Bus St. Louis, MO to Lafayette, LA: Compare prices and save money

Compare all timetables for the bus from St. Louis, MO to Lafayette, LA

Here is a selection of the cheapest bus trips from the schedule from St. Louis, MO to Lafayette, LA from various bus operators like Greyhound US or FlixBus for the next days.

today

$150

tomorrow

Sunday

Monday

$145

Tuesday

Wednesday

$122

Thursday

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	20h 10m	1:00 AM	St. Louis, MO	Gateway Station	9:10 PM	Lafayette, LA	Bus Stop	Economy	$150	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/5/2025 1:00:00 AM to Bus Stop, Lafayette, LA (USA) arriving at 12/5/2025 9:10:00 PM. 50 Economy ticket for $150 per person are available. Travel duration is 20h 10m
FlixBus	27h 35m	11:30 PM	St. Louis, MO	Gateway Station	3:05 AM	Lafayette, LA	Bus Stop	Economy	$150	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/5/2025 11:30:00 PM to Bus Stop, Lafayette, LA (USA) arriving at 12/7/2025 3:05:00 AM. 50 Economy ticket for $150 per person are available. Travel duration is 27h 35m
Greyhound US	26h 10m	1:30 AM	St. Louis, MO	Gateway Station	3:40 AM	Lafayette, LA	Bus Stop	Economy	$151	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/5/2025 1:30:00 AM to Bus Stop, Lafayette, LA (USA) arriving at 12/6/2025 3:40:00 AM. 50 Economy ticket for $151 per person are available. Travel duration is 26h 10m
FlixBus	16h 15m	4:00 PM	St. Louis, MO	Gateway Station	8:15 AM	Lafayette, LA	TA Travel Center	Economy	$151	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/5/2025 4:00:00 PM to TA Travel Center, Lafayette, LA (USA) arriving at 12/6/2025 8:15:00 AM. 50 Economy ticket for $151 per person are available. Travel duration is 16h 15m
Greyhound US	24h 25m	1:00 AM	St. Louis, MO	Gateway Station	1:25 AM	Lafayette, LA	TA Travel Center	Economy	$153	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/5/2025 1:00:00 AM to TA Travel Center, Lafayette, LA (USA) arriving at 12/6/2025 1:25:00 AM. 50 Economy ticket for $153 per person are available. Travel duration is 24h 25m

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	16h 15m	4:00 PM	St. Louis, MO	Gateway Station	8:15 AM	Lafayette, LA	TA Travel Center	Economy	$145	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/8/2025 4:00:00 PM to TA Travel Center, Lafayette, LA (USA) arriving at 12/9/2025 8:15:00 AM. 50 Economy ticket for $145 per person are available. Travel duration is 16h 15m
FlixBus	17h 5m	4:00 PM	St. Louis, MO	Gateway Station	9:05 AM	Lafayette, LA	Bus Stop	Economy	$147	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/8/2025 4:00:00 PM to Bus Stop, Lafayette, LA (USA) arriving at 12/9/2025 9:05:00 AM. 50 Economy ticket for $147 per person are available. Travel duration is 17h 5m
Greyhound US	24h 25m	1:00 AM	St. Louis, MO	Gateway Station	1:25 AM	Lafayette, LA	TA Travel Center	Economy	$148	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/8/2025 1:00:00 AM to TA Travel Center, Lafayette, LA (USA) arriving at 12/9/2025 1:25:00 AM. 50 Economy ticket for $148 per person are available. Travel duration is 24h 25m
FlixBus	27h 35m	11:30 PM	St. Louis, MO	Gateway Station	3:05 AM	Lafayette, LA	Bus Stop	Economy	$148	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/8/2025 11:30:00 PM to Bus Stop, Lafayette, LA (USA) arriving at 12/10/2025 3:05:00 AM. 50 Economy ticket for $148 per person are available. Travel duration is 27h 35m
Greyhound US	20h 10m	1:00 AM	St. Louis, MO	Gateway Station	9:10 PM	Lafayette, LA	Bus Stop	Economy	$150	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/8/2025 1:00:00 AM to Bus Stop, Lafayette, LA (USA) arriving at 12/8/2025 9:10:00 PM. 50 Economy ticket for $150 per person are available. Travel duration is 20h 10m

Did you know that if you travel from St. Louis, MO to Lafayette, LA via New Orleans, LA, you can save more than $53? You can find the corresponding connections below.
- Busbud
  
  20h 10m
  
  0
  
  1:00 AM
  
  St. Louis, MO
  Gateway Station
  
  5:50 PM
  
  New Orleans, LA
  Central Bus Station
  
  0
  
  Economy
  
  $70
  
  A Bus from Busbud goes from Gateway Station, St. Louis, MO (USA) at 12/8/2025 1:00:00 AM to Central Bus Station, New Orleans, LA (USA) arriving at 12/8/2025 5:50:00 PM. 50 Economy ticket for $70 per person are available. Travel duration is 16h 50m
- Busbud
  
  3h 15m
  
  0
  
  5:55 PM
  
  New Orleans, LA
  Central Bus Station
  
  9:10 PM
  
  Lafayette, LA
  Bus Stop
  
  0
  
  Economy
  
  $21
  
  A Bus from Busbud goes from Central Bus Station, New Orleans, LA (USA) at 12/8/2025 5:55:00 PM to Bus Stop, Lafayette, LA (USA) arriving at 12/8/2025 9:10:00 PM. 50 Economy ticket for $21 per person are available. Travel duration is 3h 15m
Travel time is 3h 55m longer, but you will save $53

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	20h 10m	1:00 AM	St. Louis, MO	Gateway Station	9:10 PM	Lafayette, LA	Bus Stop	Economy	$122	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/10/2025 1:00:00 AM to Bus Stop, Lafayette, LA (USA) arriving at 12/10/2025 9:10:00 PM. 50 Economy ticket for $122 per person are available. Travel duration is 20h 10m
Greyhound US	31h 25m	1:45 PM	St. Louis, MO	Gateway Station	9:10 PM	Lafayette, LA	Bus Stop	Economy	$124	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/10/2025 1:45:00 PM to Bus Stop, Lafayette, LA (USA) arriving at 12/11/2025 9:10:00 PM. 50 Economy ticket for $124 per person are available. Travel duration is 31h 25m
Greyhound US	29h 0m	1:45 PM	St. Louis, MO	Gateway Station	6:45 PM	Lafayette, LA	TA Travel Center	Economy	$124	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/10/2025 1:45:00 PM to TA Travel Center, Lafayette, LA (USA) arriving at 12/11/2025 6:45:00 PM. 50 Economy ticket for $124 per person are available. Travel duration is 29h 0m
Greyhound US	29h 35m	1:20 AM	St. Louis, MO	Gateway Station	6:55 AM	Lafayette, LA	Bus Stop	Economy	$125	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/10/2025 1:20:00 AM to Bus Stop, Lafayette, LA (USA) arriving at 12/11/2025 6:55:00 AM. 50 Economy ticket for $125 per person are available. Travel duration is 29h 35m
Greyhound US	35h 30m	1:55 PM	St. Louis, MO	Gateway Station	1:25 AM	Lafayette, LA	TA Travel Center	Economy	$144	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/10/2025 1:55:00 PM to TA Travel Center, Lafayette, LA (USA) arriving at 12/12/2025 1:25:00 AM. 50 Economy ticket for $144 per person are available. Travel duration is 35h 30m

Did you know that if you travel from St. Louis, MO to Lafayette, LA via New Orleans, LA, you can save more than $32? You can find the corresponding connections below.
- Busbud
  
  24h 25m
  
  0
  
  1:00 AM
  
  St. Louis, MO
  Gateway Station
  
  5:50 PM
  
  New Orleans, LA
  Central Bus Station
  
  0
  
  Economy
  
  $70
  
  A Bus from Busbud goes from Gateway Station, St. Louis, MO (USA) at 12/8/2025 1:00:00 AM to Central Bus Station, New Orleans, LA (USA) arriving at 12/8/2025 5:50:00 PM. 50 Economy ticket for $70 per person are available. Travel duration is 16h 50m
- Busbud
  
  2h 25m
  
  0
  
  11:00 PM
  
  New Orleans, LA
  Central Bus Station
  
  1:25 AM
  
  Lafayette, LA
  TA Travel Center
  
  0
  
  Economy
  
  $20
  
  A Bus from Busbud goes from Central Bus Station, New Orleans, LA (USA) at 12/8/2025 11:00:00 PM to TA Travel Center, Lafayette, LA (USA) arriving at 12/9/2025 1:25:00 AM. 50 Economy ticket for $20 per person are available. Travel duration is 2h 25m
Travel time is 4h 15m longer, but you will save $32

Best Price Offer: The price for the cheapest bus from St. Louis, MO to Lafayette, LA is $122 on 12/10/2025. Flexible travelers save on ticket prices.

Frequency of bus connections between St. Louis, MO and Lafayette, LA

See here how frequent the connections between St. Louis, MO and Lafayette, LA are, during different times and days of the week.

Monday is the busiest day, with more than 6 daily buses from St. Louis, MO to Lafayette, LA. Wednesday has instead the fewest connections, with only 5 daily coaches between St. Louis, MO and Lafayette, LA.

The busiest time of the day is the Night, with 8 buses from St. Louis, MO to Lafayette, LA, while Evening sees the fewest connections between St. Louis, MO and Lafayette, LA, with 2 offers.

Facts about the bus from St. Louis, MO to Lafayette, LA

Compare all providers like Greyhound US and FlixBus that travel 5 times every day by bus from St. Louis, MO to Lafayette, LA in one click! Book your bus ticket from St. Louis, MO to Lafayette, LA starting from $122!

Cheapest Bus	$122
Fastest Bus	16h 15m
Earliest Bus	1:00 AM
Latest Bus	1:55 PM
Daily Bus Routes	5 Ø
Distance	589.7 miles
Bus Companies	Greyhound US and FlixBus

Cheapest bus connections from St. Louis, MO to Lafayette, LA

Every day, 5 buses from 2 bus companies leave St. Louis, MO for Lafayette, LA: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/05/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 11/30

Monday 12/01

Tuesday 12/02

Wednesday 12/03

Thursday 12/04

Friday 12/05

$150

Saturday 12/06

Sunday 12/07

Monday 12/08

$145

Tuesday 12/09

Wednesday 12/10

$122

Thursday 12/11

Friday 12/12

Saturday 12/13

Sunday 12/14

Monday 12/15

Tuesday 12/16

Wednesday 12/17

Thursday 12/18

Friday 12/19

Saturday 12/20

Sunday 12/21

Monday 12/22

Tuesday 12/23

Wednesday 12/24

Thursday 12/25

Friday 12/26

Saturday 12/27

The cheapest time to travel from St. Louis, MO to Lafayette, LA

See here on which day and which time of the day you can find the cheapest bus ticket from St. Louis, MO to Lafayette, LA, for the next 30 days.

With a price starting from $122, Wednesday is the cheapest day for a bus from St. Louis, MO to Lafayette, LA. Friday instead is the most expensive day with prices starting from $150.

Night is the cheapest day time for bus tickets from St. Louis, MO to Lafayette, LA, with $122. Evening is the most expensive time of the day with prices starting from $148.

How to save money travelling from St. Louis, MO to Lafayette, LA

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from St. Louis, MO to Lafayette, LA in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from St. Louis, MO to Lafayette, LA, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from St. Louis, MO to Lafayette, LA are also emptier.

All bus stations and stops in St. Louis, MO and Lafayette, LA

In the map below, you can see where to find all bus stations in St. Louis, MO and Lafayette, LA.

Gateway Station

S 15th St 430

Skinker Boulevard

Boulevard between Lindell Blvd. and Lagoon Drive

Lindbergh @ Hackberry NB Bus Stop

Bus Stop

Lee Ave 100

TA Travel Center

N University Ave 1701

Cameron Street & Alley Five Bus Stop

Cameron St 2405

Service and Comfort on the bus from St. Louis, MO to Lafayette, LA

Want to know which seat classes are available on the buses from St. Louis, MO to Lafayette, LA? Or which bus companies serve the route St. Louis, MO to Lafayette, LA? Below you will find answers to your questions.

FAQs about the St. Louis, MO to Lafayette, LA bus

How much does a St. Louis, MO Lafayette, LA bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $122 and takes 20h 10m to reach Lafayette, LA. Compare offers to save money!

How much could I save by comparing buses from St. Louis, MO to Lafayette, LA?

This route is offered by 2 companies with a range of ticket prices between $122 and $153. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Lafayette, LA.

On average, how many connections are available from St. Louis, MO to Lafayette, LA each day?

Every day, the St. Louis, MO to Lafayette, LA bus route is served by approximately 5 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from St. Louis, MO to Lafayette, LA take?

The fastest bus from St. Louis, MO to Lafayette, LA is offered by FlixBus and takes 16h 15m. Bus tickets for this connection cost $151. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from St. Louis, MO to Lafayette, LA?

The earliest bus arriving in Lafayette, LA from St. Louis, MO starts at 1:00 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from St. Louis, MO to Lafayette, LA?

The latest bus trip departing from St. Louis, MO for Lafayette, LA starts at 1:55 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the St. Louis, MO Lafayette, LA route?

When traveling by bus from St. Louis, MO to Lafayette, LA, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between St. Louis, MO and Lafayette, LA?

You can check all the direct connections between St. Louis, MO and Lafayette, LA by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the St. Louis, MO to Lafayette, LA bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the St. Louis, MO Lafayette, LA bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the St. Louis, MO Lafayette, LA bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from St. Louis, MO to Lafayette, LA on your planned travel date.

Available seat classes which are offered on the bus route St. Louis, MO to Lafayette, LA

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to St. Louis, MO and to Lafayette, LA

Here’s an overview of the most popular bus routes to St. Louis, MO and to Lafayette, LA. Simply click on the connection of your choice, and you will find all the details about your bus route!