Bus from Palermo to Milan from $52

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Compare all timetables for the bus from Palermo to Milan

Here is a selection of the cheapest bus trips from the schedule from Palermo to Milan from various bus operators like FlixBus or Autoservizi Salemi for the next days.

today
$91
tomorrow
$56
Wednesday
$52
Thursday
$66
Friday
$59
Saturday
$63
Sunday
$52

Cheapest bus trips today

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Autoservizi Salemi 19h 10m 6:00 PM Palermo Via Tommaso Fazello Bus Stop 1:10 PM Milan San Donato Bus Station  Basic $91
Autoservizi Salemi 19h 50m 6:00 PM Palermo Via Tommaso Fazello Bus Stop 1:50 PM Milan Lampugnano Bus Station  Basic $91
FlixBus 25h 20m 5:10 PM Palermo Via Tommaso Fazello Bus Stop 6:30 PM Milan San Donato Bus Station  Economy $104
FlixBus 24h 5m 5:10 PM Palermo Via Tommaso Fazello Bus Stop 5:15 PM Milan Lampugnano Bus Station  Economy $105
FlixBus 23h 10m 3:25 PM Palermo Via Tommaso Fazello Bus Stop 2:35 PM Milan San Donato Bus Station  Economy $113

Cheapest bus trips tomorrow

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 27h 5m 3:25 PM Palermo Via Tommaso Fazello Bus Stop 6:30 PM Milan San Donato Bus Station  Economy $56
FlixBus 22h 15m 3:25 PM Palermo Via Tommaso Fazello Bus Stop 1:40 PM Milan Lampugnano Bus Station  Economy $87

Cheapest bus trips Wednesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 23h 10m 3:25 PM Palermo Via Tommaso Fazello Bus Stop 2:35 PM Milan San Donato Bus Station  Economy $52
FlixBus 22h 15m 3:25 PM Palermo Via Tommaso Fazello Bus Stop 1:40 PM Milan Lampugnano Bus Station  Economy $71
Autoservizi Salemi 19h 10m 6:00 PM Palermo Via Tommaso Fazello Bus Stop 1:10 PM Milan San Donato Bus Station  Basic $91
Autoservizi Salemi 19h 50m 6:00 PM Palermo Via Tommaso Fazello Bus Stop 1:50 PM Milan Lampugnano Bus Station  Basic $91

Cheapest bus trips Thursday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 23h 10m 3:25 PM Palermo Via Tommaso Fazello Bus Stop 2:35 PM Milan San Donato Bus Station  Economy $66
FlixBus 24h 5m 5:10 PM Palermo Via Tommaso Fazello Bus Stop 5:15 PM Milan Lampugnano Bus Station  Economy $66
FlixBus 25h 20m 5:10 PM Palermo Via Tommaso Fazello Bus Stop 6:30 PM Milan San Donato Bus Station  Economy $68
FlixBus 22h 15m 3:25 PM Palermo Via Tommaso Fazello Bus Stop 1:40 PM Milan Lampugnano Bus Station  Economy $90
  • Did you know that if you travel from Palermo to Milan via Siena, you can save more than $10? You can find the corresponding connections below.
    • FlixBus
      28h 35m
      0
      5:10 PM
      Palermo
      Via Tommaso Fazello Bus Stop
      12:20 PM
      Siena
      Train Station
      0
      FlixBus
      Economy
      $38
      • Waiting Time 2h 5m
    • FlixBus
      7h 20m
      0
      2:25 PM
      Siena
      Train Station
      9:45 PM
      Milan
      Lampugnano Bus Station
      0
      FlixBus
      Economy
      $17
    Travel time is 6h 20m longer, but you will save $10

Cheapest bus trips Friday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 24h 5m 5:10 PM Palermo Via Tommaso Fazello Bus Stop 5:15 PM Milan Lampugnano Bus Station  Economy $59
FlixBus 23h 10m 3:25 PM Palermo Via Tommaso Fazello Bus Stop 2:35 PM Milan San Donato Bus Station  Economy $66
FlixBus 25h 20m 5:10 PM Palermo Via Tommaso Fazello Bus Stop 6:30 PM Milan San Donato Bus Station  Economy $66
Autoservizi Salemi 19h 10m 6:00 PM Palermo Via Tommaso Fazello Bus Stop 1:10 PM Milan San Donato Bus Station  Basic $91
Autoservizi Salemi 19h 50m 6:00 PM Palermo Via Tommaso Fazello Bus Stop 1:50 PM Milan Lampugnano Bus Station  Basic $91

Cheapest bus trips Saturday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 24h 5m 5:10 PM Palermo Via Tommaso Fazello Bus Stop 5:15 PM Milan Lampugnano Bus Station  Economy $63
FlixBus 23h 10m 3:25 PM Palermo Via Tommaso Fazello Bus Stop 2:35 PM Milan San Donato Bus Station  Economy $72
FlixBus 25h 20m 5:10 PM Palermo Via Tommaso Fazello Bus Stop 6:30 PM Milan San Donato Bus Station  Economy $72
Autoservizi Salemi 19h 10m 6:00 PM Palermo Via Tommaso Fazello Bus Stop 1:10 PM Milan San Donato Bus Station  Basic $91
Autoservizi Salemi 19h 50m 6:00 PM Palermo Via Tommaso Fazello Bus Stop 1:50 PM Milan Lampugnano Bus Station  Basic $91
  • Did you know that if you travel from Palermo to Milan via Siena, you can save more than $7? You can find the corresponding connections below.
    • FlixBus
      28h 35m
      0
      5:10 PM
      Palermo
      Via Tommaso Fazello Bus Stop
      12:20 PM
      Siena
      Train Station
      0
      FlixBus
      Economy
      $38
      • Waiting Time 2h 5m
    • FlixBus
      7h 20m
      0
      2:25 PM
      Siena
      Train Station
      9:45 PM
      Milan
      Lampugnano Bus Station
      0
      FlixBus
      Economy
      $17
    Travel time is 9h 25m longer, but you will save $7

Cheapest bus trips Sunday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 25h 25m 5:10 PM Palermo Via Tommaso Fazello Bus Stop 6:35 PM Milan Lampugnano Bus Station  Economy $52
FlixBus 25h 20m 5:10 PM Palermo Via Tommaso Fazello Bus Stop 6:30 PM Milan San Donato Bus Station  Economy $54
FlixBus 23h 10m 3:25 PM Palermo Via Tommaso Fazello Bus Stop 2:35 PM Milan San Donato Bus Station  Economy $55
FlixBus 22h 15m 3:25 PM Palermo Via Tommaso Fazello Bus Stop 1:40 PM Milan Lampugnano Bus Station  Economy $90

Best Price Offer: The price for the cheapest bus from Palermo to Milan is $52 on 1/14/2026. Flexible travelers save on ticket prices.


Frequency of bus connections between Palermo and Milan

See here how frequent the connections between Palermo and Milan are, during different times and days of the week.
Monday is the busiest day, with more than 6 daily buses from Palermo to Milan. Tuesday has instead the fewest connections, with only 2 daily coaches between Palermo and Milan.
The busiest time of the day is the Afternoon, with 24 buses from Palermo to Milan, while Evening sees the fewest connections between Palermo and Milan, with 8 offers.

Facts about the bus from Palermo to Milan

Compare all providers like FlixBus and Autoservizi Salemi that travel 4 times every day by bus from Palermo to Milan in one click! Book your bus ticket from Palermo to Milan starting from $52!

Cheapest Bus $52
Fastest Bus 19h 10m
Earliest Bus 3:25 PM
Latest Bus 5:10 PM
Daily Bus Routes 4 Ø
Distance 551.5 miles
Bus Companies FlixBus and Autoservizi Salemi

Cheapest bus connections from Palermo to Milan

Every day, 4 buses from 2 bus companies leave Palermo for Milan: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 01/12/2026 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 01/11
Monday 01/12
$104
Tuesday 01/13
$56
Wednesday 01/14
$91
Thursday 01/15
$66
Friday 01/16
$59
Saturday 01/17
$63
Sunday 01/18
$52
Monday 01/19
$62
Tuesday 01/20
$57
Wednesday 01/21
Thursday 01/22
$67
Friday 01/23
$56
Saturday 01/24
$69
Sunday 01/25
$56
Monday 01/26
$53
Tuesday 01/27
$54
Wednesday 01/28
Thursday 01/29
$58
Friday 01/30
$59
Saturday 01/31
$56
Sunday 02/01
$58
Monday 02/02
$57
Tuesday 02/03
Wednesday 02/04
$55
Thursday 02/05
$56
Friday 02/06
$65
Saturday 02/07

The cheapest time to travel from Palermo to Milan

See here on which day and which time of the day you can find the cheapest bus ticket from Palermo to Milan, for the next 30 days.
With a price starting from $52, Wednesday is the cheapest day for a bus from Palermo to Milan. Thursday instead is the most expensive day with prices starting from $56.
Afternoon is the cheapest day time for bus tickets from Palermo to Milan, with $52. Evening is the most expensive time of the day with prices starting from $91.

How to save money travelling from Palermo to Milan

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Palermo to Milan in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Palermo to Milan, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Palermo to Milan are also emptier.

Beloved bus companies from Palermo to Milan

These are the most booked bus companies between Palermo to Milan from our users.

Autoservizi Salemi from Palermo to Milan

Autoservizi Salemi

Here you will find the key facts about the Autoservizi Salemi bus route Palermo to Milan:

Cheapest Price $91
Fastest Bus 19h 10m
Earliest Bus 6:00 PM
Last Bus 6:00 PM
Daily Connections 2 Ø
Found on 1/9/2026

All bus stations and stops in Palermo and Milan

In the map below, you can see where to find all bus stations in Palermo and Milan.

Service and Comfort on the bus from Palermo to Milan

Want to know which seat classes are available on the buses from Palermo to Milan? Or which bus companies serve the route Palermo to Milan? Below you will find answers to your questions.

FAQs about the Palermo to Milan bus

How much does a Palermo Milan bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $52 and takes 23h 10m to reach Milan. Compare offers to save money!

How much could I save by comparing buses from Palermo to Milan?

This route is offered by 2 companies with a range of ticket prices between $52 and $141. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Milan.

On average, how many connections are available from Palermo to Milan each day?

Every day, the Palermo to Milan bus route is served by approximately 4 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Palermo to Milan take?

The fastest bus from Palermo to Milan is offered by Autoservizi Salemi and takes 19h 10m. Bus tickets for this connection cost $91. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Palermo to Milan?

The earliest bus arriving in Milan from Palermo starts at 3:25 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Palermo to Milan?

The latest bus trip departing from Palermo for Milan starts at 5:10 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Palermo Milan route?

When traveling by bus from Palermo to Milan, passengers can travel with FlixBus and Autoservizi Salemi. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Palermo and Milan?

You can check all the direct connections between Palermo and Milan by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Autoservizi Salemi.

What can I take with me on the Palermo to Milan bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Palermo Milan bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Palermo Milan bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Palermo to Milan on your planned travel date.

How does CheckMyBus find the best bus deals from Palermo to Milan?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 4 daily trips between Palermo and Milan. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Palermo to Milan?

Prices and availability for 4 trips between Palermo and Milan change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Palermo to Milan

Basic
Basic

Name referring to the typical seat you will find with companies that don’t distinguish between different classes.

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Palermo and to Milan

Here’s an overview of the most popular bus routes to Palermo and to Milan. Simply click on the connection of your choice, and you will find all the details about your bus route!
Bus Catania - Palermo Bus Catania - Palermo
Buses Cefalù to Palermo Buses Cefalù to Palermo
Buses Trapani to Palermo Buses Trapani to Palermo
Buses Taormina - Palermo Buses Taormina - Palermo
Bus to Milan from Lucerne Bus to Milan from Lucerne
Buses to Milan from Bern Buses to Milan from Bern
Buses Chamonix - Milan Buses Chamonix - Milan
Bus Bolzano - Milan Bus Bolzano - Milan
Popular Airport Shuttles to Palermo and to Milan
CheckMyBus › Buses in Italy › Bus to Palermo › Bus to Milan

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