Bus from Knoxville, TN to Chicago from $78

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Compare all timetables for the bus from Knoxville, TN to Chicago

Here is a selection of the cheapest bus trips from the schedule from Knoxville, TN to Chicago from various bus operators like Greyhound US for the next days.

today
tomorrow
$151
Sunday
$153
Monday
Tuesday
Wednesday
Thursday
$86

Cheapest bus trips tomorrow

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 20h 35m 10:00 PM Knoxville, TN Greyhound Bus Station 5:35 PM Chicago Downtown Bus Station  Economy $151
Greyhound US 15h 15m 6:10 PM Knoxville, TN Greyhound Bus Station 8:25 AM Chicago Downtown Bus Station  Economy $152
Greyhound US 20h 35m 7:40 PM Knoxville, TN Greyhound Bus Station 3:15 PM Chicago Downtown Bus Station  Economy $152
Greyhound US 14h 50m 6:10 PM Knoxville, TN Greyhound Bus Station 8:00 AM Chicago Union Station  Economy $152
  • Did you know that if you travel from Knoxville, TN to Chicago via Nashville, you can save more than $38? You can find the corresponding connections below.
    • FlixBus
      20h 30m
      0
      6:10 PM
      Knoxville, TN
      Greyhound Bus Station
      7:55 PM
      Nashville
      5th Ave South Station
      0
      FlixBus
      Economy
      $38
      • Waiting Time 7h 0m
    • FlixBus
      10h 45m
      0
      2:55 AM
      Nashville
      5th Ave South Station
      1:40 PM
      Chicago
      95th Red Line Station
      0
      FlixBus
      Economy
      $75
    Travel time is 6h 40m longer, but you will save $38

Cheapest bus trips Sunday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 14h 50m 6:10 PM Knoxville, TN Greyhound Bus Station 8:00 AM Chicago Union Station  Economy $153
Greyhound US 15h 15m 6:10 PM Knoxville, TN Greyhound Bus Station 8:25 AM Chicago Downtown Bus Station  Economy $153
Greyhound US 20h 35m 7:40 PM Knoxville, TN Greyhound Bus Station 3:15 PM Chicago Downtown Bus Station  Economy $156
Greyhound US 20h 35m 10:00 PM Knoxville, TN Greyhound Bus Station 5:35 PM Chicago Downtown Bus Station  Economy $156
  • Did you know that if you travel from Knoxville, TN to Chicago via Nashville, you can save more than $49? You can find the corresponding connections below.
    • FlixBus
      14h 50m
      0
      6:10 PM
      Knoxville, TN
      Greyhound Bus Station
      7:55 PM
      Nashville
      5th Ave South Station
      0
      FlixBus
      Economy
      $38
      • Waiting Time 2h 20m
    • Busbud
      9h 45m
      0
      10:15 PM
      Nashville
      5th Ave South Station
      8:00 AM
      Chicago
      Canal & Van Buren
      0
      Busbud
      Economy
      $66
    Travel time is 1h 0m longer, but you will save $49

Cheapest bus trips Thursday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 20h 0m 10:00 PM Knoxville, TN Knoxville Area Transit Bus Stop 5:00 PM Chicago 95th Red Line Station  Economy $86
Greyhound US 16h 40m 6:10 PM Knoxville, TN Knoxville Area Transit Bus Stop 9:50 AM Chicago 95th Red Line Station  Economy $89
Greyhound US 20h 35m 7:40 PM Knoxville, TN Knoxville Area Transit Bus Stop 3:15 PM Chicago Downtown Bus Station  Economy $112
Greyhound US 20h 35m 10:00 PM Knoxville, TN Knoxville Area Transit Bus Stop 5:35 PM Chicago Downtown Bus Station  Economy $112
Greyhound US 14h 50m 6:10 PM Knoxville, TN Knoxville Area Transit Bus Stop 8:00 AM Chicago Canal & Van Buren  Economy $115

Best Price Offer: The price for the cheapest bus from Knoxville, TN to Chicago is $78 on 2/15/2026. Flexible travelers save on ticket prices.


Facts about the bus from Knoxville, TN to Chicago

Compare all providers like Greyhound US that travel 6 times every day by bus from Knoxville, TN to Chicago in one click! Book your bus ticket from Knoxville, TN to Chicago starting from $78!

Cheapest Bus $78
Fastest Bus 13h 50m
Earliest Bus 6:10 PM
Latest Bus 10:00 PM
Daily Bus Routes 6 Ø
Distance 455.0 miles
Bus Companies Greyhound US

Cheapest bus connections from Knoxville, TN to Chicago

Every day, 6 buses from 1 bus companies leave Knoxville, TN for Chicago: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 02/06/2026 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 02/01
Monday 02/02
Tuesday 02/03
Wednesday 02/04
Thursday 02/05
Friday 02/06
Saturday 02/07
$151
Sunday 02/08
$153
Monday 02/09
Tuesday 02/10
Wednesday 02/11
Thursday 02/12
$86
Friday 02/13
$152
Saturday 02/14
$140
Sunday 02/15
$78
Monday 02/16
Tuesday 02/17
Wednesday 02/18
Thursday 02/19
$105
Friday 02/20
$99
Saturday 02/21
$129
Sunday 02/22
Monday 02/23
$94
Tuesday 02/24
Wednesday 02/25
$110
Thursday 02/26
$87
Friday 02/27
Saturday 02/28

How to save money travelling from Knoxville, TN to Chicago

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Knoxville, TN to Chicago in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Knoxville, TN to Chicago, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Knoxville, TN to Chicago are also emptier.

Beloved bus companies from Knoxville, TN to Chicago

These are the most booked bus companies between Knoxville, TN to Chicago from our users.

Greyhound US from Knoxville, TN to Chicago

Greyhound US

Here you will find the key facts about the Greyhound US bus route Knoxville, TN to Chicago:

Cheapest Price $86
Fastest Bus 13h 50m
Earliest Bus 6:10 PM
Last Bus 10:00 PM
Daily Connections 6 Ø
Found on 1/31/2026

All bus stations and stops in Knoxville, TN and Chicago

In the map below, you can see where to find all bus stations in Knoxville, TN and Chicago.

Service and Comfort on the bus from Knoxville, TN to Chicago

Want to know which seat classes are available on the buses from Knoxville, TN to Chicago? Or which bus companies serve the route Knoxville, TN to Chicago? Below you will find answers to your questions.

FAQs about the Knoxville, TN to Chicago bus

How much does a Knoxville, TN Chicago bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $78 and takes 19h 0m to reach Chicago. Compare offers to save money!

How much could I save by comparing buses from Knoxville, TN to Chicago?

This route is offered by 1 companies with a range of ticket prices between $78 and $156. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Chicago.

On average, how many connections are available from Knoxville, TN to Chicago each day?

Every day, the Knoxville, TN to Chicago bus route is served by approximately 6 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Knoxville, TN to Chicago take?

The fastest bus from Knoxville, TN to Chicago is offered by Greyhound US and takes 13h 50m. Bus tickets for this connection cost $152. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Knoxville, TN to Chicago?

The earliest bus arriving in Chicago from Knoxville, TN starts at 6:10 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Knoxville, TN to Chicago?

The latest bus trip departing from Knoxville, TN for Chicago starts at 10:00 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Knoxville, TN Chicago route?

When traveling by bus from Knoxville, TN to Chicago, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Knoxville, TN and Chicago?

You can check all the direct connections between Knoxville, TN and Chicago by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Knoxville, TN to Chicago bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Knoxville, TN Chicago bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Knoxville, TN Chicago bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Knoxville, TN to Chicago on your planned travel date.

How does CheckMyBus find the best bus deals from Knoxville, TN to Chicago?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 6 daily trips between Knoxville, TN and Chicago. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Knoxville, TN to Chicago?

Prices and availability for 6 trips between Knoxville, TN and Chicago change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Knoxville, TN to Chicago

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Knoxville, TN and to Chicago

Here’s an overview of the most popular bus routes to Knoxville, TN and to Chicago. Simply click on the connection of your choice, and you will find all the details about your bus route!
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