Bus from Florence, SC to Chicago from $79

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Compare all timetables for the bus from Florence, SC to Chicago

Here is a selection of the cheapest bus trips from the schedule from Florence, SC to Chicago from various bus operators like Greyhound US or FlixBus for the next days.

today
$109
tomorrow
$91
Monday
$79
Tuesday
$91
Wednesday
Thursday
$95
Friday
$107

Cheapest bus trips today

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 30h 20m 6:35 PM Florence, SC Bus Station 11:55 PM Chicago 95th Red Line Station  Economy $109
Greyhound US 30h 35m 6:35 PM Florence, SC Bus Station 12:10 AM Chicago Downtown Bus Station  Economy $122
Greyhound US 28h 30m 2:55 PM Florence, SC Bus Station 6:25 PM Chicago 95th Red Line Station  Economy $129
FlixBus 29h 35m 5:45 AM Florence, SC TA Travel Center 10:20 AM Chicago 95th Red Line Station  Economy $152
FlixBus 27h 40m 5:45 AM Florence, SC TA Travel Center 8:25 AM Chicago Downtown Bus Station  Economy $160

Cheapest bus trips tomorrow

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 23h 55m 12:10 PM Florence, SC Bus Station 11:05 AM Chicago 95th Red Line Station  Economy $91
Greyhound US 28h 30m 2:55 PM Florence, SC Bus Station 6:25 PM Chicago 95th Red Line Station  Economy $92
Greyhound US 29h 35m 7:20 PM Florence, SC Bus Station 11:55 PM Chicago 95th Red Line Station  Economy $94
FlixBus 27h 40m 5:45 AM Florence, SC TA Travel Center 8:25 AM Chicago Downtown Bus Station  Economy $133
FlixBus 27h 15m 5:45 AM Florence, SC TA Travel Center 8:00 AM Chicago Union Station  Economy $133

Cheapest bus trips Monday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 24h 0m 12:05 PM Florence, SC Bus Station 11:05 AM Chicago 95th Red Line Station  Economy $79
Greyhound US 29h 35m 7:20 PM Florence, SC Bus Station 11:55 PM Chicago 95th Red Line Station  Economy $80
Greyhound US 33h 35m 2:55 PM Florence, SC Bus Station 11:30 PM Chicago 95th Red Line Station  Economy $81
FlixBus 29h 35m 5:45 AM Florence, SC TA Travel Center 10:20 AM Chicago 95th Red Line Station  Economy $108
FlixBus 30h 35m 12:05 AM Florence, SC TA Travel Center 5:40 AM Chicago 95th Red Line Station  Economy $123

Cheapest bus trips Tuesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 24h 0m 12:05 PM Florence, SC Bus Station 11:05 AM Chicago 95th Red Line Station  Economy $91
Greyhound US 29h 45m 2:55 PM Florence, SC Bus Station 7:40 PM Chicago 95th Red Line Station  Economy $92
Greyhound US 41h 30m 6:35 PM Florence, SC Bus Station 11:05 AM Chicago 95th Red Line Station  Economy $95
FlixBus 35h 15m 12:05 AM Florence, SC TA Travel Center 10:20 AM Chicago 95th Red Line Station  Economy $109
FlixBus 32h 55m 12:05 AM Florence, SC TA Travel Center 8:00 AM Chicago Union Station  Economy $116

Cheapest bus trips Thursday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 29h 35m 5:45 AM Florence, SC TA Travel Center 10:20 AM Chicago 95th Red Line Station  Economy $95
FlixBus 27h 15m 5:45 AM Florence, SC TA Travel Center 8:00 AM Chicago Union Station  Economy $131
FlixBus 27h 40m 5:45 AM Florence, SC TA Travel Center 8:25 AM Chicago Downtown Bus Station  Economy $131

Cheapest bus trips Friday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 29h 35m 5:45 AM Florence, SC TA Travel Center 10:20 AM Chicago 95th Red Line Station  Economy $107
FlixBus 30h 35m 12:05 AM Florence, SC TA Travel Center 5:40 AM Chicago 95th Red Line Station  Economy $120
FlixBus 27h 40m 5:45 AM Florence, SC TA Travel Center 8:25 AM Chicago Downtown Bus Station  Economy $141
FlixBus 27h 15m 5:45 AM Florence, SC TA Travel Center 8:00 AM Chicago Union Station  Economy $141
FlixBus 31h 5m 12:05 AM Florence, SC TA Travel Center 6:10 AM Chicago Downtown Bus Station  Economy $152

Best Price Offer: The price for the cheapest bus from Florence, SC to Chicago is $79 on 10/19/2026. Flexible travelers save on ticket prices.


Frequency of bus connections between Florence, SC and Chicago

See here how frequent the connections between Florence, SC and Chicago are, during different times and days of the week.
Tuesday is the busiest day, with more than 21 daily buses from Florence, SC to Chicago. Thursday has instead the fewest connections, with only 3 daily coaches between Florence, SC and Chicago.
The busiest time of the day is the Afternoon, with 36 buses from Florence, SC to Chicago, while Evening sees the fewest connections between Florence, SC and Chicago, with 18 offers.

Facts about the bus from Florence, SC to Chicago

Compare all providers like Greyhound US and FlixBus that travel 12 times every day by bus from Florence, SC to Chicago in one click! Book your bus ticket from Florence, SC to Chicago starting from $79!

Cheapest Bus $79
Fastest Bus 22h 55m
Earliest Bus 5:45 AM
Latest Bus 5:45 AM
Daily Bus Routes 12 Ø
Distance 681.8 miles
Bus Companies Greyhound US and FlixBus

Cheapest bus connections from Florence, SC to Chicago

Every day, 12 buses from 2 bus companies leave Florence, SC for Chicago: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 10/17/2026 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 10/11
Monday 10/12
Tuesday 10/13
Wednesday 10/14
Thursday 10/15
Friday 10/16
Saturday 10/17
$109
Sunday 10/18
$133
Monday 10/19
$79
Tuesday 10/20
$91
Wednesday 10/21
Thursday 10/22
$95
Friday 10/23
$107
Saturday 10/24
$93
Sunday 10/25
$115
Monday 10/26
$90
Tuesday 10/27
$85
Wednesday 10/28
Thursday 10/29
$131
Friday 10/30
$101
Saturday 10/31
$106
Sunday 11/01
Monday 11/02
Tuesday 11/03
$129
Wednesday 11/04
$86
Thursday 11/05
$82
Friday 11/06
$85
Saturday 11/07

The cheapest time to travel from Florence, SC to Chicago

See here on which day and which time of the day you can find the cheapest bus ticket from Florence, SC to Chicago, for the next 30 days.
With a price starting from $79, Monday is the cheapest day for a bus from Florence, SC to Chicago. Saturday instead is the most expensive day with prices starting from $93.
Afternoon is the cheapest day time for bus tickets from Florence, SC to Chicago, with $79. Evening is the most expensive time of the day with prices starting from $80.

How to save money travelling from Florence, SC to Chicago

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Florence, SC to Chicago in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Florence, SC to Chicago, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Florence, SC to Chicago are also emptier.

Beloved bus companies from Florence, SC to Chicago

These are the most booked bus companies between Florence, SC to Chicago from our users.

Greyhound US from Florence, SC to Chicago

Greyhound US

Here you will find the key facts about the Greyhound US bus route Florence, SC to Chicago:

Cheapest Price $79
Fastest Bus 22h 55m
Earliest Bus 12:05 PM
Last Bus 6:35 PM
Daily Connections 13 Ø
Found on 10/8/2026

All bus stations and stops in Florence, SC and Chicago

In the map below, you can see where to find all bus stations in Florence, SC and Chicago.

Service and Comfort on the bus from Florence, SC to Chicago

Want to know which seat classes are available on the buses from Florence, SC to Chicago? Or which bus companies serve the route Florence, SC to Chicago? Below you will find answers to your questions.

FAQs about the Florence, SC to Chicago bus

How much does a Florence, SC Chicago bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $79 and takes 23h 0m to reach Chicago. Compare offers to save money!

How much could I save by comparing buses from Florence, SC to Chicago?

This route is offered by 2 companies with a range of ticket prices between $79 and $173. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Chicago.

On average, how many connections are available from Florence, SC to Chicago each day?

Every day, the Florence, SC to Chicago bus route is served by approximately 12 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Florence, SC to Chicago take?

The fastest bus from Florence, SC to Chicago is offered by Greyhound US and takes 22h 55m. Bus tickets for this connection cost $91. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Florence, SC to Chicago?

The earliest bus arriving in Chicago from Florence, SC starts at 5:45 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Florence, SC to Chicago?

The latest bus trip departing from Florence, SC for Chicago starts at 5:45 AM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Florence, SC Chicago route?

When traveling by bus from Florence, SC to Chicago, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Florence, SC and Chicago?

You can check all the direct connections between Florence, SC and Chicago by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the Florence, SC to Chicago bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Florence, SC Chicago bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Florence, SC Chicago bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Florence, SC to Chicago on your planned travel date.

How does CheckMyBus find the best bus deals from Florence, SC to Chicago?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 12 daily trips between Florence, SC and Chicago. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Florence, SC to Chicago?

Prices and availability for 12 trips between Florence, SC and Chicago change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Florence, SC to Chicago

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Florence, SC and to Chicago

Here’s an overview of the most popular bus routes to Florence, SC and to Chicago. Simply click on the connection of your choice, and you will find all the details about your bus route!
Bus from Ocala, FL to Florence, SC Bus from Ocala, FL to Florence, SC
Bus to Florence, SC from Utica, NY Bus to Florence, SC from Utica, NY
Bus to Florence, SC from Greenville, SC Bus to Florence, SC from Greenville, SC
Bus from Bakersfield, CA to Florence, SC Bus from Bakersfield, CA to Florence, SC
Bus Matamoros to Chicago Bus Matamoros to Chicago
Bus Mesa, AZ to Chicago Bus Mesa, AZ to Chicago
Bus to Chicago from Hamilton, ON Bus to Chicago from Hamilton, ON
Bus to Chicago from Holland, MI Bus to Chicago from Holland, MI
Popular Airport Shuttles to Florence, SC and to Chicago
CheckMyBus › Buses in USA › Bus to Florence, SC › Bus to Chicago

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