Bus San Antonio, TX to Louisville, KY: Compare prices and save money

Compare all timetables for the bus from San Antonio, TX to Louisville, KY

Here is a selection of the cheapest bus trips from the schedule from San Antonio, TX to Louisville, KY from various bus operators like FlixBus, Greyhound Lines Mexico or Greyhound US for the next days.

today

tomorrow

$124

Sunday

$123

Monday

Tuesday

$116

Wednesday

$128

Thursday

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound Lines Mexico	22h 50m	1:30 AM	San Antonio, TX	Bus Station	1:20 AM	Louisville, KY	Greyhound Bus Station	Economy	$124	A Bus from Greyhound Lines Mexico goes from Bus Station, San Antonio, TX (USA) at 6/13/2026 1:30:00 AM to Greyhound Bus Station, Louisville, KY (USA) arriving at 6/14/2026 1:20:00 AM. 50 Economy ticket for $124 per person are available. Travel duration is 22h 50m
Greyhound Lines Mexico	26h 45m	5:50 AM	San Antonio, TX	Bus Station	9:35 AM	Louisville, KY	Greyhound Bus Station	Economy	$124	A Bus from Greyhound Lines Mexico goes from Bus Station, San Antonio, TX (USA) at 6/13/2026 5:50:00 AM to Greyhound Bus Station, Louisville, KY (USA) arriving at 6/14/2026 9:35:00 AM. 50 Economy ticket for $124 per person are available. Travel duration is 26h 45m
Greyhound US	24h 35m	12:35 PM	San Antonio, TX	Bus Station	2:10 PM	Louisville, KY	Greyhound Bus Station	Economy	$124	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 6/13/2026 12:35:00 PM to Greyhound Bus Station, Louisville, KY (USA) arriving at 6/14/2026 2:10:00 PM. 50 Economy ticket for $124 per person are available. Travel duration is 24h 35m
FlixBus	26h 25m	9:55 PM	San Antonio, TX	Bus Station	1:20 AM	Louisville, KY	Greyhound Bus Station	Economy	$124	A Bus from FlixBus goes from Bus Station, San Antonio, TX (USA) at 6/13/2026 9:55:00 PM to Greyhound Bus Station, Louisville, KY (USA) arriving at 6/15/2026 1:20:00 AM. 50 Economy ticket for $124 per person are available. Travel duration is 26h 25m
FlixBus	33h 15m	7:45 AM	San Antonio, TX	Pearl District	6:00 PM	Louisville, KY	Greyhound Bus Station	Economy	$125	A Bus from FlixBus goes from Pearl District, San Antonio, TX (USA) at 6/13/2026 7:45:00 AM to Greyhound Bus Station, Louisville, KY (USA) arriving at 6/14/2026 6:00:00 PM. 50 Economy ticket for $125 per person are available. Travel duration is 33h 15m

Did you know that if you travel from San Antonio, TX to Louisville, KY via Austin, you can save more than $23? You can find the corresponding connections below.
- FlixBus
  
  29h 25m
  
  0
  
  7:45 AM
  
  San Antonio, TX
  Pearl District
  
  9:15 AM
  
  Austin
  Austin South Congress Bus Stop
  
  0
  
  Economy
  
  $12
  
  A Bus from FlixBus goes from Pearl District, San Antonio, TX (USA) at 6/13/2026 7:45:00 AM to Austin South Congress Bus Stop, Austin (USA) arriving at 6/13/2026 9:15:00 AM. 50 Economy ticket for $12 per person are available. Travel duration is 1h 30m
- Greyhound US
  
  22h 50m
  
  0
  
  2:20 PM
  
  Austin
  5119 Eastside Bus Plaza
  
  2:10 PM
  
  Louisville, KY
  Greyhound Bus Station
  
  0
  
  Economy
  
  $89
  
  A Bus from Greyhound US goes from 5119 Eastside Bus Plaza, Austin (USA) at 6/13/2026 2:20:00 PM to Greyhound Bus Station, Louisville, KY (USA) arriving at 6/14/2026 2:10:00 PM. 50 Economy ticket for $89 per person are available. Travel duration is 22h 50m
Travel time is 5h 35m longer, but you will save $23

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound Lines Mexico	22h 50m	1:30 AM	San Antonio, TX	Bus Station	1:20 AM	Louisville, KY	Greyhound Bus Station	Economy	$123	A Bus from Greyhound Lines Mexico goes from Bus Station, San Antonio, TX (USA) at 6/14/2026 1:30:00 AM to Greyhound Bus Station, Louisville, KY (USA) arriving at 6/15/2026 1:20:00 AM. 50 Economy ticket for $123 per person are available. Travel duration is 22h 50m
Greyhound Lines Mexico	26h 45m	5:50 AM	San Antonio, TX	Bus Station	9:35 AM	Louisville, KY	Greyhound Bus Station	Economy	$123	A Bus from Greyhound Lines Mexico goes from Bus Station, San Antonio, TX (USA) at 6/14/2026 5:50:00 AM to Greyhound Bus Station, Louisville, KY (USA) arriving at 6/15/2026 9:35:00 AM. 50 Economy ticket for $123 per person are available. Travel duration is 26h 45m
Greyhound US	24h 35m	12:35 PM	San Antonio, TX	Bus Station	2:10 PM	Louisville, KY	Greyhound Bus Station	Economy	$123	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 6/14/2026 12:35:00 PM to Greyhound Bus Station, Louisville, KY (USA) arriving at 6/15/2026 2:10:00 PM. 50 Economy ticket for $123 per person are available. Travel duration is 24h 35m
FlixBus	26h 25m	9:55 PM	San Antonio, TX	Bus Station	1:20 AM	Louisville, KY	Greyhound Bus Station	Economy	$123	A Bus from FlixBus goes from Bus Station, San Antonio, TX (USA) at 6/14/2026 9:55:00 PM to Greyhound Bus Station, Louisville, KY (USA) arriving at 6/16/2026 1:20:00 AM. 50 Economy ticket for $123 per person are available. Travel duration is 26h 25m
FlixBus	33h 15m	7:45 AM	San Antonio, TX	Pearl District	6:00 PM	Louisville, KY	Greyhound Bus Station	Economy	$123	A Bus from FlixBus goes from Pearl District, San Antonio, TX (USA) at 6/14/2026 7:45:00 AM to Greyhound Bus Station, Louisville, KY (USA) arriving at 6/15/2026 6:00:00 PM. 50 Economy ticket for $123 per person are available. Travel duration is 33h 15m

Did you know that if you travel from San Antonio, TX to Louisville, KY via Austin, you can save more than $22? You can find the corresponding connections below.
- FlixBus
  
  29h 25m
  
  0
  
  7:45 AM
  
  San Antonio, TX
  Pearl District
  
  9:15 AM
  
  Austin
  Austin South Congress Bus Stop
  
  0
  
  Economy
  
  $12
  
  A Bus from FlixBus goes from Pearl District, San Antonio, TX (USA) at 6/13/2026 7:45:00 AM to Austin South Congress Bus Stop, Austin (USA) arriving at 6/13/2026 9:15:00 AM. 50 Economy ticket for $12 per person are available. Travel duration is 1h 30m
- Greyhound US
  
  22h 50m
  
  0
  
  2:20 PM
  
  Austin
  5119 Eastside Bus Plaza
  
  2:10 PM
  
  Louisville, KY
  Greyhound Bus Station
  
  0
  
  Economy
  
  $89
  
  A Bus from Greyhound US goes from 5119 Eastside Bus Plaza, Austin (USA) at 6/13/2026 2:20:00 PM to Greyhound Bus Station, Louisville, KY (USA) arriving at 6/14/2026 2:10:00 PM. 50 Economy ticket for $89 per person are available. Travel duration is 22h 50m
Travel time is 5h 35m longer, but you will save $22

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	26h 45m	5:50 AM	San Antonio, TX	Bus Station	9:35 AM	Louisville, KY	Greyhound Bus Station	Economy	$116	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 6/16/2026 5:50:00 AM to Greyhound Bus Station, Louisville, KY (USA) arriving at 6/17/2026 9:35:00 AM. 50 Economy ticket for $116 per person are available. Travel duration is 26h 45m
Greyhound US	24h 35m	12:35 PM	San Antonio, TX	Bus Station	2:10 PM	Louisville, KY	Greyhound Bus Station	Economy	$116	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 6/16/2026 12:35:00 PM to Greyhound Bus Station, Louisville, KY (USA) arriving at 6/17/2026 2:10:00 PM. 50 Economy ticket for $116 per person are available. Travel duration is 24h 35m
FlixBus	26h 25m	9:55 PM	San Antonio, TX	Bus Station	1:20 AM	Louisville, KY	Greyhound Bus Station	Economy	$116	A Bus from FlixBus goes from Bus Station, San Antonio, TX (USA) at 6/16/2026 9:55:00 PM to Greyhound Bus Station, Louisville, KY (USA) arriving at 6/18/2026 1:20:00 AM. 50 Economy ticket for $116 per person are available. Travel duration is 26h 25m
Greyhound US	22h 50m	1:30 AM	San Antonio, TX	Bus Station	1:20 AM	Louisville, KY	Greyhound Bus Station	Economy	$123	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 6/16/2026 1:30:00 AM to Greyhound Bus Station, Louisville, KY (USA) arriving at 6/17/2026 1:20:00 AM. 50 Economy ticket for $123 per person are available. Travel duration is 22h 50m

Did you know that if you travel from San Antonio, TX to Louisville, KY via Austin, you can save more than $15? You can find the corresponding connections below.
- FlixBus
  
  29h 25m
  
  0
  
  7:45 AM
  
  San Antonio, TX
  Pearl District
  
  9:15 AM
  
  Austin
  Austin South Congress Bus Stop
  
  0
  
  Economy
  
  $12
  
  A Bus from FlixBus goes from Pearl District, San Antonio, TX (USA) at 6/13/2026 7:45:00 AM to Austin South Congress Bus Stop, Austin (USA) arriving at 6/13/2026 9:15:00 AM. 50 Economy ticket for $12 per person are available. Travel duration is 1h 30m
- Greyhound US
  
  22h 50m
  
  0
  
  2:20 PM
  
  Austin
  5119 Eastside Bus Plaza
  
  2:10 PM
  
  Louisville, KY
  Greyhound Bus Station
  
  0
  
  Economy
  
  $89
  
  A Bus from Greyhound US goes from 5119 Eastside Bus Plaza, Austin (USA) at 6/13/2026 2:20:00 PM to Greyhound Bus Station, Louisville, KY (USA) arriving at 6/14/2026 2:10:00 PM. 50 Economy ticket for $89 per person are available. Travel duration is 22h 50m
Travel time is 5h 35m longer, but you will save $15

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound Lines Mexico	22h 50m	1:30 AM	San Antonio, TX	Bus Station	1:20 AM	Louisville, KY	Greyhound Bus Station	Economy	$128	A Bus from Greyhound Lines Mexico goes from Bus Station, San Antonio, TX (USA) at 6/17/2026 1:30:00 AM to Greyhound Bus Station, Louisville, KY (USA) arriving at 6/18/2026 1:20:00 AM. 50 Economy ticket for $128 per person are available. Travel duration is 22h 50m
Greyhound Lines Mexico	26h 45m	5:50 AM	San Antonio, TX	Bus Station	9:35 AM	Louisville, KY	Greyhound Bus Station	Economy	$128	A Bus from Greyhound Lines Mexico goes from Bus Station, San Antonio, TX (USA) at 6/17/2026 5:50:00 AM to Greyhound Bus Station, Louisville, KY (USA) arriving at 6/18/2026 9:35:00 AM. 50 Economy ticket for $128 per person are available. Travel duration is 26h 45m
Greyhound US	24h 35m	12:35 PM	San Antonio, TX	Bus Station	2:10 PM	Louisville, KY	Greyhound Bus Station	Economy	$128	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 6/17/2026 12:35:00 PM to Greyhound Bus Station, Louisville, KY (USA) arriving at 6/18/2026 2:10:00 PM. 50 Economy ticket for $128 per person are available. Travel duration is 24h 35m
FlixBus	27h 20m	9:00 PM	San Antonio, TX	Bus Station	1:20 AM	Louisville, KY	Greyhound Bus Station	Economy	$128	A Bus from FlixBus goes from Bus Station, San Antonio, TX (USA) at 6/17/2026 9:00:00 PM to Greyhound Bus Station, Louisville, KY (USA) arriving at 6/19/2026 1:20:00 AM. 50 Economy ticket for $128 per person are available. Travel duration is 27h 20m
FlixBus	43h 55m	7:45 AM	San Antonio, TX	Pearl District	4:40 AM	Louisville, KY	Greyhound Bus Station	Economy	$132	A Bus from FlixBus goes from Pearl District, San Antonio, TX (USA) at 6/17/2026 7:45:00 AM to Greyhound Bus Station, Louisville, KY (USA) arriving at 6/19/2026 4:40:00 AM. 50 Economy ticket for $132 per person are available. Travel duration is 43h 55m

Did you know that if you travel from San Antonio, TX to Louisville, KY via Austin, you can save more than $27? You can find the corresponding connections below.
- FlixBus
  
  29h 25m
  
  0
  
  7:45 AM
  
  San Antonio, TX
  Pearl District
  
  9:15 AM
  
  Austin
  Austin South Congress Bus Stop
  
  0
  
  Economy
  
  $12
  
  A Bus from FlixBus goes from Pearl District, San Antonio, TX (USA) at 6/13/2026 7:45:00 AM to Austin South Congress Bus Stop, Austin (USA) arriving at 6/13/2026 9:15:00 AM. 50 Economy ticket for $12 per person are available. Travel duration is 1h 30m
- Greyhound US
  
  22h 50m
  
  0
  
  2:20 PM
  
  Austin
  5119 Eastside Bus Plaza
  
  2:10 PM
  
  Louisville, KY
  Greyhound Bus Station
  
  0
  
  Economy
  
  $89
  
  A Bus from Greyhound US goes from 5119 Eastside Bus Plaza, Austin (USA) at 6/13/2026 2:20:00 PM to Greyhound Bus Station, Louisville, KY (USA) arriving at 6/14/2026 2:10:00 PM. 50 Economy ticket for $89 per person are available. Travel duration is 22h 50m
Travel time is 5h 35m longer, but you will save $27

Best Price Offer: The price for the cheapest bus from San Antonio, TX to Louisville, KY is $106 on 6/25/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between San Antonio, TX and Louisville, KY

See here how frequent the connections between San Antonio, TX and Louisville, KY are, during different times and days of the week.

Sunday is the busiest day, with more than 5 daily buses from San Antonio, TX to Louisville, KY. Tuesday has instead the fewest connections, with only 4 daily coaches between San Antonio, TX and Louisville, KY.

The busiest time of the day is the Night, with 8 buses from San Antonio, TX to Louisville, KY, while Morning sees the fewest connections between San Antonio, TX and Louisville, KY, with 3 offers.

Facts about the bus from San Antonio, TX to Louisville, KY

Compare all providers like FlixBus, Greyhound Lines Mexico and Greyhound US that travel 4 times every day by bus from San Antonio, TX to Louisville, KY in one click! Book your bus ticket from San Antonio, TX to Louisville, KY starting from $106!

Cheapest Bus	$106
Fastest Bus	23h 50m
Earliest Bus	1:30 AM
Latest Bus	9:00 PM
Daily Bus Routes	4 Ø
Distance	949.9 miles
Bus Companies	FlixBus, Greyhound Lines Mexico and Greyhound US

Cheapest bus connections from San Antonio, TX to Louisville, KY

Every day, 4 buses from 3 bus companies leave San Antonio, TX for Louisville, KY: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 06/12/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 06/07

Monday 06/08

Tuesday 06/09

Wednesday 06/10

Thursday 06/11

Friday 06/12

Saturday 06/13

$124

Sunday 06/14

$123

Monday 06/15

Tuesday 06/16

$116

Wednesday 06/17

$128

Thursday 06/18

Friday 06/19

$113

Saturday 06/20

$128

Sunday 06/21

$124

Monday 06/22

Tuesday 06/23

$132

Wednesday 06/24

Thursday 06/25

$106

Friday 06/26

Saturday 06/27

$123

Sunday 06/28

$110

Monday 06/29

Tuesday 06/30

Wednesday 07/01

Thursday 07/02

Friday 07/03

Saturday 07/04

The cheapest time to travel from San Antonio, TX to Louisville, KY

See here on which day and which time of the day you can find the cheapest bus ticket from San Antonio, TX to Louisville, KY, for the next 30 days.

With a price starting from $110, Sunday is the cheapest day for a bus from San Antonio, TX to Louisville, KY. Wednesday instead is the most expensive day with prices starting from $128.

Night is the cheapest day time for bus tickets from San Antonio, TX to Louisville, KY, with $106. Morning is the most expensive time of the day with prices starting from $123.

How to save money travelling from San Antonio, TX to Louisville, KY

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from San Antonio, TX to Louisville, KY in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from San Antonio, TX to Louisville, KY, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from San Antonio, TX to Louisville, KY are also emptier.

All bus stations and stops in San Antonio, TX and Louisville, KY

In the map below, you can see where to find all bus stations in San Antonio, TX and Louisville, KY.

Bus Station

N St Mary's St 500

San Antonio

Pearl District

Avenue A 699-599

Commerce & Bowie Bus Stop

W. Southcross & Buffalo Bus Stop

Greyhound Bus Station

W Muhammad Ali Blvd 720

Convention Center

S 3rd St 300

BP Gas Station

Newburg Rd 3301

W Muhammad Ali Blvd

East Broadway, under the I-65 overpass between S 1st Street and S Brook Street

International Airport

Service and Comfort on the bus from San Antonio, TX to Louisville, KY

Want to know which seat classes are available on the buses from San Antonio, TX to Louisville, KY? Or which bus companies serve the route San Antonio, TX to Louisville, KY? Below you will find answers to your questions.

FAQs about the San Antonio, TX to Louisville, KY bus

How much does a San Antonio, TX Louisville, KY bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $106 and takes 27h 45m to reach Louisville, KY. Compare offers to save money!

How much could I save by comparing buses from San Antonio, TX to Louisville, KY?

This route is offered by 3 companies with a range of ticket prices between $106 and $132. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Louisville, KY.

On average, how many connections are available from San Antonio, TX to Louisville, KY each day?

Every day, the San Antonio, TX to Louisville, KY bus route is served by approximately 4 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from San Antonio, TX to Louisville, KY take?

The fastest bus from San Antonio, TX to Louisville, KY is offered by Greyhound Lines Mexico and takes 23h 50m. Bus tickets for this connection cost $124. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from San Antonio, TX to Louisville, KY?

The earliest bus arriving in Louisville, KY from San Antonio, TX starts at 1:30 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from San Antonio, TX to Louisville, KY?

The latest bus trip departing from San Antonio, TX for Louisville, KY starts at 9:00 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the San Antonio, TX Louisville, KY route?

When traveling by bus from San Antonio, TX to Louisville, KY, passengers can travel with FlixBus, Greyhound Lines Mexico and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between San Antonio, TX and Louisville, KY?

You can check all the direct connections between San Antonio, TX and Louisville, KY by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus, Greyhound Lines Mexico and Greyhound US.

What can I take with me on the San Antonio, TX to Louisville, KY bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the San Antonio, TX Louisville, KY bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the San Antonio, TX Louisville, KY bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from San Antonio, TX to Louisville, KY on your planned travel date.

How does CheckMyBus find the best bus deals from San Antonio, TX to Louisville, KY?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 4 daily trips between San Antonio, TX and Louisville, KY. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from San Antonio, TX to Louisville, KY?

Prices and availability for 4 trips between San Antonio, TX and Louisville, KY change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route San Antonio, TX to Louisville, KY

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to San Antonio, TX and to Louisville, KY

Here’s an overview of the most popular bus routes to San Antonio, TX and to Louisville, KY. Simply click on the connection of your choice, and you will find all the details about your bus route!