Bus Florence, SC to Lewiston, ME - Compare all Companies

Compare all timetables for the bus from Florence, SC to Lewiston, ME

Here is a selection of the cheapest bus trips from the schedule from Florence, SC to Lewiston, ME from various bus operators like FlixBus or Greyhound US for the next days.

today

tomorrow

$122

Friday

Saturday

$124

Sunday

$125

Monday

Tuesday

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	29h 30m	4:30 PM	Florence, SC	Bus Station	10:00 PM	Lewiston, ME	Bus Stop	Economy	$122	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 2/5/2026 4:30:00 PM to Bus Stop, Lewiston, ME (USA) arriving at 2/6/2026 10:00:00 PM. 50 Economy ticket for $122 per person are available. Travel duration is 29h 30m
Greyhound US	29h 25m	4:30 PM	Florence, SC	Bus Station	9:55 PM	Lewiston, ME	Bus Stop	Economy	$122	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 2/5/2026 4:30:00 PM to Bus Stop, Lewiston, ME (USA) arriving at 2/6/2026 9:55:00 PM. 50 Economy ticket for $122 per person are available. Travel duration is 29h 25m
FlixBus	40h 15m	5:45 AM	Florence, SC	TA Travel Center	10:00 PM	Lewiston, ME	Bus Stop	Economy	$226	A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 2/5/2026 5:45:00 AM to Bus Stop, Lewiston, ME (USA) arriving at 2/6/2026 10:00:00 PM. 50 Economy ticket for $226 per person are available. Travel duration is 40h 15m
FlixBus	40h 10m	5:45 AM	Florence, SC	TA Travel Center	9:55 PM	Lewiston, ME	Bus Stop	Economy	$226	A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 2/5/2026 5:45:00 AM to Bus Stop, Lewiston, ME (USA) arriving at 2/6/2026 9:55:00 PM. 50 Economy ticket for $226 per person are available. Travel duration is 40h 10m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	29h 25m	4:30 PM	Florence, SC	Bus Station	9:55 PM	Lewiston, ME	Bus Stop	Economy	$124	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 2/7/2026 4:30:00 PM to Bus Stop, Lewiston, ME (USA) arriving at 2/8/2026 9:55:00 PM. 50 Economy ticket for $124 per person are available. Travel duration is 29h 25m
Greyhound US	29h 30m	4:30 PM	Florence, SC	Bus Station	10:00 PM	Lewiston, ME	Bus Stop	Economy	$125	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 2/7/2026 4:30:00 PM to Bus Stop, Lewiston, ME (USA) arriving at 2/8/2026 10:00:00 PM. 50 Economy ticket for $125 per person are available. Travel duration is 29h 30m
FlixBus	40h 15m	5:45 AM	Florence, SC	TA Travel Center	10:00 PM	Lewiston, ME	Bus Stop	Economy	$229	A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 2/7/2026 5:45:00 AM to Bus Stop, Lewiston, ME (USA) arriving at 2/8/2026 10:00:00 PM. 50 Economy ticket for $229 per person are available. Travel duration is 40h 15m
FlixBus	40h 10m	5:45 AM	Florence, SC	TA Travel Center	9:55 PM	Lewiston, ME	Bus Stop	Economy	$229	A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 2/7/2026 5:45:00 AM to Bus Stop, Lewiston, ME (USA) arriving at 2/8/2026 9:55:00 PM. 50 Economy ticket for $229 per person are available. Travel duration is 40h 10m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	29h 30m	4:30 PM	Florence, SC	Bus Station	10:00 PM	Lewiston, ME	Bus Stop	Economy	$125	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 2/8/2026 4:30:00 PM to Bus Stop, Lewiston, ME (USA) arriving at 2/9/2026 10:00:00 PM. 50 Economy ticket for $125 per person are available. Travel duration is 29h 30m
Greyhound US	29h 25m	4:30 PM	Florence, SC	Bus Station	9:55 PM	Lewiston, ME	Bus Stop	Economy	$125	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 2/8/2026 4:30:00 PM to Bus Stop, Lewiston, ME (USA) arriving at 2/9/2026 9:55:00 PM. 50 Economy ticket for $125 per person are available. Travel duration is 29h 25m
FlixBus	40h 15m	5:45 AM	Florence, SC	TA Travel Center	10:00 PM	Lewiston, ME	Bus Stop	Economy	$229	A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 2/8/2026 5:45:00 AM to Bus Stop, Lewiston, ME (USA) arriving at 2/9/2026 10:00:00 PM. 50 Economy ticket for $229 per person are available. Travel duration is 40h 15m
FlixBus	40h 10m	5:45 AM	Florence, SC	TA Travel Center	9:55 PM	Lewiston, ME	Bus Stop	Economy	$229	A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 2/8/2026 5:45:00 AM to Bus Stop, Lewiston, ME (USA) arriving at 2/9/2026 9:55:00 PM. 50 Economy ticket for $229 per person are available. Travel duration is 40h 10m

Best Price Offer: The price for the cheapest bus from Florence, SC to Lewiston, ME is $122 on 2/5/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Florence, SC and Lewiston, ME

See here how frequent the connections between Florence, SC and Lewiston, ME are, during different times and days of the week.

Sunday is the busiest day, with more than 4 daily buses from Florence, SC to Lewiston, ME. Sunday has instead the fewest connections, with only 4 daily coaches between Florence, SC and Lewiston, ME.

The busiest time of the day is the Afternoon, with 6 buses from Florence, SC to Lewiston, ME, while Afternoon sees the fewest connections between Florence, SC and Lewiston, ME, with 6 offers.

Facts about the bus from Florence, SC to Lewiston, ME

Compare all providers like FlixBus and Greyhound US that travel 4 times every day by bus from Florence, SC to Lewiston, ME in one click! Book your bus ticket from Florence, SC to Lewiston, ME starting from $122!

Cheapest Bus	$122
Fastest Bus	29h 25m
Earliest Bus	5:45 AM
Latest Bus	4:30 PM
Daily Bus Routes	4 Ø
Distance	853.4 miles
Bus Companies	FlixBus and Greyhound US

Cheapest bus connections from Florence, SC to Lewiston, ME

Every day, 4 buses from 2 bus companies leave Florence, SC for Lewiston, ME: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 02/04/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 02/01

Monday 02/02

Tuesday 02/03

Wednesday 02/04

Thursday 02/05

$122

Friday 02/06

Saturday 02/07

$124

Sunday 02/08

$125

Monday 02/09

Tuesday 02/10

Wednesday 02/11

$122

Thursday 02/12

Friday 02/13

$122

Saturday 02/14

Sunday 02/15

Monday 02/16

Tuesday 02/17

Wednesday 02/18

Thursday 02/19

Friday 02/20

Saturday 02/21

Sunday 02/22

Monday 02/23

Tuesday 02/24

Wednesday 02/25

Thursday 02/26

Friday 02/27

Saturday 02/28

The cheapest time to travel from Florence, SC to Lewiston, ME

See here on which day and which time of the day you can find the cheapest bus ticket from Florence, SC to Lewiston, ME, for the next 30 days.

With a price starting from $122, Thursday is the cheapest day for a bus from Florence, SC to Lewiston, ME. Sunday instead is the most expensive day with prices starting from $125.

Afternoon is the cheapest day time for bus tickets from Florence, SC to Lewiston, ME, with $122. Afternoon is the most expensive time of the day with prices starting from $122.

How to save money travelling from Florence, SC to Lewiston, ME

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Florence, SC to Lewiston, ME in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Florence, SC to Lewiston, ME, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Florence, SC to Lewiston, ME are also emptier.

All bus stations and stops in Florence, SC and Lewiston, ME

In the map below, you can see where to find all bus stations in Florence, SC and Lewiston, ME.

Bus Station

S Irby St 611

TA Travel Center

W Lucas St 2301

Exxon Gas Station

W Lucas Street 1901

McDonalds

W. Lucas St. 1908

Shell Gas Station

W Lucas Street 1832

Bus Stop

Bates St 111

Circle K

Main Street 674

Bates College

94 Russell St

Service and Comfort on the bus from Florence, SC to Lewiston, ME

Want to know which seat classes are available on the buses from Florence, SC to Lewiston, ME? Or which bus companies serve the route Florence, SC to Lewiston, ME? Below you will find answers to your questions.

FAQs about the Florence, SC to Lewiston, ME bus

How much does a Florence, SC Lewiston, ME bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $122 and takes 29h 30m to reach Lewiston, ME. Compare offers to save money!

How much could I save by comparing buses from Florence, SC to Lewiston, ME?

This route is offered by 2 companies with a range of ticket prices between $122 and $229. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Lewiston, ME.

On average, how many connections are available from Florence, SC to Lewiston, ME each day?

Every day, the Florence, SC to Lewiston, ME bus route is served by approximately 4 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Florence, SC to Lewiston, ME take?

The fastest bus from Florence, SC to Lewiston, ME is offered by Greyhound US and takes 29h 25m. Bus tickets for this connection cost $122. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Florence, SC to Lewiston, ME?

The earliest bus arriving in Lewiston, ME from Florence, SC starts at 5:45 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Florence, SC to Lewiston, ME?

The latest bus trip departing from Florence, SC for Lewiston, ME starts at 4:30 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Florence, SC Lewiston, ME route?

When traveling by bus from Florence, SC to Lewiston, ME, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Florence, SC and Lewiston, ME?

You can check all the direct connections between Florence, SC and Lewiston, ME by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the Florence, SC to Lewiston, ME bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Florence, SC Lewiston, ME bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Florence, SC Lewiston, ME bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Florence, SC to Lewiston, ME on your planned travel date.

How does CheckMyBus find the best bus deals from Florence, SC to Lewiston, ME?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 4 daily trips between Florence, SC and Lewiston, ME. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Florence, SC to Lewiston, ME?

Prices and availability for 4 trips between Florence, SC and Lewiston, ME change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Florence, SC to Lewiston, ME

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Florence, SC and to Lewiston, ME

Here’s an overview of the most popular bus routes to Florence, SC and to Lewiston, ME. Simply click on the connection of your choice, and you will find all the details about your bus route!