Bus Lewiston, ME to Florence, SC: Compare prices and save money

Compare all timetables for the bus from Lewiston, ME to Florence, SC

Here is a selection of the cheapest bus trips from the schedule from Lewiston, ME to Florence, SC from various bus operators like Greyhound US for the next days.

today

$115

tomorrow

$140

Friday

$115

Saturday

Sunday

$117

Monday

Tuesday

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	23h 0m	12:45 PM	Lewiston, ME	Bus Stop	11:45 AM	Florence, SC	Bus Station	Economy	$115	A Bus from Greyhound US goes from Bus Stop, Lewiston, ME (USA) at 4/29/2026 12:45:00 PM to Bus Station, Florence, SC (USA) arriving at 4/30/2026 11:45:00 AM. 50 Economy ticket for $115 per person are available. Travel duration is 23h 0m
Greyhound US	23h 5m	12:40 PM	Lewiston, ME	Bus Stop	11:45 AM	Florence, SC	Bus Station	Economy	$117	A Bus from Greyhound US goes from Bus Stop, Lewiston, ME (USA) at 4/29/2026 12:40:00 PM to Bus Station, Florence, SC (USA) arriving at 4/30/2026 11:45:00 AM. 50 Economy ticket for $117 per person are available. Travel duration is 23h 5m
Greyhound US	41h 0m	12:45 PM	Lewiston, ME	Bus Stop	5:45 AM	Florence, SC	TA Travel Center	Economy	$230	A Bus from Greyhound US goes from Bus Stop, Lewiston, ME (USA) at 4/29/2026 12:45:00 PM to TA Travel Center, Florence, SC (USA) arriving at 5/1/2026 5:45:00 AM. 50 Economy ticket for $230 per person are available. Travel duration is 41h 0m
Greyhound US	41h 5m	12:40 PM	Lewiston, ME	Bus Stop	5:45 AM	Florence, SC	TA Travel Center	Economy	$231	A Bus from Greyhound US goes from Bus Stop, Lewiston, ME (USA) at 4/29/2026 12:40:00 PM to TA Travel Center, Florence, SC (USA) arriving at 5/1/2026 5:45:00 AM. 50 Economy ticket for $231 per person are available. Travel duration is 41h 5m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	23h 0m	12:45 PM	Lewiston, ME	Bus Stop	11:45 AM	Florence, SC	Bus Station	Economy	$140	A Bus from Greyhound US goes from Bus Stop, Lewiston, ME (USA) at 4/30/2026 12:45:00 PM to Bus Station, Florence, SC (USA) arriving at 5/1/2026 11:45:00 AM. 50 Economy ticket for $140 per person are available. Travel duration is 23h 0m
Greyhound US	23h 5m	12:40 PM	Lewiston, ME	Bus Stop	11:45 AM	Florence, SC	Bus Station	Economy	$142	A Bus from Greyhound US goes from Bus Stop, Lewiston, ME (USA) at 4/30/2026 12:40:00 PM to Bus Station, Florence, SC (USA) arriving at 5/1/2026 11:45:00 AM. 50 Economy ticket for $142 per person are available. Travel duration is 23h 5m
Greyhound US	41h 5m	12:40 PM	Lewiston, ME	Bus Stop	5:45 AM	Florence, SC	TA Travel Center	Economy	$221	A Bus from Greyhound US goes from Bus Stop, Lewiston, ME (USA) at 4/30/2026 12:40:00 PM to TA Travel Center, Florence, SC (USA) arriving at 5/2/2026 5:45:00 AM. 50 Economy ticket for $221 per person are available. Travel duration is 41h 5m
Greyhound US	41h 0m	12:45 PM	Lewiston, ME	Bus Stop	5:45 AM	Florence, SC	TA Travel Center	Economy	$221	A Bus from Greyhound US goes from Bus Stop, Lewiston, ME (USA) at 4/30/2026 12:45:00 PM to TA Travel Center, Florence, SC (USA) arriving at 5/2/2026 5:45:00 AM. 50 Economy ticket for $221 per person are available. Travel duration is 41h 0m

Did you know that if you travel from Lewiston, ME to Florence, SC via Boston, MA, you can save more than $15? You can find the corresponding connections below.
- Greyhound US
  
  23h 0m
  
  0
  
  12:45 PM
  
  Lewiston, ME
  Bus Stop
  
  4:15 PM
  
  Boston, MA
  Atlantic and Beach St
  
  0
  
  Economy
  
  $25
  
  A Bus from Greyhound US goes from Bus Stop, Lewiston, ME (USA) at 5/1/2026 12:45:00 PM to Atlantic and Beach St, Boston, MA (USA) arriving at 5/1/2026 4:15:00 PM. 50 Economy ticket for $25 per person are available. Travel duration is 3h 30m
- Greyhound US
  
  19h 0m
  
  0
  
  4:45 PM
  
  Boston, MA
  South Station
  
  11:45 AM
  
  Florence, SC
  Bus Station
  
  0
  
  Economy
  
  $100
  
  A Bus from Greyhound US goes from South Station, Boston, MA (USA) at 5/1/2026 4:45:00 PM to Bus Station, Florence, SC (USA) arriving at 5/2/2026 11:45:00 AM. 50 Economy ticket for $100 per person are available. Travel duration is 19h 0m
Travel time is the same as the direct connection, but you will save $15

Cheapest bus trips Friday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	23h 0m	12:45 PM	Lewiston, ME	Bus Stop	11:45 AM	Florence, SC	Bus Station		Economy	$115	A Bus from Greyhound US goes from Bus Stop, Lewiston, ME (USA) at 5/1/2026 12:45:00 PM to Bus Station, Florence, SC (USA) arriving at 5/2/2026 11:45:00 AM. 50 Economy ticket for $115 per person are available. Travel duration is 23h 0m
	Greyhound US	23h 5m	12:40 PM	Lewiston, ME	Bus Stop	11:45 AM	Florence, SC	Bus Station		Economy	$117	A Bus from Greyhound US goes from Bus Stop, Lewiston, ME (USA) at 5/1/2026 12:40:00 PM to Bus Station, Florence, SC (USA) arriving at 5/2/2026 11:45:00 AM. 50 Economy ticket for $117 per person are available. Travel duration is 23h 5m

Cheapest bus trips Sunday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	23h 5m	12:40 PM	Lewiston, ME	Bus Stop	11:45 AM	Florence, SC	Bus Station		Economy	$117	A Bus from Greyhound US goes from Bus Stop, Lewiston, ME (USA) at 5/3/2026 12:40:00 PM to Bus Station, Florence, SC (USA) arriving at 5/4/2026 11:45:00 AM. 50 Economy ticket for $117 per person are available. Travel duration is 23h 5m
	Greyhound US	23h 0m	12:45 PM	Lewiston, ME	Bus Stop	11:45 AM	Florence, SC	Bus Station		Economy	$117	A Bus from Greyhound US goes from Bus Stop, Lewiston, ME (USA) at 5/3/2026 12:45:00 PM to Bus Station, Florence, SC (USA) arriving at 5/4/2026 11:45:00 AM. 50 Economy ticket for $117 per person are available. Travel duration is 23h 0m

Best Price Offer: The price for the cheapest bus from Lewiston, ME to Florence, SC is $115 on 4/29/2026. Flexible travelers save on ticket prices.

Facts about the bus from Lewiston, ME to Florence, SC

Compare all providers like Greyhound US that travel 3 times every day by bus from Lewiston, ME to Florence, SC in one click! Book your bus ticket from Lewiston, ME to Florence, SC starting from $115!

Cheapest Bus	$115
Fastest Bus	23h 0m
Earliest Bus	12:40 PM
Latest Bus	12:45 PM
Daily Bus Routes	3 Ø
Distance	853.4 miles
Bus Companies	Greyhound US

Cheapest bus connections from Lewiston, ME to Florence, SC

Every day, 3 buses from 1 bus companies leave Lewiston, ME for Florence, SC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 04/29/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 04/26

Monday 04/27

Tuesday 04/28

Wednesday 04/29

$115

Thursday 04/30

$140

Friday 05/01

$115

Saturday 05/02

Sunday 05/03

$117

Monday 05/04

Tuesday 05/05

Wednesday 05/06

Thursday 05/07

Friday 05/08

$117

Saturday 05/09

Sunday 05/10

$117

Monday 05/11

$122

Tuesday 05/12

$122

Wednesday 05/13

$122

Thursday 05/14

$121

Friday 05/15

$136

Saturday 05/16

$122

Sunday 05/17

Monday 05/18

$122

Tuesday 05/19

$118

Wednesday 05/20

$120

Thursday 05/21

$118

Friday 05/22

$122

Saturday 05/23

How to save money travelling from Lewiston, ME to Florence, SC

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Lewiston, ME to Florence, SC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Lewiston, ME to Florence, SC, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Lewiston, ME to Florence, SC are also emptier.

All bus stations and stops in Lewiston, ME and Florence, SC

In the map below, you can see where to find all bus stations in Lewiston, ME and Florence, SC.

Bus Stop

Bates St 111

Circle K

Main Street 674

Bates College

94 Russell St

Bus Station

S Irby St 611

TA Travel Center

W Lucas St 2301

Exxon Gas Station

W Lucas Street 1901

McDonalds

W. Lucas St. 1908

Shell Gas Station

W Lucas Street 1832

Service and Comfort on the bus from Lewiston, ME to Florence, SC

Want to know which seat classes are available on the buses from Lewiston, ME to Florence, SC? Or which bus companies serve the route Lewiston, ME to Florence, SC? Below you will find answers to your questions.

FAQs about the Lewiston, ME to Florence, SC bus

How much does a Lewiston, ME Florence, SC bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $115 and takes 23h 0m to reach Florence, SC. Compare offers to save money!

How much could I save by comparing buses from Lewiston, ME to Florence, SC?

This route is offered by 1 companies with a range of ticket prices between $115 and $231. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Florence, SC.

On average, how many connections are available from Lewiston, ME to Florence, SC each day?

Every day, the Lewiston, ME to Florence, SC bus route is served by approximately 3 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Lewiston, ME to Florence, SC take?

The fastest bus from Lewiston, ME to Florence, SC is offered by Greyhound US and takes 23h 0m. Bus tickets for this connection cost $119. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Lewiston, ME to Florence, SC?

The earliest bus arriving in Florence, SC from Lewiston, ME starts at 12:40 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Lewiston, ME to Florence, SC?

The latest bus trip departing from Lewiston, ME for Florence, SC starts at 12:45 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Lewiston, ME Florence, SC route?

When traveling by bus from Lewiston, ME to Florence, SC, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Lewiston, ME and Florence, SC?

You can check all the direct connections between Lewiston, ME and Florence, SC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Lewiston, ME to Florence, SC bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Lewiston, ME Florence, SC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Lewiston, ME Florence, SC bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Lewiston, ME to Florence, SC on your planned travel date.

How does CheckMyBus find the best bus deals from Lewiston, ME to Florence, SC?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 3 daily trips between Lewiston, ME and Florence, SC. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Lewiston, ME to Florence, SC?

Prices and availability for 3 trips between Lewiston, ME and Florence, SC change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Lewiston, ME to Florence, SC

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Lewiston, ME and to Florence, SC

Here’s an overview of the most popular bus routes to Lewiston, ME and to Florence, SC. Simply click on the connection of your choice, and you will find all the details about your bus route!