Bus Durham, NC to San Diego - Compare all Companies

Compare all timetables for the bus from Durham, NC to San Diego

Here is a selection of the cheapest bus trips from the schedule from Durham, NC to San Diego from various bus operators like FlixBus or Greyhound US for the next days.

today

$345

tomorrow

Sunday

$291

Monday

Tuesday

$232

Wednesday

$225

Thursday

Cheapest bus trips today
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	FlixBus	63h 30m	10:05 PM	Durham, NC	Exxon	10:35 AM	San Diego	San Ysidro Transit Center		Economy	$345	A Bus from FlixBus goes from Exxon, Durham, NC (USA) at 12/19/2025 10:05:00 PM to San Ysidro Transit Center, San Diego (USA) arriving at 12/22/2025 10:35:00 AM. 50 Economy ticket for $345 per person are available. Travel duration is 63h 30m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	60h 50m	8:30 AM	Durham, NC	Exxon	6:20 PM	San Diego	San Ysidro Transit Center	Economy	$291	A Bus from FlixBus goes from Exxon, Durham, NC (USA) at 12/21/2025 8:30:00 AM to San Ysidro Transit Center, San Diego (USA) arriving at 12/23/2025 6:20:00 PM. 50 Economy ticket for $291 per person are available. Travel duration is 60h 50m
FlixBus	63h 30m	10:05 PM	Durham, NC	Exxon	10:35 AM	San Diego	San Ysidro Transit Center	Economy	$301	A Bus from FlixBus goes from Exxon, Durham, NC (USA) at 12/21/2025 10:05:00 PM to San Ysidro Transit Center, San Diego (USA) arriving at 12/24/2025 10:35:00 AM. 50 Economy ticket for $301 per person are available. Travel duration is 63h 30m
FlixBus	70h 5m	10:05 PM	Durham, NC	Exxon	5:10 PM	San Diego	San Ysidro Transit Center	Economy	$309	A Bus from FlixBus goes from Exxon, Durham, NC (USA) at 12/21/2025 10:05:00 PM to San Ysidro Transit Center, San Diego (USA) arriving at 12/24/2025 5:10:00 PM. 50 Economy ticket for $309 per person are available. Travel duration is 70h 5m

Cheapest bus trips Tuesday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	69h 10m	4:25 PM	Durham, NC	Exxon	10:35 AM	San Diego	San Ysidro Transit Center		Economy	$232	A Bus from Greyhound US goes from Exxon, Durham, NC (USA) at 12/23/2025 4:25:00 PM to San Ysidro Transit Center, San Diego (USA) arriving at 12/26/2025 10:35:00 AM. 50 Economy ticket for $232 per person are available. Travel duration is 69h 10m
	FlixBus	61h 15m	8:30 AM	Durham, NC	Exxon	6:45 PM	San Diego	San Ysidro Transit Center		Economy	$264	A Bus from FlixBus goes from Exxon, Durham, NC (USA) at 12/23/2025 8:30:00 AM to San Ysidro Transit Center, San Diego (USA) arriving at 12/25/2025 6:45:00 PM. 50 Economy ticket for $264 per person are available. Travel duration is 61h 15m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	69h 10m	4:25 PM	Durham, NC	Exxon	10:35 AM	San Diego	San Ysidro Transit Center	Economy	$225	A Bus from Greyhound US goes from Exxon, Durham, NC (USA) at 12/24/2025 4:25:00 PM to San Ysidro Transit Center, San Diego (USA) arriving at 12/27/2025 10:35:00 AM. 50 Economy ticket for $225 per person are available. Travel duration is 69h 10m
Greyhound US	68h 40m	4:25 PM	Durham, NC	Exxon	10:05 AM	San Diego	Seaport Village	Economy	$227	A Bus from Greyhound US goes from Exxon, Durham, NC (USA) at 12/24/2025 4:25:00 PM to Seaport Village, San Diego (USA) arriving at 12/27/2025 10:05:00 AM. 50 Economy ticket for $227 per person are available. Travel duration is 68h 40m
Greyhound US	70h 20m	4:25 PM	Durham, NC	Exxon	11:45 AM	San Diego	Old Town Transit Center	Economy	$227	A Bus from Greyhound US goes from Exxon, Durham, NC (USA) at 12/24/2025 4:25:00 PM to Old Town Transit Center, San Diego (USA) arriving at 12/27/2025 11:45:00 AM. 50 Economy ticket for $227 per person are available. Travel duration is 70h 20m
FlixBus	94h 55m	9:15 PM	Durham, NC	Exxon	5:10 PM	San Diego	San Ysidro Transit Center	Economy	$233	A Bus from FlixBus goes from Exxon, Durham, NC (USA) at 12/24/2025 9:15:00 PM to San Ysidro Transit Center, San Diego (USA) arriving at 12/28/2025 5:10:00 PM. 50 Economy ticket for $233 per person are available. Travel duration is 94h 55m
FlixBus	64h 45m	8:30 AM	Durham, NC	Exxon	10:15 PM	San Diego	Seaport Village	Economy	$235	A Bus from FlixBus goes from Exxon, Durham, NC (USA) at 12/24/2025 8:30:00 AM to Seaport Village, San Diego (USA) arriving at 12/26/2025 10:15:00 PM. 50 Economy ticket for $235 per person are available. Travel duration is 64h 45m

Best Price Offer: The price for the cheapest bus from Durham, NC to San Diego is $222 on 12/15/2025. Flexible travelers save on ticket prices.

Frequency of bus connections between Durham, NC and San Diego

See here how frequent the connections between Durham, NC and San Diego are, during different times and days of the week.

Wednesday is the busiest day, with more than 13 daily buses from Durham, NC to San Diego. Friday has instead the fewest connections, with only 1 daily coaches between Durham, NC and San Diego.

The busiest time of the day is the Morning, with 7 buses from Durham, NC to San Diego, while Evening sees the fewest connections between Durham, NC and San Diego, with 5 offers.

Facts about the bus from Durham, NC to San Diego

Compare all providers like FlixBus and Greyhound US that travel 4 times every day by bus from Durham, NC to San Diego in one click! Book your bus ticket from Durham, NC to San Diego starting from $222!

Cheapest Bus	$222
Fastest Bus	57h 5m
Earliest Bus	10:05 PM
Latest Bus	9:15 PM
Daily Bus Routes	4 Ø
Distance	2,179.8 miles
Bus Companies	FlixBus and Greyhound US

Cheapest bus connections from Durham, NC to San Diego

Every day, 4 buses from 2 bus companies leave Durham, NC for San Diego: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/19/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 12/14

Monday 12/15

Tuesday 12/16

Wednesday 12/17

Thursday 12/18

Friday 12/19

$303

Saturday 12/20

Sunday 12/21

$291

Monday 12/22

Tuesday 12/23

$232

Wednesday 12/24

$225

Thursday 12/25

Friday 12/26

$250

Saturday 12/27

Sunday 12/28

Monday 12/29

Tuesday 12/30

Wednesday 12/31

Thursday 01/01

Friday 01/02

Saturday 01/03

Sunday 01/04

Monday 01/05

Tuesday 01/06

Wednesday 01/07

Thursday 01/08

Friday 01/09

Saturday 01/10

The cheapest time to travel from Durham, NC to San Diego

See here on which day and which time of the day you can find the cheapest bus ticket from Durham, NC to San Diego, for the next 30 days.

With a price starting from $225, Wednesday is the cheapest day for a bus from Durham, NC to San Diego. Sunday instead is the most expensive day with prices starting from $291.

Afternoon is the cheapest day time for bus tickets from Durham, NC to San Diego, with $225. Morning is the most expensive time of the day with prices starting from $235.

How to save money travelling from Durham, NC to San Diego

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Durham, NC to San Diego in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Durham, NC to San Diego, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Durham, NC to San Diego are also emptier.

All bus stations and stops in Durham, NC and San Diego

In the map below, you can see where to find all bus stations in Durham, NC and San Diego.

Transportation Center

W Pettigrew St 515

Exxon

Hillsborough Rd 3454

BP Guess Road

Guess Road 2918

BP Hillandale Rd

Hillandale Rd 1815

Chapel Hill and Willard St

W Chapel Hill

Old Town Transit Center

Congress Street 2727

San Ysidro Transit Center

E San Ysidro Blvd 723

Santa Fe Depot

Kettner Blvd 1050

Seaport Village

W Harbor Dr 789

La Jolla Village

Hyatt Regency

Service and Comfort on the bus from Durham, NC to San Diego

Want to know which seat classes are available on the buses from Durham, NC to San Diego? Or which bus companies serve the route Durham, NC to San Diego? Below you will find answers to your questions.

FAQs about the Durham, NC to San Diego bus

How much does a Durham, NC San Diego bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $222 and takes 66h 10m to reach San Diego. Compare offers to save money!

How much could I save by comparing buses from Durham, NC to San Diego?

This route is offered by 2 companies with a range of ticket prices between $222 and $345. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to San Diego.

On average, how many connections are available from Durham, NC to San Diego each day?

Every day, the Durham, NC to San Diego bus route is served by approximately 4 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Durham, NC to San Diego take?

The fastest bus from Durham, NC to San Diego is offered by FlixBus and takes 57h 5m. Bus tickets for this connection cost $252. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Durham, NC to San Diego?

The earliest bus arriving in San Diego from Durham, NC starts at 10:05 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Durham, NC to San Diego?

The latest bus trip departing from Durham, NC for San Diego starts at 9:15 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Durham, NC San Diego route?

When traveling by bus from Durham, NC to San Diego, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Durham, NC and San Diego?

You can check all the direct connections between Durham, NC and San Diego by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the Durham, NC to San Diego bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Durham, NC San Diego bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Durham, NC San Diego bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Durham, NC to San Diego on your planned travel date.

How does CheckMyBus find the best bus deals from Durham, NC to San Diego?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 4 daily trips between Durham, NC and San Diego. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Durham, NC to San Diego?

Prices and availability for 4 trips between Durham, NC and San Diego change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Durham, NC to San Diego

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Durham, NC and to San Diego

Here’s an overview of the most popular bus routes to Durham, NC and to San Diego. Simply click on the connection of your choice, and you will find all the details about your bus route!