Bus Greenville, SC to Chicago: Compare prices and save money

Compare all timetables for the bus from Greenville, SC to Chicago

Here is a selection of the cheapest bus trips from the schedule from Greenville, SC to Chicago from various bus operators like FlixBus or Greyhound US for the next days.

today

$125

tomorrow

$155

Friday

$129

Saturday

Sunday

$118

Monday

$169

Tuesday

$181

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	19h 55m	1:20 PM	Greenville, SC	Woodruff Rd	8:15 AM	Chicago	Downtown Bus Station	Economy	$125	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 12/10/2025 1:20:00 PM to Downtown Bus Station, Chicago (USA) arriving at 12/11/2025 8:15:00 AM. 50 Economy ticket for $125 per person are available. Travel duration is 19h 55m
FlixBus	19h 30m	1:20 PM	Greenville, SC	Woodruff Rd	7:50 AM	Chicago	Canal & Van Buren	Economy	$125	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 12/10/2025 1:20:00 PM to Canal & Van Buren, Chicago (USA) arriving at 12/11/2025 7:50:00 AM. 50 Economy ticket for $125 per person are available. Travel duration is 19h 30m
Greyhound US	24h 25m	2:45 PM	Greenville, SC	Woodruff Rd	2:10 PM	Chicago	Canal & Van Buren	Economy	$125	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 12/10/2025 2:45:00 PM to Canal & Van Buren, Chicago (USA) arriving at 12/11/2025 2:10:00 PM. 50 Economy ticket for $125 per person are available. Travel duration is 24h 25m
FlixBus	27h 10m	10:00 PM	Greenville, SC	Woodruff Rd	12:10 AM	Chicago	Downtown Bus Station	Economy	$126	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 12/10/2025 10:00:00 PM to Downtown Bus Station, Chicago (USA) arriving at 12/12/2025 12:10:00 AM. 50 Economy ticket for $126 per person are available. Travel duration is 27h 10m
Greyhound US	21h 45m	2:45 PM	Greenville, SC	Woodruff Rd	11:30 AM	Chicago	Downtown Bus Station	Economy	$126	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 12/10/2025 2:45:00 PM to Downtown Bus Station, Chicago (USA) arriving at 12/11/2025 11:30:00 AM. 50 Economy ticket for $126 per person are available. Travel duration is 21h 45m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	21h 20m	2:45 PM	Greenville, SC	Woodruff Rd	11:05 AM	Chicago	95th Red Line Station	Economy	$155	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 12/11/2025 2:45:00 PM to 95th Red Line Station, Chicago (USA) arriving at 12/12/2025 11:05:00 AM. 50 Economy ticket for $155 per person are available. Travel duration is 21h 20m
FlixBus	26h 0m	10:00 PM	Greenville, SC	Woodruff Rd	11:00 PM	Chicago	95th Red Line Station	Economy	$157	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 12/11/2025 10:00:00 PM to 95th Red Line Station, Chicago (USA) arriving at 12/12/2025 11:00:00 PM. 50 Economy ticket for $157 per person are available. Travel duration is 26h 0m
FlixBus	21h 30m	1:20 PM	Greenville, SC	Woodruff Rd	9:50 AM	Chicago	95th Red Line Station	Economy	$165	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 12/11/2025 1:20:00 PM to 95th Red Line Station, Chicago (USA) arriving at 12/12/2025 9:50:00 AM. 50 Economy ticket for $165 per person are available. Travel duration is 21h 30m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	21h 10m	7:45 PM	Greenville, SC	Woodruff Rd	3:55 PM	Chicago	95th Red Line Station	Economy	$129	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 12/12/2025 7:45:00 PM to 95th Red Line Station, Chicago (USA) arriving at 12/13/2025 3:55:00 PM. 50 Economy ticket for $129 per person are available. Travel duration is 21h 10m
FlixBus	26h 0m	10:00 PM	Greenville, SC	Woodruff Rd	11:00 PM	Chicago	95th Red Line Station	Economy	$130	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 12/12/2025 10:00:00 PM to 95th Red Line Station, Chicago (USA) arriving at 12/13/2025 11:00:00 PM. 50 Economy ticket for $130 per person are available. Travel duration is 26h 0m
Greyhound US	21h 20m	2:45 PM	Greenville, SC	Woodruff Rd	11:05 AM	Chicago	95th Red Line Station	Economy	$130	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 12/12/2025 2:45:00 PM to 95th Red Line Station, Chicago (USA) arriving at 12/13/2025 11:05:00 AM. 50 Economy ticket for $130 per person are available. Travel duration is 21h 20m
FlixBus	21h 30m	1:20 PM	Greenville, SC	Woodruff Rd	9:50 AM	Chicago	95th Red Line Station	Economy	$131	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 12/12/2025 1:20:00 PM to 95th Red Line Station, Chicago (USA) arriving at 12/13/2025 9:50:00 AM. 50 Economy ticket for $131 per person are available. Travel duration is 21h 30m
Greyhound US	21h 45m	2:45 PM	Greenville, SC	Woodruff Rd	11:30 AM	Chicago	Downtown Bus Station	Economy	$135	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 12/12/2025 2:45:00 PM to Downtown Bus Station, Chicago (USA) arriving at 12/13/2025 11:30:00 AM. 50 Economy ticket for $135 per person are available. Travel duration is 21h 45m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	21h 10m	7:45 PM	Greenville, SC	Woodruff Rd	3:55 PM	Chicago	95th Red Line Station	Economy	$118	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 12/14/2025 7:45:00 PM to 95th Red Line Station, Chicago (USA) arriving at 12/15/2025 3:55:00 PM. 50 Economy ticket for $118 per person are available. Travel duration is 21h 10m
FlixBus	26h 0m	10:00 PM	Greenville, SC	Woodruff Rd	11:00 PM	Chicago	95th Red Line Station	Economy	$119	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 12/14/2025 10:00:00 PM to 95th Red Line Station, Chicago (USA) arriving at 12/15/2025 11:00:00 PM. 50 Economy ticket for $119 per person are available. Travel duration is 26h 0m
Greyhound US	21h 20m	2:45 PM	Greenville, SC	Woodruff Rd	11:05 AM	Chicago	95th Red Line Station	Economy	$119	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 12/14/2025 2:45:00 PM to 95th Red Line Station, Chicago (USA) arriving at 12/15/2025 11:05:00 AM. 50 Economy ticket for $119 per person are available. Travel duration is 21h 20m
FlixBus	21h 30m	1:20 PM	Greenville, SC	Woodruff Rd	9:50 AM	Chicago	95th Red Line Station	Economy	$120	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 12/14/2025 1:20:00 PM to 95th Red Line Station, Chicago (USA) arriving at 12/15/2025 9:50:00 AM. 50 Economy ticket for $120 per person are available. Travel duration is 21h 30m
Greyhound US	24h 25m	2:45 PM	Greenville, SC	Woodruff Rd	2:10 PM	Chicago	Canal & Van Buren	Economy	$122	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 12/14/2025 2:45:00 PM to Canal & Van Buren, Chicago (USA) arriving at 12/15/2025 2:10:00 PM. 50 Economy ticket for $122 per person are available. Travel duration is 24h 25m

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	19h 40m	1:20 PM	Greenville, SC	Woodruff Rd	8:00 AM	Chicago	Union Station	Economy	$169	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 12/15/2025 1:20:00 PM to Union Station, Chicago (USA) arriving at 12/16/2025 8:00:00 AM. 50 Economy ticket for $169 per person are available. Travel duration is 19h 40m
FlixBus	20h 5m	1:20 PM	Greenville, SC	Woodruff Rd	8:25 AM	Chicago	Downtown Bus Station	Economy	$169	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 12/15/2025 1:20:00 PM to Downtown Bus Station, Chicago (USA) arriving at 12/16/2025 8:25:00 AM. 50 Economy ticket for $169 per person are available. Travel duration is 20h 5m
FlixBus	20h 30m	7:45 PM	Greenville, SC	Woodruff Rd	3:15 PM	Chicago	Downtown Bus Station	Economy	$169	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 12/15/2025 7:45:00 PM to Downtown Bus Station, Chicago (USA) arriving at 12/16/2025 3:15:00 PM. 50 Economy ticket for $169 per person are available. Travel duration is 20h 30m
Greyhound US	21h 25m	5:45 PM	Greenville, SC	Woodruff Rd	2:10 PM	Chicago	Union Station	Economy	$169	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 12/15/2025 5:45:00 PM to Union Station, Chicago (USA) arriving at 12/16/2025 2:10:00 PM. 50 Economy ticket for $169 per person are available. Travel duration is 21h 25m
Greyhound US	21h 50m	5:45 PM	Greenville, SC	Woodruff Rd	2:35 PM	Chicago	Downtown Bus Station	Economy	$169	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 12/15/2025 5:45:00 PM to Downtown Bus Station, Chicago (USA) arriving at 12/16/2025 2:35:00 PM. 50 Economy ticket for $169 per person are available. Travel duration is 21h 50m

Did you know that if you travel from Greenville, SC to Chicago via Cincinnati, you can save more than $34? You can find the corresponding connections below.
- FlixBus
  
  22h 15m
  
  0
  
  2:45 PM
  
  Greenville, SC
  Woodruff Rd
  
  3:25 AM
  
  Cincinnati
  Greyhound Bus Station
  
  0
  
  Economy
  
  $95
  
  A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 12/13/2025 2:45:00 PM to Greyhound Bus Station, Cincinnati (USA) arriving at 12/14/2025 3:25:00 AM. 50 Economy ticket for $95 per person are available. Travel duration is 12h 40m
- Busbud
  
  6h 0m
  
  0
  
  7:00 AM
  
  Cincinnati
  University of Cincinnati
  
  12:00 PM
  
  Chicago
  Downtown Bus Station
  
  0
  
  Economy
  
  $40
  
  A Bus from Busbud goes from University of Cincinnati, Cincinnati (USA) at 12/14/2025 7:00:00 AM to Downtown Bus Station, Chicago (USA) arriving at 12/14/2025 12:00:00 PM. 50 Economy ticket for $40 per person are available. Travel duration is 6h 0m
Travel time is 3h 35m longer, but you will save $34

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	21h 30m	1:20 PM	Greenville, SC	Woodruff Rd	9:50 AM	Chicago	95th Red Line Station	Economy	$181	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 12/16/2025 1:20:00 PM to 95th Red Line Station, Chicago (USA) arriving at 12/17/2025 9:50:00 AM. 50 Economy ticket for $181 per person are available. Travel duration is 21h 30m
FlixBus	26h 0m	10:00 PM	Greenville, SC	Woodruff Rd	11:00 PM	Chicago	95th Red Line Station	Economy	$187	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 12/16/2025 10:00:00 PM to 95th Red Line Station, Chicago (USA) arriving at 12/17/2025 11:00:00 PM. 50 Economy ticket for $187 per person are available. Travel duration is 26h 0m
Greyhound US	21h 20m	2:45 PM	Greenville, SC	Woodruff Rd	11:05 AM	Chicago	95th Red Line Station	Economy	$215	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 12/16/2025 2:45:00 PM to 95th Red Line Station, Chicago (USA) arriving at 12/17/2025 11:05:00 AM. 50 Economy ticket for $215 per person are available. Travel duration is 21h 20m

Did you know that if you travel from Greenville, SC to Chicago via Cincinnati, you can save more than $46? You can find the corresponding connections below.
- FlixBus
  
  22h 15m
  
  0
  
  2:45 PM
  
  Greenville, SC
  Woodruff Rd
  
  3:25 AM
  
  Cincinnati
  Greyhound Bus Station
  
  0
  
  Economy
  
  $95
  
  A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 12/13/2025 2:45:00 PM to Greyhound Bus Station, Cincinnati (USA) arriving at 12/14/2025 3:25:00 AM. 50 Economy ticket for $95 per person are available. Travel duration is 12h 40m
- Busbud
  
  6h 0m
  
  0
  
  7:00 AM
  
  Cincinnati
  University of Cincinnati
  
  12:00 PM
  
  Chicago
  Downtown Bus Station
  
  0
  
  Economy
  
  $40
  
  A Bus from Busbud goes from University of Cincinnati, Cincinnati (USA) at 12/14/2025 7:00:00 AM to Downtown Bus Station, Chicago (USA) arriving at 12/14/2025 12:00:00 PM. 50 Economy ticket for $40 per person are available. Travel duration is 6h 0m
Travel time is 1h 55m longer, but you will save $46

Best Price Offer: The price for the cheapest bus from Greenville, SC to Chicago is $96 on 12/7/2025. Flexible travelers save on ticket prices.

Frequency of bus connections between Greenville, SC and Chicago

See here how frequent the connections between Greenville, SC and Chicago are, during different times and days of the week.

Sunday is the busiest day, with more than 22 daily buses from Greenville, SC to Chicago. Tuesday has instead the fewest connections, with only 3 daily coaches between Greenville, SC and Chicago.

The busiest time of the day is the Afternoon, with 48 buses from Greenville, SC to Chicago, while Evening sees the fewest connections between Greenville, SC and Chicago, with 33 offers.

Facts about the bus from Greenville, SC to Chicago

Compare all providers like FlixBus and Greyhound US that travel 13 times every day by bus from Greenville, SC to Chicago in one click! Book your bus ticket from Greenville, SC to Chicago starting from $96!

Cheapest Bus	$96
Fastest Bus	18h 30m
Earliest Bus	1:20 PM
Latest Bus	10:00 PM
Daily Bus Routes	13 Ø
Distance	562.3 miles
Bus Companies	FlixBus and Greyhound US

Cheapest bus connections from Greenville, SC to Chicago

Every day, 13 buses from 2 bus companies leave Greenville, SC for Chicago: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/10/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 12/07

Monday 12/08

Tuesday 12/09

Wednesday 12/10

$131

Thursday 12/11

$155

Friday 12/12

$129

Saturday 12/13

Sunday 12/14

$118

Monday 12/15

$169

Tuesday 12/16

$181

Wednesday 12/17

Thursday 12/18

$195

Friday 12/19

Saturday 12/20

Sunday 12/21

$136

Monday 12/22

Tuesday 12/23

$140

Wednesday 12/24

Thursday 12/25

Friday 12/26

$137

Saturday 12/27

Sunday 12/28

Monday 12/29

Tuesday 12/30

Wednesday 12/31

Thursday 01/01

Friday 01/02

Saturday 01/03

The cheapest time to travel from Greenville, SC to Chicago

See here on which day and which time of the day you can find the cheapest bus ticket from Greenville, SC to Chicago, for the next 30 days.

With a price starting from $118, Sunday is the cheapest day for a bus from Greenville, SC to Chicago. Monday instead is the most expensive day with prices starting from $169.

Evening is the cheapest day time for bus tickets from Greenville, SC to Chicago, with $118. Afternoon is the most expensive time of the day with prices starting from $119.

How to save money travelling from Greenville, SC to Chicago

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Greenville, SC to Chicago in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Greenville, SC to Chicago, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Greenville, SC to Chicago are also emptier.

All bus stations and stops in Greenville, SC and Chicago

In the map below, you can see where to find all bus stations in Greenville, SC and Chicago.

McDonald's

Woodruff Rd 1111

Woodruff Rd

Woodruff Rd 1116

Guadalajara Supermarket

White Horse Rd 2803

Greyhound Bus Station

Hendrix Dr 9

N Church St

95th Red Line Station

W. 95th St 14

Downtown Bus Station

West Harrison Street 630-670

Union Station

S Canal St 225

Cumberland CTA

N Cumberland Ave 5800

Canal & Van Buren

S Canal St 310-320

Service and Comfort on the bus from Greenville, SC to Chicago

Want to know which seat classes are available on the buses from Greenville, SC to Chicago? Or which bus companies serve the route Greenville, SC to Chicago? Below you will find answers to your questions.

FAQs about the Greenville, SC to Chicago bus

How much does a Greenville, SC Chicago bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $96 and takes 20h 10m to reach Chicago. Compare offers to save money!

How much could I save by comparing buses from Greenville, SC to Chicago?

This route is offered by 2 companies with a range of ticket prices between $96 and $215. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Chicago.

On average, how many connections are available from Greenville, SC to Chicago each day?

Every day, the Greenville, SC to Chicago bus route is served by approximately 13 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Greenville, SC to Chicago take?

The fastest bus from Greenville, SC to Chicago is offered by FlixBus and takes 18h 30m. Bus tickets for this connection cost $125. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Greenville, SC to Chicago?

The earliest bus arriving in Chicago from Greenville, SC starts at 1:20 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Greenville, SC to Chicago?

The latest bus trip departing from Greenville, SC for Chicago starts at 10:00 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Greenville, SC Chicago route?

When traveling by bus from Greenville, SC to Chicago, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Greenville, SC and Chicago?

You can check all the direct connections between Greenville, SC and Chicago by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the Greenville, SC to Chicago bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Greenville, SC Chicago bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Greenville, SC Chicago bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Greenville, SC to Chicago on your planned travel date.

Available seat classes which are offered on the bus route Greenville, SC to Chicago

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Greenville, SC and to Chicago

Here’s an overview of the most popular bus routes to Greenville, SC and to Chicago. Simply click on the connection of your choice, and you will find all the details about your bus route!