Bus Knoxville, TN to Chicago: Compare prices and save money

Compare all timetables for the bus from Knoxville, TN to Chicago

Here is a selection of the cheapest bus trips from the schedule from Knoxville, TN to Chicago from various bus operators like Greyhound US for the next days.

today

$114

tomorrow

$122

Sunday

$101

Monday

$99

Tuesday

$115

Wednesday

$102

Thursday

$109

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	20h 0m	10:00 PM	Knoxville, TN	Greyhound Bus Station	5:00 PM	Chicago	95th Red Line Station	Economy	$114	A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 4/10/2026 10:00:00 PM to 95th Red Line Station, Chicago (USA) arriving at 4/11/2026 5:00:00 PM. 50 Economy ticket for $114 per person are available. Travel duration is 20h 0m
Greyhound US	16h 40m	6:10 PM	Knoxville, TN	Greyhound Bus Station	9:50 AM	Chicago	95th Red Line Station	Economy	$120	A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 4/10/2026 6:10:00 PM to 95th Red Line Station, Chicago (USA) arriving at 4/11/2026 9:50:00 AM. 50 Economy ticket for $120 per person are available. Travel duration is 16h 40m
Greyhound US	16h 25m	10:00 PM	Knoxville, TN	Greyhound Bus Station	1:25 PM	Chicago	Downtown Bus Station	Economy	$129	A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 4/10/2026 10:00:00 PM to Downtown Bus Station, Chicago (USA) arriving at 4/11/2026 1:25:00 PM. 50 Economy ticket for $129 per person are available. Travel duration is 16h 25m
Greyhound US	14h 50m	6:10 PM	Knoxville, TN	Greyhound Bus Station	8:00 AM	Chicago	Union Station	Economy	$136	A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 4/10/2026 6:10:00 PM to Union Station, Chicago (USA) arriving at 4/11/2026 8:00:00 AM. 50 Economy ticket for $136 per person are available. Travel duration is 14h 50m
Greyhound US	15h 15m	6:10 PM	Knoxville, TN	Greyhound Bus Station	8:25 AM	Chicago	Downtown Bus Station	Economy	$136	A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 4/10/2026 6:10:00 PM to Downtown Bus Station, Chicago (USA) arriving at 4/11/2026 8:25:00 AM. 50 Economy ticket for $136 per person are available. Travel duration is 15h 15m

Did you know that if you travel from Knoxville, TN to Chicago via Indianapolis, you can save more than $12? You can find the corresponding connections below.
- Greyhound US
  
  17h 55m
  
  0
  
  6:10 PM
  
  Knoxville, TN
  Knoxville Area Transit Bus Stop
  
  8:25 AM
  
  Indianapolis
  Downtown Transit Center
  
  0
  
  Economy
  
  $69
  
  A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 4/11/2026 6:10:00 PM to Downtown Transit Center, Indianapolis (USA) arriving at 4/12/2026 8:25:00 AM. 50 Economy ticket for $69 per person are available. Travel duration is 14h 15m
- FlixBus
  
  3h 30m
  
  0
  
  8:35 AM
  
  Indianapolis
  Downtown Transit Center
  
  11:05 AM
  
  Chicago
  95th Red Line Station
  
  0
  
  Economy
  
  $33
  
  A Bus from FlixBus goes from Downtown Transit Center, Indianapolis (USA) at 4/12/2026 8:35:00 AM to 95th Red Line Station, Chicago (USA) arriving at 4/12/2026 11:05:00 AM. 50 Economy ticket for $33 per person are available. Travel duration is 3h 30m
Travel time is 4h 5m longer, but you will save $12

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	20h 0m	10:00 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	5:00 PM	Chicago	95th Red Line Station	Economy	$122	A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 4/11/2026 10:00:00 PM to 95th Red Line Station, Chicago (USA) arriving at 4/12/2026 5:00:00 PM. 50 Economy ticket for $122 per person are available. Travel duration is 20h 0m
Greyhound US	16h 25m	10:00 PM	Knoxville, TN	Greyhound Bus Station	1:25 PM	Chicago	Downtown Bus Station	Economy	$158	A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 4/11/2026 10:00:00 PM to Downtown Bus Station, Chicago (USA) arriving at 4/12/2026 1:25:00 PM. 50 Economy ticket for $158 per person are available. Travel duration is 16h 25m
Greyhound US	16h 40m	6:10 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	9:50 AM	Chicago	95th Red Line Station	Economy	$163	A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 4/11/2026 6:10:00 PM to 95th Red Line Station, Chicago (USA) arriving at 4/12/2026 9:50:00 AM. 50 Economy ticket for $163 per person are available. Travel duration is 16h 40m
Greyhound US	14h 50m	6:10 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	8:00 AM	Chicago	Canal & Van Buren	Economy	$204	A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 4/11/2026 6:10:00 PM to Canal & Van Buren, Chicago (USA) arriving at 4/12/2026 8:00:00 AM. 50 Economy ticket for $204 per person are available. Travel duration is 14h 50m
Greyhound US	15h 15m	6:10 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	8:25 AM	Chicago	Downtown Bus Station	Economy	$204	A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 4/11/2026 6:10:00 PM to Downtown Bus Station, Chicago (USA) arriving at 4/12/2026 8:25:00 AM. 50 Economy ticket for $204 per person are available. Travel duration is 15h 15m

Did you know that if you travel from Knoxville, TN to Chicago via Lexington, KY, you can save more than $34? You can find the corresponding connections below.
- Greyhound US
  
  20h 0m
  
  0
  
  10:00 PM
  
  Knoxville, TN
  Greyhound Bus Station
  
  1:45 AM
  
  Lexington, KY
  Greyhound Bus Station
  
  0
  
  Economy
  
  $31
  
  A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 4/12/2026 10:00:00 PM to Greyhound Bus Station, Lexington, KY (USA) arriving at 4/13/2026 1:45:00 AM. 50 Economy ticket for $31 per person are available. Travel duration is 3h 45m
- Greyhound US
  
  16h 5m
  
  0
  
  1:55 AM
  
  Lexington, KY
  Greyhound Bus Station
  
  5:00 PM
  
  Chicago
  95th Red Line Station
  
  0
  
  Economy
  
  $57
  
  A Bus from Greyhound US goes from Greyhound Bus Station, Lexington, KY (USA) at 4/13/2026 1:55:00 AM to 95th Red Line Station, Chicago (USA) arriving at 4/13/2026 5:00:00 PM. 50 Economy ticket for $57 per person are available. Travel duration is 16h 5m
Travel time is 6h 10m longer, but you will save $34

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	16h 40m	6:10 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	9:50 AM	Chicago	95th Red Line Station	Economy	$101	A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 4/12/2026 6:10:00 PM to 95th Red Line Station, Chicago (USA) arriving at 4/13/2026 9:50:00 AM. 50 Economy ticket for $101 per person are available. Travel duration is 16h 40m
Greyhound US	20h 0m	10:00 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	5:00 PM	Chicago	95th Red Line Station	Economy	$101	A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 4/12/2026 10:00:00 PM to 95th Red Line Station, Chicago (USA) arriving at 4/13/2026 5:00:00 PM. 50 Economy ticket for $101 per person are available. Travel duration is 20h 0m
Greyhound US	14h 50m	6:10 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	8:00 AM	Chicago	Canal & Van Buren	Economy	$130	A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 4/12/2026 6:10:00 PM to Canal & Van Buren, Chicago (USA) arriving at 4/13/2026 8:00:00 AM. 50 Economy ticket for $130 per person are available. Travel duration is 14h 50m
Greyhound US	15h 15m	6:10 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	8:25 AM	Chicago	Downtown Bus Station	Economy	$130	A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 4/12/2026 6:10:00 PM to Downtown Bus Station, Chicago (USA) arriving at 4/13/2026 8:25:00 AM. 50 Economy ticket for $130 per person are available. Travel duration is 15h 15m
Greyhound US	16h 25m	10:00 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	1:25 PM	Chicago	Downtown Bus Station	Economy	$131	A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 4/12/2026 10:00:00 PM to Downtown Bus Station, Chicago (USA) arriving at 4/13/2026 1:25:00 PM. 50 Economy ticket for $131 per person are available. Travel duration is 16h 25m

Did you know that if you travel from Knoxville, TN to Chicago via Lexington, KY, you can save more than $19? You can find the corresponding connections below.
- Greyhound US
  
  20h 0m
  
  0
  
  10:00 PM
  
  Knoxville, TN
  Knoxville Area Transit Bus Stop
  
  1:45 AM
  
  Lexington, KY
  Greyhound Bus Station
  
  0
  
  Economy
  
  $26
  
  A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 4/13/2026 10:00:00 PM to Greyhound Bus Station, Lexington, KY (USA) arriving at 4/14/2026 1:45:00 AM. 50 Economy ticket for $26 per person are available. Travel duration is 3h 45m
- Greyhound US
  
  16h 5m
  
  0
  
  1:55 AM
  
  Lexington, KY
  Greyhound Bus Station
  
  5:00 PM
  
  Chicago
  95th Red Line Station
  
  0
  
  Economy
  
  $56
  
  A Bus from Greyhound US goes from Greyhound Bus Station, Lexington, KY (USA) at 4/14/2026 1:55:00 AM to 95th Red Line Station, Chicago (USA) arriving at 4/14/2026 5:00:00 PM. 50 Economy ticket for $56 per person are available. Travel duration is 16h 5m
Travel time is 6h 10m longer, but you will save $19

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	16h 40m	6:10 PM	Knoxville, TN	Greyhound Bus Station	9:50 AM	Chicago	95th Red Line Station	Economy	$99	A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 4/13/2026 6:10:00 PM to 95th Red Line Station, Chicago (USA) arriving at 4/14/2026 9:50:00 AM. 50 Economy ticket for $99 per person are available. Travel duration is 16h 40m
Greyhound US	20h 0m	10:00 PM	Knoxville, TN	Greyhound Bus Station	5:00 PM	Chicago	95th Red Line Station	Economy	$100	A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 4/13/2026 10:00:00 PM to 95th Red Line Station, Chicago (USA) arriving at 4/14/2026 5:00:00 PM. 50 Economy ticket for $100 per person are available. Travel duration is 20h 0m
Greyhound US	14h 50m	6:10 PM	Knoxville, TN	Greyhound Bus Station	8:00 AM	Chicago	Union Station	Economy	$116	A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 4/13/2026 6:10:00 PM to Union Station, Chicago (USA) arriving at 4/14/2026 8:00:00 AM. 50 Economy ticket for $116 per person are available. Travel duration is 14h 50m
Greyhound US	15h 15m	6:10 PM	Knoxville, TN	Greyhound Bus Station	8:25 AM	Chicago	Downtown Bus Station	Economy	$116	A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 4/13/2026 6:10:00 PM to Downtown Bus Station, Chicago (USA) arriving at 4/14/2026 8:25:00 AM. 50 Economy ticket for $116 per person are available. Travel duration is 15h 15m
Greyhound US	16h 25m	10:00 PM	Knoxville, TN	Greyhound Bus Station	1:25 PM	Chicago	Downtown Bus Station	Economy	$117	A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 4/13/2026 10:00:00 PM to Downtown Bus Station, Chicago (USA) arriving at 4/14/2026 1:25:00 PM. 50 Economy ticket for $117 per person are available. Travel duration is 16h 25m

Did you know that if you travel from Knoxville, TN to Chicago via Lexington, KY, you can save more than $17? You can find the corresponding connections below.
- Greyhound US
  
  20h 0m
  
  0
  
  10:00 PM
  
  Knoxville, TN
  Knoxville Area Transit Bus Stop
  
  1:45 AM
  
  Lexington, KY
  Greyhound Bus Station
  
  0
  
  Economy
  
  $26
  
  A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 4/13/2026 10:00:00 PM to Greyhound Bus Station, Lexington, KY (USA) arriving at 4/14/2026 1:45:00 AM. 50 Economy ticket for $26 per person are available. Travel duration is 3h 45m
- Greyhound US
  
  16h 5m
  
  0
  
  1:55 AM
  
  Lexington, KY
  Greyhound Bus Station
  
  5:00 PM
  
  Chicago
  95th Red Line Station
  
  0
  
  Economy
  
  $56
  
  A Bus from Greyhound US goes from Greyhound Bus Station, Lexington, KY (USA) at 4/14/2026 1:55:00 AM to 95th Red Line Station, Chicago (USA) arriving at 4/14/2026 5:00:00 PM. 50 Economy ticket for $56 per person are available. Travel duration is 16h 5m
Travel time is 6h 10m longer, but you will save $17

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	20h 0m	10:00 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	5:00 PM	Chicago	95th Red Line Station	Economy	$115	A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 4/14/2026 10:00:00 PM to 95th Red Line Station, Chicago (USA) arriving at 4/15/2026 5:00:00 PM. 50 Economy ticket for $115 per person are available. Travel duration is 20h 0m
Greyhound US	16h 40m	6:10 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	9:50 AM	Chicago	95th Red Line Station	Economy	$117	A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 4/14/2026 6:10:00 PM to 95th Red Line Station, Chicago (USA) arriving at 4/15/2026 9:50:00 AM. 50 Economy ticket for $117 per person are available. Travel duration is 16h 40m
Greyhound US	15h 15m	6:10 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	8:25 AM	Chicago	Downtown Bus Station	Economy	$143	A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 4/14/2026 6:10:00 PM to Downtown Bus Station, Chicago (USA) arriving at 4/15/2026 8:25:00 AM. 50 Economy ticket for $143 per person are available. Travel duration is 15h 15m
Greyhound US	20h 35m	7:40 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	3:15 PM	Chicago	Downtown Bus Station	Economy	$143	A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 4/14/2026 7:40:00 PM to Downtown Bus Station, Chicago (USA) arriving at 4/15/2026 3:15:00 PM. 50 Economy ticket for $143 per person are available. Travel duration is 20h 35m
Greyhound US	14h 50m	6:10 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	8:00 AM	Chicago	Canal & Van Buren	Economy	$143	A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 4/14/2026 6:10:00 PM to Canal & Van Buren, Chicago (USA) arriving at 4/15/2026 8:00:00 AM. 50 Economy ticket for $143 per person are available. Travel duration is 14h 50m

Did you know that if you travel from Knoxville, TN to Chicago via Lexington, KY, you can save more than $33? You can find the corresponding connections below.
- Greyhound US
  
  20h 0m
  
  0
  
  10:00 PM
  
  Knoxville, TN
  Knoxville Area Transit Bus Stop
  
  1:45 AM
  
  Lexington, KY
  Greyhound Bus Station
  
  0
  
  Economy
  
  $26
  
  A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 4/13/2026 10:00:00 PM to Greyhound Bus Station, Lexington, KY (USA) arriving at 4/14/2026 1:45:00 AM. 50 Economy ticket for $26 per person are available. Travel duration is 3h 45m
- Greyhound US
  
  16h 5m
  
  0
  
  1:55 AM
  
  Lexington, KY
  Greyhound Bus Station
  
  5:00 PM
  
  Chicago
  95th Red Line Station
  
  0
  
  Economy
  
  $56
  
  A Bus from Greyhound US goes from Greyhound Bus Station, Lexington, KY (USA) at 4/14/2026 1:55:00 AM to 95th Red Line Station, Chicago (USA) arriving at 4/14/2026 5:00:00 PM. 50 Economy ticket for $56 per person are available. Travel duration is 16h 5m
Travel time is 6h 10m longer, but you will save $33

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	16h 40m	6:10 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	9:50 AM	Chicago	95th Red Line Station	Economy	$102	A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 4/15/2026 6:10:00 PM to 95th Red Line Station, Chicago (USA) arriving at 4/16/2026 9:50:00 AM. 50 Economy ticket for $102 per person are available. Travel duration is 16h 40m
Greyhound US	20h 0m	10:00 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	5:00 PM	Chicago	95th Red Line Station	Economy	$102	A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 4/15/2026 10:00:00 PM to 95th Red Line Station, Chicago (USA) arriving at 4/16/2026 5:00:00 PM. 50 Economy ticket for $102 per person are available. Travel duration is 20h 0m
Greyhound US	14h 50m	6:10 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	8:00 AM	Chicago	Canal & Van Buren	Economy	$110	A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 4/15/2026 6:10:00 PM to Canal & Van Buren, Chicago (USA) arriving at 4/16/2026 8:00:00 AM. 50 Economy ticket for $110 per person are available. Travel duration is 14h 50m
Greyhound US	15h 15m	6:10 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	8:25 AM	Chicago	Downtown Bus Station	Economy	$110	A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 4/15/2026 6:10:00 PM to Downtown Bus Station, Chicago (USA) arriving at 4/16/2026 8:25:00 AM. 50 Economy ticket for $110 per person are available. Travel duration is 15h 15m
Greyhound US	20h 35m	7:40 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	3:15 PM	Chicago	Downtown Bus Station	Economy	$113	A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 4/15/2026 7:40:00 PM to Downtown Bus Station, Chicago (USA) arriving at 4/16/2026 3:15:00 PM. 50 Economy ticket for $113 per person are available. Travel duration is 20h 35m

Did you know that if you travel from Knoxville, TN to Chicago via Lexington, KY, you can save more than $20? You can find the corresponding connections below.
- Greyhound US
  
  20h 0m
  
  0
  
  10:00 PM
  
  Knoxville, TN
  Knoxville Area Transit Bus Stop
  
  1:45 AM
  
  Lexington, KY
  Greyhound Bus Station
  
  0
  
  Economy
  
  $26
  
  A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 4/13/2026 10:00:00 PM to Greyhound Bus Station, Lexington, KY (USA) arriving at 4/14/2026 1:45:00 AM. 50 Economy ticket for $26 per person are available. Travel duration is 3h 45m
- Greyhound US
  
  16h 5m
  
  0
  
  1:55 AM
  
  Lexington, KY
  Greyhound Bus Station
  
  5:00 PM
  
  Chicago
  95th Red Line Station
  
  0
  
  Economy
  
  $56
  
  A Bus from Greyhound US goes from Greyhound Bus Station, Lexington, KY (USA) at 4/14/2026 1:55:00 AM to 95th Red Line Station, Chicago (USA) arriving at 4/14/2026 5:00:00 PM. 50 Economy ticket for $56 per person are available. Travel duration is 16h 5m
Travel time is 6h 10m longer, but you will save $20

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	16h 40m	6:10 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	9:50 AM	Chicago	95th Red Line Station	Economy	$109	A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 4/16/2026 6:10:00 PM to 95th Red Line Station, Chicago (USA) arriving at 4/17/2026 9:50:00 AM. 50 Economy ticket for $109 per person are available. Travel duration is 16h 40m
Greyhound US	20h 0m	10:00 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	5:00 PM	Chicago	95th Red Line Station	Economy	$109	A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 4/16/2026 10:00:00 PM to 95th Red Line Station, Chicago (USA) arriving at 4/17/2026 5:00:00 PM. 50 Economy ticket for $109 per person are available. Travel duration is 20h 0m
Greyhound US	16h 25m	10:00 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	1:25 PM	Chicago	Downtown Bus Station	Economy	$133	A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 4/16/2026 10:00:00 PM to Downtown Bus Station, Chicago (USA) arriving at 4/17/2026 1:25:00 PM. 50 Economy ticket for $133 per person are available. Travel duration is 16h 25m
Greyhound US	14h 50m	6:10 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	8:00 AM	Chicago	Canal & Van Buren	Economy	$135	A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 4/16/2026 6:10:00 PM to Canal & Van Buren, Chicago (USA) arriving at 4/17/2026 8:00:00 AM. 50 Economy ticket for $135 per person are available. Travel duration is 14h 50m
Greyhound US	15h 15m	6:10 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	8:25 AM	Chicago	Downtown Bus Station	Economy	$135	A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 4/16/2026 6:10:00 PM to Downtown Bus Station, Chicago (USA) arriving at 4/17/2026 8:25:00 AM. 50 Economy ticket for $135 per person are available. Travel duration is 15h 15m

Did you know that if you travel from Knoxville, TN to Chicago via Lexington, KY, you can save more than $27? You can find the corresponding connections below.
- Greyhound US
  
  20h 0m
  
  0
  
  10:00 PM
  
  Knoxville, TN
  Knoxville Area Transit Bus Stop
  
  1:45 AM
  
  Lexington, KY
  Greyhound Bus Station
  
  0
  
  Economy
  
  $26
  
  A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 4/13/2026 10:00:00 PM to Greyhound Bus Station, Lexington, KY (USA) arriving at 4/14/2026 1:45:00 AM. 50 Economy ticket for $26 per person are available. Travel duration is 3h 45m
- Greyhound US
  
  16h 5m
  
  0
  
  1:55 AM
  
  Lexington, KY
  Greyhound Bus Station
  
  5:00 PM
  
  Chicago
  95th Red Line Station
  
  0
  
  Economy
  
  $56
  
  A Bus from Greyhound US goes from Greyhound Bus Station, Lexington, KY (USA) at 4/14/2026 1:55:00 AM to 95th Red Line Station, Chicago (USA) arriving at 4/14/2026 5:00:00 PM. 50 Economy ticket for $56 per person are available. Travel duration is 16h 5m
Travel time is 6h 10m longer, but you will save $27

Best Price Offer: The price for the cheapest bus from Knoxville, TN to Chicago is $92 on 4/17/2026. Flexible travelers save on ticket prices.

Facts about the bus from Knoxville, TN to Chicago

Compare all providers like Greyhound US that travel 8 times every day by bus from Knoxville, TN to Chicago in one click! Book your bus ticket from Knoxville, TN to Chicago starting from $92!

Cheapest Bus	$92
Fastest Bus	13h 50m
Earliest Bus	6:10 PM
Latest Bus	10:00 PM
Daily Bus Routes	8 Ø
Distance	455.0 miles
Bus Companies	Greyhound US

Cheapest bus connections from Knoxville, TN to Chicago

Every day, 8 buses from 1 bus companies leave Knoxville, TN for Chicago: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 04/10/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 04/05

Monday 04/06

Tuesday 04/07

Wednesday 04/08

Thursday 04/09

Friday 04/10

$114

Saturday 04/11

$122

Sunday 04/12

$101

Monday 04/13

$99

Tuesday 04/14

$115

Wednesday 04/15

$102

Thursday 04/16

$109

Friday 04/17

$92

Saturday 04/18

Sunday 04/19

$98

Monday 04/20

$97

Tuesday 04/21

$108

Wednesday 04/22

$105

Thursday 04/23

$115

Friday 04/24

$106

Saturday 04/25

Sunday 04/26

$101

Monday 04/27

$108

Tuesday 04/28

$109

Wednesday 04/29

$111

Thursday 04/30

$137

Friday 05/01

$135

Saturday 05/02

How to save money travelling from Knoxville, TN to Chicago

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Knoxville, TN to Chicago in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Knoxville, TN to Chicago, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Knoxville, TN to Chicago are also emptier.

All bus stations and stops in Knoxville, TN and Chicago

In the map below, you can see where to find all bus stations in Knoxville, TN and Chicago.

Kingston Pike

Kingston Pike 6927

Walker Springs Plaza Shopping Center

Kingston Pike 8509

Greyhound Bus Station

E Magnolia Ave 100

Transit Center

E Church Ave 301

Knoxville Area Transit Bus Stop

Knoxville Area Transit Bus Stop Knoxville Area Transit Bus Stop

95th Red Line Station

W. 95th St 14

Downtown Bus Station

West Harrison Street 630-670

Union Station

S Canal St 225

Cumberland CTA

N Cumberland Ave 5800

Canal & Van Buren

S Canal St 310-320

Service and Comfort on the bus from Knoxville, TN to Chicago

Want to know which seat classes are available on the buses from Knoxville, TN to Chicago? Or which bus companies serve the route Knoxville, TN to Chicago? Below you will find answers to your questions.

FAQs about the Knoxville, TN to Chicago bus

How much does a Knoxville, TN Chicago bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $92 and takes 15h 40m to reach Chicago. Compare offers to save money!

How much could I save by comparing buses from Knoxville, TN to Chicago?

This route is offered by 1 companies with a range of ticket prices between $92 and $239. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Chicago.

On average, how many connections are available from Knoxville, TN to Chicago each day?

Every day, the Knoxville, TN to Chicago bus route is served by approximately 8 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Knoxville, TN to Chicago take?

The fastest bus from Knoxville, TN to Chicago is offered by Greyhound US and takes 13h 50m. Bus tickets for this connection cost $136. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Knoxville, TN to Chicago?

The earliest bus arriving in Chicago from Knoxville, TN starts at 6:10 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Knoxville, TN to Chicago?

The latest bus trip departing from Knoxville, TN for Chicago starts at 10:00 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Knoxville, TN Chicago route?

When traveling by bus from Knoxville, TN to Chicago, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Knoxville, TN and Chicago?

You can check all the direct connections between Knoxville, TN and Chicago by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Knoxville, TN to Chicago bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Knoxville, TN Chicago bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Knoxville, TN Chicago bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Knoxville, TN to Chicago on your planned travel date.

How does CheckMyBus find the best bus deals from Knoxville, TN to Chicago?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 8 daily trips between Knoxville, TN and Chicago. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Knoxville, TN to Chicago?

Prices and availability for 8 trips between Knoxville, TN and Chicago change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Knoxville, TN to Chicago

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Knoxville, TN and to Chicago

Here’s an overview of the most popular bus routes to Knoxville, TN and to Chicago. Simply click on the connection of your choice, and you will find all the details about your bus route!