Which bus from Greenville, SC to Port Saint Lucie, FL is the cheapest?

Compare all bus companies and find the best price: Bus tickets from $84
The Best Deals Save up to 70%
The Most Choices Millions of routes worldwide
Easy and Transparent Compare offers with 1 click

Compare all timetables for the bus from Greenville, SC to Port Saint Lucie, FL

Here is a selection of the cheapest bus trips from the schedule from Greenville, SC to Port Saint Lucie, FL from various bus operators like FlixBus or Greyhound US for the next days.

today
$101
tomorrow
$101
Saturday
$98
Sunday
$102
Monday
$102
Tuesday
$96
Wednesday
$96

Cheapest bus trips today

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 20h 20m 2:45 PM Greenville, SC Woodruff Rd 11:05 AM Port Saint Lucie, FL RaceTrac Gas Station  Economy $101
FlixBus 27h 35m 10:00 PM Greenville, SC Woodruff Rd 1:35 AM Port Saint Lucie, FL RaceTrac Gas Station  Economy $104
Greyhound US 16h 0m 11:15 AM Greenville, SC Woodruff Rd 3:15 AM Port Saint Lucie, FL RaceTrac Gas Station  Economy $105

Cheapest bus trips tomorrow

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 15h 25m 7:40 PM Greenville, SC Woodruff Rd 11:05 AM Port Saint Lucie, FL SW Gatlin Blvd & SW Brescia St Bus Stop  Economy $101
Greyhound US 16h 0m 11:15 AM Greenville, SC Woodruff Rd 3:15 AM Port Saint Lucie, FL SW Gatlin Blvd & SW Brescia St Bus Stop  Economy $109
FlixBus 29h 15m 10:00 PM Greenville, SC Woodruff Rd 3:15 AM Port Saint Lucie, FL SW Gatlin Blvd & SW Brescia St Bus Stop  Economy $112
  • Did you know that if you travel from Greenville, SC to Port Saint Lucie, FL via Orlando, FL, you can save more than $10? You can find the corresponding connections below.
    • Greyhound US
      20h 5m
      0
      7:10 AM
      Greenville, SC
      Woodruff Rd
      9:15 PM
      Orlando, FL
      Bus Station
      0
      Greyhound US
      Economy
      $68
      • Waiting Time 3h 30m
    • FlixBus
      2h 30m
      0
      12:45 AM
      Orlando, FL
      Bus Station
      3:15 AM
      Port Saint Lucie, FL
      SW Gatlin Blvd & SW Brescia St Bus Stop
      0
      FlixBus
      Economy
      $23
    Travel time is 4h 40m longer, but you will save $10

Cheapest bus trips Saturday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 27h 35m 10:00 PM Greenville, SC Woodruff Rd 1:35 AM Port Saint Lucie, FL SW Gatlin Blvd & SW Brescia St Bus Stop  Economy $98
Greyhound US 16h 0m 11:15 AM Greenville, SC Woodruff Rd 3:15 AM Port Saint Lucie, FL SW Gatlin Blvd & SW Brescia St Bus Stop  Economy $112
FlixBus 15h 25m 7:40 PM Greenville, SC Woodruff Rd 11:05 AM Port Saint Lucie, FL SW Gatlin Blvd & SW Brescia St Bus Stop  Economy $127

Cheapest bus trips Sunday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 15h 25m 7:40 PM Greenville, SC Woodruff Rd 11:05 AM Port Saint Lucie, FL SW Gatlin Blvd & SW Brescia St Bus Stop  Economy $102
FlixBus 27h 35m 10:00 PM Greenville, SC Woodruff Rd 1:35 AM Port Saint Lucie, FL SW Gatlin Blvd & SW Brescia St Bus Stop  Economy $105
Greyhound US 16h 0m 11:15 AM Greenville, SC Woodruff Rd 3:15 AM Port Saint Lucie, FL SW Gatlin Blvd & SW Brescia St Bus Stop  Economy $107
  • Did you know that if you travel from Greenville, SC to Port Saint Lucie, FL via Orlando, FL, you can save more than $18? You can find the corresponding connections below.
    • Greyhound US
      16h 0m
      0
      11:15 AM
      Greenville, SC
      Woodruff Rd
      11:20 PM
      Orlando, FL
      Bus Station
      0
      Greyhound US
      Economy
      $65
      • Waiting Time 1h 25m
    • FlixBus
      2h 30m
      0
      12:45 AM
      Orlando, FL
      Bus Station
      3:15 AM
      Port Saint Lucie, FL
      SW Gatlin Blvd & SW Brescia St Bus Stop
      0
      FlixBus
      Economy
      $19
    Travel time is 0h 35m longer, but you will save $18

Cheapest bus trips Monday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 16h 0m 11:15 AM Greenville, SC Woodruff Rd 3:15 AM Port Saint Lucie, FL SW Gatlin Blvd & SW Brescia St Bus Stop  Economy $102
FlixBus 15h 25m 7:40 PM Greenville, SC Woodruff Rd 11:05 AM Port Saint Lucie, FL SW Gatlin Blvd & SW Brescia St Bus Stop  Economy $102
FlixBus 29h 15m 10:00 PM Greenville, SC Woodruff Rd 3:15 AM Port Saint Lucie, FL SW Gatlin Blvd & SW Brescia St Bus Stop  Economy $103
  • Did you know that if you travel from Greenville, SC to Port Saint Lucie, FL via Orlando, FL, you can save more than $18? You can find the corresponding connections below.
    • Greyhound US
      16h 0m
      0
      11:15 AM
      Greenville, SC
      Woodruff Rd
      11:20 PM
      Orlando, FL
      Bus Station
      0
      Greyhound US
      Economy
      $65
      • Waiting Time 1h 25m
    • FlixBus
      2h 30m
      0
      12:45 AM
      Orlando, FL
      Bus Station
      3:15 AM
      Port Saint Lucie, FL
      SW Gatlin Blvd & SW Brescia St Bus Stop
      0
      FlixBus
      Economy
      $19
    Travel time is 0h 35m longer, but you will save $18

Cheapest bus trips Tuesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 16h 0m 11:15 AM Greenville, SC Woodruff Rd 3:15 AM Port Saint Lucie, FL SW Gatlin Blvd & SW Brescia St Bus Stop  Economy $96
FlixBus 27h 35m 10:00 PM Greenville, SC Woodruff Rd 1:35 AM Port Saint Lucie, FL SW Gatlin Blvd & SW Brescia St Bus Stop  Economy $98
FlixBus 15h 25m 7:40 PM Greenville, SC Woodruff Rd 11:05 AM Port Saint Lucie, FL SW Gatlin Blvd & SW Brescia St Bus Stop  Economy $101
  • Did you know that if you travel from Greenville, SC to Port Saint Lucie, FL via Orlando, FL, you can save more than $12? You can find the corresponding connections below.
    • Greyhound US
      16h 0m
      0
      11:15 AM
      Greenville, SC
      Woodruff Rd
      11:20 PM
      Orlando, FL
      Bus Station
      0
      Greyhound US
      Economy
      $65
      • Waiting Time 1h 25m
    • FlixBus
      2h 30m
      0
      12:45 AM
      Orlando, FL
      Bus Station
      3:15 AM
      Port Saint Lucie, FL
      SW Gatlin Blvd & SW Brescia St Bus Stop
      0
      FlixBus
      Economy
      $19
    Travel time is 0h 35m longer, but you will save $12

Cheapest bus trips Wednesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 20h 20m 2:45 PM Greenville, SC Woodruff Rd 11:05 AM Port Saint Lucie, FL RaceTrac Gas Station  Economy $96
Greyhound US 16h 0m 11:15 AM Greenville, SC Woodruff Rd 3:15 AM Port Saint Lucie, FL RaceTrac Gas Station  Economy $98
FlixBus 27h 35m 10:00 PM Greenville, SC Woodruff Rd 1:35 AM Port Saint Lucie, FL RaceTrac Gas Station  Economy $100
  • Did you know that if you travel from Greenville, SC to Port Saint Lucie, FL via Orlando, FL, you can save more than $12? You can find the corresponding connections below.
    • Greyhound US
      16h 0m
      0
      11:15 AM
      Greenville, SC
      Woodruff Rd
      11:20 PM
      Orlando, FL
      Bus Station
      0
      Greyhound US
      Economy
      $65
      • Waiting Time 1h 25m
    • FlixBus
      2h 30m
      0
      12:45 AM
      Orlando, FL
      Bus Station
      3:15 AM
      Port Saint Lucie, FL
      SW Gatlin Blvd & SW Brescia St Bus Stop
      0
      FlixBus
      Economy
      $19
    Travel time is the same as the direct connection, but you will save $12

Best Price Offer: The price for the cheapest bus from Greenville, SC to Port Saint Lucie, FL is $84 on 6/19/2026. Flexible travelers save on ticket prices.


Frequency of bus connections between Greenville, SC and Port Saint Lucie, FL

See here how frequent the connections between Greenville, SC and Port Saint Lucie, FL are, during different times and days of the week.
Sunday is the busiest day, with more than 6 daily buses from Greenville, SC to Port Saint Lucie, FL. Monday has instead the fewest connections, with only 3 daily coaches between Greenville, SC and Port Saint Lucie, FL.
The busiest time of the day is the Evening, with 16 buses from Greenville, SC to Port Saint Lucie, FL, while Afternoon sees the fewest connections between Greenville, SC and Port Saint Lucie, FL, with 2 offers.

Facts about the bus from Greenville, SC to Port Saint Lucie, FL

Compare all providers like FlixBus and Greyhound US that travel 3 times every day by bus from Greenville, SC to Port Saint Lucie, FL in one click! Book your bus ticket from Greenville, SC to Port Saint Lucie, FL starting from $84!

Cheapest Bus $84
Fastest Bus 15h 25m
Earliest Bus 11:15 AM
Latest Bus 10:00 PM
Daily Bus Routes 3 Ø
Distance 537.5 miles
Bus Companies FlixBus and Greyhound US

Cheapest bus connections from Greenville, SC to Port Saint Lucie, FL

Every day, 3 buses from 2 bus companies leave Greenville, SC for Port Saint Lucie, FL: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 06/04/2026 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 05/31
Monday 06/01
Tuesday 06/02
Wednesday 06/03
Thursday 06/04
$101
Friday 06/05
$101
Saturday 06/06
$98
Sunday 06/07
$102
Monday 06/08
$102
Tuesday 06/09
$96
Wednesday 06/10
$96
Thursday 06/11
$93
Friday 06/12
$93
Saturday 06/13
$91
Sunday 06/14
$86
Monday 06/15
Tuesday 06/16
$91
Wednesday 06/17
$91
Thursday 06/18
$97
Friday 06/19
$84
Saturday 06/20
$88
Sunday 06/21
$89
Monday 06/22
$87
Tuesday 06/23
Wednesday 06/24
$85
Thursday 06/25
$88
Friday 06/26
$91
Saturday 06/27

The cheapest time to travel from Greenville, SC to Port Saint Lucie, FL

See here on which day and which time of the day you can find the cheapest bus ticket from Greenville, SC to Port Saint Lucie, FL, for the next 30 days.
With a price starting from $84, Friday is the cheapest day for a bus from Greenville, SC to Port Saint Lucie, FL. Tuesday instead is the most expensive day with prices starting from $91.
Afternoon is the cheapest day time for bus tickets from Greenville, SC to Port Saint Lucie, FL, with $96. Evening is the most expensive time of the day with prices starting from $98.

How to save money travelling from Greenville, SC to Port Saint Lucie, FL

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Greenville, SC to Port Saint Lucie, FL in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Greenville, SC to Port Saint Lucie, FL, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Greenville, SC to Port Saint Lucie, FL are also emptier.

All bus stations and stops in Greenville, SC and Port Saint Lucie, FL

In the map below, you can see where to find all bus stations in Greenville, SC and Port Saint Lucie, FL.

Service and Comfort on the bus from Greenville, SC to Port Saint Lucie, FL

Want to know which seat classes are available on the buses from Greenville, SC to Port Saint Lucie, FL? Or which bus companies serve the route Greenville, SC to Port Saint Lucie, FL? Below you will find answers to your questions.

FAQs about the Greenville, SC to Port Saint Lucie, FL bus

How much does a Greenville, SC Port Saint Lucie, FL bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $84 and takes 20h 20m to reach Port Saint Lucie, FL. Compare offers to save money!

How much could I save by comparing buses from Greenville, SC to Port Saint Lucie, FL?

This route is offered by 2 companies with a range of ticket prices between $84 and $127. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Port Saint Lucie, FL.

On average, how many connections are available from Greenville, SC to Port Saint Lucie, FL each day?

Every day, the Greenville, SC to Port Saint Lucie, FL bus route is served by approximately 3 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Greenville, SC to Port Saint Lucie, FL take?

The fastest bus from Greenville, SC to Port Saint Lucie, FL is offered by FlixBus and takes 15h 25m. Bus tickets for this connection cost $105. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Greenville, SC to Port Saint Lucie, FL?

The earliest bus arriving in Port Saint Lucie, FL from Greenville, SC starts at 11:15 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Greenville, SC to Port Saint Lucie, FL?

The latest bus trip departing from Greenville, SC for Port Saint Lucie, FL starts at 10:00 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Greenville, SC Port Saint Lucie, FL route?

When traveling by bus from Greenville, SC to Port Saint Lucie, FL, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Greenville, SC and Port Saint Lucie, FL?

You can check all the direct connections between Greenville, SC and Port Saint Lucie, FL by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the Greenville, SC to Port Saint Lucie, FL bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Greenville, SC Port Saint Lucie, FL bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Greenville, SC Port Saint Lucie, FL bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Greenville, SC to Port Saint Lucie, FL on your planned travel date.

How does CheckMyBus find the best bus deals from Greenville, SC to Port Saint Lucie, FL?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 3 daily trips between Greenville, SC and Port Saint Lucie, FL. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Greenville, SC to Port Saint Lucie, FL?

Prices and availability for 3 trips between Greenville, SC and Port Saint Lucie, FL change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Greenville, SC to Port Saint Lucie, FL

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Greenville, SC and to Port Saint Lucie, FL

Here’s an overview of the most popular bus routes to Greenville, SC and to Port Saint Lucie, FL. Simply click on the connection of your choice, and you will find all the details about your bus route!
Toledo, OH to Greenville, SC bus Toledo, OH to Greenville, SC bus
Buses to Greenville, SC from Silver Spring, MD Buses to Greenville, SC from Silver Spring, MD
Buses from Clarksville, TN to Greenville, SC Buses from Clarksville, TN to Greenville, SC
Buses Syracuse, NY to Greenville, SC Buses Syracuse, NY to Greenville, SC
From Norcross, GA to Port Saint Lucie, FL bus From Norcross, GA to Port Saint Lucie, FL bus
Bus from Rockledge, FL to Port Saint Lucie, FL Bus from Rockledge, FL to Port Saint Lucie, FL
Bus to Port Saint Lucie, FL from Titusville, FL Bus to Port Saint Lucie, FL from Titusville, FL
Bus Denver to Port Saint Lucie, FL Bus Denver to Port Saint Lucie, FL
Popular Airport Shuttles to Greenville, SC and to Port Saint Lucie, FL
CheckMyBus › Buses in USA › Bus to Greenville, SC › Bus to Port Saint Lucie, FL

The CheckMyBus App

Free Download

App Store
CheckMyBus App
Close
GPDR CheckMyBus shield

We value your privacy!

To

show

you

the

best

bus

offers,

we

and

our

partners

use

technical,

analytical,

and

marketing

cookies

to

personalize

the

ads.

We

remember

your

anonymized

details

to

provide

a

personalized

experience.