Bus Santa Ana, CA to St. Louis, MO - Compare all Companies

Compare all timetables for the bus from Santa Ana, CA to St. Louis, MO

Here is a selection of the cheapest bus trips from the schedule from Santa Ana, CA to St. Louis, MO from various bus operators like Greyhound US for the next days.

today

$215

tomorrow

$241

Sunday

Monday

Tuesday

Wednesday

Thursday

$253

Cheapest bus trips today
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	47h 20m	11:35 AM	Santa Ana, CA	Bus Stop	12:55 PM	St. Louis, MO	Gateway Station		Economy	$215	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 12/5/2025 11:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/7/2025 12:55:00 PM. 50 Economy ticket for $215 per person are available. Travel duration is 47h 20m
	Greyhound US	44h 25m	8:45 AM	Santa Ana, CA	Bus Stop	7:10 AM	St. Louis, MO	Gateway Station		Economy	$220	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 12/5/2025 8:45:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/7/2025 7:10:00 AM. 50 Economy ticket for $220 per person are available. Travel duration is 44h 25m

Cheapest bus trips tomorrow
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	47h 20m	11:35 AM	Santa Ana, CA	Bus Stop	12:55 PM	St. Louis, MO	Gateway Station		Economy	$241	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 12/6/2025 11:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/8/2025 12:55:00 PM. 50 Economy ticket for $241 per person are available. Travel duration is 47h 20m
	Greyhound US	44h 25m	8:45 AM	Santa Ana, CA	Bus Stop	7:10 AM	St. Louis, MO	Gateway Station		Economy	$248	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 12/6/2025 8:45:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/8/2025 7:10:00 AM. 50 Economy ticket for $248 per person are available. Travel duration is 44h 25m

Cheapest bus trips Thursday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	47h 20m	11:35 AM	Santa Ana, CA	Bus Stop	12:55 PM	St. Louis, MO	Gateway Station		Economy	$253	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 12/11/2025 11:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/13/2025 12:55:00 PM. 50 Economy ticket for $253 per person are available. Travel duration is 47h 20m
	Greyhound US	44h 25m	8:45 AM	Santa Ana, CA	Bus Stop	7:10 AM	St. Louis, MO	Gateway Station		Economy	$256	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 12/11/2025 8:45:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/13/2025 7:10:00 AM. 50 Economy ticket for $256 per person are available. Travel duration is 44h 25m

Did you know that if you travel from Santa Ana, CA to St. Louis, MO via Phoenix, AZ, you can save more than $78? You can find the corresponding connections below.
- Busbud
  
  44h 25m
  
  0
  
  8:45 AM
  
  Santa Ana, CA
  Bus Stop
  
  10:15 PM
  
  Phoenix, AZ
  Bus Station
  
  0
  
  Economy
  
  $48
  
  A Bus from Busbud goes from Bus Stop, Santa Ana, CA (USA) at 12/10/2025 8:45:00 AM to Bus Station, Phoenix, AZ (USA) arriving at 12/10/2025 10:15:00 PM. 50 Economy ticket for $48 per person are available. Travel duration is 12h 30m
- FlixBus
  
  30h 25m
  
  0
  
  11:45 PM
  
  Phoenix, AZ
  Bus Station
  
  7:10 AM
  
  St. Louis, MO
  Gateway Station
  
  0
  
  Economy
  
  $127
  
  A Bus from FlixBus goes from Bus Station, Phoenix, AZ (USA) at 12/10/2025 11:45:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/12/2025 7:10:00 AM. 50 Economy ticket for $127 per person are available. Travel duration is 30h 25m
Travel Time is 2h 0m shorter, and you will save $78

Best Price Offer: The price for the cheapest bus from Santa Ana, CA to St. Louis, MO is $197 on 12/3/2025. Flexible travelers save on ticket prices.

Facts about the bus from Santa Ana, CA to St. Louis, MO

Compare all providers like Greyhound US that travel 2 times every day by bus from Santa Ana, CA to St. Louis, MO in one click! Book your bus ticket from Santa Ana, CA to St. Louis, MO starting from $197!

Cheapest Bus	$197
Fastest Bus	46h 25m
Earliest Bus	8:45 AM
Latest Bus	11:35 AM
Daily Bus Routes	2 Ø
Distance	1,573.3 miles
Bus Companies	Greyhound US

Cheapest bus connections from Santa Ana, CA to St. Louis, MO

Every day, 2 buses from 1 bus companies leave Santa Ana, CA for St. Louis, MO: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/05/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 11/30

Monday 12/01

Tuesday 12/02

Wednesday 12/03

Thursday 12/04

Friday 12/05

$215

Saturday 12/06

$241

Sunday 12/07

Monday 12/08

Tuesday 12/09

Wednesday 12/10

Thursday 12/11

$253

Friday 12/12

Saturday 12/13

Sunday 12/14

Monday 12/15

Tuesday 12/16

Wednesday 12/17

Thursday 12/18

Friday 12/19

Saturday 12/20

Sunday 12/21

Monday 12/22

Tuesday 12/23

Wednesday 12/24

Thursday 12/25

Friday 12/26

Saturday 12/27

How to save money travelling from Santa Ana, CA to St. Louis, MO

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Santa Ana, CA to St. Louis, MO in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Santa Ana, CA to St. Louis, MO, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Santa Ana, CA to St. Louis, MO are also emptier.

All bus stations and stops in Santa Ana, CA and St. Louis, MO

In the map below, you can see where to find all bus stations in Santa Ana, CA and St. Louis, MO.

Bus Stop

1000 E Santa Ana Blvd 105

Gateway Station

S 15th St 430

Skinker Boulevard

Boulevard between Lindell Blvd. and Lagoon Drive

Lindbergh @ Hackberry NB Bus Stop

Service and Comfort on the bus from Santa Ana, CA to St. Louis, MO

Want to know which seat classes are available on the buses from Santa Ana, CA to St. Louis, MO? Or which bus companies serve the route Santa Ana, CA to St. Louis, MO? Below you will find answers to your questions.

FAQs about the Santa Ana, CA to St. Louis, MO bus

How much does a Santa Ana, CA St. Louis, MO bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $197 and takes 49h 20m to reach St. Louis, MO. Compare offers to save money!

How much could I save by comparing buses from Santa Ana, CA to St. Louis, MO?

This route is offered by 1 companies with a range of ticket prices between $197 and $256. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to St. Louis, MO.

On average, how many connections are available from Santa Ana, CA to St. Louis, MO each day?

Every day, the Santa Ana, CA to St. Louis, MO bus route is served by approximately 2 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Santa Ana, CA to St. Louis, MO take?

The fastest bus from Santa Ana, CA to St. Louis, MO is offered by Greyhound US and takes 46h 25m. Bus tickets for this connection cost $220. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Santa Ana, CA to St. Louis, MO?

The earliest bus arriving in St. Louis, MO from Santa Ana, CA starts at 8:45 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Santa Ana, CA to St. Louis, MO?

The latest bus trip departing from Santa Ana, CA for St. Louis, MO starts at 11:35 AM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Santa Ana, CA St. Louis, MO route?

When traveling by bus from Santa Ana, CA to St. Louis, MO, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Santa Ana, CA and St. Louis, MO?

You can check all the direct connections between Santa Ana, CA and St. Louis, MO by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Santa Ana, CA to St. Louis, MO bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Santa Ana, CA St. Louis, MO bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Santa Ana, CA St. Louis, MO bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Santa Ana, CA to St. Louis, MO on your planned travel date.

Available seat classes which are offered on the bus route Santa Ana, CA to St. Louis, MO

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Santa Ana, CA and to St. Louis, MO

Here’s an overview of the most popular bus routes to Santa Ana, CA and to St. Louis, MO. Simply click on the connection of your choice, and you will find all the details about your bus route!