Bus Pittsburgh to Greenville, SC: Compare prices and save money

Compare all timetables for the bus from Pittsburgh to Greenville, SC

Here is a selection of the cheapest bus trips from the schedule from Pittsburgh to Greenville, SC from various bus operators like Greyhound US for the next days.

today

tomorrow

$106

Sunday

Monday

$113

Tuesday

Wednesday

Thursday

$110

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	29h 30m	1:35 AM	Pittsburgh	Grant Street Transportation Center	7:05 AM	Greenville, SC	Woodruff Rd	Economy	$106	A Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 12/6/2025 1:35:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 12/7/2025 7:05:00 AM. 50 Economy ticket for $106 per person are available. Travel duration is 29h 30m
Greyhound US	25h 10m	10:50 AM	Pittsburgh	Grant Street Transportation Center	12:00 PM	Greenville, SC	Woodruff Rd	Economy	$106	A Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 12/6/2025 10:50:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 12/7/2025 12:00:00 PM. 50 Economy ticket for $106 per person are available. Travel duration is 25h 10m
Greyhound US	18h 10m	1:30 AM	Pittsburgh	Grant Street Transportation Center	7:40 PM	Greenville, SC	Woodruff Rd	Economy	$107	A Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 12/6/2025 1:30:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 12/6/2025 7:40:00 PM. 50 Economy ticket for $107 per person are available. Travel duration is 18h 10m
Greyhound US	24h 5m	8:30 AM	Pittsburgh	Grant Street Transportation Center	8:35 AM	Greenville, SC	Woodruff Rd	Economy	$107	A Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 12/6/2025 8:30:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 12/7/2025 8:35:00 AM. 50 Economy ticket for $107 per person are available. Travel duration is 24h 5m
Greyhound US	17h 35m	9:00 PM	Pittsburgh	Grant Street Transportation Center	2:35 PM	Greenville, SC	Woodruff Rd	Economy	$107	A Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 12/6/2025 9:00:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/7/2025 2:35:00 PM. 50 Economy ticket for $107 per person are available. Travel duration is 17h 35m

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	18h 10m	1:30 AM	Pittsburgh	Grant Street Transportation Center	7:40 PM	Greenville, SC	Woodruff Rd	Economy	$113	A Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 12/8/2025 1:30:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 12/8/2025 7:40:00 PM. 50 Economy ticket for $113 per person are available. Travel duration is 18h 10m
Greyhound US	29h 30m	1:35 AM	Pittsburgh	Grant Street Transportation Center	7:05 AM	Greenville, SC	Woodruff Rd	Economy	$113	A Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 12/8/2025 1:35:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 12/9/2025 7:05:00 AM. 50 Economy ticket for $113 per person are available. Travel duration is 29h 30m
Greyhound US	26h 20m	8:30 AM	Pittsburgh	Grant Street Transportation Center	10:50 AM	Greenville, SC	Woodruff Rd	Economy	$113	A Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 12/8/2025 8:30:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 12/9/2025 10:50:00 AM. 50 Economy ticket for $113 per person are available. Travel duration is 26h 20m
Greyhound US	17h 35m	9:00 PM	Pittsburgh	Grant Street Transportation Center	2:35 PM	Greenville, SC	Woodruff Rd	Economy	$113	A Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 12/8/2025 9:00:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/9/2025 2:35:00 PM. 50 Economy ticket for $113 per person are available. Travel duration is 17h 35m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	17h 35m	9:00 PM	Pittsburgh	Grant Street Transportation Center	2:35 PM	Greenville, SC	Woodruff Rd	Economy	$110	A Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 12/11/2025 9:00:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 12/12/2025 2:35:00 PM. 50 Economy ticket for $110 per person are available. Travel duration is 17h 35m
Greyhound US	24h 5m	8:30 AM	Pittsburgh	Grant Street Transportation Center	8:35 AM	Greenville, SC	Woodruff Rd	Economy	$111	A Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 12/11/2025 8:30:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 12/12/2025 8:35:00 AM. 50 Economy ticket for $111 per person are available. Travel duration is 24h 5m
Greyhound US	29h 30m	1:35 AM	Pittsburgh	Grant Street Transportation Center	7:05 AM	Greenville, SC	Woodruff Rd	Economy	$113	A Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 12/11/2025 1:35:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 12/12/2025 7:05:00 AM. 50 Economy ticket for $113 per person are available. Travel duration is 29h 30m
Greyhound US	25h 10m	10:50 AM	Pittsburgh	Grant Street Transportation Center	12:00 PM	Greenville, SC	Woodruff Rd	Economy	$114	A Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 12/11/2025 10:50:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 12/12/2025 12:00:00 PM. 50 Economy ticket for $114 per person are available. Travel duration is 25h 10m

Best Price Offer: The price for the cheapest bus from Pittsburgh to Greenville, SC is $106 on 12/6/2025. Flexible travelers save on ticket prices.

Frequency of bus connections between Pittsburgh and Greenville, SC

See here how frequent the connections between Pittsburgh and Greenville, SC are, during different times and days of the week.

Saturday is the busiest day, with more than 5 daily buses from Pittsburgh to Greenville, SC. Monday has instead the fewest connections, with only 4 daily coaches between Pittsburgh and Greenville, SC.

The busiest time of the day is the Morning, with 5 buses from Pittsburgh to Greenville, SC, while Evening sees the fewest connections between Pittsburgh and Greenville, SC, with 3 offers.

Facts about the bus from Pittsburgh to Greenville, SC

Compare all providers like Greyhound US that travel 4 times every day by bus from Pittsburgh to Greenville, SC in one click! Book your bus ticket from Pittsburgh to Greenville, SC starting from $106!

Cheapest Bus	$106
Fastest Bus	17h 35m
Earliest Bus	1:30 AM
Latest Bus	9:00 PM
Daily Bus Routes	4 Ø
Distance	408.1 miles
Bus Companies	Greyhound US

Cheapest bus connections from Pittsburgh to Greenville, SC

Every day, 4 buses from 1 bus companies leave Pittsburgh for Greenville, SC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/05/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 11/30

Monday 12/01

Tuesday 12/02

Wednesday 12/03

Thursday 12/04

Friday 12/05

Saturday 12/06

$106

Sunday 12/07

Monday 12/08

$113

Tuesday 12/09

Wednesday 12/10

Thursday 12/11

$110

Friday 12/12

Saturday 12/13

Sunday 12/14

Monday 12/15

Tuesday 12/16

Wednesday 12/17

Thursday 12/18

Friday 12/19

Saturday 12/20

Sunday 12/21

Monday 12/22

Tuesday 12/23

Wednesday 12/24

Thursday 12/25

Friday 12/26

Saturday 12/27

The cheapest time to travel from Pittsburgh to Greenville, SC

See here on which day and which time of the day you can find the cheapest bus ticket from Pittsburgh to Greenville, SC, for the next 30 days.

With a price starting from $106, Saturday is the cheapest day for a bus from Pittsburgh to Greenville, SC. Monday instead is the most expensive day with prices starting from $113.

Morning is the cheapest day time for bus tickets from Pittsburgh to Greenville, SC, with $106. Evening is the most expensive time of the day with prices starting from $107.

How to save money travelling from Pittsburgh to Greenville, SC

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Pittsburgh to Greenville, SC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Pittsburgh to Greenville, SC, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Pittsburgh to Greenville, SC are also emptier.

Beloved bus companies from Pittsburgh to Greenville, SC

These are the most booked bus companies between Pittsburgh to Greenville, SC from our users.

Greyhound US from Pittsburgh to Greenville, SC

Here you will find the key facts about the Greyhound US bus route Pittsburgh to Greenville, SC:

Cheapest Price	$106
Fastest Bus	17h 35m
Earliest Bus	1:30 AM
Last Bus	9:00 PM
Daily Connections	4 Ø
Found on	12/3/2025

All bus stations and stops in Pittsburgh and Greenville, SC

In the map below, you can see where to find all bus stations in Pittsburgh and Greenville, SC.

Grant Street Transportation Center

11th St 55

David L. Lawrence Convention Center

10th St Pittsburgh 131-199

Carnegie Mellon

Forbes Ave

University of

Central Station

McDonald's

Woodruff Rd 1111

Woodruff Rd

Woodruff Rd 1116

Guadalajara Supermarket

White Horse Rd 2803

Greyhound Bus Station

Hendrix Dr 9

N Church St

Service and Comfort on the bus from Pittsburgh to Greenville, SC

Want to know which seat classes are available on the buses from Pittsburgh to Greenville, SC? Or which bus companies serve the route Pittsburgh to Greenville, SC? Below you will find answers to your questions.

FAQs about the Pittsburgh to Greenville, SC bus

How much does a Pittsburgh Greenville, SC bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $106 and takes 29h 30m to reach Greenville, SC. Compare offers to save money!

How much could I save by comparing buses from Pittsburgh to Greenville, SC?

This route is offered by 1 companies with a range of ticket prices between $106 and $114. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Greenville, SC.

On average, how many connections are available from Pittsburgh to Greenville, SC each day?

Every day, the Pittsburgh to Greenville, SC bus route is served by approximately 4 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Pittsburgh to Greenville, SC take?

The fastest bus from Pittsburgh to Greenville, SC is offered by Greyhound US and takes 17h 35m. Bus tickets for this connection cost $107. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Pittsburgh to Greenville, SC?

The earliest bus arriving in Greenville, SC from Pittsburgh starts at 1:30 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Pittsburgh to Greenville, SC?

The latest bus trip departing from Pittsburgh for Greenville, SC starts at 9:00 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Pittsburgh Greenville, SC route?

When traveling by bus from Pittsburgh to Greenville, SC, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Pittsburgh and Greenville, SC?

You can check all the direct connections between Pittsburgh and Greenville, SC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Pittsburgh to Greenville, SC bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Pittsburgh Greenville, SC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Pittsburgh Greenville, SC bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Pittsburgh to Greenville, SC on your planned travel date.

Available seat classes which are offered on the bus route Pittsburgh to Greenville, SC

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Pittsburgh and to Greenville, SC

Here’s an overview of the most popular bus routes to Pittsburgh and to Greenville, SC. Simply click on the connection of your choice, and you will find all the details about your bus route!