Bus Tupelo, MS to St. Louis, MO: Compare prices and save money

Compare all timetables for the bus from Tupelo, MS to St. Louis, MO

Here is a selection of the cheapest bus trips from the schedule from Tupelo, MS to St. Louis, MO from various bus operators like Greyhound US for the next days.

today

$71

tomorrow

Monday

$80

Tuesday

Wednesday

Thursday

$85

Friday

Cheapest bus trips today
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	18h 20m	9:35 PM	Tupelo, MS	Bus Stop	3:55 PM	St. Louis, MO	Gateway Station		Economy	$71	A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 12/6/2025 9:35:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/7/2025 3:55:00 PM. 50 Economy ticket for $71 per person are available. Travel duration is 18h 20m
	Greyhound US	10h 10m	5:35 AM	Tupelo, MS	Bus Stop	3:45 PM	St. Louis, MO	Gateway Station		Economy	$79	A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 12/6/2025 5:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/6/2025 3:45:00 PM. 50 Economy ticket for $79 per person are available. Travel duration is 10h 10m

Cheapest bus trips Monday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	10h 10m	5:35 AM	Tupelo, MS	Bus Stop	3:45 PM	St. Louis, MO	Gateway Station		Economy	$80	A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 12/8/2025 5:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/8/2025 3:45:00 PM. 50 Economy ticket for $80 per person are available. Travel duration is 10h 10m
	Greyhound US	18h 20m	9:35 PM	Tupelo, MS	Bus Stop	3:55 PM	St. Louis, MO	Gateway Station		Economy	$81	A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 12/8/2025 9:35:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/9/2025 3:55:00 PM. 50 Economy ticket for $81 per person are available. Travel duration is 18h 20m

Cheapest bus trips Thursday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	22h 15m	10:55 AM	Tupelo, MS	Bus Stop	9:10 AM	St. Louis, MO	Gateway Station		Economy	$85	A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 12/11/2025 10:55:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/12/2025 9:10:00 AM. 50 Economy ticket for $85 per person are available. Travel duration is 22h 15m
	Greyhound US	18h 20m	9:35 PM	Tupelo, MS	Bus Stop	3:55 PM	St. Louis, MO	Gateway Station		Economy	$85	A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 12/11/2025 9:35:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/12/2025 3:55:00 PM. 50 Economy ticket for $85 per person are available. Travel duration is 18h 20m

Best Price Offer: The price for the cheapest bus from Tupelo, MS to St. Louis, MO is $69 on 12/13/2025. Flexible travelers save on ticket prices.

Frequency of bus connections between Tupelo, MS and St. Louis, MO

See here how frequent the connections between Tupelo, MS and St. Louis, MO are, during different times and days of the week.

Monday is the busiest day, with more than 2 daily buses from Tupelo, MS to St. Louis, MO. Monday has instead the fewest connections, with only 2 daily coaches between Tupelo, MS and St. Louis, MO.

The busiest time of the day is the Evening, with 3 buses from Tupelo, MS to St. Louis, MO, while Morning sees the fewest connections between Tupelo, MS and St. Louis, MO, with 1 offers.

Facts about the bus from Tupelo, MS to St. Louis, MO

Compare all providers like Greyhound US that travel 2 times every day by bus from Tupelo, MS to St. Louis, MO in one click! Book your bus ticket from Tupelo, MS to St. Louis, MO starting from $69!

Cheapest Bus	$69
Fastest Bus	10h 10m
Earliest Bus	5:35 AM
Latest Bus	9:35 PM
Daily Bus Routes	2 Ø
Distance	313.1 miles
Bus Companies	Greyhound US

Cheapest bus connections from Tupelo, MS to St. Louis, MO

Every day, 2 buses from 1 bus companies leave Tupelo, MS for St. Louis, MO: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/06/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 11/30

Monday 12/01

Tuesday 12/02

Wednesday 12/03

Thursday 12/04

Friday 12/05

Saturday 12/06

$71

Sunday 12/07

Monday 12/08

$80

Tuesday 12/09

Wednesday 12/10

Thursday 12/11

$85

Friday 12/12

Saturday 12/13

$69

Sunday 12/14

Monday 12/15

Tuesday 12/16

Wednesday 12/17

Thursday 12/18

Friday 12/19

Saturday 12/20

Sunday 12/21

Monday 12/22

Tuesday 12/23

Wednesday 12/24

Thursday 12/25

Friday 12/26

Saturday 12/27

The cheapest time to travel from Tupelo, MS to St. Louis, MO

See here on which day and which time of the day you can find the cheapest bus ticket from Tupelo, MS to St. Louis, MO, for the next 30 days.

With a price starting from $69, Saturday is the cheapest day for a bus from Tupelo, MS to St. Louis, MO. Thursday instead is the most expensive day with prices starting from $85.

Night is the cheapest day time for bus tickets from Tupelo, MS to St. Louis, MO, with $69. Morning is the most expensive time of the day with prices starting from $85.

How to save money travelling from Tupelo, MS to St. Louis, MO

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Tupelo, MS to St. Louis, MO in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Tupelo, MS to St. Louis, MO, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Tupelo, MS to St. Louis, MO are also emptier.

All bus stations and stops in Tupelo, MS and St. Louis, MO

In the map below, you can see where to find all bus stations in Tupelo, MS and St. Louis, MO.

Bus Stop

S Eason Blvd 2831

Gateway Station

S 15th St 430

Skinker Boulevard

Boulevard between Lindell Blvd. and Lagoon Drive

Lindbergh @ Hackberry NB Bus Stop

Service and Comfort on the bus from Tupelo, MS to St. Louis, MO

Want to know which seat classes are available on the buses from Tupelo, MS to St. Louis, MO? Or which bus companies serve the route Tupelo, MS to St. Louis, MO? Below you will find answers to your questions.

FAQs about the Tupelo, MS to St. Louis, MO bus

How much does a Tupelo, MS St. Louis, MO bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $69 and takes 18h 20m to reach St. Louis, MO. Compare offers to save money!

How much could I save by comparing buses from Tupelo, MS to St. Louis, MO?

This route is offered by 1 companies with a range of ticket prices between $69 and $85. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to St. Louis, MO.

On average, how many connections are available from Tupelo, MS to St. Louis, MO each day?

Every day, the Tupelo, MS to St. Louis, MO bus route is served by approximately 2 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Tupelo, MS to St. Louis, MO take?

The fastest bus from Tupelo, MS to St. Louis, MO is offered by Greyhound US and takes 10h 10m. Bus tickets for this connection cost $79. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Tupelo, MS to St. Louis, MO?

The earliest bus arriving in St. Louis, MO from Tupelo, MS starts at 5:35 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Tupelo, MS to St. Louis, MO?

The latest bus trip departing from Tupelo, MS for St. Louis, MO starts at 9:35 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Tupelo, MS St. Louis, MO route?

When traveling by bus from Tupelo, MS to St. Louis, MO, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Tupelo, MS and St. Louis, MO?

You can check all the direct connections between Tupelo, MS and St. Louis, MO by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Tupelo, MS to St. Louis, MO bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Tupelo, MS St. Louis, MO bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Tupelo, MS St. Louis, MO bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Tupelo, MS to St. Louis, MO on your planned travel date.

Available seat classes which are offered on the bus route Tupelo, MS to St. Louis, MO

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Tupelo, MS and to St. Louis, MO

Here’s an overview of the most popular bus routes to Tupelo, MS and to St. Louis, MO. Simply click on the connection of your choice, and you will find all the details about your bus route!