/2026 11:00:00 AM to Carlos Oviedo Cavada Bus Station, Antofagasta (Chile) arriving at 3/25/2026 4:45:00 AM. 50 Economy ticket for $32 per person are available. Travel duration is 17h 45m
Cormar Bus	18h 40m	12:00 PM	Santiago, RM	Terminal San Borja	6:40 AM	Antofagasta	Camus Bus Station	Premium Economy	$36	A Bus from Cormar Bus goes from Terminal San Borja, Santiago, RM (Chile) at 3/24/2026 12:00:00 PM to Camus Bus Station, Antofagasta (Chile) arriving at 3/25/2026 6:40:00 AM. 50 Premium Economy ticket for $36 per person are available. Travel duration is 18h 40m
Pullman San Andres	18h 40m	3:30 PM	Santiago, RM	Terminal San Borja	10:10 AM	Antofagasta	Carlos Oviedo Cavada Bus Station	Premium Economy	$38	A Bus from Pullman San Andres goes from Terminal San Borja, Santiago, RM (Chile) at 3/24/2026 3:30:00 PM to Carlos Oviedo Cavada Bus Station, Antofagasta (Chile) arriving at 3/25/2026 10:10:00 AM. 50 Premium Economy ticket for $38 per person are available. Travel duration is 18h 40m
Pluss Chile	17h 55m	7:45 AM	Santiago, RM	Sur Bus Station	1:40 AM	Antofagasta	Carlos Oviedo Cavada Bus Station	Premium Economy	$38	A Bus from Pluss Chile goes from Sur Bus Station, Santiago, RM (Chile) at 3/24/2026 7:45:00 AM to Carlos Oviedo Cavada Bus Station, Antofagasta (Chile) arriving at 3/25/2026 1:40:00 AM. 50 Premium Economy ticket for $38 per person are available. Travel duration is 17h 55m
FlixBus	18h 40m	10:05 AM	Santiago, RM	Los Libertadores Bus Stop	4:45 AM	Antofagasta	Carlos Oviedo Cavada Bus Station	Economy	$39	A Bus from FlixBus goes from Los Libertadores Bus Stop, Santiago, RM (Chile) at 3/24/2026 10:05:00 AM to Carlos Oviedo Cavada Bus Station, Antofagasta (Chile) arriving at 3/25/2026 4:45:00 AM. 50 Economy ticket for $39 per person are available. Travel duration is 18h 40m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	18h 35m	9:00 AM	Santiago, RM	Terminal San Borja	3:35 AM	Antofagasta	Carlos Oviedo Cavada Bus Station	Economy	$35	A Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 3/25/2026 9:00:00 AM to Carlos Oviedo Cavada Bus Station, Antofagasta (Chile) arriving at 3/26/2026 3:35:00 AM. 50 Economy ticket for $35 per person are available. Travel duration is 18h 35m
Cormar Bus	18h 40m	12:00 PM	Santiago, RM	Terminal San Borja	6:40 AM	Antofagasta	Camus Bus Station	Premium Economy	$36	A Bus from Cormar Bus goes from Terminal San Borja, Santiago, RM (Chile) at 3/25/2026 12:00:00 PM to Camus Bus Station, Antofagasta (Chile) arriving at 3/26/2026 6:40:00 AM. 50 Premium Economy ticket for $36 per person are available. Travel duration is 18h 40m
Gentour	16h 30m	11:30 AM	Santiago, RM	Terminal San Borja	4:00 AM	Antofagasta	Maipú	Premium Economy	$38	A Bus from Gentour goes from Terminal San Borja, Santiago, RM (Chile) at 3/25/2026 11:30:00 AM to Maipú, Antofagasta (Chile) arriving at 3/26/2026 4:00:00 AM. 50 Premium Economy ticket for $38 per person are available. Travel duration is 16h 30m
Pullman San Andres	18h 40m	3:30 PM	Santiago, RM	Terminal San Borja	10:10 AM	Antofagasta	Carlos Oviedo Cavada Bus Station	Premium Economy	$38	A Bus from Pullman San Andres goes from Terminal San Borja, Santiago, RM (Chile) at 3/25/2026 3:30:00 PM to Carlos Oviedo Cavada Bus Station, Antofagasta (Chile) arriving at 3/26/2026 10:10:00 AM. 50 Premium Economy ticket for $38 per person are available. Travel duration is 18h 40m
Pluss Chile	17h 55m	7:45 AM	Santiago, RM	Sur Bus Station	1:40 AM	Antofagasta	Carlos Oviedo Cavada Bus Station	Premium Economy	$38	A Bus from Pluss Chile goes from Sur Bus Station, Santiago, RM (Chile) at 3/25/2026 7:45:00 AM to Carlos Oviedo Cavada Bus Station, Antofagasta (Chile) arriving at 3/26/2026 1:40:00 AM. 50 Premium Economy ticket for $38 per person are available. Travel duration is 17h 55m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	18h 35m	12:15 PM	Santiago, RM	Terminal San Borja	6:50 AM	Antofagasta	Carlos Oviedo Cavada Bus Station	Economy	$31	A Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 3/26/2026 12:15:00 PM to Carlos Oviedo Cavada Bus Station, Antofagasta (Chile) arriving at 3/27/2026 6:50:00 AM. 50 Economy ticket for $31 per person are available. Travel duration is 18h 35m
Pullman San Andres	18h 40m	5:00 PM	Santiago, RM	Terminal San Borja	11:40 AM	Antofagasta	Carlos Oviedo Cavada Bus Station	Premium Economy	$38	A Bus from Pullman San Andres goes from Terminal San Borja, Santiago, RM (Chile) at 3/26/2026 5:00:00 PM to Carlos Oviedo Cavada Bus Station, Antofagasta (Chile) arriving at 3/27/2026 11:40:00 AM. 50 Premium Economy ticket for $38 per person are available. Travel duration is 18h 40m
Cikbus Elité	19h 0m	7:30 AM	Santiago, RM	Sur Bus Station	2:30 AM	Antofagasta	Carlos Oviedo Cavada Bus Station	Premium Economy	$38	A Bus from Cikbus Elité goes from Sur Bus Station, Santiago, RM (Chile) at 3/26/2026 7:30:00 AM to Carlos Oviedo Cavada Bus Station, Antofagasta (Chile) arriving at 3/27/2026 2:30:00 AM. 50 Premium Economy ticket for $38 per person are available. Travel duration is 19h 0m
Pluss Chile	17h 55m	7:45 AM	Santiago, RM	Sur Bus Station	1:40 AM	Antofagasta	Carlos Oviedo Cavada Bus Station	Premium Economy	$38	A Bus from Pluss Chile goes from Sur Bus Station, Santiago, RM (Chile) at 3/26/2026 7:45:00 AM to Carlos Oviedo Cavada Bus Station, Antofagasta (Chile) arriving at 3/27/2026 1:40:00 AM. 50 Premium Economy ticket for $38 per person are available. Travel duration is 17h 55m
Pullman Bus	18h 50m	11:00 AM	Santiago, RM	Terminal San Borja	5:50 AM	Antofagasta	Camus Bus Station	First Class	$38	A Bus from Pullman Bus goes from Terminal San Borja, Santiago, RM (Chile) at 3/26/2026 11:00:00 AM to Camus Bus Station, Antofagasta (Chile) arriving at 3/27/2026 5:50:00 AM. 50 First Class ticket for $38 per person are available. Travel duration is 18h 50m

Did you know that if you travel from Santiago, RM to Antofagasta via La Serena, you can save more than $13? You can find the corresponding connections below.
- Pluss Chile
  
  26h 20m
  
  0
  
  11:15 PM
  
  Santiago, RM
  Sur Bus Station
  
  5:35 AM
  
  La Serena
  Central Bus Station
  
  0
  
  Premium Economy
  
  $11
  
  A Bus from Pluss Chile goes from Sur Bus Station, Santiago, RM (Chile) at 3/27/2026 11:15:00 PM to Central Bus Station, La Serena (Chile) arriving at 3/28/2026 5:35:00 AM. 50 Premium Economy ticket for $11 per person are available. Travel duration is 6h 20m
- Nueva Andimar Vip
  
  11h 35m
  
  0
  
  2:00 PM
  
  La Serena
  Central Bus Station
  
  1:35 AM
  
  Antofagasta
  Carlos Oviedo Cavada Bus Station
  
  0
  
  Economy
  
  $6
  
  A Bus from Nueva Andimar Vip goes from Central Bus Station, La Serena (Chile) at 3/28/2026 2:00:00 PM to Carlos Oviedo Cavada Bus Station, Antofagasta (Chile) arriving at 3/29/2026 1:35:00 AM. 50 Economy ticket for $6 per person are available. Travel duration is 11h 35m
Travel time is 8h 25m longer, but you will save $13

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	18h 35m	12:15 PM	Santiago, RM	Terminal San Borja	6:50 AM	Antofagasta	Carlos Oviedo Cavada Bus Station	Economy	$31	A Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 3/27/2026 12:15:00 PM to Carlos Oviedo Cavada Bus Station, Antofagasta (Chile) arriving at 3/28/2026 6:50:00 AM. 50 Economy ticket for $31 per person are available. Travel duration is 18h 35m
Nueva Andimar Vip	17h 45m	7:50 AM	Santiago, RM	Terminal San Borja	1:35 AM	Antofagasta	Carlos Oviedo Cavada Bus Station	Economy	$32	A Bus from Nueva Andimar Vip goes from Terminal San Borja, Santiago, RM (Chile) at 3/27/2026 7:50:00 AM to Carlos Oviedo Cavada Bus Station, Antofagasta (Chile) arriving at 3/28/2026 1:35:00 AM. 50 Economy ticket for $32 per person are available. Travel duration is 17h 45m
Cormar Bus	18h 40m	12:00 PM	Santiago, RM	Terminal San Borja	6:40 AM	Antofagasta	Camus Bus Station	Premium Economy	$36	A Bus from Cormar Bus goes from Terminal San Borja, Santiago, RM (Chile) at 3/27/2026 12:00:00 PM to Camus Bus Station, Antofagasta (Chile) arriving at 3/28/2026 6:40:00 AM. 50 Premium Economy ticket for $36 per person are available. Travel duration is 18h 40m
Pullman San Andres	18h 40m	3:30 PM	Santiago, RM	Terminal San Borja	10:10 AM	Antofagasta	Carlos Oviedo Cavada Bus Station	Premium Economy	$38	A Bus from Pullman San Andres goes from Terminal San Borja, Santiago, RM (Chile) at 3/27/2026 3:30:00 PM to Carlos Oviedo Cavada Bus Station, Antofagasta (Chile) arriving at 3/28/2026 10:10:00 AM. 50 Premium Economy ticket for $38 per person are available. Travel duration is 18h 40m
Pullman Bus	18h 50m	11:00 AM	Santiago, RM	Terminal San Borja	5:50 AM	Antofagasta	Camus Bus Station	First Class	$38	A Bus from Pullman Bus goes from Terminal San Borja, Santiago, RM (Chile) at 3/27/2026 11:00:00 AM to Camus Bus Station, Antofagasta (Chile) arriving at 3/28/2026 5:50:00 AM. 50 First Class ticket for $38 per person are available. Travel duration is 18h 50m

Did you know that if you travel from Santiago, RM to Antofagasta via La Serena, you can save more than $14? You can find the corresponding connections below.
- Turbus
  
  18h 0m
  
  0
  
  1:50 PM
  
  Santiago, RM
  Terminal Alameda
  
  8:00 PM
  
  La Serena
  Avda. Fco de Aguirre Station
  
  0
  
  Premium Economy
  
  $11
  
  A Bus from Turbus goes from Terminal Alameda, Santiago, RM (Chile) at 3/28/2026 1:50:00 PM to Avda. Fco de Aguirre Station, La Serena (Chile) arriving at 3/28/2026 8:00:00 PM. 50 Premium Economy ticket for $11 per person are available. Travel duration is 6h 10m
- Nueva Andimar Vip
  
  11h 35m
  
  0
  
  8:15 PM
  
  La Serena
  Central Bus Station
  
  7:50 AM
  
  Antofagasta
  Carlos Oviedo Cavada Bus Station
  
  0
  
  Economy
  
  $6
  
  A Bus from Nueva Andimar Vip goes from Central Bus Station, La Serena (Chile) at 3/28/2026 8:15:00 PM to Carlos Oviedo Cavada Bus Station, Antofagasta (Chile) arriving at 3/29/2026 7:50:00 AM. 50 Economy ticket for $6 per person are available. Travel duration is 11h 35m
Travel time is 0h 15m longer, but you will save $14

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Nueva Andimar Vip	17h 45m	7:50 AM	Santiago, RM	Terminal San Borja	1:35 AM	Antofagasta	Carlos Oviedo Cavada Bus Station	Economy	$33	A Bus from Nueva Andimar Vip goes from Terminal San Borja, Santiago, RM (Chile) at 3/28/2026 7:50:00 AM to Carlos Oviedo Cavada Bus Station, Antofagasta (Chile) arriving at 3/29/2026 1:35:00 AM. 50 Economy ticket for $33 per person are available. Travel duration is 17h 45m
Cormar Bus	18h 40m	12:00 PM	Santiago, RM	Terminal San Borja	6:40 AM	Antofagasta	Camus Bus Station	Premium Economy	$36	A Bus from Cormar Bus goes from Terminal San Borja, Santiago, RM (Chile) at 3/28/2026 12:00:00 PM to Camus Bus Station, Antofagasta (Chile) arriving at 3/29/2026 6:40:00 AM. 50 Premium Economy ticket for $36 per person are available. Travel duration is 18h 40m
Pluss Chile	17h 55m	7:45 AM	Santiago, RM	Sur Bus Station	1:40 AM	Antofagasta	Carlos Oviedo Cavada Bus Station	Premium Economy	$38	A Bus from Pluss Chile goes from Sur Bus Station, Santiago, RM (Chile) at 3/28/2026 7:45:00 AM to Carlos Oviedo Cavada Bus Station, Antofagasta (Chile) arriving at 3/29/2026 1:40:00 AM. 50 Premium Economy ticket for $38 per person are available. Travel duration is 17h 55m
Pullman San Andres	18h 40m	3:30 PM	Santiago, RM	Terminal San Borja	10:10 AM	Antofagasta	Carlos Oviedo Cavada Bus Station	Premium Economy	$38	A Bus from Pullman San Andres goes from Terminal San Borja, Santiago, RM (Chile) at 3/28/2026 3:30:00 PM to Carlos Oviedo Cavada Bus Station, Antofagasta (Chile) arriving at 3/29/2026 10:10:00 AM. 50 Premium Economy ticket for $38 per person are available. Travel duration is 18h 40m
Pullman Bus	18h 50m	11:00 AM	Santiago, RM	Terminal San Borja	5:50 AM	Antofagasta	Camus Bus Station	First Class	$38	A Bus from Pullman Bus goes from Terminal San Borja, Santiago, RM (Chile) at 3/28/2026 11:00:00 AM to Camus Bus Station, Antofagasta (Chile) arriving at 3/29/2026 5:50:00 AM. 50 First Class ticket for $38 per person are available. Travel duration is 18h 50m

Did you know that if you travel from Santiago, RM to Antofagasta via La Serena, you can save more than $16? You can find the corresponding connections below.
- Turbus
  
  18h 0m
  
  0
  
  1:50 PM
  
  Santiago, RM
  Terminal Alameda
  
  8:00 PM
  
  La Serena
  Avda. Fco de Aguirre Station
  
  0
  
  Premium Economy
  
  $11
  
  A Bus from Turbus goes from Terminal Alameda, Santiago, RM (Chile) at 3/28/2026 1:50:00 PM to Avda. Fco de Aguirre Station, La Serena (Chile) arriving at 3/28/2026 8:00:00 PM. 50 Premium Economy ticket for $11 per person are available. Travel duration is 6h 10m
- Nueva Andimar Vip
  
  11h 35m
  
  0
  
  8:15 PM
  
  La Serena
  Central Bus Station
  
  7:50 AM
  
  Antofagasta
  Carlos Oviedo Cavada Bus Station
  
  0
  
  Economy
  
  $6
  
  A Bus from Nueva Andimar Vip goes from Central Bus Station, La Serena (Chile) at 3/28/2026 8:15:00 PM to Carlos Oviedo Cavada Bus Station, Antofagasta (Chile) arriving at 3/29/2026 7:50:00 AM. 50 Economy ticket for $6 per person are available. Travel duration is 11h 35m
Travel time is 0h 15m longer, but you will save $16

Best Price Offer: The price for the cheapest bus from Santiago, RM to Antofagasta is $29 on 4/9/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Santiago, RM and Antofagasta

See here how frequent the connections between Santiago, RM and Antofagasta are, during different times and days of the week.

Sunday is the busiest day, with more than 158 daily buses from Santiago, RM to Antofagasta. Saturday has instead the fewest connections, with only 76 daily coaches between Santiago, RM and Antofagasta.

The busiest time of the day is the Morning, with 265 buses from Santiago, RM to Antofagasta, while Night sees the fewest connections between Santiago, RM and Antofagasta, with 1 offers.

Facts about the bus from Santiago, RM to Antofagasta

Compare all providers like Pullman San Andres, Pluss Chile and Pullman Bus that travel 107 times every day by bus from Santiago, RM to Antofagasta in one click! Book your bus ticket from Santiago, RM to Antofagasta starting from $29!

Cheapest Bus	$29
Fastest Bus	16h 30m
Earliest Bus	6:50 AM
Latest Bus	11:30 PM
Daily Bus Routes	107 Ø
Distance	677.0 miles
Bus Companies	Pullman San Andres, Pluss Chile, Pullman Bus, Cikbus Elité, FlixBus, Cormar Bus, Nueva Andimar Vip, Gentour, Buses Norte Azul, Ramos Cholele and 2 more.

Cheapest bus connections from Santiago, RM to Antofagasta

Every day, 107 buses from 12 bus companies leave Santiago, RM for Antofagasta: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 03/22/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 03/22

$36

Monday 03/23

$36

Tuesday 03/24

$32

Wednesday 03/25

$35

Thursday 03/26

$34

Friday 03/27

$31

Saturday 03/28

$38

Sunday 03/29

$40

Monday 03/30

$36

Tuesday 03/31

$30

Wednesday 04/01

$34

Thursday 04/02

$55

Friday 04/03

$36

Saturday 04/04

$34

Sunday 04/05

$36

Monday 04/06

$30

Tuesday 04/07

$29

Wednesday 04/08

$30

Thursday 04/09

$29

Friday 04/10

$30

Saturday 04/11

$30

Sunday 04/12

$29

Monday 04/13

$29

Tuesday 04/14

$29

Wednesday 04/15

$29

Thursday 04/16

$29

Friday 04/17

$29

Saturday 04/18

The cheapest time to travel from Santiago, RM to Antofagasta

See here on which day and which time of the day you can find the cheapest bus ticket from Santiago, RM to Antofagasta, for the next 30 days.

With a price starting from $29, Monday is the cheapest day for a bus from Santiago, RM to Antofagasta. Saturday instead is the most expensive day with prices starting from $30.

Night is the cheapest day time for bus tickets from Santiago, RM to Antofagasta, with $29. Evening is the most expensive time of the day with prices starting from $38.

How to save money travelling from Santiago, RM to Antofagasta

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Santiago, RM to Antofagasta in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Santiago, RM to Antofagasta, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Santiago, RM to Antofagasta are also emptier.

Beloved bus companies from Santiago, RM to Antofagasta

These are the most booked bus companies between Santiago, RM to Antofagasta from our users.

Cikbus Elité from Santiago, RM to Antofagasta

Here you will find the key facts about the Cikbus Elité bus route Santiago, RM to Antofagasta:

Cheapest Price	$38
Fastest Bus	17h 15m
Earliest Bus	7:30 AM
Last Bus	11:00 PM
Daily Connections	16 Ø
Found on	3/21/2026

Pluss Chile from Santiago, RM to Antofagasta

Here you will find the key facts about the Pluss Chile bus route Santiago, RM to Antofagasta:

Cheapest Price	$38
Fastest Bus	17h 20m
Earliest Bus	7:45 AM
Last Bus	11:15 PM
Daily Connections	27 Ø
Found on	3/22/2026

FlixBus from Santiago, RM to Antofagasta

Here you will find the key facts about the FlixBus bus route Santiago, RM to Antofagasta:

Cheapest Price	$31
Fastest Bus	17h 45m
Earliest Bus	7:50 AM
Last Bus	1:15 PM
Daily Connections	11 Ø
Found on	3/22/2026

Latest reviews for bus companies on the route Santiago, RM - Antofagasta

German Burgos, 9/1/2025

Bus con muy mal olor, sube gente tomando y fuman en los baños asientos incómodos. Super malo el servicio dejan a las personas fuera de los terminales en la calle. El bus no entra a los terminales. Pa ... Bus con muy mal olor, sube gente tomando y fuman en los baños asientos incómodos. Super malo el servicio dejan a las personas fuera de los terminales en la calle. El bus no entra a los terminales. Para nunca más con Gentour.

All bus stations and stops in Santiago, RM and Antofagasta

In the map below, you can see where to find all bus stations in Santiago, RM and Antofagasta.

Sur Bus Station

Av Libertador Bernardo O'Higgins 3850

Terminal San Borja

San Francisco de Borja 198-180

Terminal Alameda

Av Libertador Bernardo O'Higgins 3750

Terminal Pajaritos

Av. Gral. Óscar Bonilla 5935-5939

Los Héroes Station

Tucapel Jiménez 22

Camus Bus Station

Carlos Oviedo Cavada Bus Station

Avenida Pedro Aguirre Cerda 5750

Terminal Tur Bus

Almte. Juan José Latorre 2751

Pedro Aguirre Cerda esq. Nicolas Tirado Bus Stop

La Portada

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from Santiago, RM to Antofagasta? Compare all modes of transports from Santiago, RM to Antofagasta.

Service and Comfort on the bus from Santiago, RM to Antofagasta

Want to know which seat classes are available on the buses from Santiago, RM to Antofagasta? Or which bus companies serve the route Santiago, RM to Antofagasta? Below you will find answers to your questions.

FAQs about the Santiago, RM to Antofagasta bus

How much does a Santiago, RM Antofagasta bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $29 and takes 18h 35m to reach Antofagasta. Compare offers to save money!

How much could I save by comparing buses from Santiago, RM to Antofagasta?

This route is offered by 12 companies with a range of ticket prices between $29 and $94. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Antofagasta.

On average, how many connections are available from Santiago, RM to Antofagasta each day?

Every day, the Santiago, RM to Antofagasta bus route is served by approximately 107 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Santiago, RM to Antofagasta take?

The fastest bus from Santiago, RM to Antofagasta is offered by Gentour and takes 16h 30m. Bus tickets for this connection cost $53. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Santiago, RM to Antofagasta?

The earliest bus arriving in Antofagasta from Santiago, RM starts at 6:50 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Santiago, RM to Antofagasta?

The latest bus trip departing from Santiago, RM for Antofagasta starts at 11:30 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Santiago, RM Antofagasta route?

When traveling by bus from Santiago, RM to Antofagasta, passengers can travel with Pullman San Andres, Pluss Chile and Pullman Bus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Santiago, RM and Antofagasta?

You can check all the direct connections between Santiago, RM and Antofagasta by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Pullman San Andres, Pluss Chile and Pullman Bus.

What can I take with me on the Santiago, RM to Antofagasta bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Santiago, RM Antofagasta bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Santiago, RM Antofagasta bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Santiago, RM to Antofagasta on your planned travel date.

How does CheckMyBus find the best bus deals from Santiago, RM to Antofagasta?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 107 daily trips between Santiago, RM and Antofagasta. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Santiago, RM to Antofagasta?

Prices and availability for 107 trips between Santiago, RM and Antofagasta change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Santiago, RM to Antofagasta

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

Premium Economy

A mix between Economy and Business, it offers extra legroom, WI-FI and possible snacks.

First Class

Best of the best: you will find the most comfortable accommodation to work or relax during your travel.

More bus routes to Santiago, RM and to Antofagasta

Here’s an overview of the most popular bus routes to Santiago, RM and to Antofagasta. Simply click on the connection of your choice, and you will find all the details about your bus route!