Bus from Florence, SC to Chicago from $81

Compare all the bus companies and find the best price with CheckMyBus
The Best Deals Save up to 70%
The Most Choices Millions of routes worldwide
Easy and Transparent Compare offers with 1 click

Compare all timetables for the bus from Florence, SC to Chicago

Here is a selection of the cheapest bus trips from the schedule from Florence, SC to Chicago from various bus operators like Greyhound US or FlixBus for the next days.

today
$94
tomorrow
$89
Wednesday
$88
Thursday
Friday
$89
Saturday
$88
Sunday
$84

Cheapest bus trips today

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 23h 55m 12:10 PM Florence, SC Bus Station 11:05 AM Chicago 95th Red Line Station  Economy $94
Greyhound US 27h 15m 4:10 PM Florence, SC Bus Station 6:25 PM Chicago 95th Red Line Station  Economy $95
Greyhound US 29h 35m 7:20 PM Florence, SC Bus Station 11:55 PM Chicago 95th Red Line Station  Economy $95
FlixBus 29h 5m 5:45 AM Florence, SC TA Travel Center 9:50 AM Chicago 95th Red Line Station  Economy $114
FlixBus 27h 40m 5:45 AM Florence, SC TA Travel Center 8:25 AM Chicago Downtown Bus Station  Economy $119

Cheapest bus trips tomorrow

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 29h 35m 7:20 PM Florence, SC Bus Station 11:55 PM Chicago 95th Red Line Station  Economy $89
Greyhound US 27h 15m 4:10 PM Florence, SC Bus Station 6:25 PM Chicago 95th Red Line Station  Economy $97
Greyhound US 29h 50m 7:20 PM Florence, SC Bus Station 12:10 AM Chicago Downtown Bus Station  Economy $101
FlixBus 34h 45m 12:05 AM Florence, SC TA Travel Center 9:50 AM Chicago 95th Red Line Station  Economy $125

Cheapest bus trips Wednesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 29h 35m 7:20 PM Florence, SC Bus Station 11:55 PM Chicago 95th Red Line Station  Economy $88
Greyhound US 23h 55m 12:10 PM Florence, SC Bus Station 11:05 AM Chicago 95th Red Line Station  Economy $90
Greyhound US 28h 30m 4:10 PM Florence, SC Bus Station 7:40 PM Chicago 95th Red Line Station  Economy $91
Greyhound US 29h 50m 7:20 PM Florence, SC Bus Station 12:10 AM Chicago Downtown Bus Station  Economy $106
Greyhound US 24h 5m 4:10 PM Florence, SC Bus Station 3:15 PM Chicago Downtown Bus Station  Economy $108

Cheapest bus trips Friday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 29h 35m 7:20 PM Florence, SC Bus Station 11:55 PM Chicago 95th Red Line Station  Economy $89
Greyhound US 23h 55m 12:10 PM Florence, SC Bus Station 11:05 AM Chicago 95th Red Line Station  Economy $91
Greyhound US 27h 15m 4:10 PM Florence, SC Bus Station 6:25 PM Chicago 95th Red Line Station  Economy $92
Greyhound US 24h 5m 4:10 PM Florence, SC Bus Station 3:15 PM Chicago Downtown Bus Station  Economy $111
Greyhound US 29h 50m 7:20 PM Florence, SC Bus Station 12:10 AM Chicago Downtown Bus Station  Economy $111

Cheapest bus trips Saturday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 23h 55m 12:10 PM Florence, SC Bus Station 11:05 AM Chicago 95th Red Line Station  Economy $88
Greyhound US 27h 15m 4:10 PM Florence, SC Bus Station 6:25 PM Chicago 95th Red Line Station  Economy $89
Greyhound US 29h 35m 7:20 PM Florence, SC Bus Station 11:55 PM Chicago 95th Red Line Station  Economy $89
Greyhound US 24h 20m 12:10 PM Florence, SC Bus Station 11:30 AM Chicago Downtown Bus Station  Economy $109
Greyhound US 24h 5m 4:10 PM Florence, SC Bus Station 3:15 PM Chicago Downtown Bus Station  Economy $109

Cheapest bus trips Sunday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 29h 35m 7:20 PM Florence, SC Bus Station 11:55 PM Chicago 95th Red Line Station  Economy $84
Greyhound US 23h 55m 12:10 PM Florence, SC Bus Station 11:05 AM Chicago 95th Red Line Station  Economy $85
Greyhound US 27h 15m 4:10 PM Florence, SC Bus Station 6:25 PM Chicago 95th Red Line Station  Economy $86
Greyhound US 24h 20m 12:10 PM Florence, SC Bus Station 11:30 AM Chicago Downtown Bus Station  Economy $109
Greyhound US 24h 5m 4:10 PM Florence, SC Bus Station 3:15 PM Chicago Downtown Bus Station  Economy $109

Best Price Offer: The price for the cheapest bus from Florence, SC to Chicago is $81 on 9/17/2026. Flexible travelers save on ticket prices.


Frequency of bus connections between Florence, SC and Chicago

See here how frequent the connections between Florence, SC and Chicago are, during different times and days of the week.
Monday is the busiest day, with more than 13 daily buses from Florence, SC to Chicago. Sunday has instead the fewest connections, with only 8 daily coaches between Florence, SC and Chicago.
The busiest time of the day is the Afternoon, with 30 buses from Florence, SC to Chicago, while Night sees the fewest connections between Florence, SC and Chicago, with 6 offers.

Facts about the bus from Florence, SC to Chicago

Compare all providers like Greyhound US and FlixBus that travel 9 times every day by bus from Florence, SC to Chicago in one click! Book your bus ticket from Florence, SC to Chicago starting from $81!

Cheapest Bus $81
Fastest Bus 22h 55m
Earliest Bus 12:05 AM
Latest Bus 7:20 PM
Daily Bus Routes 9 Ø
Distance 681.8 miles
Bus Companies Greyhound US and FlixBus

Cheapest bus connections from Florence, SC to Chicago

Every day, 9 buses from 2 bus companies leave Florence, SC for Chicago: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 08/24/2026 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 08/23
Monday 08/24
$114
Tuesday 08/25
$89
Wednesday 08/26
$88
Thursday 08/27
Friday 08/28
$89
Saturday 08/29
$88
Sunday 08/30
$84
Monday 08/31
Tuesday 09/01
$131
Wednesday 09/02
Thursday 09/03
$108
Friday 09/04
$145
Saturday 09/05
$135
Sunday 09/06
$128
Monday 09/07
Tuesday 09/08
$146
Wednesday 09/09
$111
Thursday 09/10
$105
Friday 09/11
$123
Saturday 09/12
$101
Sunday 09/13
Monday 09/14
$95
Tuesday 09/15
$84
Wednesday 09/16
Thursday 09/17
$81
Friday 09/18
$111
Saturday 09/19

The cheapest time to travel from Florence, SC to Chicago

See here on which day and which time of the day you can find the cheapest bus ticket from Florence, SC to Chicago, for the next 30 days.
With a price starting from $84, Sunday is the cheapest day for a bus from Florence, SC to Chicago. Monday instead is the most expensive day with prices starting from $94.
Night is the cheapest day time for bus tickets from Florence, SC to Chicago, with $81. Afternoon is the most expensive time of the day with prices starting from $85.

How to save money travelling from Florence, SC to Chicago

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Florence, SC to Chicago in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Florence, SC to Chicago, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Florence, SC to Chicago are also emptier.

All bus stations and stops in Florence, SC and Chicago

In the map below, you can see where to find all bus stations in Florence, SC and Chicago.

Service and Comfort on the bus from Florence, SC to Chicago

Want to know which seat classes are available on the buses from Florence, SC to Chicago? Or which bus companies serve the route Florence, SC to Chicago? Below you will find answers to your questions.

FAQs about the Florence, SC to Chicago bus

How much does a Florence, SC Chicago bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $81 and takes 28h 35m to reach Chicago. Compare offers to save money!

How much could I save by comparing buses from Florence, SC to Chicago?

This route is offered by 2 companies with a range of ticket prices between $81 and $152. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Chicago.

On average, how many connections are available from Florence, SC to Chicago each day?

Every day, the Florence, SC to Chicago bus route is served by approximately 9 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Florence, SC to Chicago take?

The fastest bus from Florence, SC to Chicago is offered by Greyhound US and takes 22h 55m. Bus tickets for this connection cost $94. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Florence, SC to Chicago?

The earliest bus arriving in Chicago from Florence, SC starts at 12:05 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Florence, SC to Chicago?

The latest bus trip departing from Florence, SC for Chicago starts at 7:20 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Florence, SC Chicago route?

When traveling by bus from Florence, SC to Chicago, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Florence, SC and Chicago?

You can check all the direct connections between Florence, SC and Chicago by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the Florence, SC to Chicago bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Florence, SC Chicago bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Florence, SC Chicago bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Florence, SC to Chicago on your planned travel date.

How does CheckMyBus find the best bus deals from Florence, SC to Chicago?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 9 daily trips between Florence, SC and Chicago. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Florence, SC to Chicago?

Prices and availability for 9 trips between Florence, SC and Chicago change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Florence, SC to Chicago

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Florence, SC and to Chicago

Here’s an overview of the most popular bus routes to Florence, SC and to Chicago. Simply click on the connection of your choice, and you will find all the details about your bus route!
Bus Phoenix, AZ - Florence, SC Bus Phoenix, AZ - Florence, SC
Bus from Toledo, OH to Florence, SC Bus from Toledo, OH to Florence, SC
Bus Conyers, GA - Florence, SC Bus Conyers, GA - Florence, SC
Bus from Oklahoma City, OK to Florence, SC Bus from Oklahoma City, OK to Florence, SC
Bus to Chicago from Ciudad Hidalgo Bus to Chicago from Ciudad Hidalgo
Bus Salvatierra to Chicago Bus Salvatierra to Chicago
Bus from New Britain, CT to Chicago Bus from New Britain, CT to Chicago
Buses Grand Rapids, MI - Chicago Buses Grand Rapids, MI - Chicago
Popular Airport Shuttles to Florence, SC and to Chicago
CheckMyBus › Buses in USA › Bus to Florence, SC › Bus to Chicago

The CheckMyBus App

Free Download

App Store
CheckMyBus App
Close
GPDR CheckMyBus shield

We value your privacy!

To

show

you

the

best

bus

offers,

we

and

our

partners

use

technical,

analytical,

and

marketing

cookies

to

personalize

the

ads.

We

remember

your

anonymized

details

to

provide

a

personalized

experience.