Compare all timetables for the bus from Florence, SC to Orlando, FL
| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Greyhound US | 17h 55m | 11:55 AM | Florence, SC | Bus Station | 5:50 AM | Orlando, FL | Bus Station | Economy | $83 |
A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 6/4/2026 11:55:00 AM to Bus Station, Orlando, FL (USA) arriving at 6/5/2026 5:50:00 AM. 50 Economy ticket for $83 per person are available. Travel duration is 17h 55m
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| FlixBus | 9h 35m | 4:15 PM | Florence, SC | Bus Station | 1:50 AM | Orlando, FL | Bus Station | Economy | $84 |
A Bus from FlixBus goes from Bus Station, Florence, SC (USA) at 6/4/2026 4:15:00 PM to Bus Station, Orlando, FL (USA) arriving at 6/5/2026 1:50:00 AM. 50 Economy ticket for $84 per person are available. Travel duration is 9h 35m
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| Greyhound US | 15h 40m | 4:10 PM | Florence, SC | Bus Station | 7:50 AM | Orlando, FL | Bus Station | Economy | $108 |
A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 6/4/2026 4:10:00 PM to Bus Station, Orlando, FL (USA) arriving at 6/5/2026 7:50:00 AM. 50 Economy ticket for $108 per person are available. Travel duration is 15h 40m
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| Greyhound US | 19h 55m | 11:55 AM | Florence, SC | Bus Station | 7:50 AM | Orlando, FL | Bus Station | Economy | $109 |
A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 6/4/2026 11:55:00 AM to Bus Station, Orlando, FL (USA) arriving at 6/5/2026 7:50:00 AM. 50 Economy ticket for $109 per person are available. Travel duration is 19h 55m
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FlixBus9h 35m04:15 PMFlorence, SCBus Station9:25 PMJacksonville, FLDowntown Bus Stop0EconomyA Bus from FlixBus goes from Bus Station, Florence, SC (USA) at 6/5/2026 4:15:00 PM to Downtown Bus Stop, Jacksonville, FL (USA) arriving at 6/5/2026 9:25:00 PM. 50 Economy ticket for $43 per person are available. Travel duration is 5h 10m
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FlixBus2h 35m011:15 PMJacksonville, FLDowntown Bus Stop1:50 AMOrlando, FLBus Station0EconomyA Bus from FlixBus goes from Downtown Bus Stop, Jacksonville, FL (USA) at 6/5/2026 11:15:00 PM to Bus Station, Orlando, FL (USA) arriving at 6/6/2026 1:50:00 AM. 50 Economy ticket for $22 per person are available. Travel duration is 2h 35m
Waiting Time 1h 50m -
| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Greyhound US | 17h 55m | 11:55 AM | Florence, SC | Bus Station | 5:50 AM | Orlando, FL | Bus Station | Economy | $99 |
A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 6/5/2026 11:55:00 AM to Bus Station, Orlando, FL (USA) arriving at 6/6/2026 5:50:00 AM. 50 Economy ticket for $99 per person are available. Travel duration is 17h 55m
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| FlixBus | 9h 35m | 4:15 PM | Florence, SC | Bus Station | 1:50 AM | Orlando, FL | Bus Station | Economy | $100 |
A Bus from FlixBus goes from Bus Station, Florence, SC (USA) at 6/5/2026 4:15:00 PM to Bus Station, Orlando, FL (USA) arriving at 6/6/2026 1:50:00 AM. 50 Economy ticket for $100 per person are available. Travel duration is 9h 35m
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| Greyhound US | 19h 55m | 11:55 AM | Florence, SC | Bus Station | 7:50 AM | Orlando, FL | Bus Station | Economy | $106 |
A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 6/5/2026 11:55:00 AM to Bus Station, Orlando, FL (USA) arriving at 6/6/2026 7:50:00 AM. 50 Economy ticket for $106 per person are available. Travel duration is 19h 55m
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| Greyhound US | 15h 40m | 4:10 PM | Florence, SC | Bus Station | 7:50 AM | Orlando, FL | Bus Station | Economy | $107 |
A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 6/5/2026 4:10:00 PM to Bus Station, Orlando, FL (USA) arriving at 6/6/2026 7:50:00 AM. 50 Economy ticket for $107 per person are available. Travel duration is 15h 40m
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FlixBus9h 35m04:15 PMFlorence, SCBus Station9:25 PMJacksonville, FLDowntown Bus Stop0EconomyA Bus from FlixBus goes from Bus Station, Florence, SC (USA) at 6/5/2026 4:15:00 PM to Downtown Bus Stop, Jacksonville, FL (USA) arriving at 6/5/2026 9:25:00 PM. 50 Economy ticket for $43 per person are available. Travel duration is 5h 10m
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FlixBus2h 35m011:15 PMJacksonville, FLDowntown Bus Stop1:50 AMOrlando, FLBus Station0EconomyA Bus from FlixBus goes from Downtown Bus Stop, Jacksonville, FL (USA) at 6/5/2026 11:15:00 PM to Bus Station, Orlando, FL (USA) arriving at 6/6/2026 1:50:00 AM. 50 Economy ticket for $22 per person are available. Travel duration is 2h 35m
Waiting Time 1h 50m -
| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FlixBus | 8h 25m | 5:45 AM | Florence, SC | TA Travel Center | 2:10 PM | Orlando, FL | Bus Station | Economy | $64 |
A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 6/6/2026 5:45:00 AM to Bus Station, Orlando, FL (USA) arriving at 6/6/2026 2:10:00 PM. 50 Economy ticket for $64 per person are available. Travel duration is 8h 25m
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| Greyhound US | 17h 55m | 11:55 AM | Florence, SC | Bus Station | 5:50 AM | Orlando, FL | Bus Station | Economy | $96 |
A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 6/6/2026 11:55:00 AM to Bus Station, Orlando, FL (USA) arriving at 6/7/2026 5:50:00 AM. 50 Economy ticket for $96 per person are available. Travel duration is 17h 55m
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| FlixBus | 9h 35m | 4:15 PM | Florence, SC | Bus Station | 1:50 AM | Orlando, FL | Bus Station | Economy | $97 |
A Bus from FlixBus goes from Bus Station, Florence, SC (USA) at 6/6/2026 4:15:00 PM to Bus Station, Orlando, FL (USA) arriving at 6/7/2026 1:50:00 AM. 50 Economy ticket for $97 per person are available. Travel duration is 9h 35m
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| Greyhound US | 19h 55m | 11:55 AM | Florence, SC | Bus Station | 7:50 AM | Orlando, FL | Bus Station | Economy | $121 |
A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 6/6/2026 11:55:00 AM to Bus Station, Orlando, FL (USA) arriving at 6/7/2026 7:50:00 AM. 50 Economy ticket for $121 per person are available. Travel duration is 19h 55m
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| Greyhound US | 15h 40m | 4:10 PM | Florence, SC | Bus Station | 7:50 AM | Orlando, FL | Bus Station | Economy | $121 |
A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 6/6/2026 4:10:00 PM to Bus Station, Orlando, FL (USA) arriving at 6/7/2026 7:50:00 AM. 50 Economy ticket for $121 per person are available. Travel duration is 15h 40m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FlixBus | 8h 55m | 4:00 PM | Florence, SC | Bus Station | 12:55 AM | Orlando, FL | Bus Station | Economy | $62 |
A Bus from FlixBus goes from Bus Station, Florence, SC (USA) at 6/7/2026 4:00:00 PM to Bus Station, Orlando, FL (USA) arriving at 6/8/2026 12:55:00 AM. 50 Economy ticket for $62 per person are available. Travel duration is 8h 55m
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| Greyhound US | 17h 55m | 11:55 AM | Florence, SC | Bus Station | 5:50 AM | Orlando, FL | Bus Station | Economy | $69 |
A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 6/7/2026 11:55:00 AM to Bus Station, Orlando, FL (USA) arriving at 6/8/2026 5:50:00 AM. 50 Economy ticket for $69 per person are available. Travel duration is 17h 55m
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| Greyhound US | 19h 55m | 11:55 AM | Florence, SC | Bus Station | 7:50 AM | Orlando, FL | Bus Station | Economy | $69 |
A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 6/7/2026 11:55:00 AM to Bus Station, Orlando, FL (USA) arriving at 6/8/2026 7:50:00 AM. 50 Economy ticket for $69 per person are available. Travel duration is 19h 55m
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| Greyhound US | 15h 40m | 4:10 PM | Florence, SC | Bus Station | 7:50 AM | Orlando, FL | Bus Station | Economy | $70 |
A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 6/7/2026 4:10:00 PM to Bus Station, Orlando, FL (USA) arriving at 6/8/2026 7:50:00 AM. 50 Economy ticket for $70 per person are available. Travel duration is 15h 40m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FlixBus | 8h 55m | 4:00 PM | Florence, SC | Bus Station | 12:55 AM | Orlando, FL | Bus Station | Economy | $55 |
A Bus from FlixBus goes from Bus Station, Florence, SC (USA) at 6/8/2026 4:00:00 PM to Bus Station, Orlando, FL (USA) arriving at 6/9/2026 12:55:00 AM. 50 Economy ticket for $55 per person are available. Travel duration is 8h 55m
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| FlixBus | 8h 25m | 5:45 AM | Florence, SC | TA Travel Center | 2:10 PM | Orlando, FL | Bus Station | Economy | $62 |
A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 6/8/2026 5:45:00 AM to Bus Station, Orlando, FL (USA) arriving at 6/8/2026 2:10:00 PM. 50 Economy ticket for $62 per person are available. Travel duration is 8h 25m
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| Greyhound US | 15h 40m | 4:10 PM | Florence, SC | Bus Station | 7:50 AM | Orlando, FL | Bus Station | Economy | $74 |
A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 6/8/2026 4:10:00 PM to Bus Station, Orlando, FL (USA) arriving at 6/9/2026 7:50:00 AM. 50 Economy ticket for $74 per person are available. Travel duration is 15h 40m
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| Greyhound US | 17h 55m | 11:55 AM | Florence, SC | Bus Station | 5:50 AM | Orlando, FL | Bus Station | Economy | $75 |
A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 6/8/2026 11:55:00 AM to Bus Station, Orlando, FL (USA) arriving at 6/9/2026 5:50:00 AM. 50 Economy ticket for $75 per person are available. Travel duration is 17h 55m
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| Greyhound US | 19h 55m | 11:55 AM | Florence, SC | Bus Station | 7:50 AM | Orlando, FL | Bus Station | Economy | $75 |
A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 6/8/2026 11:55:00 AM to Bus Station, Orlando, FL (USA) arriving at 6/9/2026 7:50:00 AM. 50 Economy ticket for $75 per person are available. Travel duration is 19h 55m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FlixBus | 8h 25m | 5:45 AM | Florence, SC | TA Travel Center | 2:10 PM | Orlando, FL | Bus Station | Economy | $68 |
A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 6/10/2026 5:45:00 AM to Bus Station, Orlando, FL (USA) arriving at 6/10/2026 2:10:00 PM. 50 Economy ticket for $68 per person are available. Travel duration is 8h 25m
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| Greyhound US | 17h 55m | 11:55 AM | Florence, SC | Bus Station | 5:50 AM | Orlando, FL | Bus Station | Economy | $95 |
A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 6/10/2026 11:55:00 AM to Bus Station, Orlando, FL (USA) arriving at 6/11/2026 5:50:00 AM. 50 Economy ticket for $95 per person are available. Travel duration is 17h 55m
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| Greyhound US | 15h 40m | 4:10 PM | Florence, SC | Bus Station | 7:50 AM | Orlando, FL | Bus Station | Economy | $126 |
A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 6/10/2026 4:10:00 PM to Bus Station, Orlando, FL (USA) arriving at 6/11/2026 7:50:00 AM. 50 Economy ticket for $126 per person are available. Travel duration is 15h 40m
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| Greyhound US | 19h 55m | 11:55 AM | Florence, SC | Bus Station | 7:50 AM | Orlando, FL | Bus Station | Economy | $128 |
A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 6/10/2026 11:55:00 AM to Bus Station, Orlando, FL (USA) arriving at 6/11/2026 7:50:00 AM. 50 Economy ticket for $128 per person are available. Travel duration is 19h 55m
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FlixBus8h 40m04:15 PMFlorence, SCBus Station9:25 PMJacksonville, FLDowntown Bus Stop0EconomyA Bus from FlixBus goes from Bus Station, Florence, SC (USA) at 6/9/2026 4:15:00 PM to Downtown Bus Stop, Jacksonville, FL (USA) arriving at 6/9/2026 9:25:00 PM. 50 Economy ticket for $41 per person are available. Travel duration is 5h 10m
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FlixBus2h 50m010:05 PMJacksonville, FLDowntown Bus Stop12:55 AMOrlando, FLBus Station0EconomyA Bus from FlixBus goes from Downtown Bus Stop, Jacksonville, FL (USA) at 6/9/2026 10:05:00 PM to Bus Station, Orlando, FL (USA) arriving at 6/10/2026 12:55:00 AM. 50 Economy ticket for $20 per person are available. Travel duration is 2h 50m
Waiting Time 0h 40m -
Best Price Offer: The price for the cheapest bus from Florence, SC to Orlando, FL is $55 on 6/8/2026. Flexible travelers save on ticket prices.
Frequency of bus connections between Florence, SC and Orlando, FL
Facts about the bus from Florence, SC to Orlando, FL
Compare all providers like Greyhound US and FlixBus that travel 5 times every day by bus from Florence, SC to Orlando, FL in one click! Book your bus ticket from Florence, SC to Orlando, FL starting from $55!
| Cheapest Bus | $55 |
| Fastest Bus | 8h 25m |
| Earliest Bus | 11:55 AM |
| Latest Bus | 4:10 PM |
| Daily Bus Routes | 5 Ø |
| Distance | 402.2 miles |
| Bus Companies | Greyhound US and FlixBus |
Cheapest bus connections from Florence, SC to Orlando, FL
Every day, 5 buses from 2 bus companies leave Florence, SC for Orlando, FL: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 06/04/2026 and for the following days.
The cheapest time to travel from Florence, SC to Orlando, FL
How to save money travelling from Florence, SC to Orlando, FL
Book the ticket from Florence, SC to Orlando, FL in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Florence, SC to Orlando, FL, compared instead if you buy it at the last moment, or directly at the station.
If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Florence, SC to Orlando, FL are also emptier.All bus stations and stops in Florence, SC and Orlando, FL
In the map below, you can see where to find all bus stations in Florence, SC and Orlando, FL.
Service and Comfort on the bus from Florence, SC to Orlando, FL
FAQs about the Florence, SC to Orlando, FL bus
How much does a Florence, SC Orlando, FL bus trip cost?
How much could I save by comparing buses from Florence, SC to Orlando, FL?
On average, how many connections are available from Florence, SC to Orlando, FL each day?
How long does a bus journey from Florence, SC to Orlando, FL take?
What time is the first bus from Florence, SC to Orlando, FL?
What time is the last bus from Florence, SC to Orlando, FL?
Which bus companies operate the Florence, SC Orlando, FL route?
Is there a direct bus between Florence, SC and Orlando, FL?
What can I take with me on the Florence, SC to Orlando, FL bus route?
What equipment is available for the Florence, SC Orlando, FL bus route?
How does CheckMyBus find the best bus deals from Florence, SC to Orlando, FL?
How does CheckMyBus technology work for trips from Florence, SC to Orlando, FL?
Available seat classes which are offered on the bus route Florence, SC to Orlando, FL
The cheapest option available for your ticket, it usually comes with reclinable seats and AC.
More bus routes to Florence, SC and to Orlando, FL
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