Bus St. Louis, MO to Santa Ana, CA: Compare prices and save money

Compare all timetables for the bus from St. Louis, MO to Santa Ana, CA

Here is a selection of the cheapest bus trips from the schedule from St. Louis, MO to Santa Ana, CA from various bus operators like Greyhound US for the next days.

today

$250

tomorrow

Sunday

Monday

$257

Tuesday

Wednesday

Thursday

$289

Cheapest bus trips today
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	44h 10m	1:20 AM	St. Louis, MO	Gateway Station	7:30 PM	Santa Ana, CA	Bus Stop		Economy	$250	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/5/2025 1:20:00 AM to Bus Stop, Santa Ana, CA (USA) arriving at 12/6/2025 7:30:00 PM. 50 Economy ticket for $250 per person are available. Travel duration is 44h 10m

Cheapest bus trips Monday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	44h 10m	1:20 AM	St. Louis, MO	Gateway Station	7:30 PM	Santa Ana, CA	Bus Stop		Economy	$257	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/8/2025 1:20:00 AM to Bus Stop, Santa Ana, CA (USA) arriving at 12/9/2025 7:30:00 PM. 50 Economy ticket for $257 per person are available. Travel duration is 44h 10m

Did you know that if you travel from St. Louis, MO to Santa Ana, CA via Las Vegas, you can save more than $58? You can find the corresponding connections below.
- FlixBus
  
  45h 0m
  
  0
  
  4:30 PM
  
  St. Louis, MO
  Gateway Station
  
  1:35 AM
  
  Las Vegas
  South Strip Transit Terminal
  
  0
  
  Economy
  
  $166
  
  A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/8/2025 4:30:00 PM to South Strip Transit Terminal, Las Vegas (USA) arriving at 12/10/2025 1:35:00 AM. 50 Economy ticket for $166 per person are available. Travel duration is 35h 5m
- Busbud
  
  5h 40m
  
  0
  
  5:50 AM
  
  Las Vegas
  South Strip Transit Terminal
  
  11:30 AM
  
  Santa Ana, CA
  Bus Stop
  
  0
  
  Economy
  
  $33
  
  A Bus from Busbud goes from South Strip Transit Terminal, Las Vegas (USA) at 12/10/2025 5:50:00 AM to Bus Stop, Santa Ana, CA (USA) arriving at 12/10/2025 11:30:00 AM. 50 Economy ticket for $33 per person are available. Travel duration is 5h 40m
Travel time is 2h 50m longer, but you will save $58

Cheapest bus trips Thursday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	44h 10m	1:20 AM	St. Louis, MO	Gateway Station	7:30 PM	Santa Ana, CA	Bus Stop		Economy	$289	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/11/2025 1:20:00 AM to Bus Stop, Santa Ana, CA (USA) arriving at 12/12/2025 7:30:00 PM. 50 Economy ticket for $289 per person are available. Travel duration is 44h 10m

Did you know that if you travel from St. Louis, MO to Santa Ana, CA via Las Vegas, you can save more than $90? You can find the corresponding connections below.
- FlixBus
  
  45h 0m
  
  0
  
  4:30 PM
  
  St. Louis, MO
  Gateway Station
  
  1:35 AM
  
  Las Vegas
  South Strip Transit Terminal
  
  0
  
  Economy
  
  $166
  
  A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/8/2025 4:30:00 PM to South Strip Transit Terminal, Las Vegas (USA) arriving at 12/10/2025 1:35:00 AM. 50 Economy ticket for $166 per person are available. Travel duration is 35h 5m
- Busbud
  
  5h 40m
  
  0
  
  5:50 AM
  
  Las Vegas
  South Strip Transit Terminal
  
  11:30 AM
  
  Santa Ana, CA
  Bus Stop
  
  0
  
  Economy
  
  $33
  
  A Bus from Busbud goes from South Strip Transit Terminal, Las Vegas (USA) at 12/10/2025 5:50:00 AM to Bus Stop, Santa Ana, CA (USA) arriving at 12/10/2025 11:30:00 AM. 50 Economy ticket for $33 per person are available. Travel duration is 5h 40m
Travel time is 2h 50m longer, but you will save $90

Best Price Offer: The price for the cheapest bus from St. Louis, MO to Santa Ana, CA is $250 on 12/5/2025. Flexible travelers save on ticket prices.

Facts about the bus from St. Louis, MO to Santa Ana, CA

Compare all providers like Greyhound US that travel 1 times every day by bus from St. Louis, MO to Santa Ana, CA in one click! Book your bus ticket from St. Louis, MO to Santa Ana, CA starting from $250!

Cheapest Bus	$250
Fastest Bus	42h 10m
Earliest Bus	1:20 AM
Latest Bus	1:20 AM
Daily Bus Routes	1 Ø
Distance	1,573.3 miles
Bus Companies	Greyhound US

Cheapest bus connections from St. Louis, MO to Santa Ana, CA

Every day, 1 buses from 1 bus companies leave St. Louis, MO for Santa Ana, CA: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/05/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 11/30

Monday 12/01

Tuesday 12/02

Wednesday 12/03

Thursday 12/04

Friday 12/05

$250

Saturday 12/06

Sunday 12/07

Monday 12/08

$257

Tuesday 12/09

Wednesday 12/10

Thursday 12/11

$289

Friday 12/12

Saturday 12/13

Sunday 12/14

Monday 12/15

Tuesday 12/16

Wednesday 12/17

Thursday 12/18

Friday 12/19

Saturday 12/20

Sunday 12/21

Monday 12/22

Tuesday 12/23

Wednesday 12/24

Thursday 12/25

Friday 12/26

Saturday 12/27

How to save money travelling from St. Louis, MO to Santa Ana, CA

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from St. Louis, MO to Santa Ana, CA in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from St. Louis, MO to Santa Ana, CA, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from St. Louis, MO to Santa Ana, CA are also emptier.

All bus stations and stops in St. Louis, MO and Santa Ana, CA

In the map below, you can see where to find all bus stations in St. Louis, MO and Santa Ana, CA.

Gateway Station

S 15th St 430

Skinker Boulevard

Boulevard between Lindell Blvd. and Lagoon Drive

Lindbergh @ Hackberry NB Bus Stop

Bus Stop

1000 E Santa Ana Blvd 105

Service and Comfort on the bus from St. Louis, MO to Santa Ana, CA

Want to know which seat classes are available on the buses from St. Louis, MO to Santa Ana, CA? Or which bus companies serve the route St. Louis, MO to Santa Ana, CA? Below you will find answers to your questions.

FAQs about the St. Louis, MO to Santa Ana, CA bus

How much does a St. Louis, MO Santa Ana, CA bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $250 and takes 42h 10m to reach Santa Ana, CA. Compare offers to save money!

How much could I save by comparing buses from St. Louis, MO to Santa Ana, CA?

This route is offered by 1 companies with a range of ticket prices between $250 and $289. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Santa Ana, CA.

On average, how many connections are available from St. Louis, MO to Santa Ana, CA each day?

Every day, the St. Louis, MO to Santa Ana, CA bus route is served by approximately 1 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from St. Louis, MO to Santa Ana, CA take?

The fastest bus from St. Louis, MO to Santa Ana, CA is offered by Greyhound US and takes 42h 10m. Bus tickets for this connection cost $250. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from St. Louis, MO to Santa Ana, CA?

The earliest bus arriving in Santa Ana, CA from St. Louis, MO starts at 1:20 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from St. Louis, MO to Santa Ana, CA?

The latest bus trip departing from St. Louis, MO for Santa Ana, CA starts at 1:20 AM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the St. Louis, MO Santa Ana, CA route?

When traveling by bus from St. Louis, MO to Santa Ana, CA, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between St. Louis, MO and Santa Ana, CA?

You can check all the direct connections between St. Louis, MO and Santa Ana, CA by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the St. Louis, MO to Santa Ana, CA bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the St. Louis, MO Santa Ana, CA bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the St. Louis, MO Santa Ana, CA bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from St. Louis, MO to Santa Ana, CA on your planned travel date.

Available seat classes which are offered on the bus route St. Louis, MO to Santa Ana, CA

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to St. Louis, MO and to Santa Ana, CA

Here’s an overview of the most popular bus routes to St. Louis, MO and to Santa Ana, CA. Simply click on the connection of your choice, and you will find all the details about your bus route!