Compare all timetables for the bus from Knoxville, TN to Chicago
| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Greyhound US | 20h 35m | 10:00 PM | Knoxville, TN | Greyhound Bus Station | 5:35 PM | Chicago | Downtown Bus Station | Economy | $151 |
A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 2/7/2026 10:00:00 PM to Downtown Bus Station, Chicago (USA) arriving at 2/8/2026 5:35:00 PM. 50 Economy ticket for $151 per person are available. Travel duration is 20h 35m
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| Greyhound US | 15h 15m | 6:10 PM | Knoxville, TN | Greyhound Bus Station | 8:25 AM | Chicago | Downtown Bus Station | Economy | $152 |
A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 2/7/2026 6:10:00 PM to Downtown Bus Station, Chicago (USA) arriving at 2/8/2026 8:25:00 AM. 50 Economy ticket for $152 per person are available. Travel duration is 15h 15m
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| Greyhound US | 20h 35m | 7:40 PM | Knoxville, TN | Greyhound Bus Station | 3:15 PM | Chicago | Downtown Bus Station | Economy | $152 |
A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 2/7/2026 7:40:00 PM to Downtown Bus Station, Chicago (USA) arriving at 2/8/2026 3:15:00 PM. 50 Economy ticket for $152 per person are available. Travel duration is 20h 35m
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| Greyhound US | 14h 50m | 6:10 PM | Knoxville, TN | Greyhound Bus Station | 8:00 AM | Chicago | Union Station | Economy | $152 |
A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 2/7/2026 6:10:00 PM to Union Station, Chicago (USA) arriving at 2/8/2026 8:00:00 AM. 50 Economy ticket for $152 per person are available. Travel duration is 14h 50m
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FlixBus20h 30m06:10 PMKnoxville, TNGreyhound Bus Station7:55 PMNashville5th Ave South Station0EconomyA Bus from FlixBus goes from Greyhound Bus Station, Knoxville, TN (USA) at 2/7/2026 6:10:00 PM to 5th Ave South Station, Nashville (USA) arriving at 2/7/2026 7:55:00 PM. 50 Economy ticket for $38 per person are available. Travel duration is 2h 45m
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FlixBus10h 45m02:55 AMNashville5th Ave South Station1:40 PMChicago95th Red Line Station0EconomyA Bus from FlixBus goes from 5th Ave South Station, Nashville (USA) at 2/8/2026 2:55:00 AM to 95th Red Line Station, Chicago (USA) arriving at 2/8/2026 1:40:00 PM. 50 Economy ticket for $75 per person are available. Travel duration is 10h 45m
Waiting Time 7h 0m -
| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Greyhound US | 14h 50m | 6:10 PM | Knoxville, TN | Greyhound Bus Station | 8:00 AM | Chicago | Union Station | Economy | $153 |
A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 2/8/2026 6:10:00 PM to Union Station, Chicago (USA) arriving at 2/9/2026 8:00:00 AM. 50 Economy ticket for $153 per person are available. Travel duration is 14h 50m
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| Greyhound US | 15h 15m | 6:10 PM | Knoxville, TN | Greyhound Bus Station | 8:25 AM | Chicago | Downtown Bus Station | Economy | $153 |
A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 2/8/2026 6:10:00 PM to Downtown Bus Station, Chicago (USA) arriving at 2/9/2026 8:25:00 AM. 50 Economy ticket for $153 per person are available. Travel duration is 15h 15m
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| Greyhound US | 20h 35m | 7:40 PM | Knoxville, TN | Greyhound Bus Station | 3:15 PM | Chicago | Downtown Bus Station | Economy | $156 |
A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 2/8/2026 7:40:00 PM to Downtown Bus Station, Chicago (USA) arriving at 2/9/2026 3:15:00 PM. 50 Economy ticket for $156 per person are available. Travel duration is 20h 35m
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| Greyhound US | 20h 35m | 10:00 PM | Knoxville, TN | Greyhound Bus Station | 5:35 PM | Chicago | Downtown Bus Station | Economy | $156 |
A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 2/8/2026 10:00:00 PM to Downtown Bus Station, Chicago (USA) arriving at 2/9/2026 5:35:00 PM. 50 Economy ticket for $156 per person are available. Travel duration is 20h 35m
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FlixBus14h 50m06:10 PMKnoxville, TNGreyhound Bus Station7:55 PMNashville5th Ave South Station0EconomyA Bus from FlixBus goes from Greyhound Bus Station, Knoxville, TN (USA) at 2/10/2026 6:10:00 PM to 5th Ave South Station, Nashville (USA) arriving at 2/10/2026 7:55:00 PM. 50 Economy ticket for $38 per person are available. Travel duration is 2h 45m
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Busbud9h 45m010:15 PMNashville5th Ave South Station8:00 AMChicagoCanal & Van Buren0EconomyA Bus from Busbud goes from 5th Ave South Station, Nashville (USA) at 2/10/2026 10:15:00 PM to Canal & Van Buren, Chicago (USA) arriving at 2/11/2026 8:00:00 AM. 50 Economy ticket for $66 per person are available. Travel duration is 9h 45m
Waiting Time 2h 20m -
| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Greyhound US | 20h 0m | 10:00 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | 5:00 PM | Chicago | 95th Red Line Station | Economy | $86 |
A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 2/12/2026 10:00:00 PM to 95th Red Line Station, Chicago (USA) arriving at 2/13/2026 5:00:00 PM. 50 Economy ticket for $86 per person are available. Travel duration is 20h 0m
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| Greyhound US | 16h 40m | 6:10 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | 9:50 AM | Chicago | 95th Red Line Station | Economy | $89 |
A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 2/12/2026 6:10:00 PM to 95th Red Line Station, Chicago (USA) arriving at 2/13/2026 9:50:00 AM. 50 Economy ticket for $89 per person are available. Travel duration is 16h 40m
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| Greyhound US | 20h 35m | 7:40 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | 3:15 PM | Chicago | Downtown Bus Station | Economy | $112 |
A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 2/12/2026 7:40:00 PM to Downtown Bus Station, Chicago (USA) arriving at 2/13/2026 3:15:00 PM. 50 Economy ticket for $112 per person are available. Travel duration is 20h 35m
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| Greyhound US | 20h 35m | 10:00 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | 5:35 PM | Chicago | Downtown Bus Station | Economy | $112 |
A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 2/12/2026 10:00:00 PM to Downtown Bus Station, Chicago (USA) arriving at 2/13/2026 5:35:00 PM. 50 Economy ticket for $112 per person are available. Travel duration is 20h 35m
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| Greyhound US | 14h 50m | 6:10 PM | Knoxville, TN | Knoxville Area Transit Bus Stop | 8:00 AM | Chicago | Canal & Van Buren | Economy | $115 |
A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 2/12/2026 6:10:00 PM to Canal & Van Buren, Chicago (USA) arriving at 2/13/2026 8:00:00 AM. 50 Economy ticket for $115 per person are available. Travel duration is 14h 50m
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Best Price Offer: The price for the cheapest bus from Knoxville, TN to Chicago is $78 on 2/15/2026. Flexible travelers save on ticket prices.
Facts about the bus from Knoxville, TN to Chicago
Compare all providers like Greyhound US that travel 6 times every day by bus from Knoxville, TN to Chicago in one click! Book your bus ticket from Knoxville, TN to Chicago starting from $78!
| Cheapest Bus | $78 |
| Fastest Bus | 13h 50m |
| Earliest Bus | 6:10 PM |
| Latest Bus | 10:00 PM |
| Daily Bus Routes | 6 Ø |
| Distance | 455.0 miles |
| Bus Companies | Greyhound US |
Cheapest bus connections from Knoxville, TN to Chicago
Every day, 6 buses from 1 bus companies leave Knoxville, TN for Chicago: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 02/06/2026 and for the following days.
How to save money travelling from Knoxville, TN to Chicago
Book the ticket from Knoxville, TN to Chicago in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Knoxville, TN to Chicago, compared instead if you buy it at the last moment, or directly at the station.
If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Knoxville, TN to Chicago are also emptier.Beloved bus companies from Knoxville, TN to Chicago
Greyhound US from Knoxville, TN to Chicago
Here you will find the key facts about the Greyhound US bus route Knoxville, TN to Chicago:
| Cheapest Price | $86 |
| Fastest Bus | 13h 50m |
| Earliest Bus | 6:10 PM |
| Last Bus | 10:00 PM |
| Daily Connections | 6 Ø |
| Found on | 1/31/2026 |
All bus stations and stops in Knoxville, TN and Chicago
In the map below, you can see where to find all bus stations in Knoxville, TN and Chicago.
Service and Comfort on the bus from Knoxville, TN to Chicago
FAQs about the Knoxville, TN to Chicago bus
How much does a Knoxville, TN Chicago bus trip cost?
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Which bus companies operate the Knoxville, TN Chicago route?
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Available seat classes which are offered on the bus route Knoxville, TN to Chicago
The cheapest option available for your ticket, it usually comes with reclinable seats and AC.
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