Bus Greenville, SC to Pittsburgh - Compare all Companies

Compare all timetables for the bus from Greenville, SC to Pittsburgh

Here is a selection of the cheapest bus trips from the schedule from Greenville, SC to Pittsburgh from various bus operators like FlixBus or Greyhound US for the next days.

today

tomorrow

$94

Wednesday

$93

Thursday

$85

Friday

$100

Saturday

Sunday

$90

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	18h 0m	4:15 PM	Greenville, SC	Woodruff Rd	10:15 AM	Pittsburgh	Grant Street Transportation Center	Economy	$94	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 4/21/2026 4:15:00 PM to Grant Street Transportation Center, Pittsburgh (USA) arriving at 4/22/2026 10:15:00 AM. 50 Economy ticket for $94 per person are available. Travel duration is 18h 0m
FlixBus	19h 50m	10:00 PM	Greenville, SC	Woodruff Rd	5:50 PM	Pittsburgh	Grant Street Transportation Center	Economy	$94	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 4/21/2026 10:00:00 PM to Grant Street Transportation Center, Pittsburgh (USA) arriving at 4/22/2026 5:50:00 PM. 50 Economy ticket for $94 per person are available. Travel duration is 19h 50m
Greyhound US	20h 45m	10:50 AM	Greenville, SC	Woodruff Rd	7:35 AM	Pittsburgh	Grant Street Transportation Center	Economy	$95	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 4/21/2026 10:50:00 AM to Grant Street Transportation Center, Pittsburgh (USA) arriving at 4/22/2026 7:35:00 AM. 50 Economy ticket for $95 per person are available. Travel duration is 20h 45m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	18h 0m	4:15 PM	Greenville, SC	Woodruff Rd	10:15 AM	Pittsburgh	Grant Street Transportation Center	Economy	$93	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 4/22/2026 4:15:00 PM to Grant Street Transportation Center, Pittsburgh (USA) arriving at 4/23/2026 10:15:00 AM. 50 Economy ticket for $93 per person are available. Travel duration is 18h 0m
FlixBus	19h 50m	10:00 PM	Greenville, SC	Woodruff Rd	5:50 PM	Pittsburgh	Grant Street Transportation Center	Economy	$93	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 4/22/2026 10:00:00 PM to Grant Street Transportation Center, Pittsburgh (USA) arriving at 4/23/2026 5:50:00 PM. 50 Economy ticket for $93 per person are available. Travel duration is 19h 50m
Greyhound US	20h 45m	10:50 AM	Greenville, SC	Woodruff Rd	7:35 AM	Pittsburgh	Grant Street Transportation Center	Economy	$94	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 4/22/2026 10:50:00 AM to Grant Street Transportation Center, Pittsburgh (USA) arriving at 4/23/2026 7:35:00 AM. 50 Economy ticket for $94 per person are available. Travel duration is 20h 45m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	19h 50m	10:00 PM	Greenville, SC	Woodruff Rd	5:50 PM	Pittsburgh	Grant Street Transportation Center	Economy	$85	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 4/23/2026 10:00:00 PM to Grant Street Transportation Center, Pittsburgh (USA) arriving at 4/24/2026 5:50:00 PM. 50 Economy ticket for $85 per person are available. Travel duration is 19h 50m
FlixBus	19h 20m	12:15 PM	Greenville, SC	Woodruff Rd	7:35 AM	Pittsburgh	Grant Street Transportation Center	Economy	$86	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 4/23/2026 12:15:00 PM to Grant Street Transportation Center, Pittsburgh (USA) arriving at 4/24/2026 7:35:00 AM. 50 Economy ticket for $86 per person are available. Travel duration is 19h 20m
FlixBus	18h 0m	4:15 PM	Greenville, SC	Woodruff Rd	10:15 AM	Pittsburgh	Grant Street Transportation Center	Economy	$86	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 4/23/2026 4:15:00 PM to Grant Street Transportation Center, Pittsburgh (USA) arriving at 4/24/2026 10:15:00 AM. 50 Economy ticket for $86 per person are available. Travel duration is 18h 0m

Cheapest bus trips Friday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	FlixBus	19h 20m	12:15 PM	Greenville, SC	Woodruff Rd	7:35 AM	Pittsburgh	Grant Street Transportation Center		Economy	$100	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 4/24/2026 12:15:00 PM to Grant Street Transportation Center, Pittsburgh (USA) arriving at 4/25/2026 7:35:00 AM. 50 Economy ticket for $100 per person are available. Travel duration is 19h 20m
	FlixBus	18h 0m	4:15 PM	Greenville, SC	Woodruff Rd	10:15 AM	Pittsburgh	Grant Street Transportation Center		Economy	$100	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 4/24/2026 4:15:00 PM to Grant Street Transportation Center, Pittsburgh (USA) arriving at 4/25/2026 10:15:00 AM. 50 Economy ticket for $100 per person are available. Travel duration is 18h 0m

Cheapest bus trips Sunday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	FlixBus	19h 20m	12:15 PM	Greenville, SC	Woodruff Rd	7:35 AM	Pittsburgh	Grant Street Transportation Center		Economy	$90	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 4/26/2026 12:15:00 PM to Grant Street Transportation Center, Pittsburgh (USA) arriving at 4/27/2026 7:35:00 AM. 50 Economy ticket for $90 per person are available. Travel duration is 19h 20m
	FlixBus	18h 0m	4:15 PM	Greenville, SC	Woodruff Rd	10:15 AM	Pittsburgh	Grant Street Transportation Center		Economy	$90	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 4/26/2026 4:15:00 PM to Grant Street Transportation Center, Pittsburgh (USA) arriving at 4/27/2026 10:15:00 AM. 50 Economy ticket for $90 per person are available. Travel duration is 18h 0m

Best Price Offer: The price for the cheapest bus from Greenville, SC to Pittsburgh is $83 on 5/15/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Greenville, SC and Pittsburgh

See here how frequent the connections between Greenville, SC and Pittsburgh are, during different times and days of the week.

Sunday is the busiest day, with more than 4 daily buses from Greenville, SC to Pittsburgh. Friday has instead the fewest connections, with only 2 daily coaches between Greenville, SC and Pittsburgh.

The busiest time of the day is the Afternoon, with 10 buses from Greenville, SC to Pittsburgh, while Morning sees the fewest connections between Greenville, SC and Pittsburgh, with 2 offers.

Facts about the bus from Greenville, SC to Pittsburgh

Compare all providers like FlixBus and Greyhound US that travel 3 times every day by bus from Greenville, SC to Pittsburgh in one click! Book your bus ticket from Greenville, SC to Pittsburgh starting from $83!

Cheapest Bus	$83
Fastest Bus	18h 0m
Earliest Bus	10:50 AM
Latest Bus	4:15 PM
Daily Bus Routes	3 Ø
Distance	408.1 miles
Bus Companies	FlixBus and Greyhound US

Cheapest bus connections from Greenville, SC to Pittsburgh

Every day, 3 buses from 2 bus companies leave Greenville, SC for Pittsburgh: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 04/20/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 04/19

Monday 04/20

Tuesday 04/21

$94

Wednesday 04/22

$93

Thursday 04/23

$85

Friday 04/24

$100

Saturday 04/25

Sunday 04/26

$94

Monday 04/27

Tuesday 04/28

$85

Wednesday 04/29

$93

Thursday 04/30

Friday 05/01

Saturday 05/02

Sunday 05/03

Monday 05/04

$90

Tuesday 05/05

Wednesday 05/06

Thursday 05/07

Friday 05/08

$87

Saturday 05/09

$96

Sunday 05/10

$94

Monday 05/11

$91

Tuesday 05/12

$94

Wednesday 05/13

$93

Thursday 05/14

$85

Friday 05/15

$83

Saturday 05/16

The cheapest time to travel from Greenville, SC to Pittsburgh

See here on which day and which time of the day you can find the cheapest bus ticket from Greenville, SC to Pittsburgh, for the next 30 days.

With a price starting from $83, Friday is the cheapest day for a bus from Greenville, SC to Pittsburgh. Wednesday instead is the most expensive day with prices starting from $93.

Evening is the cheapest day time for bus tickets from Greenville, SC to Pittsburgh, with $85. Morning is the most expensive time of the day with prices starting from $94.

How to save money travelling from Greenville, SC to Pittsburgh

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Greenville, SC to Pittsburgh in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Greenville, SC to Pittsburgh, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Greenville, SC to Pittsburgh are also emptier.

All bus stations and stops in Greenville, SC and Pittsburgh

In the map below, you can see where to find all bus stations in Greenville, SC and Pittsburgh.

McDonald's

Woodruff Rd 1111

Woodruff Rd

Woodruff Rd 1116

N Church St

Greyhound Bus Station

Hendrix Dr 9

Guadalajara Supermarket

White Horse Rd 2803

Grant Street Transportation Center

11th St 55

David L. Lawrence Convention Center

10th St Pittsburgh 131-199

Carnegie Mellon

Forbes Ave

University of

Central Station

Service and Comfort on the bus from Greenville, SC to Pittsburgh

Want to know which seat classes are available on the buses from Greenville, SC to Pittsburgh? Or which bus companies serve the route Greenville, SC to Pittsburgh? Below you will find answers to your questions.

FAQs about the Greenville, SC to Pittsburgh bus

How much does a Greenville, SC Pittsburgh bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $83 and takes 19h 50m to reach Pittsburgh. Compare offers to save money!

How much could I save by comparing buses from Greenville, SC to Pittsburgh?

This route is offered by 2 companies with a range of ticket prices between $83 and $100. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Pittsburgh.

On average, how many connections are available from Greenville, SC to Pittsburgh each day?

Every day, the Greenville, SC to Pittsburgh bus route is served by approximately 3 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Greenville, SC to Pittsburgh take?

The fastest bus from Greenville, SC to Pittsburgh is offered by FlixBus and takes 18h 0m. Bus tickets for this connection cost $94. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Greenville, SC to Pittsburgh?

The earliest bus arriving in Pittsburgh from Greenville, SC starts at 10:50 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Greenville, SC to Pittsburgh?

The latest bus trip departing from Greenville, SC for Pittsburgh starts at 4:15 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Greenville, SC Pittsburgh route?

When traveling by bus from Greenville, SC to Pittsburgh, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Greenville, SC and Pittsburgh?

You can check all the direct connections between Greenville, SC and Pittsburgh by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the Greenville, SC to Pittsburgh bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Greenville, SC Pittsburgh bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Greenville, SC Pittsburgh bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Greenville, SC to Pittsburgh on your planned travel date.

How does CheckMyBus find the best bus deals from Greenville, SC to Pittsburgh?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 3 daily trips between Greenville, SC and Pittsburgh. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Greenville, SC to Pittsburgh?

Prices and availability for 3 trips between Greenville, SC and Pittsburgh change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Greenville, SC to Pittsburgh

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Greenville, SC and to Pittsburgh

Here’s an overview of the most popular bus routes to Greenville, SC and to Pittsburgh. Simply click on the connection of your choice, and you will find all the details about your bus route!