Bus Greenville, SC to Jacksonville, FL

Compare all timetables for the bus from Greenville, SC to Jacksonville, FL

Here is a selection of the cheapest bus trips from the schedule from Greenville, SC to Jacksonville, FL from various bus operators like FlixBus or Greyhound US for the next days.

today

tomorrow

Sunday

$122

Monday

Tuesday

Wednesday

Thursday

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	10h 35m	10:50 AM	Greenville, SC	Woodruff Rd	9:25 PM	Jacksonville, FL	Amtrak Train Station	Economy	$122	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 12/21/2025 10:50:00 AM to Amtrak Train Station, Jacksonville, FL (USA) arriving at 12/21/2025 9:25:00 PM. 50 Economy ticket for $122 per person are available. Travel duration is 10h 35m
Greyhound US	10h 50m	7:25 AM	Greenville, SC	Woodruff Rd	6:15 PM	Jacksonville, FL	Amtrak Train Station	Economy	$125	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 12/21/2025 7:25:00 AM to Amtrak Train Station, Jacksonville, FL (USA) arriving at 12/21/2025 6:15:00 PM. 50 Economy ticket for $125 per person are available. Travel duration is 10h 50m
FlixBus	15h 35m	10:00 PM	Greenville, SC	Woodruff Rd	1:35 PM	Jacksonville, FL	Amtrak Train Station	Economy	$134	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 12/21/2025 10:00:00 PM to Amtrak Train Station, Jacksonville, FL (USA) arriving at 12/22/2025 1:35:00 PM. 50 Economy ticket for $134 per person are available. Travel duration is 15h 35m
FlixBus	11h 15m	7:45 PM	Greenville, SC	Woodruff Rd	7:00 AM	Jacksonville, FL	Amtrak Train Station	Economy	$138	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 12/21/2025 7:45:00 PM to Amtrak Train Station, Jacksonville, FL (USA) arriving at 12/22/2025 7:00:00 AM. 50 Economy ticket for $138 per person are available. Travel duration is 11h 15m

Did you know that if you travel from Greenville, SC to Jacksonville, FL via Atlanta, GA, you can save more than $22? You can find the corresponding connections below.
- Busbud
  
  11h 15m
  
  0
  
  7:45 PM
  
  Greenville, SC
  Woodruff Rd
  
  10:15 PM
  
  Atlanta, GA
  Garnett Transit Station
  
  0
  
  Economy
  
  $30
  
  A Bus from Busbud goes from Woodruff Rd, Greenville, SC (USA) at 12/21/2025 7:45:00 PM to Garnett Transit Station, Atlanta, GA (USA) arriving at 12/21/2025 10:15:00 PM. 50 Economy ticket for $30 per person are available. Travel duration is 2h 30m
- FlixBus
  
  6h 35m
  
  0
  
  12:25 AM
  
  Atlanta, GA
  Garnett Transit Station
  
  7:00 AM
  
  Jacksonville, FL
  Amtrak Train Station
  
  0
  
  Economy
  
  $70
  
  A Bus from FlixBus goes from Garnett Transit Station, Atlanta, GA (USA) at 12/22/2025 12:25:00 AM to Amtrak Train Station, Jacksonville, FL (USA) arriving at 12/22/2025 7:00:00 AM. 50 Economy ticket for $70 per person are available. Travel duration is 6h 35m
Travel time is 0h 40m longer, but you will save $22

Best Price Offer: The price for the cheapest bus from Greenville, SC to Jacksonville, FL is $94 on 12/15/2025. Flexible travelers save on ticket prices.

Facts about the bus from Greenville, SC to Jacksonville, FL

Compare all providers like FlixBus and Greyhound US that travel 4 times every day by bus from Greenville, SC to Jacksonville, FL in one click! Book your bus ticket from Greenville, SC to Jacksonville, FL starting from $94!

Cheapest Bus	$94
Fastest Bus	10h 35m
Earliest Bus	7:25 AM
Latest Bus	10:00 PM
Daily Bus Routes	4 Ø
Distance	315.5 miles
Bus Companies	FlixBus and Greyhound US

Cheapest bus connections from Greenville, SC to Jacksonville, FL

Every day, 4 buses from 2 bus companies leave Greenville, SC for Jacksonville, FL: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/19/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 12/14

Monday 12/15

Tuesday 12/16

Wednesday 12/17

Thursday 12/18

Friday 12/19

Saturday 12/20

Sunday 12/21

$122

Monday 12/22

Tuesday 12/23

Wednesday 12/24

Thursday 12/25

Friday 12/26

$101

Saturday 12/27

Sunday 12/28

$114

Monday 12/29

Tuesday 12/30

Wednesday 12/31

Thursday 01/01

Friday 01/02

Saturday 01/03

Sunday 01/04

Monday 01/05

Tuesday 01/06

Wednesday 01/07

Thursday 01/08

Friday 01/09

Saturday 01/10

How to save money travelling from Greenville, SC to Jacksonville, FL

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Greenville, SC to Jacksonville, FL in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Greenville, SC to Jacksonville, FL, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Greenville, SC to Jacksonville, FL are also emptier.

All bus stations and stops in Greenville, SC and Jacksonville, FL

In the map below, you can see where to find all bus stations in Greenville, SC and Jacksonville, FL.

McDonald's

Woodruff Rd 1111

Woodruff Rd

Woodruff Rd 1116

Guadalajara Supermarket

White Horse Rd 2803

Greyhound Bus Station

Hendrix Dr 9

N Church St

Downtown Bus Stop

West Forsyth Street 1111

Central Bus Station

Beaver St. & Ocean St. Bus Stop

Friendship Fountain

Southpoint Bus Stop

Service and Comfort on the bus from Greenville, SC to Jacksonville, FL

Want to know which seat classes are available on the buses from Greenville, SC to Jacksonville, FL? Or which bus companies serve the route Greenville, SC to Jacksonville, FL? Below you will find answers to your questions.

FAQs about the Greenville, SC to Jacksonville, FL bus

How much does a Greenville, SC Jacksonville, FL bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $94 and takes 10h 35m to reach Jacksonville, FL. Compare offers to save money!

How much could I save by comparing buses from Greenville, SC to Jacksonville, FL?

This route is offered by 2 companies with a range of ticket prices between $94 and $138. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Jacksonville, FL.

On average, how many connections are available from Greenville, SC to Jacksonville, FL each day?

Every day, the Greenville, SC to Jacksonville, FL bus route is served by approximately 4 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Greenville, SC to Jacksonville, FL take?

The fastest bus from Greenville, SC to Jacksonville, FL is offered by Greyhound US and takes 10h 35m. Bus tickets for this connection cost $122. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Greenville, SC to Jacksonville, FL?

The earliest bus arriving in Jacksonville, FL from Greenville, SC starts at 7:25 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Greenville, SC to Jacksonville, FL?

The latest bus trip departing from Greenville, SC for Jacksonville, FL starts at 10:00 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Greenville, SC Jacksonville, FL route?

When traveling by bus from Greenville, SC to Jacksonville, FL, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Greenville, SC and Jacksonville, FL?

You can check all the direct connections between Greenville, SC and Jacksonville, FL by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the Greenville, SC to Jacksonville, FL bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Greenville, SC Jacksonville, FL bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Greenville, SC Jacksonville, FL bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Greenville, SC to Jacksonville, FL on your planned travel date.

How does CheckMyBus find the best bus deals from Greenville, SC to Jacksonville, FL?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 4 daily trips between Greenville, SC and Jacksonville, FL. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Greenville, SC to Jacksonville, FL?

Prices and availability for 4 trips between Greenville, SC and Jacksonville, FL change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Greenville, SC to Jacksonville, FL

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Greenville, SC and to Jacksonville, FL

Here’s an overview of the most popular bus routes to Greenville, SC and to Jacksonville, FL. Simply click on the connection of your choice, and you will find all the details about your bus route!