Bus from Port Saint Lucie, FL to Greenville, SC from $97

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Compare all timetables for the bus from Port Saint Lucie, FL to Greenville, SC

Here is a selection of the cheapest bus trips from the schedule from Port Saint Lucie, FL to Greenville, SC from various bus operators like Greyhound US or FlixBus for the next days.

today
tomorrow
$105
Wednesday
Thursday
Friday
Saturday
$106
Sunday

Cheapest bus trips tomorrow

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 22h 10m 8:55 AM Port Saint Lucie, FL RaceTrac Gas Station 7:05 AM Greenville, SC Woodruff Rd  Economy $105
Greyhound US 30h 10m 3:45 PM Port Saint Lucie, FL RaceTrac Gas Station 9:55 PM Greenville, SC Woodruff Rd  Economy $107

Cheapest bus trips Saturday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 17h 45m 1:40 AM Port Saint Lucie, FL RaceTrac Gas Station 7:25 PM Greenville, SC Woodruff Rd  Economy $106
Greyhound US 22h 10m 8:55 AM Port Saint Lucie, FL RaceTrac Gas Station 7:05 AM Greenville, SC Woodruff Rd  Economy $106
Greyhound US 27h 40m 3:45 PM Port Saint Lucie, FL RaceTrac Gas Station 7:25 PM Greenville, SC Woodruff Rd  Economy $106

Best Price Offer: The price for the cheapest bus from Port Saint Lucie, FL to Greenville, SC is $97 on 1/26/2026. Flexible travelers save on ticket prices.


Frequency of bus connections between Port Saint Lucie, FL and Greenville, SC

See here how frequent the connections between Port Saint Lucie, FL and Greenville, SC are, during different times and days of the week.
Saturday is the busiest day, with more than 3 daily buses from Port Saint Lucie, FL to Greenville, SC. Tuesday has instead the fewest connections, with only 2 daily coaches between Port Saint Lucie, FL and Greenville, SC.
The busiest time of the day is the Morning, with 2 buses from Port Saint Lucie, FL to Greenville, SC, while Night sees the fewest connections between Port Saint Lucie, FL and Greenville, SC, with 1 offers.

Facts about the bus from Port Saint Lucie, FL to Greenville, SC

Compare all providers like Greyhound US and FlixBus that travel 2 times every day by bus from Port Saint Lucie, FL to Greenville, SC in one click! Book your bus ticket from Port Saint Lucie, FL to Greenville, SC starting from $97!

Cheapest Bus $97
Fastest Bus 17h 45m
Earliest Bus 8:55 AM
Latest Bus 3:45 PM
Daily Bus Routes 2 Ø
Distance 537.5 miles
Bus Companies Greyhound US and FlixBus

Cheapest bus connections from Port Saint Lucie, FL to Greenville, SC

Every day, 2 buses from 2 bus companies leave Port Saint Lucie, FL for Greenville, SC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 01/19/2026 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 01/18
Monday 01/19
Tuesday 01/20
$105
Wednesday 01/21
Thursday 01/22
Friday 01/23
Saturday 01/24
$106
Sunday 01/25
Monday 01/26
$97
Tuesday 01/27
Wednesday 01/28
Thursday 01/29
Friday 01/30
Saturday 01/31
Sunday 02/01
Monday 02/02
Tuesday 02/03
Wednesday 02/04
Thursday 02/05
Friday 02/06
Saturday 02/07
Sunday 02/08
Monday 02/09
Tuesday 02/10
Wednesday 02/11
Thursday 02/12
Friday 02/13
Saturday 02/14

The cheapest time to travel from Port Saint Lucie, FL to Greenville, SC

See here on which day and which time of the day you can find the cheapest bus ticket from Port Saint Lucie, FL to Greenville, SC, for the next 30 days.
With a price starting from $105, Tuesday is the cheapest day for a bus from Port Saint Lucie, FL to Greenville, SC. Saturday instead is the most expensive day with prices starting from $106.
Night is the cheapest day time for bus tickets from Port Saint Lucie, FL to Greenville, SC, with $97. Afternoon is the most expensive time of the day with prices starting from $106.

How to save money travelling from Port Saint Lucie, FL to Greenville, SC

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Port Saint Lucie, FL to Greenville, SC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Port Saint Lucie, FL to Greenville, SC, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Port Saint Lucie, FL to Greenville, SC are also emptier.

All bus stations and stops in Port Saint Lucie, FL and Greenville, SC

In the map below, you can see where to find all bus stations in Port Saint Lucie, FL and Greenville, SC.

Service and Comfort on the bus from Port Saint Lucie, FL to Greenville, SC

Want to know which seat classes are available on the buses from Port Saint Lucie, FL to Greenville, SC? Or which bus companies serve the route Port Saint Lucie, FL to Greenville, SC? Below you will find answers to your questions.

FAQs about the Port Saint Lucie, FL to Greenville, SC bus

How much does a Port Saint Lucie, FL Greenville, SC bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $97 and takes 22h 10m to reach Greenville, SC. Compare offers to save money!

How much could I save by comparing buses from Port Saint Lucie, FL to Greenville, SC?

This route is offered by 2 companies with a range of ticket prices between $97 and $107. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Greenville, SC.

On average, how many connections are available from Port Saint Lucie, FL to Greenville, SC each day?

Every day, the Port Saint Lucie, FL to Greenville, SC bus route is served by approximately 2 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Port Saint Lucie, FL to Greenville, SC take?

The fastest bus from Port Saint Lucie, FL to Greenville, SC is offered by FlixBus and takes 17h 45m. Bus tickets for this connection cost $106. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Port Saint Lucie, FL to Greenville, SC?

The earliest bus arriving in Greenville, SC from Port Saint Lucie, FL starts at 8:55 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Port Saint Lucie, FL to Greenville, SC?

The latest bus trip departing from Port Saint Lucie, FL for Greenville, SC starts at 3:45 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Port Saint Lucie, FL Greenville, SC route?

When traveling by bus from Port Saint Lucie, FL to Greenville, SC, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Port Saint Lucie, FL and Greenville, SC?

You can check all the direct connections between Port Saint Lucie, FL and Greenville, SC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the Port Saint Lucie, FL to Greenville, SC bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Port Saint Lucie, FL Greenville, SC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Port Saint Lucie, FL Greenville, SC bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Port Saint Lucie, FL to Greenville, SC on your planned travel date.

How does CheckMyBus find the best bus deals from Port Saint Lucie, FL to Greenville, SC?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 2 daily trips between Port Saint Lucie, FL and Greenville, SC. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Port Saint Lucie, FL to Greenville, SC?

Prices and availability for 2 trips between Port Saint Lucie, FL and Greenville, SC change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Port Saint Lucie, FL to Greenville, SC

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Port Saint Lucie, FL and to Greenville, SC

Here’s an overview of the most popular bus routes to Port Saint Lucie, FL and to Greenville, SC. Simply click on the connection of your choice, and you will find all the details about your bus route!
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Popular Airport Shuttles to Port Saint Lucie, FL and to Greenville, SC
CheckMyBus › Buses in USA › Bus to Port Saint Lucie, FL › Bus to Greenville, SC

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