Bus Florence, SC to Madison, WI - Compare all Companies

Compare all timetables for the bus from Florence, SC to Madison, WI

Here is a selection of the cheapest bus trips from the schedule from Florence, SC to Madison, WI from various bus operators like Greyhound US or FlixBus for the next days.

today

$131

tomorrow

Wednesday

$132

Thursday

$128

Friday

$132

Saturday

$128

Sunday

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	31h 40m	5:45 AM	Florence, SC	TA Travel Center	12:25 PM	Madison, WI	W Transfer Point	Economy	$131	A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 4/20/2026 5:45:00 AM to W Transfer Point, Madison, WI (USA) arriving at 4/21/2026 12:25:00 PM. 50 Economy ticket for $131 per person are available. Travel duration is 31h 40m
FlixBus	32h 0m	5:45 AM	Florence, SC	TA Travel Center	12:45 PM	Madison, WI	University Wisconsin-Madison	Economy	$131	A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 4/20/2026 5:45:00 AM to University Wisconsin-Madison, Madison, WI (USA) arriving at 4/21/2026 12:45:00 PM. 50 Economy ticket for $131 per person are available. Travel duration is 32h 0m
Greyhound US	31h 45m	11:55 AM	Florence, SC	Bus Station	6:40 PM	Madison, WI	W Transfer Point	Economy	$132	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 4/20/2026 11:55:00 AM to W Transfer Point, Madison, WI (USA) arriving at 4/21/2026 6:40:00 PM. 50 Economy ticket for $132 per person are available. Travel duration is 31h 45m
Greyhound US	32h 5m	11:55 AM	Florence, SC	Bus Station	7:00 PM	Madison, WI	University Wisconsin-Madison	Economy	$133	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 4/20/2026 11:55:00 AM to University Wisconsin-Madison, Madison, WI (USA) arriving at 4/21/2026 7:00:00 PM. 50 Economy ticket for $133 per person are available. Travel duration is 32h 5m
Greyhound US	44h 55m	4:30 PM	Florence, SC	Bus Station	12:25 PM	Madison, WI	W Transfer Point	Economy	$220	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 4/20/2026 4:30:00 PM to W Transfer Point, Madison, WI (USA) arriving at 4/22/2026 12:25:00 PM. 50 Economy ticket for $220 per person are available. Travel duration is 44h 55m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	28h 40m	11:55 AM	Florence, SC	Bus Station	3:35 PM	Madison, WI	W Transfer Point	Economy	$132	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 4/22/2026 11:55:00 AM to W Transfer Point, Madison, WI (USA) arriving at 4/23/2026 3:35:00 PM. 50 Economy ticket for $132 per person are available. Travel duration is 28h 40m
Greyhound US	28h 55m	11:55 AM	Florence, SC	Bus Station	3:50 PM	Madison, WI	University Wisconsin-Madison	Economy	$132	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 4/22/2026 11:55:00 AM to University Wisconsin-Madison, Madison, WI (USA) arriving at 4/23/2026 3:50:00 PM. 50 Economy ticket for $132 per person are available. Travel duration is 28h 55m
Greyhound US	44h 55m	4:30 PM	Florence, SC	Bus Station	12:25 PM	Madison, WI	W Transfer Point	Economy	$221	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 4/22/2026 4:30:00 PM to W Transfer Point, Madison, WI (USA) arriving at 4/24/2026 12:25:00 PM. 50 Economy ticket for $221 per person are available. Travel duration is 44h 55m
Greyhound US	45h 15m	4:30 PM	Florence, SC	Bus Station	12:45 PM	Madison, WI	University Wisconsin-Madison	Economy	$221	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 4/22/2026 4:30:00 PM to University Wisconsin-Madison, Madison, WI (USA) arriving at 4/24/2026 12:45:00 PM. 50 Economy ticket for $221 per person are available. Travel duration is 45h 15m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	28h 55m	11:55 AM	Florence, SC	Bus Station	3:50 PM	Madison, WI	Chazen Museum	Economy	$128	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 4/23/2026 11:55:00 AM to Chazen Museum, Madison, WI (USA) arriving at 4/24/2026 3:50:00 PM. 50 Economy ticket for $128 per person are available. Travel duration is 28h 55m
Greyhound US	28h 40m	11:55 AM	Florence, SC	Bus Station	3:35 PM	Madison, WI	Dutch Mill Park & Ride	Economy	$129	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 4/23/2026 11:55:00 AM to Dutch Mill Park & Ride, Madison, WI (USA) arriving at 4/24/2026 3:35:00 PM. 50 Economy ticket for $129 per person are available. Travel duration is 28h 40m
Greyhound US	44h 55m	4:30 PM	Florence, SC	Bus Station	12:25 PM	Madison, WI	Dutch Mill Park & Ride	Economy	$217	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 4/23/2026 4:30:00 PM to Dutch Mill Park & Ride, Madison, WI (USA) arriving at 4/25/2026 12:25:00 PM. 50 Economy ticket for $217 per person are available. Travel duration is 44h 55m
Greyhound US	45h 15m	4:30 PM	Florence, SC	Bus Station	12:45 PM	Madison, WI	Chazen Museum	Economy	$217	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 4/23/2026 4:30:00 PM to Chazen Museum, Madison, WI (USA) arriving at 4/25/2026 12:45:00 PM. 50 Economy ticket for $217 per person are available. Travel duration is 45h 15m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	28h 40m	11:55 AM	Florence, SC	Bus Station	3:35 PM	Madison, WI	W Transfer Point	Economy	$132	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 4/24/2026 11:55:00 AM to W Transfer Point, Madison, WI (USA) arriving at 4/25/2026 3:35:00 PM. 50 Economy ticket for $132 per person are available. Travel duration is 28h 40m
Greyhound US	28h 55m	11:55 AM	Florence, SC	Bus Station	3:50 PM	Madison, WI	University Wisconsin-Madison	Economy	$132	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 4/24/2026 11:55:00 AM to University Wisconsin-Madison, Madison, WI (USA) arriving at 4/25/2026 3:50:00 PM. 50 Economy ticket for $132 per person are available. Travel duration is 28h 55m
FlixBus	31h 40m	5:45 AM	Florence, SC	TA Travel Center	12:25 PM	Madison, WI	W Transfer Point	Economy	$147	A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 4/24/2026 5:45:00 AM to W Transfer Point, Madison, WI (USA) arriving at 4/25/2026 12:25:00 PM. 50 Economy ticket for $147 per person are available. Travel duration is 31h 40m
FlixBus	32h 0m	5:45 AM	Florence, SC	TA Travel Center	12:45 PM	Madison, WI	University Wisconsin-Madison	Economy	$147	A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 4/24/2026 5:45:00 AM to University Wisconsin-Madison, Madison, WI (USA) arriving at 4/25/2026 12:45:00 PM. 50 Economy ticket for $147 per person are available. Travel duration is 32h 0m
Greyhound US	45h 15m	4:30 PM	Florence, SC	Bus Station	12:45 PM	Madison, WI	University Wisconsin-Madison	Economy	$221	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 4/24/2026 4:30:00 PM to University Wisconsin-Madison, Madison, WI (USA) arriving at 4/26/2026 12:45:00 PM. 50 Economy ticket for $221 per person are available. Travel duration is 45h 15m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	28h 40m	11:55 AM	Florence, SC	Bus Station	3:35 PM	Madison, WI	Dutch Mill Park & Ride	Economy	$128	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 4/25/2026 11:55:00 AM to Dutch Mill Park & Ride, Madison, WI (USA) arriving at 4/26/2026 3:35:00 PM. 50 Economy ticket for $128 per person are available. Travel duration is 28h 40m
Greyhound US	28h 55m	11:55 AM	Florence, SC	Bus Station	3:50 PM	Madison, WI	Chazen Museum	Economy	$128	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 4/25/2026 11:55:00 AM to Chazen Museum, Madison, WI (USA) arriving at 4/26/2026 3:50:00 PM. 50 Economy ticket for $128 per person are available. Travel duration is 28h 55m
Greyhound US	44h 55m	4:30 PM	Florence, SC	Bus Station	12:25 PM	Madison, WI	Dutch Mill Park & Ride	Economy	$217	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 4/25/2026 4:30:00 PM to Dutch Mill Park & Ride, Madison, WI (USA) arriving at 4/27/2026 12:25:00 PM. 50 Economy ticket for $217 per person are available. Travel duration is 44h 55m
Greyhound US	45h 15m	4:30 PM	Florence, SC	Bus Station	12:45 PM	Madison, WI	Chazen Museum	Economy	$217	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 4/25/2026 4:30:00 PM to Chazen Museum, Madison, WI (USA) arriving at 4/27/2026 12:45:00 PM. 50 Economy ticket for $217 per person are available. Travel duration is 45h 15m

Best Price Offer: The price for the cheapest bus from Florence, SC to Madison, WI is $127 on 4/25/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Florence, SC and Madison, WI

See here how frequent the connections between Florence, SC and Madison, WI are, during different times and days of the week.

Monday is the busiest day, with more than 6 daily buses from Florence, SC to Madison, WI. Wednesday has instead the fewest connections, with only 4 daily coaches between Florence, SC and Madison, WI.

The busiest time of the day is the Morning, with 10 buses from Florence, SC to Madison, WI, while Night sees the fewest connections between Florence, SC and Madison, WI, with 4 offers.

Facts about the bus from Florence, SC to Madison, WI

Compare all providers like Greyhound US and FlixBus that travel 4 times every day by bus from Florence, SC to Madison, WI in one click! Book your bus ticket from Florence, SC to Madison, WI starting from $127!

Cheapest Bus	$127
Fastest Bus	27h 40m
Earliest Bus	5:45 AM
Latest Bus	4:30 PM
Daily Bus Routes	4 Ø
Distance	803.5 miles
Bus Companies	Greyhound US and FlixBus

Cheapest bus connections from Florence, SC to Madison, WI

Every day, 4 buses from 2 bus companies leave Florence, SC for Madison, WI: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 04/20/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 04/19

Monday 04/20

$131

Tuesday 04/21

Wednesday 04/22

$132

Thursday 04/23

$128

Friday 04/24

$132

Saturday 04/25

$127

Sunday 04/26

Monday 04/27

$132

Tuesday 04/28

$132

Wednesday 04/29

Thursday 04/30

$132

Friday 05/01

$132

Saturday 05/02

$128

Sunday 05/03

Monday 05/04

$131

Tuesday 05/05

Wednesday 05/06

Thursday 05/07

Friday 05/08

$138

Saturday 05/09

Sunday 05/10

$129

Monday 05/11

Tuesday 05/12

Wednesday 05/13

$133

Thursday 05/14

$129

Friday 05/15

$148

Saturday 05/16

The cheapest time to travel from Florence, SC to Madison, WI

See here on which day and which time of the day you can find the cheapest bus ticket from Florence, SC to Madison, WI, for the next 30 days.

With a price starting from $127, Saturday is the cheapest day for a bus from Florence, SC to Madison, WI. Wednesday instead is the most expensive day with prices starting from $132.

Night is the cheapest day time for bus tickets from Florence, SC to Madison, WI, with $127. Afternoon is the most expensive time of the day with prices starting from $217.

How to save money travelling from Florence, SC to Madison, WI

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Florence, SC to Madison, WI in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Florence, SC to Madison, WI, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Florence, SC to Madison, WI are also emptier.

Beloved bus companies from Florence, SC to Madison, WI

These are the most booked bus companies between Florence, SC to Madison, WI from our users.

Greyhound US from Florence, SC to Madison, WI

Here you will find the key facts about the Greyhound US bus route Florence, SC to Madison, WI:

Cheapest Price	$128
Fastest Bus	27h 40m
Earliest Bus	11:55 AM
Last Bus	4:30 PM
Daily Connections	4 Ø
Found on	3/25/2026

All bus stations and stops in Florence, SC and Madison, WI

In the map below, you can see where to find all bus stations in Florence, SC and Madison, WI.

Bus Station

S Irby St 611

TA Travel Center

W Lucas St 2301

Exxon Gas Station

W Lucas Street 1901

McDonalds

W. Lucas St. 1908

Shell Gas Station

W Lucas Street 1832

Dutch Mill Park & Ride

E Broadway

University Wisconsin-Madison

North Lake Street 200

Bus Stop

Memorial Union Building

Langdon Street 800

Chazen Museum

University Avenue 750-800

Service and Comfort on the bus from Florence, SC to Madison, WI

Want to know which seat classes are available on the buses from Florence, SC to Madison, WI? Or which bus companies serve the route Florence, SC to Madison, WI? Below you will find answers to your questions.

FAQs about the Florence, SC to Madison, WI bus

How much does a Florence, SC Madison, WI bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $127 and takes 27h 40m to reach Madison, WI. Compare offers to save money!

How much could I save by comparing buses from Florence, SC to Madison, WI?

This route is offered by 2 companies with a range of ticket prices between $127 and $231. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Madison, WI.

On average, how many connections are available from Florence, SC to Madison, WI each day?

Every day, the Florence, SC to Madison, WI bus route is served by approximately 4 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Florence, SC to Madison, WI take?

The fastest bus from Florence, SC to Madison, WI is offered by Greyhound US and takes 27h 40m. Bus tickets for this connection cost $132. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Florence, SC to Madison, WI?

The earliest bus arriving in Madison, WI from Florence, SC starts at 5:45 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Florence, SC to Madison, WI?

The latest bus trip departing from Florence, SC for Madison, WI starts at 4:30 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Florence, SC Madison, WI route?

When traveling by bus from Florence, SC to Madison, WI, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Florence, SC and Madison, WI?

You can check all the direct connections between Florence, SC and Madison, WI by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the Florence, SC to Madison, WI bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Florence, SC Madison, WI bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Florence, SC Madison, WI bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Florence, SC to Madison, WI on your planned travel date.

How does CheckMyBus find the best bus deals from Florence, SC to Madison, WI?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 4 daily trips between Florence, SC and Madison, WI. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Florence, SC to Madison, WI?

Prices and availability for 4 trips between Florence, SC and Madison, WI change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Florence, SC to Madison, WI

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Florence, SC and to Madison, WI

Here’s an overview of the most popular bus routes to Florence, SC and to Madison, WI. Simply click on the connection of your choice, and you will find all the details about your bus route!