Bus Tupelo, MS to San Antonio, TX: Compare prices and save money

Compare all timetables for the bus from Tupelo, MS to San Antonio, TX

Here is a selection of the cheapest bus trips from the schedule from Tupelo, MS to San Antonio, TX from various bus operators like Greyhound US for the next days.

today

tomorrow

Tuesday

Wednesday

Thursday

Friday

$99

Saturday

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	18h 20m	5:35 AM	Tupelo, MS	Bus Stop	11:55 PM	San Antonio, TX	Bus Station	Economy	$99	A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 3/27/2026 5:35:00 AM to Bus Station, San Antonio, TX (USA) arriving at 3/27/2026 11:55:00 PM. 50 Economy ticket for $99 per person are available. Travel duration is 18h 20m
Greyhound US	20h 0m	9:35 PM	Tupelo, MS	Bus Stop	5:35 PM	San Antonio, TX	Bus Station	Economy	$99	A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 3/27/2026 9:35:00 PM to Bus Station, San Antonio, TX (USA) arriving at 3/28/2026 5:35:00 PM. 50 Economy ticket for $99 per person are available. Travel duration is 20h 0m
Greyhound US	24h 40m	11:15 PM	Tupelo, MS	Bus Stop	11:55 PM	San Antonio, TX	Bus Station	Economy	$100	A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 3/27/2026 11:15:00 PM to Bus Station, San Antonio, TX (USA) arriving at 3/28/2026 11:55:00 PM. 50 Economy ticket for $100 per person are available. Travel duration is 24h 40m
Greyhound US	28h 25m	10:55 AM	Tupelo, MS	Bus Stop	3:20 PM	San Antonio, TX	Bus Station	Economy	$101	A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 3/27/2026 10:55:00 AM to Bus Station, San Antonio, TX (USA) arriving at 3/28/2026 3:20:00 PM. 50 Economy ticket for $101 per person are available. Travel duration is 28h 25m

Best Price Offer: The price for the cheapest bus from Tupelo, MS to San Antonio, TX is $86 on 4/2/2026. Flexible travelers save on ticket prices.

Facts about the bus from Tupelo, MS to San Antonio, TX

Compare all providers like Greyhound US that travel 4 times every day by bus from Tupelo, MS to San Antonio, TX in one click! Book your bus ticket from Tupelo, MS to San Antonio, TX starting from $86!

Cheapest Bus	$86
Fastest Bus	18h 20m
Earliest Bus	5:35 AM
Latest Bus	11:15 PM
Daily Bus Routes	4 Ø
Distance	663.8 miles
Bus Companies	Greyhound US

Cheapest bus connections from Tupelo, MS to San Antonio, TX

Every day, 4 buses from 1 bus companies leave Tupelo, MS for San Antonio, TX: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 03/22/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 03/22

Monday 03/23

Tuesday 03/24

Wednesday 03/25

Thursday 03/26

Friday 03/27

$99

Saturday 03/28

Sunday 03/29

Monday 03/30

Tuesday 03/31

Wednesday 04/01

Thursday 04/02

$86

Friday 04/03

Saturday 04/04

Sunday 04/05

$99

Monday 04/06

Tuesday 04/07

Wednesday 04/08

$100

Thursday 04/09

Friday 04/10

Saturday 04/11

Sunday 04/12

$96

Monday 04/13

$96

Tuesday 04/14

Wednesday 04/15

$100

Thursday 04/16

Friday 04/17

Saturday 04/18

How to save money travelling from Tupelo, MS to San Antonio, TX

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Tupelo, MS to San Antonio, TX in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Tupelo, MS to San Antonio, TX, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Tupelo, MS to San Antonio, TX are also emptier.

Beloved bus companies from Tupelo, MS to San Antonio, TX

These are the most booked bus companies between Tupelo, MS to San Antonio, TX from our users.

Greyhound US from Tupelo, MS to San Antonio, TX

Here you will find the key facts about the Greyhound US bus route Tupelo, MS to San Antonio, TX:

Cheapest Price	$99
Fastest Bus	18h 20m
Earliest Bus	5:35 AM
Last Bus	11:15 PM
Daily Connections	4 Ø
Found on	2/24/2026

All bus stations and stops in Tupelo, MS and San Antonio, TX

In the map below, you can see where to find all bus stations in Tupelo, MS and San Antonio, TX.

Bus Stop

S Eason Blvd 2831

Bus Station

N St Mary's St 500

San Antonio

Pearl District

Avenue A 699-599

Commerce & Bowie Bus Stop

W. Southcross & Buffalo Bus Stop

Service and Comfort on the bus from Tupelo, MS to San Antonio, TX

Want to know which seat classes are available on the buses from Tupelo, MS to San Antonio, TX? Or which bus companies serve the route Tupelo, MS to San Antonio, TX? Below you will find answers to your questions.

FAQs about the Tupelo, MS to San Antonio, TX bus

How much does a Tupelo, MS San Antonio, TX bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $86 and takes 18h 20m to reach San Antonio, TX. Compare offers to save money!

How much could I save by comparing buses from Tupelo, MS to San Antonio, TX?

This route is offered by 1 companies with a range of ticket prices between $86 and $101. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to San Antonio, TX.

On average, how many connections are available from Tupelo, MS to San Antonio, TX each day?

Every day, the Tupelo, MS to San Antonio, TX bus route is served by approximately 4 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Tupelo, MS to San Antonio, TX take?

The fastest bus from Tupelo, MS to San Antonio, TX is offered by Greyhound US and takes 18h 20m. Bus tickets for this connection cost $99. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Tupelo, MS to San Antonio, TX?

The earliest bus arriving in San Antonio, TX from Tupelo, MS starts at 5:35 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Tupelo, MS to San Antonio, TX?

The latest bus trip departing from Tupelo, MS for San Antonio, TX starts at 11:15 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Tupelo, MS San Antonio, TX route?

When traveling by bus from Tupelo, MS to San Antonio, TX, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Tupelo, MS and San Antonio, TX?

You can check all the direct connections between Tupelo, MS and San Antonio, TX by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Tupelo, MS to San Antonio, TX bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Tupelo, MS San Antonio, TX bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Tupelo, MS San Antonio, TX bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Tupelo, MS to San Antonio, TX on your planned travel date.

How does CheckMyBus find the best bus deals from Tupelo, MS to San Antonio, TX?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 4 daily trips between Tupelo, MS and San Antonio, TX. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Tupelo, MS to San Antonio, TX?

Prices and availability for 4 trips between Tupelo, MS and San Antonio, TX change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Tupelo, MS to San Antonio, TX

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Tupelo, MS and to San Antonio, TX

Here’s an overview of the most popular bus routes to Tupelo, MS and to San Antonio, TX. Simply click on the connection of your choice, and you will find all the details about your bus route!