Bus from Port Saint Lucie, FL to Greenville, SC from $89

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Compare all timetables for the bus from Port Saint Lucie, FL to Greenville, SC

Here is a selection of the cheapest bus trips from the schedule from Port Saint Lucie, FL to Greenville, SC from various bus operators like Greyhound US or FlixBus for the next days.

today
$100
tomorrow
Sunday
Monday
$91
Tuesday
Wednesday
$89
Thursday

Cheapest bus trips today

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 18h 0m 1:40 AM Port Saint Lucie, FL RaceTrac Gas Station 7:40 PM Greenville, SC Woodruff Rd  Economy $100
Greyhound US 27h 55m 3:45 PM Port Saint Lucie, FL RaceTrac Gas Station 7:40 PM Greenville, SC Woodruff Rd  Economy $103
Greyhound US 22h 10m 8:55 AM Port Saint Lucie, FL RaceTrac Gas Station 7:05 AM Greenville, SC Woodruff Rd  Economy $104

Cheapest bus trips Monday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 22h 10m 8:55 AM Port Saint Lucie, FL RaceTrac Gas Station 7:05 AM Greenville, SC Woodruff Rd  Economy $91
Greyhound US 30h 10m 3:45 PM Port Saint Lucie, FL RaceTrac Gas Station 9:55 PM Greenville, SC Woodruff Rd  Economy $91
FlixBus 18h 0m 1:40 AM Port Saint Lucie, FL RaceTrac Gas Station 7:40 PM Greenville, SC Woodruff Rd  Economy $129

Cheapest bus trips Wednesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 20h 15m 1:40 AM Port Saint Lucie, FL RaceTrac Gas Station 9:55 PM Greenville, SC Woodruff Rd  Economy $89
Greyhound US 22h 10m 8:55 AM Port Saint Lucie, FL RaceTrac Gas Station 7:05 AM Greenville, SC Woodruff Rd  Economy $89
Greyhound US 30h 10m 3:45 PM Port Saint Lucie, FL RaceTrac Gas Station 9:55 PM Greenville, SC Woodruff Rd  Economy $89

Best Price Offer: The price for the cheapest bus from Port Saint Lucie, FL to Greenville, SC is $89 on 12/10/2025. Flexible travelers save on ticket prices.


Frequency of bus connections between Port Saint Lucie, FL and Greenville, SC

See here how frequent the connections between Port Saint Lucie, FL and Greenville, SC are, during different times and days of the week.
Monday is the busiest day, with more than 3 daily buses from Port Saint Lucie, FL to Greenville, SC. Monday has instead the fewest connections, with only 3 daily coaches between Port Saint Lucie, FL and Greenville, SC.
The busiest time of the day is the Morning, with 3 buses from Port Saint Lucie, FL to Greenville, SC, while Morning sees the fewest connections between Port Saint Lucie, FL and Greenville, SC, with 3 offers.

Facts about the bus from Port Saint Lucie, FL to Greenville, SC

Compare all providers like Greyhound US and FlixBus that travel 3 times every day by bus from Port Saint Lucie, FL to Greenville, SC in one click! Book your bus ticket from Port Saint Lucie, FL to Greenville, SC starting from $89!

Cheapest Bus $89
Fastest Bus 18h 0m
Earliest Bus 1:40 AM
Latest Bus 3:45 PM
Daily Bus Routes 3 Ø
Distance 537.5 miles
Bus Companies Greyhound US and FlixBus

Cheapest bus connections from Port Saint Lucie, FL to Greenville, SC

Every day, 3 buses from 2 bus companies leave Port Saint Lucie, FL for Greenville, SC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/05/2025 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 11/30
Monday 12/01
Tuesday 12/02
Wednesday 12/03
Thursday 12/04
Friday 12/05
$100
Saturday 12/06
Sunday 12/07
Monday 12/08
$91
Tuesday 12/09
Wednesday 12/10
$89
Thursday 12/11
Friday 12/12
Saturday 12/13
$98
Sunday 12/14
Monday 12/15
Tuesday 12/16
Wednesday 12/17
Thursday 12/18
Friday 12/19
Saturday 12/20
Sunday 12/21
Monday 12/22
Tuesday 12/23
Wednesday 12/24
Thursday 12/25
Friday 12/26
Saturday 12/27

The cheapest time to travel from Port Saint Lucie, FL to Greenville, SC

See here on which day and which time of the day you can find the cheapest bus ticket from Port Saint Lucie, FL to Greenville, SC, for the next 30 days.
With a price starting from $89, Wednesday is the cheapest day for a bus from Port Saint Lucie, FL to Greenville, SC. Friday instead is the most expensive day with prices starting from $100.
Morning is the cheapest day time for bus tickets from Port Saint Lucie, FL to Greenville, SC, with $89. Morning is the most expensive time of the day with prices starting from $89.

How to save money travelling from Port Saint Lucie, FL to Greenville, SC

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Port Saint Lucie, FL to Greenville, SC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Port Saint Lucie, FL to Greenville, SC, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Port Saint Lucie, FL to Greenville, SC are also emptier.

Beloved bus companies from Port Saint Lucie, FL to Greenville, SC

These are the most booked bus companies between Port Saint Lucie, FL to Greenville, SC from our users.

FlixBus from Port Saint Lucie, FL to Greenville, SC

FlixBus

Here you will find the key facts about the FlixBus bus route Port Saint Lucie, FL to Greenville, SC:

Cheapest Price $89
Fastest Bus 18h 0m
Earliest Bus 1:40 AM
Last Bus 1:40 AM
Daily Connections 1 Ø
Found on 12/1/2025

All bus stations and stops in Port Saint Lucie, FL and Greenville, SC

In the map below, you can see where to find all bus stations in Port Saint Lucie, FL and Greenville, SC.

Service and Comfort on the bus from Port Saint Lucie, FL to Greenville, SC

Want to know which seat classes are available on the buses from Port Saint Lucie, FL to Greenville, SC? Or which bus companies serve the route Port Saint Lucie, FL to Greenville, SC? Below you will find answers to your questions.

FAQs about the Port Saint Lucie, FL to Greenville, SC bus

How much does a Port Saint Lucie, FL Greenville, SC bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $89 and takes 22h 10m to reach Greenville, SC. Compare offers to save money!

How much could I save by comparing buses from Port Saint Lucie, FL to Greenville, SC?

This route is offered by 2 companies with a range of ticket prices between $89 and $129. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Greenville, SC.

On average, how many connections are available from Port Saint Lucie, FL to Greenville, SC each day?

Every day, the Port Saint Lucie, FL to Greenville, SC bus route is served by approximately 3 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Port Saint Lucie, FL to Greenville, SC take?

The fastest bus from Port Saint Lucie, FL to Greenville, SC is offered by FlixBus and takes 18h 0m. Bus tickets for this connection cost $100. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Port Saint Lucie, FL to Greenville, SC?

The earliest bus arriving in Greenville, SC from Port Saint Lucie, FL starts at 1:40 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Port Saint Lucie, FL to Greenville, SC?

The latest bus trip departing from Port Saint Lucie, FL for Greenville, SC starts at 3:45 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Port Saint Lucie, FL Greenville, SC route?

When traveling by bus from Port Saint Lucie, FL to Greenville, SC, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Port Saint Lucie, FL and Greenville, SC?

You can check all the direct connections between Port Saint Lucie, FL and Greenville, SC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the Port Saint Lucie, FL to Greenville, SC bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Port Saint Lucie, FL Greenville, SC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Port Saint Lucie, FL Greenville, SC bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Port Saint Lucie, FL to Greenville, SC on your planned travel date.

Available seat classes which are offered on the bus route Port Saint Lucie, FL to Greenville, SC

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Port Saint Lucie, FL and to Greenville, SC

Here’s an overview of the most popular bus routes to Port Saint Lucie, FL and to Greenville, SC. Simply click on the connection of your choice, and you will find all the details about your bus route!
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Bus to Greenville, SC from Jacksonville, FL Bus to Greenville, SC from Jacksonville, FL
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Bus from Houston to Greenville, SC Bus from Houston to Greenville, SC
Bus to Greenville, SC from Orlando, FL Bus to Greenville, SC from Orlando, FL
Popular Airport Shuttles to Port Saint Lucie, FL and to Greenville, SC
CheckMyBus › Buses in USA › Bus to Port Saint Lucie, FL › Bus to Greenville, SC

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