Bus Fort Pierce, FL to Knoxville, TN

Compare all timetables for the bus from Fort Pierce, FL to Knoxville, TN

Here is a selection of the cheapest bus trips from the schedule from Fort Pierce, FL to Knoxville, TN from various bus operators like FlixBus or Greyhound US for the next days.

today

$114

tomorrow

$115

Wednesday

$122

Thursday

Friday

$117

Saturday

$119

Sunday

$119

Cheapest bus trips today
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	FlixBus	19h 55m	1:55 AM	Fort Pierce, FL	Okeechobee Road	9:50 PM	Knoxville, TN	Greyhound Bus Station		Economy	$114	A Bus from FlixBus goes from Okeechobee Road, Fort Pierce, FL (USA) at 4/20/2026 1:55:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 4/20/2026 9:50:00 PM. 50 Economy ticket for $114 per person are available. Travel duration is 19h 55m
	Greyhound US	25h 20m	8:30 PM	Fort Pierce, FL	Greyhound Bus Station	9:50 PM	Knoxville, TN	Greyhound Bus Station		Economy	$114	A Bus from Greyhound US goes from Greyhound Bus Station, Fort Pierce, FL (USA) at 4/20/2026 8:30:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 4/21/2026 9:50:00 PM. 50 Economy ticket for $114 per person are available. Travel duration is 25h 20m

Cheapest bus trips tomorrow
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	FlixBus	19h 55m	1:55 AM	Fort Pierce, FL	Okeechobee Road	9:50 PM	Knoxville, TN	Knoxville Area Transit Bus Stop		Economy	$115	A Bus from FlixBus goes from Okeechobee Road, Fort Pierce, FL (USA) at 4/21/2026 1:55:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 4/21/2026 9:50:00 PM. 50 Economy ticket for $115 per person are available. Travel duration is 19h 55m
	Greyhound US	25h 20m	8:30 PM	Fort Pierce, FL	Greyhound Bus Station	9:50 PM	Knoxville, TN	Knoxville Area Transit Bus Stop		Economy	$115	A Bus from Greyhound US goes from Greyhound Bus Station, Fort Pierce, FL (USA) at 4/21/2026 8:30:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 4/22/2026 9:50:00 PM. 50 Economy ticket for $115 per person are available. Travel duration is 25h 20m

Cheapest bus trips Wednesday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	25h 20m	8:30 PM	Fort Pierce, FL	Greyhound Bus Station	9:50 PM	Knoxville, TN	Knoxville Area Transit Bus Stop		Economy	$122	A Bus from Greyhound US goes from Greyhound Bus Station, Fort Pierce, FL (USA) at 4/22/2026 8:30:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 4/23/2026 9:50:00 PM. 50 Economy ticket for $122 per person are available. Travel duration is 25h 20m
	FlixBus	19h 55m	1:55 AM	Fort Pierce, FL	Okeechobee Road	9:50 PM	Knoxville, TN	Knoxville Area Transit Bus Stop		Economy	$126	A Bus from FlixBus goes from Okeechobee Road, Fort Pierce, FL (USA) at 4/22/2026 1:55:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 4/22/2026 9:50:00 PM. 50 Economy ticket for $126 per person are available. Travel duration is 19h 55m

Did you know that if you travel from Fort Pierce, FL to Knoxville, TN via Atlanta, GA, you can save more than $14? You can find the corresponding connections below.
- FlixBus
  
  19h 55m
  
  0
  
  1:55 AM
  
  Fort Pierce, FL
  Okeechobee Road
  
  3:25 PM
  
  Atlanta, GA
  Garnett Transit Station
  
  0
  
  Economy
  
  $77
  
  A Bus from FlixBus goes from Okeechobee Road, Fort Pierce, FL (USA) at 4/23/2026 1:55:00 AM to Garnett Transit Station, Atlanta, GA (USA) arriving at 4/23/2026 3:25:00 PM. 50 Economy ticket for $77 per person are available. Travel duration is 13h 30m
- Greyhound US
  
  3h 45m
  
  0
  
  6:05 PM
  
  Atlanta, GA
  Garnett Transit Station
  
  9:50 PM
  
  Knoxville, TN
  Greyhound Bus Station
  
  0
  
  Economy
  
  $31
  
  A Bus from Greyhound US goes from Garnett Transit Station, Atlanta, GA (USA) at 4/23/2026 6:05:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 4/23/2026 9:50:00 PM. 50 Economy ticket for $31 per person are available. Travel duration is 3h 45m
Travel time is the same as the direct connection, but you will save $14

Cheapest bus trips Friday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	FlixBus	19h 55m	1:55 AM	Fort Pierce, FL	Okeechobee Road	9:50 PM	Knoxville, TN	Greyhound Bus Station		Economy	$117	A Bus from FlixBus goes from Okeechobee Road, Fort Pierce, FL (USA) at 4/24/2026 1:55:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 4/24/2026 9:50:00 PM. 50 Economy ticket for $117 per person are available. Travel duration is 19h 55m
	Greyhound US	25h 20m	8:30 PM	Fort Pierce, FL	Greyhound Bus Station	9:50 PM	Knoxville, TN	Greyhound Bus Station		Economy	$124	A Bus from Greyhound US goes from Greyhound Bus Station, Fort Pierce, FL (USA) at 4/24/2026 8:30:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 4/25/2026 9:50:00 PM. 50 Economy ticket for $124 per person are available. Travel duration is 25h 20m

Cheapest bus trips Saturday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	25h 20m	8:30 PM	Fort Pierce, FL	Greyhound Bus Station	9:50 PM	Knoxville, TN	Knoxville Area Transit Bus Stop		Economy	$119	A Bus from Greyhound US goes from Greyhound Bus Station, Fort Pierce, FL (USA) at 4/25/2026 8:30:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 4/26/2026 9:50:00 PM. 50 Economy ticket for $119 per person are available. Travel duration is 25h 20m
	FlixBus	19h 55m	1:55 AM	Fort Pierce, FL	Okeechobee Road	9:50 PM	Knoxville, TN	Knoxville Area Transit Bus Stop		Economy	$120	A Bus from FlixBus goes from Okeechobee Road, Fort Pierce, FL (USA) at 4/25/2026 1:55:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 4/25/2026 9:50:00 PM. 50 Economy ticket for $120 per person are available. Travel duration is 19h 55m

Cheapest bus trips Sunday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	25h 20m	8:30 PM	Fort Pierce, FL	Greyhound Bus Station	9:50 PM	Knoxville, TN	Knoxville Area Transit Bus Stop		Economy	$119	A Bus from Greyhound US goes from Greyhound Bus Station, Fort Pierce, FL (USA) at 4/26/2026 8:30:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 4/27/2026 9:50:00 PM. 50 Economy ticket for $119 per person are available. Travel duration is 25h 20m
	FlixBus	19h 55m	1:55 AM	Fort Pierce, FL	Okeechobee Road	9:50 PM	Knoxville, TN	Knoxville Area Transit Bus Stop		Economy	$124	A Bus from FlixBus goes from Okeechobee Road, Fort Pierce, FL (USA) at 4/26/2026 1:55:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 4/26/2026 9:50:00 PM. 50 Economy ticket for $124 per person are available. Travel duration is 19h 55m

Best Price Offer: The price for the cheapest bus from Fort Pierce, FL to Knoxville, TN is $106 on 5/3/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Fort Pierce, FL and Knoxville, TN

See here how frequent the connections between Fort Pierce, FL and Knoxville, TN are, during different times and days of the week.

Sunday is the busiest day, with more than 4 daily buses from Fort Pierce, FL to Knoxville, TN. Monday has instead the fewest connections, with only 2 daily coaches between Fort Pierce, FL and Knoxville, TN.

The busiest time of the day is the Evening, with 9 buses from Fort Pierce, FL to Knoxville, TN, while Evening sees the fewest connections between Fort Pierce, FL and Knoxville, TN, with 9 offers.

Facts about the bus from Fort Pierce, FL to Knoxville, TN

Compare all providers like FlixBus and Greyhound US that travel 3 times every day by bus from Fort Pierce, FL to Knoxville, TN in one click! Book your bus ticket from Fort Pierce, FL to Knoxville, TN starting from $106!

Cheapest Bus	$106
Fastest Bus	19h 55m
Earliest Bus	1:55 AM
Latest Bus	8:30 PM
Daily Bus Routes	3 Ø
Distance	625.3 miles
Bus Companies	FlixBus and Greyhound US

Cheapest bus connections from Fort Pierce, FL to Knoxville, TN

Every day, 3 buses from 2 bus companies leave Fort Pierce, FL for Knoxville, TN: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 04/20/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 04/19

Monday 04/20

$114

Tuesday 04/21

$115

Wednesday 04/22

$126

Thursday 04/23

Friday 04/24

$117

Saturday 04/25

$119

Sunday 04/26

$119

Monday 04/27

$113

Tuesday 04/28

Wednesday 04/29

Thursday 04/30

Friday 05/01

$113

Saturday 05/02

$117

Sunday 05/03

$106

Monday 05/04

$106

Tuesday 05/05

$114

Wednesday 05/06

Thursday 05/07

Friday 05/08

Saturday 05/09

Sunday 05/10

Monday 05/11

$108

Tuesday 05/12

$119

Wednesday 05/13

$124

Thursday 05/14

$118

Friday 05/15

Saturday 05/16

The cheapest time to travel from Fort Pierce, FL to Knoxville, TN

See here on which day and which time of the day you can find the cheapest bus ticket from Fort Pierce, FL to Knoxville, TN, for the next 30 days.

With a price starting from $106, Sunday is the cheapest day for a bus from Fort Pierce, FL to Knoxville, TN. Wednesday instead is the most expensive day with prices starting from $122.

Night is the cheapest day time for bus tickets from Fort Pierce, FL to Knoxville, TN, with $106. Evening is the most expensive time of the day with prices starting from $114.

How to save money travelling from Fort Pierce, FL to Knoxville, TN

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Fort Pierce, FL to Knoxville, TN in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Fort Pierce, FL to Knoxville, TN, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Fort Pierce, FL to Knoxville, TN are also emptier.

All bus stations and stops in Fort Pierce, FL and Knoxville, TN

In the map below, you can see where to find all bus stations in Fort Pierce, FL and Knoxville, TN.

Greyhound Bus Station

Okeechobee Rd 7150

Bus Stop

Okeechobee Road

Okeechobee Road 5151

Juanita Ave

Kingston Pike

Kingston Pike 6927

Walker Springs Plaza Shopping Center

Kingston Pike 8509

Greyhound Bus Station

E Magnolia Ave 100

Knoxville Area Transit Bus Stop

Knoxville Area Transit Bus Stop Knoxville Area Transit Bus Stop

Transit Center

E Church Ave 301

Service and Comfort on the bus from Fort Pierce, FL to Knoxville, TN

Want to know which seat classes are available on the buses from Fort Pierce, FL to Knoxville, TN? Or which bus companies serve the route Fort Pierce, FL to Knoxville, TN? Below you will find answers to your questions.

FAQs about the Fort Pierce, FL to Knoxville, TN bus

How much does a Fort Pierce, FL Knoxville, TN bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $106 and takes 25h 20m to reach Knoxville, TN. Compare offers to save money!

How much could I save by comparing buses from Fort Pierce, FL to Knoxville, TN?

This route is offered by 2 companies with a range of ticket prices between $106 and $130. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Knoxville, TN.

On average, how many connections are available from Fort Pierce, FL to Knoxville, TN each day?

Every day, the Fort Pierce, FL to Knoxville, TN bus route is served by approximately 3 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Fort Pierce, FL to Knoxville, TN take?

The fastest bus from Fort Pierce, FL to Knoxville, TN is offered by FlixBus and takes 19h 55m. Bus tickets for this connection cost $114. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Fort Pierce, FL to Knoxville, TN?

The earliest bus arriving in Knoxville, TN from Fort Pierce, FL starts at 1:55 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Fort Pierce, FL to Knoxville, TN?

The latest bus trip departing from Fort Pierce, FL for Knoxville, TN starts at 8:30 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Fort Pierce, FL Knoxville, TN route?

When traveling by bus from Fort Pierce, FL to Knoxville, TN, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Fort Pierce, FL and Knoxville, TN?

You can check all the direct connections between Fort Pierce, FL and Knoxville, TN by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the Fort Pierce, FL to Knoxville, TN bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Fort Pierce, FL Knoxville, TN bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Fort Pierce, FL Knoxville, TN bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Fort Pierce, FL to Knoxville, TN on your planned travel date.

How does CheckMyBus find the best bus deals from Fort Pierce, FL to Knoxville, TN?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 3 daily trips between Fort Pierce, FL and Knoxville, TN. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Fort Pierce, FL to Knoxville, TN?

Prices and availability for 3 trips between Fort Pierce, FL and Knoxville, TN change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Fort Pierce, FL to Knoxville, TN

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Fort Pierce, FL and to Knoxville, TN

Here’s an overview of the most popular bus routes to Fort Pierce, FL and to Knoxville, TN. Simply click on the connection of your choice, and you will find all the details about your bus route!