Bus Greenville, SC to Pittsburgh - Compare all Companies

Compare all timetables for the bus from Greenville, SC to Pittsburgh

Here is a selection of the cheapest bus trips from the schedule from Greenville, SC to Pittsburgh from various bus operators like FlixBus for the next days.

today

tomorrow

Wednesday

Thursday

Friday

Saturday

$136

Sunday

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	19h 20m	12:15 PM	Greenville, SC	Woodruff Rd	7:35 AM	Pittsburgh	Grant Street Transportation Center	Economy	$136	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 2/14/2026 12:15:00 PM to Grant Street Transportation Center, Pittsburgh (USA) arriving at 2/15/2026 7:35:00 AM. 50 Economy ticket for $136 per person are available. Travel duration is 19h 20m
FlixBus	18h 0m	4:15 PM	Greenville, SC	Woodruff Rd	10:15 AM	Pittsburgh	Grant Street Transportation Center	Economy	$136	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 2/14/2026 4:15:00 PM to Grant Street Transportation Center, Pittsburgh (USA) arriving at 2/15/2026 10:15:00 AM. 50 Economy ticket for $136 per person are available. Travel duration is 18h 0m
FlixBus	19h 50m	10:00 PM	Greenville, SC	Woodruff Rd	5:50 PM	Pittsburgh	Grant Street Transportation Center	Economy	$166	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 2/14/2026 10:00:00 PM to Grant Street Transportation Center, Pittsburgh (USA) arriving at 2/15/2026 5:50:00 PM. 50 Economy ticket for $166 per person are available. Travel duration is 19h 50m

Did you know that if you travel from Greenville, SC to Pittsburgh via Charlotte, you can save more than $28? You can find the corresponding connections below.
- Busbud
  
  19h 50m
  
  0
  
  10:00 PM
  
  Greenville, SC
  Woodruff Rd
  
  11:50 PM
  
  Charlotte
  W Trade St
  
  0
  
  Economy
  
  $19
  
  A Bus from Busbud goes from Woodruff Rd, Greenville, SC (USA) at 2/14/2026 10:00:00 PM to W Trade St, Charlotte (USA) arriving at 2/14/2026 11:50:00 PM. 50 Economy ticket for $19 per person are available. Travel duration is 1h 50m
- Busbud
  
  15h 15m
  
  0
  
  2:35 AM
  
  Charlotte
  W Trade St
  
  5:50 PM
  
  Pittsburgh
  Grant Street Transportation Center
  
  0
  
  Economy
  
  $90
  
  A Bus from Busbud goes from W Trade St, Charlotte (USA) at 2/15/2026 2:35:00 AM to Grant Street Transportation Center, Pittsburgh (USA) arriving at 2/15/2026 5:50:00 PM. 50 Economy ticket for $90 per person are available. Travel duration is 15h 15m
Travel time is 1h 50m longer, but you will save $28

Best Price Offer: The price for the cheapest bus from Greenville, SC to Pittsburgh is $104 on 2/8/2026. Flexible travelers save on ticket prices.

Facts about the bus from Greenville, SC to Pittsburgh

Compare all providers like FlixBus that travel 3 times every day by bus from Greenville, SC to Pittsburgh in one click! Book your bus ticket from Greenville, SC to Pittsburgh starting from $104!

Cheapest Bus	$104
Fastest Bus	18h 0m
Earliest Bus	12:15 PM
Latest Bus	10:00 PM
Daily Bus Routes	3 Ø
Distance	408.1 miles
Bus Companies	FlixBus

Cheapest bus connections from Greenville, SC to Pittsburgh

Every day, 3 buses from 1 bus companies leave Greenville, SC for Pittsburgh: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 02/09/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 02/08

Monday 02/09

Tuesday 02/10

Wednesday 02/11

Thursday 02/12

Friday 02/13

Saturday 02/14

$136

Sunday 02/15

Monday 02/16

$107

Tuesday 02/17

Wednesday 02/18

Thursday 02/19

Friday 02/20

Saturday 02/21

Sunday 02/22

Monday 02/23

Tuesday 02/24

Wednesday 02/25

$115

Thursday 02/26

Friday 02/27

Saturday 02/28

Sunday 03/01

Monday 03/02

Tuesday 03/03

Wednesday 03/04

Thursday 03/05

Friday 03/06

Saturday 03/07

How to save money travelling from Greenville, SC to Pittsburgh

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Greenville, SC to Pittsburgh in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Greenville, SC to Pittsburgh, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Greenville, SC to Pittsburgh are also emptier.

All bus stations and stops in Greenville, SC and Pittsburgh

In the map below, you can see where to find all bus stations in Greenville, SC and Pittsburgh.

McDonald's

Woodruff Rd 1111

Woodruff Rd

Woodruff Rd 1116

Guadalajara Supermarket

White Horse Rd 2803

Greyhound Bus Station

Hendrix Dr 9

N Church St

Grant Street Transportation Center

11th St 55

David L. Lawrence Convention Center

10th St Pittsburgh 131-199

Carnegie Mellon

Forbes Ave

University of

Central Station

Service and Comfort on the bus from Greenville, SC to Pittsburgh

Want to know which seat classes are available on the buses from Greenville, SC to Pittsburgh? Or which bus companies serve the route Greenville, SC to Pittsburgh? Below you will find answers to your questions.

FAQs about the Greenville, SC to Pittsburgh bus

How much does a Greenville, SC Pittsburgh bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $104 and takes 19h 20m to reach Pittsburgh. Compare offers to save money!

How much could I save by comparing buses from Greenville, SC to Pittsburgh?

This route is offered by 1 companies with a range of ticket prices between $104 and $166. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Pittsburgh.

On average, how many connections are available from Greenville, SC to Pittsburgh each day?

Every day, the Greenville, SC to Pittsburgh bus route is served by approximately 3 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Greenville, SC to Pittsburgh take?

The fastest bus from Greenville, SC to Pittsburgh is offered by FlixBus and takes 18h 0m. Bus tickets for this connection cost $136. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Greenville, SC to Pittsburgh?

The earliest bus arriving in Pittsburgh from Greenville, SC starts at 12:15 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Greenville, SC to Pittsburgh?

The latest bus trip departing from Greenville, SC for Pittsburgh starts at 10:00 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Greenville, SC Pittsburgh route?

When traveling by bus from Greenville, SC to Pittsburgh, passengers can travel with FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Greenville, SC and Pittsburgh?

You can check all the direct connections between Greenville, SC and Pittsburgh by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus.

What can I take with me on the Greenville, SC to Pittsburgh bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Greenville, SC Pittsburgh bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Greenville, SC Pittsburgh bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Greenville, SC to Pittsburgh on your planned travel date.

How does CheckMyBus find the best bus deals from Greenville, SC to Pittsburgh?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 3 daily trips between Greenville, SC and Pittsburgh. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Greenville, SC to Pittsburgh?

Prices and availability for 3 trips between Greenville, SC and Pittsburgh change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Greenville, SC to Pittsburgh

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Greenville, SC and to Pittsburgh

Here’s an overview of the most popular bus routes to Greenville, SC and to Pittsburgh. Simply click on the connection of your choice, and you will find all the details about your bus route!