Bus Florence, SC to Chicago: Compare prices and save money

Compare all timetables for the bus from Florence, SC to Chicago

Here is a selection of the cheapest bus trips from the schedule from Florence, SC to Chicago from various bus operators like Greyhound US or FlixBus for the next days.

today

$109

tomorrow

$115

Wednesday

Thursday

$122

Friday

$121

Saturday

$121

Sunday

$116

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	24h 35m	11:55 AM	Florence, SC	Bus Station	11:30 AM	Chicago	Downtown Bus Station	Economy	$109	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 4/20/2026 11:55:00 AM to Downtown Bus Station, Chicago (USA) arriving at 4/21/2026 11:30:00 AM. 50 Economy ticket for $109 per person are available. Travel duration is 24h 35m
Greyhound US	24h 5m	4:10 PM	Florence, SC	Bus Station	3:15 PM	Chicago	Downtown Bus Station	Economy	$109	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 4/20/2026 4:10:00 PM to Downtown Bus Station, Chicago (USA) arriving at 4/21/2026 3:15:00 PM. 50 Economy ticket for $109 per person are available. Travel duration is 24h 5m
Greyhound US	27h 15m	11:55 AM	Florence, SC	Bus Station	2:10 PM	Chicago	Canal & Van Buren	Economy	$110	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 4/20/2026 11:55:00 AM to Canal & Van Buren, Chicago (USA) arriving at 4/21/2026 2:10:00 PM. 50 Economy ticket for $110 per person are available. Travel duration is 27h 15m
Greyhound US	32h 40m	4:30 PM	Florence, SC	Bus Station	12:10 AM	Chicago	Downtown Bus Station	Economy	$110	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 4/20/2026 4:30:00 PM to Downtown Bus Station, Chicago (USA) arriving at 4/22/2026 12:10:00 AM. 50 Economy ticket for $110 per person are available. Travel duration is 32h 40m
Greyhound US	40h 30m	4:30 PM	Florence, SC	Bus Station	8:00 AM	Chicago	Canal & Van Buren	Economy	$111	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 4/20/2026 4:30:00 PM to Canal & Van Buren, Chicago (USA) arriving at 4/22/2026 8:00:00 AM. 50 Economy ticket for $111 per person are available. Travel duration is 40h 30m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	24h 35m	11:55 AM	Florence, SC	Bus Station	11:30 AM	Chicago	Downtown Bus Station	Economy	$115	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 4/21/2026 11:55:00 AM to Downtown Bus Station, Chicago (USA) arriving at 4/22/2026 11:30:00 AM. 50 Economy ticket for $115 per person are available. Travel duration is 24h 35m
Greyhound US	24h 5m	4:10 PM	Florence, SC	Bus Station	3:15 PM	Chicago	Downtown Bus Station	Economy	$115	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 4/21/2026 4:10:00 PM to Downtown Bus Station, Chicago (USA) arriving at 4/22/2026 3:15:00 PM. 50 Economy ticket for $115 per person are available. Travel duration is 24h 5m
Greyhound US	32h 40m	4:30 PM	Florence, SC	Bus Station	12:10 AM	Chicago	Downtown Bus Station	Economy	$115	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 4/21/2026 4:30:00 PM to Downtown Bus Station, Chicago (USA) arriving at 4/23/2026 12:10:00 AM. 50 Economy ticket for $115 per person are available. Travel duration is 32h 40m
FlixBus	32h 55m	12:05 AM	Florence, SC	TA Travel Center	8:00 AM	Chicago	Union Station	Economy	$116	A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 4/21/2026 12:05:00 AM to Union Station, Chicago (USA) arriving at 4/22/2026 8:00:00 AM. 50 Economy ticket for $116 per person are available. Travel duration is 32h 55m
FlixBus	31h 5m	12:05 AM	Florence, SC	TA Travel Center	6:10 AM	Chicago	Downtown Bus Station	Economy	$121	A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 4/21/2026 12:05:00 AM to Downtown Bus Station, Chicago (USA) arriving at 4/22/2026 6:10:00 AM. 50 Economy ticket for $121 per person are available. Travel duration is 31h 5m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	40h 30m	4:30 PM	Florence, SC	Bus Station	8:00 AM	Chicago	Union Station	Economy	$122	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 4/23/2026 4:30:00 PM to Union Station, Chicago (USA) arriving at 4/25/2026 8:00:00 AM. 50 Economy ticket for $122 per person are available. Travel duration is 40h 30m
Greyhound US	24h 35m	11:55 AM	Florence, SC	Bus Station	11:30 AM	Chicago	Downtown Bus Station	Economy	$122	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 4/23/2026 11:55:00 AM to Downtown Bus Station, Chicago (USA) arriving at 4/24/2026 11:30:00 AM. 50 Economy ticket for $122 per person are available. Travel duration is 24h 35m
Greyhound US	24h 5m	4:10 PM	Florence, SC	Bus Station	3:15 PM	Chicago	Downtown Bus Station	Economy	$122	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 4/23/2026 4:10:00 PM to Downtown Bus Station, Chicago (USA) arriving at 4/24/2026 3:15:00 PM. 50 Economy ticket for $122 per person are available. Travel duration is 24h 5m
FlixBus	27h 15m	5:45 AM	Florence, SC	TA Travel Center	8:00 AM	Chicago	Union Station	Economy	$124	A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 4/23/2026 5:45:00 AM to Union Station, Chicago (USA) arriving at 4/24/2026 8:00:00 AM. 50 Economy ticket for $124 per person are available. Travel duration is 27h 15m
FlixBus	27h 40m	5:45 AM	Florence, SC	TA Travel Center	8:25 AM	Chicago	Downtown Bus Station	Economy	$124	A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 4/23/2026 5:45:00 AM to Downtown Bus Station, Chicago (USA) arriving at 4/24/2026 8:25:00 AM. 50 Economy ticket for $124 per person are available. Travel duration is 27h 40m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	24h 10m	11:55 AM	Florence, SC	Bus Station	11:05 AM	Chicago	95th Red Line Station	Economy	$121	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 4/24/2026 11:55:00 AM to 95th Red Line Station, Chicago (USA) arriving at 4/25/2026 11:05:00 AM. 50 Economy ticket for $121 per person are available. Travel duration is 24h 10m
Greyhound US	27h 25m	4:10 PM	Florence, SC	Bus Station	6:35 PM	Chicago	95th Red Line Station	Economy	$121	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 4/24/2026 4:10:00 PM to 95th Red Line Station, Chicago (USA) arriving at 4/25/2026 6:35:00 PM. 50 Economy ticket for $121 per person are available. Travel duration is 27h 25m
Greyhound US	24h 35m	11:55 AM	Florence, SC	Bus Station	11:30 AM	Chicago	Downtown Bus Station	Economy	$122	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 4/24/2026 11:55:00 AM to Downtown Bus Station, Chicago (USA) arriving at 4/25/2026 11:30:00 AM. 50 Economy ticket for $122 per person are available. Travel duration is 24h 35m
FlixBus	31h 5m	12:05 AM	Florence, SC	TA Travel Center	6:10 AM	Chicago	Downtown Bus Station	Economy	$127	A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 4/24/2026 12:05:00 AM to Downtown Bus Station, Chicago (USA) arriving at 4/25/2026 6:10:00 AM. 50 Economy ticket for $127 per person are available. Travel duration is 31h 5m
FlixBus	30h 35m	12:05 AM	Florence, SC	TA Travel Center	5:40 AM	Chicago	95th Red Line Station	Economy	$132	A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 4/24/2026 12:05:00 AM to 95th Red Line Station, Chicago (USA) arriving at 4/25/2026 5:40:00 AM. 50 Economy ticket for $132 per person are available. Travel duration is 30h 35m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	24h 10m	11:55 AM	Florence, SC	Bus Station	11:05 AM	Chicago	95th Red Line Station	Economy	$121	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 4/25/2026 11:55:00 AM to 95th Red Line Station, Chicago (USA) arriving at 4/26/2026 11:05:00 AM. 50 Economy ticket for $121 per person are available. Travel duration is 24h 10m
Greyhound US	27h 25m	4:10 PM	Florence, SC	Bus Station	6:35 PM	Chicago	95th Red Line Station	Economy	$121	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 4/25/2026 4:10:00 PM to 95th Red Line Station, Chicago (USA) arriving at 4/26/2026 6:35:00 PM. 50 Economy ticket for $121 per person are available. Travel duration is 27h 25m
FlixBus	29h 5m	5:45 AM	Florence, SC	TA Travel Center	9:50 AM	Chicago	95th Red Line Station	Economy	$122	A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 4/25/2026 5:45:00 AM to 95th Red Line Station, Chicago (USA) arriving at 4/26/2026 9:50:00 AM. 50 Economy ticket for $122 per person are available. Travel duration is 29h 5m
FlixBus	30h 35m	12:05 AM	Florence, SC	TA Travel Center	5:40 AM	Chicago	95th Red Line Station	Economy	$132	A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 4/25/2026 12:05:00 AM to 95th Red Line Station, Chicago (USA) arriving at 4/26/2026 5:40:00 AM. 50 Economy ticket for $132 per person are available. Travel duration is 30h 35m
FlixBus	27h 40m	5:45 AM	Florence, SC	TA Travel Center	8:25 AM	Chicago	Downtown Bus Station	Economy	$136	A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 4/25/2026 5:45:00 AM to Downtown Bus Station, Chicago (USA) arriving at 4/26/2026 8:25:00 AM. 50 Economy ticket for $136 per person are available. Travel duration is 27h 40m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	27h 15m	11:55 AM	Florence, SC	Bus Station	2:10 PM	Chicago	Canal & Van Buren	Economy	$116	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 4/26/2026 11:55:00 AM to Canal & Van Buren, Chicago (USA) arriving at 4/27/2026 2:10:00 PM. 50 Economy ticket for $116 per person are available. Travel duration is 27h 15m
Greyhound US	24h 10m	11:55 AM	Florence, SC	Bus Station	11:05 AM	Chicago	95th Red Line Station	Economy	$117	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 4/26/2026 11:55:00 AM to 95th Red Line Station, Chicago (USA) arriving at 4/27/2026 11:05:00 AM. 50 Economy ticket for $117 per person are available. Travel duration is 24h 10m
Greyhound US	27h 25m	4:10 PM	Florence, SC	Bus Station	6:35 PM	Chicago	95th Red Line Station	Economy	$117	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 4/26/2026 4:10:00 PM to 95th Red Line Station, Chicago (USA) arriving at 4/27/2026 6:35:00 PM. 50 Economy ticket for $117 per person are available. Travel duration is 27h 25m
FlixBus	27h 40m	5:45 AM	Florence, SC	TA Travel Center	8:25 AM	Chicago	Downtown Bus Station	Economy	$120	A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 4/26/2026 5:45:00 AM to Downtown Bus Station, Chicago (USA) arriving at 4/27/2026 8:25:00 AM. 50 Economy ticket for $120 per person are available. Travel duration is 27h 40m
FlixBus	27h 15m	5:45 AM	Florence, SC	TA Travel Center	8:00 AM	Chicago	Union Station	Economy	$120	A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 4/26/2026 5:45:00 AM to Union Station, Chicago (USA) arriving at 4/27/2026 8:00:00 AM. 50 Economy ticket for $120 per person are available. Travel duration is 27h 15m

Best Price Offer: The price for the cheapest bus from Florence, SC to Chicago is $104 on 5/9/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Florence, SC and Chicago

See here how frequent the connections between Florence, SC and Chicago are, during different times and days of the week.

Sunday is the busiest day, with more than 19 daily buses from Florence, SC to Chicago. Monday has instead the fewest connections, with only 7 daily coaches between Florence, SC and Chicago.

The busiest time of the day is the Afternoon, with 27 buses from Florence, SC to Chicago, while Morning sees the fewest connections between Florence, SC and Chicago, with 20 offers.

Facts about the bus from Florence, SC to Chicago

Compare all providers like Greyhound US and FlixBus that travel 11 times every day by bus from Florence, SC to Chicago in one click! Book your bus ticket from Florence, SC to Chicago starting from $104!

Cheapest Bus	$104
Fastest Bus	23h 5m
Earliest Bus	11:55 AM
Latest Bus	4:30 PM
Daily Bus Routes	11 Ø
Distance	681.8 miles
Bus Companies	Greyhound US and FlixBus

Cheapest bus connections from Florence, SC to Chicago

Every day, 11 buses from 2 bus companies leave Florence, SC for Chicago: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 04/20/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 04/19

Monday 04/20

$109

Tuesday 04/21

$115

Wednesday 04/22

Thursday 04/23

$122

Friday 04/24

$121

Saturday 04/25

$136

Sunday 04/26

$120

Monday 04/27

$116

Tuesday 04/28

$117

Wednesday 04/29

$117

Thursday 04/30

Friday 05/01

$121

Saturday 05/02

$121

Sunday 05/03

$121

Monday 05/04

$121

Tuesday 05/05

Wednesday 05/06

Thursday 05/07

Friday 05/08

$107

Saturday 05/09

$104

Sunday 05/10

$104

Monday 05/11

$105

Tuesday 05/12

$107

Wednesday 05/13

$118

Thursday 05/14

$109

Friday 05/15

$120

Saturday 05/16

The cheapest time to travel from Florence, SC to Chicago

See here on which day and which time of the day you can find the cheapest bus ticket from Florence, SC to Chicago, for the next 30 days.

With a price starting from $104, Sunday is the cheapest day for a bus from Florence, SC to Chicago. Thursday instead is the most expensive day with prices starting from $109.

Night is the cheapest day time for bus tickets from Florence, SC to Chicago, with $104. Morning is the most expensive time of the day with prices starting from $109.

How to save money travelling from Florence, SC to Chicago

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Florence, SC to Chicago in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Florence, SC to Chicago, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Florence, SC to Chicago are also emptier.

All bus stations and stops in Florence, SC and Chicago

In the map below, you can see where to find all bus stations in Florence, SC and Chicago.

Bus Station

S Irby St 611

TA Travel Center

W Lucas St 2301

Exxon Gas Station

W Lucas Street 1901

McDonalds

W. Lucas St. 1908

Shell Gas Station

W Lucas Street 1832

95th Red Line Station

W. 95th St 14

Downtown Bus Station

West Harrison Street 630-670

Union Station

S Canal St 225

Cumberland CTA

N Cumberland Ave 5800

Canal & Van Buren

S Canal St 310-320

Service and Comfort on the bus from Florence, SC to Chicago

Want to know which seat classes are available on the buses from Florence, SC to Chicago? Or which bus companies serve the route Florence, SC to Chicago? Below you will find answers to your questions.

FAQs about the Florence, SC to Chicago bus

How much does a Florence, SC Chicago bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $104 and takes 23h 35m to reach Chicago. Compare offers to save money!

How much could I save by comparing buses from Florence, SC to Chicago?

This route is offered by 2 companies with a range of ticket prices between $104 and $140. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Chicago.

On average, how many connections are available from Florence, SC to Chicago each day?

Every day, the Florence, SC to Chicago bus route is served by approximately 11 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Florence, SC to Chicago take?

The fastest bus from Florence, SC to Chicago is offered by Greyhound US and takes 23h 5m. Bus tickets for this connection cost $109. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Florence, SC to Chicago?

The earliest bus arriving in Chicago from Florence, SC starts at 11:55 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Florence, SC to Chicago?

The latest bus trip departing from Florence, SC for Chicago starts at 4:30 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Florence, SC Chicago route?

When traveling by bus from Florence, SC to Chicago, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Florence, SC and Chicago?

You can check all the direct connections between Florence, SC and Chicago by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the Florence, SC to Chicago bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Florence, SC Chicago bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Florence, SC Chicago bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Florence, SC to Chicago on your planned travel date.

How does CheckMyBus find the best bus deals from Florence, SC to Chicago?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 11 daily trips between Florence, SC and Chicago. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Florence, SC to Chicago?

Prices and availability for 11 trips between Florence, SC and Chicago change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Florence, SC to Chicago

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Florence, SC and to Chicago

Here’s an overview of the most popular bus routes to Florence, SC and to Chicago. Simply click on the connection of your choice, and you will find all the details about your bus route!