Bus from Tupelo, MS to San Antonio, TX from $109

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Compare all timetables for the bus from Tupelo, MS to San Antonio, TX

Here is a selection of the cheapest bus trips from the schedule from Tupelo, MS to San Antonio, TX from various bus operators like Greyhound US for the next days.

today
tomorrow
$154
Sunday
$110
Monday
Tuesday
$142
Wednesday
$161
Thursday

Cheapest bus trips tomorrow

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 18h 20m 5:35 AM Tupelo, MS Bus Stop 11:55 PM San Antonio, TX Bus Station  Economy $154
Greyhound US 28h 25m 10:55 AM Tupelo, MS Bus Stop 3:20 PM San Antonio, TX Bus Station  Economy $154
Greyhound US 20h 0m 9:35 PM Tupelo, MS Bus Stop 5:35 PM San Antonio, TX Bus Station  Economy $154
Greyhound US 24h 40m 11:15 PM Tupelo, MS Bus Stop 11:55 PM San Antonio, TX Bus Station  Economy $154
  • Did you know that if you travel from Tupelo, MS to San Antonio, TX via Memphis, you can save more than $42? You can find the corresponding connections below.
    • FlixBus
      20h 0m
      0
      9:35 PM
      Tupelo, MS
      Bus Stop
      11:25 PM
      Memphis
      Airways Transit Center
      0
      FlixBus
      Economy
      $23
      • Waiting Time 3h 10m
    • Busbud
      15h 0m
      0
      2:35 AM
      Memphis
      Airways Transit Center
      5:35 PM
      San Antonio, TX
      Bus Station
      0
      Busbud
      Economy
      $89
    Travel time is 1h 40m longer, but you will save $42

Cheapest bus trips Sunday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 18h 20m 5:35 AM Tupelo, MS Bus Stop 11:55 PM San Antonio, TX Bus Station  Economy $110
Greyhound US 20h 0m 9:35 PM Tupelo, MS Bus Stop 5:35 PM San Antonio, TX Bus Station  Economy $110
Greyhound US 24h 40m 11:15 PM Tupelo, MS Bus Stop 11:55 PM San Antonio, TX Bus Station  Economy $111
Greyhound US 28h 25m 10:55 AM Tupelo, MS Bus Stop 3:20 PM San Antonio, TX Bus Station  Economy $112

Cheapest bus trips Tuesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 20h 0m 9:35 PM Tupelo, MS Bus Stop 5:35 PM San Antonio, TX Bus Station  Economy $142
Greyhound US 24h 40m 11:15 PM Tupelo, MS Bus Stop 11:55 PM San Antonio, TX Bus Station  Economy $143
Greyhound US 28h 25m 10:55 AM Tupelo, MS Bus Stop 3:20 PM San Antonio, TX Bus Station  Economy $146
Greyhound US 18h 20m 5:35 AM Tupelo, MS Bus Stop 11:55 PM San Antonio, TX Bus Station  Economy $147
  • Did you know that if you travel from Tupelo, MS to San Antonio, TX via Memphis, you can save more than $30? You can find the corresponding connections below.
    • FlixBus
      20h 0m
      0
      9:35 PM
      Tupelo, MS
      Bus Stop
      11:25 PM
      Memphis
      Airways Transit Center
      0
      FlixBus
      Economy
      $23
      • Waiting Time 3h 10m
    • Busbud
      15h 0m
      0
      2:35 AM
      Memphis
      Airways Transit Center
      5:35 PM
      San Antonio, TX
      Bus Station
      0
      Busbud
      Economy
      $89
    Travel time is 1h 40m longer, but you will save $30

Cheapest bus trips Wednesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 18h 20m 5:35 AM Tupelo, MS Bus Stop 11:55 PM San Antonio, TX Bus Station  Economy $161
Greyhound US 20h 0m 9:35 PM Tupelo, MS Bus Stop 5:35 PM San Antonio, TX Bus Station  Economy $161
Greyhound US 28h 25m 10:55 AM Tupelo, MS Bus Stop 3:20 PM San Antonio, TX Bus Station  Economy $162
Greyhound US 24h 40m 11:15 PM Tupelo, MS Bus Stop 11:55 PM San Antonio, TX Bus Station  Economy $162
  • Did you know that if you travel from Tupelo, MS to San Antonio, TX via Memphis, you can save more than $49? You can find the corresponding connections below.
    • FlixBus
      20h 0m
      0
      9:35 PM
      Tupelo, MS
      Bus Stop
      11:25 PM
      Memphis
      Airways Transit Center
      0
      FlixBus
      Economy
      $23
      • Waiting Time 3h 10m
    • Busbud
      15h 0m
      0
      2:35 AM
      Memphis
      Airways Transit Center
      5:35 PM
      San Antonio, TX
      Bus Station
      0
      Busbud
      Economy
      $89
    Travel time is 1h 40m longer, but you will save $49

Best Price Offer: The price for the cheapest bus from Tupelo, MS to San Antonio, TX is $109 on 2/13/2026. Flexible travelers save on ticket prices.


Frequency of bus connections between Tupelo, MS and San Antonio, TX

See here how frequent the connections between Tupelo, MS and San Antonio, TX are, during different times and days of the week.
Sunday is the busiest day, with more than 4 daily buses from Tupelo, MS to San Antonio, TX. Sunday has instead the fewest connections, with only 4 daily coaches between Tupelo, MS and San Antonio, TX.
The busiest time of the day is the Evening, with 8 buses from Tupelo, MS to San Antonio, TX, while Morning sees the fewest connections between Tupelo, MS and San Antonio, TX, with 4 offers.

Facts about the bus from Tupelo, MS to San Antonio, TX

Compare all providers like Greyhound US that travel 4 times every day by bus from Tupelo, MS to San Antonio, TX in one click! Book your bus ticket from Tupelo, MS to San Antonio, TX starting from $109!

Cheapest Bus $109
Fastest Bus 18h 20m
Earliest Bus 5:35 AM
Latest Bus 11:15 PM
Daily Bus Routes 4 Ø
Distance 663.8 miles
Bus Companies Greyhound US

Cheapest bus connections from Tupelo, MS to San Antonio, TX

Every day, 4 buses from 1 bus companies leave Tupelo, MS for San Antonio, TX: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 02/06/2026 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 02/01
Monday 02/02
Tuesday 02/03
Wednesday 02/04
Thursday 02/05
Friday 02/06
Saturday 02/07
$154
Sunday 02/08
$110
Monday 02/09
Tuesday 02/10
$142
Wednesday 02/11
$161
Thursday 02/12
Friday 02/13
$109
Saturday 02/14
Sunday 02/15
Monday 02/16
Tuesday 02/17
Wednesday 02/18
Thursday 02/19
Friday 02/20
Saturday 02/21
Sunday 02/22
Monday 02/23
Tuesday 02/24
Wednesday 02/25
Thursday 02/26
Friday 02/27
Saturday 02/28

The cheapest time to travel from Tupelo, MS to San Antonio, TX

See here on which day and which time of the day you can find the cheapest bus ticket from Tupelo, MS to San Antonio, TX, for the next 30 days.
With a price starting from $110, Sunday is the cheapest day for a bus from Tupelo, MS to San Antonio, TX. Wednesday instead is the most expensive day with prices starting from $161.
Night is the cheapest day time for bus tickets from Tupelo, MS to San Antonio, TX, with $109. Morning is the most expensive time of the day with prices starting from $112.

How to save money travelling from Tupelo, MS to San Antonio, TX

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Tupelo, MS to San Antonio, TX in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Tupelo, MS to San Antonio, TX, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Tupelo, MS to San Antonio, TX are also emptier.

Beloved bus companies from Tupelo, MS to San Antonio, TX

These are the most booked bus companies between Tupelo, MS to San Antonio, TX from our users.

Greyhound US from Tupelo, MS to San Antonio, TX

Greyhound US

Here you will find the key facts about the Greyhound US bus route Tupelo, MS to San Antonio, TX:

Cheapest Price $110
Fastest Bus 18h 20m
Earliest Bus 5:35 AM
Last Bus 11:15 PM
Daily Connections 4 Ø
Found on 2/3/2026

All bus stations and stops in Tupelo, MS and San Antonio, TX

In the map below, you can see where to find all bus stations in Tupelo, MS and San Antonio, TX.

Service and Comfort on the bus from Tupelo, MS to San Antonio, TX

Want to know which seat classes are available on the buses from Tupelo, MS to San Antonio, TX? Or which bus companies serve the route Tupelo, MS to San Antonio, TX? Below you will find answers to your questions.

FAQs about the Tupelo, MS to San Antonio, TX bus

How much does a Tupelo, MS San Antonio, TX bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $109 and takes 18h 20m to reach San Antonio, TX. Compare offers to save money!

How much could I save by comparing buses from Tupelo, MS to San Antonio, TX?

This route is offered by 1 companies with a range of ticket prices between $109 and $162. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to San Antonio, TX.

On average, how many connections are available from Tupelo, MS to San Antonio, TX each day?

Every day, the Tupelo, MS to San Antonio, TX bus route is served by approximately 4 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Tupelo, MS to San Antonio, TX take?

The fastest bus from Tupelo, MS to San Antonio, TX is offered by Greyhound US and takes 18h 20m. Bus tickets for this connection cost $154. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Tupelo, MS to San Antonio, TX?

The earliest bus arriving in San Antonio, TX from Tupelo, MS starts at 5:35 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Tupelo, MS to San Antonio, TX?

The latest bus trip departing from Tupelo, MS for San Antonio, TX starts at 11:15 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Tupelo, MS San Antonio, TX route?

When traveling by bus from Tupelo, MS to San Antonio, TX, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Tupelo, MS and San Antonio, TX?

You can check all the direct connections between Tupelo, MS and San Antonio, TX by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Tupelo, MS to San Antonio, TX bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Tupelo, MS San Antonio, TX bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Tupelo, MS San Antonio, TX bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Tupelo, MS to San Antonio, TX on your planned travel date.

How does CheckMyBus find the best bus deals from Tupelo, MS to San Antonio, TX?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 4 daily trips between Tupelo, MS and San Antonio, TX. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Tupelo, MS to San Antonio, TX?

Prices and availability for 4 trips between Tupelo, MS and San Antonio, TX change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Tupelo, MS to San Antonio, TX

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Tupelo, MS and to San Antonio, TX

Here’s an overview of the most popular bus routes to Tupelo, MS and to San Antonio, TX. Simply click on the connection of your choice, and you will find all the details about your bus route!
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Popular Airport Shuttles to Tupelo, MS and to San Antonio, TX
CheckMyBus › Buses in USA › Bus to Tupelo, MS › Bus to San Antonio, TX

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