Bus Pittsburgh to Greenville, SC: Compare prices and save money

Compare all timetables for the bus from Pittsburgh to Greenville, SC

Here is a selection of the cheapest bus trips from the schedule from Pittsburgh to Greenville, SC from various bus operators like Greyhound US or FlixBus for the next days.

today

$84

tomorrow

Wednesday

Thursday

$83

Friday

$95

Saturday

Sunday

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	20h 50m	11:45 AM	Pittsburgh	Grant Street Transportation Center	8:35 AM	Greenville, SC	Woodruff Rd	Economy	$84	A Bus from FlixBus goes from Grant Street Transportation Center, Pittsburgh (USA) at 4/20/2026 11:45:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 4/21/2026 8:35:00 AM. 50 Economy ticket for $84 per person are available. Travel duration is 20h 50m
FlixBus	24h 15m	1:00 PM	Pittsburgh	Grant Street Transportation Center	1:15 PM	Greenville, SC	Woodruff Rd	Economy	$84	A Bus from FlixBus goes from Grant Street Transportation Center, Pittsburgh (USA) at 4/20/2026 1:00:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 4/21/2026 1:15:00 PM. 50 Economy ticket for $84 per person are available. Travel duration is 24h 15m
Greyhound US	17h 55m	1:30 AM	Pittsburgh	Grant Street Transportation Center	7:25 PM	Greenville, SC	Woodruff Rd	Economy	$85	A Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 4/20/2026 1:30:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 4/20/2026 7:25:00 PM. 50 Economy ticket for $85 per person are available. Travel duration is 17h 55m
Greyhound US	18h 5m	8:30 PM	Pittsburgh	Grant Street Transportation Center	2:35 PM	Greenville, SC	Woodruff Rd	Economy	$85	A Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 4/20/2026 8:30:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 4/21/2026 2:35:00 PM. 50 Economy ticket for $85 per person are available. Travel duration is 18h 5m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	18h 5m	8:30 PM	Pittsburgh	Grant Street Transportation Center	2:35 PM	Greenville, SC	Woodruff Rd	Economy	$83	A Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 4/23/2026 8:30:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 4/24/2026 2:35:00 PM. 50 Economy ticket for $83 per person are available. Travel duration is 18h 5m
Greyhound US	29h 40m	1:20 AM	Pittsburgh	Grant Street Transportation Center	7:00 AM	Greenville, SC	Woodruff Rd	Economy	$84	A Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 4/23/2026 1:20:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 4/24/2026 7:00:00 AM. 50 Economy ticket for $84 per person are available. Travel duration is 29h 40m
Greyhound US	24h 5m	8:30 AM	Pittsburgh	Grant Street Transportation Center	8:35 AM	Greenville, SC	Woodruff Rd	Economy	$85	A Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 4/23/2026 8:30:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 4/24/2026 8:35:00 AM. 50 Economy ticket for $85 per person are available. Travel duration is 24h 5m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	17h 55m	1:30 AM	Pittsburgh	Grant Street Transportation Center	7:25 PM	Greenville, SC	Woodruff Rd	Economy	$95	A Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 4/24/2026 1:30:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 4/24/2026 7:25:00 PM. 50 Economy ticket for $95 per person are available. Travel duration is 17h 55m
Greyhound US	18h 5m	8:30 PM	Pittsburgh	Grant Street Transportation Center	2:35 PM	Greenville, SC	Woodruff Rd	Economy	$95	A Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 4/24/2026 8:30:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 4/25/2026 2:35:00 PM. 50 Economy ticket for $95 per person are available. Travel duration is 18h 5m
FlixBus	20h 50m	11:45 AM	Pittsburgh	Grant Street Transportation Center	8:35 AM	Greenville, SC	Woodruff Rd	Economy	$96	A Bus from FlixBus goes from Grant Street Transportation Center, Pittsburgh (USA) at 4/24/2026 11:45:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 4/25/2026 8:35:00 AM. 50 Economy ticket for $96 per person are available. Travel duration is 20h 50m
FlixBus	24h 15m	1:00 PM	Pittsburgh	Grant Street Transportation Center	1:15 PM	Greenville, SC	Woodruff Rd	Economy	$99	A Bus from FlixBus goes from Grant Street Transportation Center, Pittsburgh (USA) at 4/24/2026 1:00:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 4/25/2026 1:15:00 PM. 50 Economy ticket for $99 per person are available. Travel duration is 24h 15m

Best Price Offer: The price for the cheapest bus from Pittsburgh to Greenville, SC is $83 on 4/23/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Pittsburgh and Greenville, SC

See here how frequent the connections between Pittsburgh and Greenville, SC are, during different times and days of the week.

Monday is the busiest day, with more than 8 daily buses from Pittsburgh to Greenville, SC. Friday has instead the fewest connections, with only 4 daily coaches between Pittsburgh and Greenville, SC.

The busiest time of the day is the Morning, with 5 buses from Pittsburgh to Greenville, SC, while Afternoon sees the fewest connections between Pittsburgh and Greenville, SC, with 3 offers.

Facts about the bus from Pittsburgh to Greenville, SC

Compare all providers like Greyhound US and FlixBus that travel 6 times every day by bus from Pittsburgh to Greenville, SC in one click! Book your bus ticket from Pittsburgh to Greenville, SC starting from $83!

Cheapest Bus	$83
Fastest Bus	17h 55m
Earliest Bus	1:30 AM
Latest Bus	8:30 PM
Daily Bus Routes	6 Ø
Distance	408.1 miles
Bus Companies	Greyhound US and FlixBus

Cheapest bus connections from Pittsburgh to Greenville, SC

Every day, 6 buses from 2 bus companies leave Pittsburgh for Greenville, SC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 04/20/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 04/19

Monday 04/20

$84

Tuesday 04/21

Wednesday 04/22

$116

Thursday 04/23

$83

Friday 04/24

$95

Saturday 04/25

Sunday 04/26

$128

Monday 04/27

$87

Tuesday 04/28

Wednesday 04/29

Thursday 04/30

$128

Friday 05/01

$95

Saturday 05/02

$87

Sunday 05/03

Monday 05/04

$128

Tuesday 05/05

Wednesday 05/06

Thursday 05/07

Friday 05/08

$93

Saturday 05/09

$129

Sunday 05/10

$128

Monday 05/11

$129

Tuesday 05/12

$96

Wednesday 05/13

$94

Thursday 05/14

$92

Friday 05/15

$131

Saturday 05/16

The cheapest time to travel from Pittsburgh to Greenville, SC

See here on which day and which time of the day you can find the cheapest bus ticket from Pittsburgh to Greenville, SC, for the next 30 days.

With a price starting from $83, Thursday is the cheapest day for a bus from Pittsburgh to Greenville, SC. Friday instead is the most expensive day with prices starting from $93.

Evening is the cheapest day time for bus tickets from Pittsburgh to Greenville, SC, with $83. Morning is the most expensive time of the day with prices starting from $84.

How to save money travelling from Pittsburgh to Greenville, SC

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Pittsburgh to Greenville, SC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Pittsburgh to Greenville, SC, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Pittsburgh to Greenville, SC are also emptier.

All bus stations and stops in Pittsburgh and Greenville, SC

In the map below, you can see where to find all bus stations in Pittsburgh and Greenville, SC.

Grant Street Transportation Center

11th St 55

David L. Lawrence Convention Center

10th St Pittsburgh 131-199

Carnegie Mellon

Forbes Ave

University of

Central Station

McDonald's

Woodruff Rd 1111

Woodruff Rd

Woodruff Rd 1116

N Church St

Greyhound Bus Station

Hendrix Dr 9

Guadalajara Supermarket

White Horse Rd 2803

Service and Comfort on the bus from Pittsburgh to Greenville, SC

Want to know which seat classes are available on the buses from Pittsburgh to Greenville, SC? Or which bus companies serve the route Pittsburgh to Greenville, SC? Below you will find answers to your questions.

FAQs about the Pittsburgh to Greenville, SC bus

How much does a Pittsburgh Greenville, SC bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $83 and takes 18h 5m to reach Greenville, SC. Compare offers to save money!

How much could I save by comparing buses from Pittsburgh to Greenville, SC?

This route is offered by 2 companies with a range of ticket prices between $83 and $99. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Greenville, SC.

On average, how many connections are available from Pittsburgh to Greenville, SC each day?

Every day, the Pittsburgh to Greenville, SC bus route is served by approximately 6 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Pittsburgh to Greenville, SC take?

The fastest bus from Pittsburgh to Greenville, SC is offered by Greyhound US and takes 17h 55m. Bus tickets for this connection cost $89. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Pittsburgh to Greenville, SC?

The earliest bus arriving in Greenville, SC from Pittsburgh starts at 1:30 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Pittsburgh to Greenville, SC?

The latest bus trip departing from Pittsburgh for Greenville, SC starts at 8:30 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Pittsburgh Greenville, SC route?

When traveling by bus from Pittsburgh to Greenville, SC, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Pittsburgh and Greenville, SC?

You can check all the direct connections between Pittsburgh and Greenville, SC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the Pittsburgh to Greenville, SC bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Pittsburgh Greenville, SC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Pittsburgh Greenville, SC bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Pittsburgh to Greenville, SC on your planned travel date.

How does CheckMyBus find the best bus deals from Pittsburgh to Greenville, SC?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 6 daily trips between Pittsburgh and Greenville, SC. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Pittsburgh to Greenville, SC?

Prices and availability for 6 trips between Pittsburgh and Greenville, SC change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Pittsburgh to Greenville, SC

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Pittsburgh and to Greenville, SC

Here’s an overview of the most popular bus routes to Pittsburgh and to Greenville, SC. Simply click on the connection of your choice, and you will find all the details about your bus route!