Compare all timetables for the bus from Port Saint Lucie, FL to Greenville, SC
Here is a selection of the cheapest bus trips from the schedule from Port Saint Lucie, FL to Greenville, SC from various bus operators like FlixBus or Greyhound US for the next days.
| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FlixBus | 17h 45m | 1:40 AM | Port Saint Lucie, FL | SW Gatlin Blvd & SW Brescia St Bus Stop | 7:25 PM | Greenville, SC | Woodruff Rd | Economy | $83 |
A Bus from FlixBus goes from SW Gatlin Blvd & SW Brescia St Bus Stop, Port Saint Lucie, FL (USA) at 7/26/2026 1:40:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 7/26/2026 7:25:00 PM. 50 Economy ticket for $83 per person are available. Travel duration is 17h 45m
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| Greyhound US | 18h 30m | 8:45 AM | Port Saint Lucie, FL | SW Gatlin Blvd & SW Brescia St Bus Stop | 3:15 AM | Greenville, SC | Woodruff Rd | Economy | $84 |
A Bus from Greyhound US goes from SW Gatlin Blvd & SW Brescia St Bus Stop, Port Saint Lucie, FL (USA) at 7/26/2026 8:45:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 7/27/2026 3:15:00 AM. 50 Economy ticket for $84 per person are available. Travel duration is 18h 30m
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| FlixBus | 16h 30m | 6:10 PM | Port Saint Lucie, FL | SW Gatlin Blvd & SW Brescia St Bus Stop | 10:40 AM | Greenville, SC | Woodruff Rd | Economy | $90 |
A Bus from FlixBus goes from SW Gatlin Blvd & SW Brescia St Bus Stop, Port Saint Lucie, FL (USA) at 7/26/2026 6:10:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 7/27/2026 10:40:00 AM. 50 Economy ticket for $90 per person are available. Travel duration is 16h 30m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Greyhound US | 18h 30m | 8:45 AM | Port Saint Lucie, FL | SW Gatlin Blvd & SW Brescia St Bus Stop | 3:15 AM | Greenville, SC | Woodruff Rd | Economy | $85 |
A Bus from Greyhound US goes from SW Gatlin Blvd & SW Brescia St Bus Stop, Port Saint Lucie, FL (USA) at 7/27/2026 8:45:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 7/28/2026 3:15:00 AM. 50 Economy ticket for $85 per person are available. Travel duration is 18h 30m
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| FlixBus | 17h 45m | 1:40 AM | Port Saint Lucie, FL | SW Gatlin Blvd & SW Brescia St Bus Stop | 7:25 PM | Greenville, SC | Woodruff Rd | Economy | $88 |
A Bus from FlixBus goes from SW Gatlin Blvd & SW Brescia St Bus Stop, Port Saint Lucie, FL (USA) at 7/27/2026 1:40:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 7/27/2026 7:25:00 PM. 50 Economy ticket for $88 per person are available. Travel duration is 17h 45m
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| FlixBus | 16h 30m | 6:10 PM | Port Saint Lucie, FL | SW Gatlin Blvd & SW Brescia St Bus Stop | 10:40 AM | Greenville, SC | Woodruff Rd | Economy | $113 |
A Bus from FlixBus goes from SW Gatlin Blvd & SW Brescia St Bus Stop, Port Saint Lucie, FL (USA) at 7/27/2026 6:10:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 7/28/2026 10:40:00 AM. 50 Economy ticket for $113 per person are available. Travel duration is 16h 30m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FlixBus | 16h 30m | 6:10 PM | Port Saint Lucie, FL | SW Gatlin Blvd & SW Brescia St Bus Stop | 10:40 AM | Greenville, SC | Woodruff Rd | Economy | $93 |
A Bus from FlixBus goes from SW Gatlin Blvd & SW Brescia St Bus Stop, Port Saint Lucie, FL (USA) at 7/28/2026 6:10:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 7/29/2026 10:40:00 AM. 50 Economy ticket for $93 per person are available. Travel duration is 16h 30m
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| Greyhound US | 18h 30m | 8:45 AM | Port Saint Lucie, FL | SW Gatlin Blvd & SW Brescia St Bus Stop | 3:15 AM | Greenville, SC | Woodruff Rd | Economy | $98 |
A Bus from Greyhound US goes from SW Gatlin Blvd & SW Brescia St Bus Stop, Port Saint Lucie, FL (USA) at 7/28/2026 8:45:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 7/29/2026 3:15:00 AM. 50 Economy ticket for $98 per person are available. Travel duration is 18h 30m
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| FlixBus | 19h 50m | 1:40 AM | Port Saint Lucie, FL | SW Gatlin Blvd & SW Brescia St Bus Stop | 9:30 PM | Greenville, SC | Woodruff Rd | Economy | $134 |
A Bus from FlixBus goes from SW Gatlin Blvd & SW Brescia St Bus Stop, Port Saint Lucie, FL (USA) at 7/28/2026 1:40:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 7/28/2026 9:30:00 PM. 50 Economy ticket for $134 per person are available. Travel duration is 19h 50m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FlixBus | 18h 30m | 1:40 AM | Port Saint Lucie, FL | SW Gatlin Blvd & SW Brescia St Bus Stop | 8:10 PM | Greenville, SC | Woodruff Rd | Economy | $92 |
A Bus from FlixBus goes from SW Gatlin Blvd & SW Brescia St Bus Stop, Port Saint Lucie, FL (USA) at 7/30/2026 1:40:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 7/30/2026 8:10:00 PM. 50 Economy ticket for $92 per person are available. Travel duration is 18h 30m
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| Greyhound US | 18h 30m | 8:45 AM | Port Saint Lucie, FL | SW Gatlin Blvd & SW Brescia St Bus Stop | 3:15 AM | Greenville, SC | Woodruff Rd | Economy | $94 |
A Bus from Greyhound US goes from SW Gatlin Blvd & SW Brescia St Bus Stop, Port Saint Lucie, FL (USA) at 7/30/2026 8:45:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 7/31/2026 3:15:00 AM. 50 Economy ticket for $94 per person are available. Travel duration is 18h 30m
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| FlixBus | 16h 30m | 6:10 PM | Port Saint Lucie, FL | SW Gatlin Blvd & SW Brescia St Bus Stop | 10:40 AM | Greenville, SC | Woodruff Rd | Economy | $99 |
A Bus from FlixBus goes from SW Gatlin Blvd & SW Brescia St Bus Stop, Port Saint Lucie, FL (USA) at 7/30/2026 6:10:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 7/31/2026 10:40:00 AM. 50 Economy ticket for $99 per person are available. Travel duration is 16h 30m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FlixBus | 17h 45m | 1:40 AM | Port Saint Lucie, FL | RaceTrac Gas Station | 7:25 PM | Greenville, SC | Woodruff Rd | Economy | $97 |
A Bus from FlixBus goes from RaceTrac Gas Station, Port Saint Lucie, FL (USA) at 7/31/2026 1:40:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 7/31/2026 7:25:00 PM. 50 Economy ticket for $97 per person are available. Travel duration is 17h 45m
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| Greyhound US | 18h 30m | 8:45 AM | Port Saint Lucie, FL | RaceTrac Gas Station | 3:15 AM | Greenville, SC | Woodruff Rd | Economy | $102 |
A Bus from Greyhound US goes from RaceTrac Gas Station, Port Saint Lucie, FL (USA) at 7/31/2026 8:45:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 8/1/2026 3:15:00 AM. 50 Economy ticket for $102 per person are available. Travel duration is 18h 30m
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| FlixBus | 16h 30m | 6:10 PM | Port Saint Lucie, FL | RaceTrac Gas Station | 10:40 AM | Greenville, SC | Woodruff Rd | Economy | $119 |
A Bus from FlixBus goes from RaceTrac Gas Station, Port Saint Lucie, FL (USA) at 7/31/2026 6:10:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 8/1/2026 10:40:00 AM. 50 Economy ticket for $119 per person are available. Travel duration is 16h 30m
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Best Price Offer: The price for the cheapest bus from Port Saint Lucie, FL to Greenville, SC is $81 on 8/10/2026. Flexible travelers save on ticket prices.
Frequency of bus connections between Port Saint Lucie, FL and Greenville, SC
Sunday
is the busiest day, with more than 3 daily buses from Port Saint Lucie, FL to Greenville, SC. Sunday has instead the fewest connections, with only 3 daily coaches between Port Saint Lucie, FL and Greenville, SC.
The busiest time of the day is the Morning, with 5 buses from Port Saint Lucie, FL to Greenville, SC, while Morning sees the fewest connections between Port Saint Lucie, FL and Greenville, SC, with 5 offers.
Facts about the bus from Port Saint Lucie, FL to Greenville, SC
Compare all providers like FlixBus and Greyhound US that travel 3 times every day by bus from Port Saint Lucie, FL to Greenville, SC in one click! Book your bus ticket from Port Saint Lucie, FL to Greenville, SC starting from $81!
| Cheapest Bus | $81 |
| Fastest Bus | 16h 30m |
| Earliest Bus | 1:40 AM |
| Latest Bus | 6:10 PM |
| Daily Bus Routes | 3 Ø |
| Distance | 537.5 miles |
| Bus Companies | FlixBus and Greyhound US |
Cheapest bus connections from Port Saint Lucie, FL to Greenville, SC
Every day, 3 buses from 2 bus companies leave Port Saint Lucie, FL for Greenville, SC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 07/25/2026 and for the following days.
Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday
07/19
Monday
07/20
Tuesday
07/21
Wednesday
07/22
Thursday
07/23
Friday
07/24
Saturday
07/25
$149
Sunday
07/26
$83
Monday
07/27
$85
Tuesday
07/28
$93
Wednesday
07/29
Thursday
07/30
$160
Friday
07/31
$97
Saturday
08/01
$147
Sunday
08/02
$149
Monday
08/03
$163
Tuesday
08/04
$85
Wednesday
08/05
$84
Thursday
08/06
$131
Friday
08/07
$84
Saturday
08/08
$88
Sunday
08/09
$161
Monday
08/10
$81
Tuesday
08/11
$138
Wednesday
08/12
$135
Thursday
08/13
$83
Friday
08/14
$87
Saturday
08/15
The cheapest time to travel from Port Saint Lucie, FL to Greenville, SC
With a price starting from $81, Monday is the cheapest day for a bus from Port Saint Lucie, FL to Greenville, SC. Tuesday instead is the most expensive day with prices starting from $85.
Night
is the cheapest day time for bus tickets from Port Saint Lucie, FL to Greenville, SC, with $78. Evening is the most expensive time of the day with prices starting from $90.
How to save money travelling from Port Saint Lucie, FL to Greenville, SC
Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:
Book the ticket from Port Saint Lucie, FL to Greenville, SC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Port Saint Lucie, FL to Greenville, SC, compared instead if you buy it at the last moment, or directly at the station.
If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Port Saint Lucie, FL to Greenville, SC are also emptier.All bus stations and stops in Port Saint Lucie, FL and Greenville, SC
In the map below, you can see where to find all bus stations in Port Saint Lucie, FL and Greenville, SC.
Service and Comfort on the bus from Port Saint Lucie, FL to Greenville, SC
Want to know which seat classes are available on the buses from Port Saint Lucie, FL to Greenville, SC? Or which bus companies serve the route Port Saint Lucie, FL to Greenville, SC? Below you will find answers to your questions.
FAQs about the Port Saint Lucie, FL to Greenville, SC bus
How much does a Port Saint Lucie, FL Greenville, SC bus trip cost?
This depends on, among other things, the day and time of travel. The cheapest trip is available from $81 and takes 17h 45m to reach Greenville, SC. Compare offers to save money!
How much could I save by comparing buses from Port Saint Lucie, FL to Greenville, SC?
This route is offered by 2 companies with a range of ticket prices between $81 and $134. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Greenville, SC.
On average, how many connections are available from Port Saint Lucie, FL to Greenville, SC each day?
Every day, the Port Saint Lucie, FL to Greenville, SC bus route is served by approximately 3 connections. With our search, you can compare bus times to find the perfect trip.
How long does a bus journey from Port Saint Lucie, FL to Greenville, SC take?
The fastest bus from Port Saint Lucie, FL to Greenville, SC is offered by FlixBus and takes 16h 30m. Bus tickets for this connection cost $90. In this context, bear in mind that the journey can take longer due to traffic.
What time is the first bus from Port Saint Lucie, FL to Greenville, SC?
The earliest bus arriving in Greenville, SC from Port Saint Lucie, FL starts at 1:40 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.
What time is the last bus from Port Saint Lucie, FL to Greenville, SC?
The latest bus trip departing from Port Saint Lucie, FL for Greenville, SC starts at 6:10 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.
Which bus companies operate the Port Saint Lucie, FL Greenville, SC route?
When traveling by bus from Port Saint Lucie, FL to Greenville, SC, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.
Is there a direct bus between Port Saint Lucie, FL and Greenville, SC?
You can check all the direct connections between Port Saint Lucie, FL and Greenville, SC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.
What can I take with me on the Port Saint Lucie, FL to Greenville, SC bus route?
Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Port Saint Lucie, FL Greenville, SC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.
What equipment is available for the Port Saint Lucie, FL Greenville, SC bus route?
The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Port Saint Lucie, FL to Greenville, SC on your planned travel date.
How does CheckMyBus find the best bus deals from Port Saint Lucie, FL to Greenville, SC?
CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 3 daily trips between Port Saint Lucie, FL and Greenville, SC. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.
How does CheckMyBus technology work for trips from Port Saint Lucie, FL to Greenville, SC?
Prices and availability for 3 trips between Port Saint Lucie, FL and Greenville, SC change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.
Available seat classes which are offered on the bus route Port Saint Lucie, FL to Greenville, SC
Economy
The cheapest option available for your ticket, it usually comes with reclinable seats and AC.
More bus routes to Port Saint Lucie, FL and to Greenville, SC
Here’s an overview of the most popular bus routes to Port Saint Lucie, FL and to Greenville, SC. Simply click on the connection of your choice, and you will find all the details about your bus route!
- Bus Routes to Port Saint Lucie, FL
- Bus from Atlanta, GA to Port Saint Lucie, FL
- Buses Boca Raton, FL - Port Saint Lucie, FL
- Buses from Cheyenne, WY to Port Saint Lucie, FL
- Buses to Port Saint Lucie, FL from Coconut Creek, FL
- Bus from Dayton, OH to Port Saint Lucie, FL
- Buses from Denver to Port Saint Lucie, FL
- Buses Fort Lauderdale, FL - Port Saint Lucie, FL
- Bus Gainesville, FL - Port Saint Lucie, FL
- From Hollywood, FL to Port Saint Lucie, FL bus
- Buses to Port Saint Lucie, FL from Jacksonville, FL
- From Kissimmee, FL to Port Saint Lucie, FL bus
- Lake Worth, FL to Port Saint Lucie, FL bus
- Buses Miami Beach, FL to Port Saint Lucie, FL
- Bus New York to Port Saint Lucie, FL
- Bus from Newark to Port Saint Lucie, FL
- Ocala, FL to Port Saint Lucie, FL bus
- Buses Sarasota, FL - Port Saint Lucie, FL
- Tallahassee, FL to Port Saint Lucie, FL bus
- Buses to Port Saint Lucie, FL from Valdosta, GA
- Bus Routes to Greenville, SC
- Bus Aguascalientes to Greenville, SC
- Bus Baltimore, MD to Greenville, SC
- Bus Durham, NC to Greenville, SC
- Bus from Florence, SC to Greenville, SC
- Buses to Greenville, SC from Indianapolis
- Buses Macon, GA to Greenville, SC
- Miami to Greenville, SC bus
- Buses to Greenville, SC from Myrtle Beach, SC
- Buses Nashville to Greenville, SC
- New York to Greenville, SC bus
- Buses Norcross, GA to Greenville, SC
- Buses to Greenville, SC from North Charleston, SC
- Bus to Greenville, SC from Orlando, FL
- Bus Phoenix, AZ to Greenville, SC
- Buses San Luis Potosí to Greenville, SC
- Bus to Greenville, SC from Savannah, GA
- Syracuse, NY to Greenville, SC bus
- Bus to Greenville, SC from Terre Haute, IN
- From Washington, DC to Greenville, SC bus
- Bus Winston-Salem, NC to Greenville, SC
Popular Airport Shuttles to Port Saint Lucie, FL and to Greenville, SC
