Bus Knoxville, TN to Chicago: Compare prices and save money

Compare all timetables for the bus from Knoxville, TN to Chicago

Here is a selection of the cheapest bus trips from the schedule from Knoxville, TN to Chicago from various bus operators like Greyhound US for the next days.

today

tomorrow

Sunday

$177

Monday

Tuesday

$189

Wednesday

$144

Thursday

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	14h 50m	6:10 PM	Knoxville, TN	Greyhound Bus Station	8:00 AM	Chicago	Union Station	Economy	$177	A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 12/21/2025 6:10:00 PM to Union Station, Chicago (USA) arriving at 12/22/2025 8:00:00 AM. 50 Economy ticket for $177 per person are available. Travel duration is 14h 50m
Greyhound US	15h 15m	6:10 PM	Knoxville, TN	Greyhound Bus Station	8:25 AM	Chicago	Downtown Bus Station	Economy	$177	A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 12/21/2025 6:10:00 PM to Downtown Bus Station, Chicago (USA) arriving at 12/22/2025 8:25:00 AM. 50 Economy ticket for $177 per person are available. Travel duration is 15h 15m
Greyhound US	21h 10m	7:05 PM	Knoxville, TN	Greyhound Bus Station	3:15 PM	Chicago	Downtown Bus Station	Economy	$178	A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 12/21/2025 7:05:00 PM to Downtown Bus Station, Chicago (USA) arriving at 12/22/2025 3:15:00 PM. 50 Economy ticket for $178 per person are available. Travel duration is 21h 10m
Greyhound US	20h 35m	10:00 PM	Knoxville, TN	Greyhound Bus Station	5:35 PM	Chicago	Downtown Bus Station	Economy	$180	A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 12/21/2025 10:00:00 PM to Downtown Bus Station, Chicago (USA) arriving at 12/22/2025 5:35:00 PM. 50 Economy ticket for $180 per person are available. Travel duration is 20h 35m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	14h 50m	6:10 PM	Knoxville, TN	Greyhound Bus Station	8:00 AM	Chicago	Union Station	Economy	$189	A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 12/23/2025 6:10:00 PM to Union Station, Chicago (USA) arriving at 12/24/2025 8:00:00 AM. 50 Economy ticket for $189 per person are available. Travel duration is 14h 50m
Greyhound US	15h 15m	6:10 PM	Knoxville, TN	Greyhound Bus Station	8:25 AM	Chicago	Downtown Bus Station	Economy	$189	A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 12/23/2025 6:10:00 PM to Downtown Bus Station, Chicago (USA) arriving at 12/24/2025 8:25:00 AM. 50 Economy ticket for $189 per person are available. Travel duration is 15h 15m
Greyhound US	20h 35m	10:00 PM	Knoxville, TN	Greyhound Bus Station	5:35 PM	Chicago	Downtown Bus Station	Economy	$190	A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 12/23/2025 10:00:00 PM to Downtown Bus Station, Chicago (USA) arriving at 12/24/2025 5:35:00 PM. 50 Economy ticket for $190 per person are available. Travel duration is 20h 35m
Greyhound US	21h 10m	7:05 PM	Knoxville, TN	Greyhound Bus Station	3:15 PM	Chicago	Downtown Bus Station	Economy	$214	A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 12/23/2025 7:05:00 PM to Downtown Bus Station, Chicago (USA) arriving at 12/24/2025 3:15:00 PM. 50 Economy ticket for $214 per person are available. Travel duration is 21h 10m

Did you know that if you travel from Knoxville, TN to Chicago via Lexington, KY, you can save more than $90? You can find the corresponding connections below.
- FlixBus
  
  20h 0m
  
  0
  
  10:00 PM
  
  Knoxville, TN
  Greyhound Bus Station
  
  1:45 AM
  
  Lexington, KY
  Greyhound Bus Station
  
  0
  
  Economy
  
  $41
  
  A Bus from FlixBus goes from Greyhound Bus Station, Knoxville, TN (USA) at 12/24/2025 10:00:00 PM to Greyhound Bus Station, Lexington, KY (USA) arriving at 12/25/2025 1:45:00 AM. 50 Economy ticket for $41 per person are available. Travel duration is 3h 45m
- Busbud
  
  16h 5m
  
  0
  
  1:55 AM
  
  Lexington, KY
  Greyhound Bus Station
  
  5:00 PM
  
  Chicago
  95th Red Line Station
  
  0
  
  Economy
  
  $58
  
  A Bus from Busbud goes from Greyhound Bus Station, Lexington, KY (USA) at 12/25/2025 1:55:00 AM to 95th Red Line Station, Chicago (USA) arriving at 12/25/2025 5:00:00 PM. 50 Economy ticket for $58 per person are available. Travel duration is 16h 5m
Travel time is 6h 10m longer, but you will save $90

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	20h 0m	10:00 PM	Knoxville, TN	Greyhound Bus Station	5:00 PM	Chicago	95th Red Line Station	Economy	$144	A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 12/24/2025 10:00:00 PM to 95th Red Line Station, Chicago (USA) arriving at 12/25/2025 5:00:00 PM. 50 Economy ticket for $144 per person are available. Travel duration is 20h 0m
Greyhound US	16h 40m	6:10 PM	Knoxville, TN	Greyhound Bus Station	9:50 AM	Chicago	95th Red Line Station	Economy	$146	A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 12/24/2025 6:10:00 PM to 95th Red Line Station, Chicago (USA) arriving at 12/25/2025 9:50:00 AM. 50 Economy ticket for $146 per person are available. Travel duration is 16h 40m
Greyhound US	21h 50m	7:05 PM	Knoxville, TN	Greyhound Bus Station	3:55 PM	Chicago	95th Red Line Station	Economy	$146	A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 12/24/2025 7:05:00 PM to 95th Red Line Station, Chicago (USA) arriving at 12/25/2025 3:55:00 PM. 50 Economy ticket for $146 per person are available. Travel duration is 21h 50m
Greyhound US	21h 10m	7:05 PM	Knoxville, TN	Greyhound Bus Station	3:15 PM	Chicago	Downtown Bus Station	Economy	$174	A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 12/24/2025 7:05:00 PM to Downtown Bus Station, Chicago (USA) arriving at 12/25/2025 3:15:00 PM. 50 Economy ticket for $174 per person are available. Travel duration is 21h 10m
Greyhound US	20h 35m	10:00 PM	Knoxville, TN	Greyhound Bus Station	5:35 PM	Chicago	Downtown Bus Station	Economy	$175	A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 12/24/2025 10:00:00 PM to Downtown Bus Station, Chicago (USA) arriving at 12/25/2025 5:35:00 PM. 50 Economy ticket for $175 per person are available. Travel duration is 20h 35m

Did you know that if you travel from Knoxville, TN to Chicago via Lexington, KY, you can save more than $45? You can find the corresponding connections below.
- FlixBus
  
  20h 0m
  
  0
  
  10:00 PM
  
  Knoxville, TN
  Greyhound Bus Station
  
  1:45 AM
  
  Lexington, KY
  Greyhound Bus Station
  
  0
  
  Economy
  
  $41
  
  A Bus from FlixBus goes from Greyhound Bus Station, Knoxville, TN (USA) at 12/24/2025 10:00:00 PM to Greyhound Bus Station, Lexington, KY (USA) arriving at 12/25/2025 1:45:00 AM. 50 Economy ticket for $41 per person are available. Travel duration is 3h 45m
- Busbud
  
  16h 5m
  
  0
  
  1:55 AM
  
  Lexington, KY
  Greyhound Bus Station
  
  5:00 PM
  
  Chicago
  95th Red Line Station
  
  0
  
  Economy
  
  $58
  
  A Bus from Busbud goes from Greyhound Bus Station, Lexington, KY (USA) at 12/25/2025 1:55:00 AM to 95th Red Line Station, Chicago (USA) arriving at 12/25/2025 5:00:00 PM. 50 Economy ticket for $58 per person are available. Travel duration is 16h 5m
Travel time is 4h 20m longer, but you will save $45

Best Price Offer: The price for the cheapest bus from Knoxville, TN to Chicago is $100 on 1/8/2026. Flexible travelers save on ticket prices.

Facts about the bus from Knoxville, TN to Chicago

Compare all providers like Greyhound US that travel 7 times every day by bus from Knoxville, TN to Chicago in one click! Book your bus ticket from Knoxville, TN to Chicago starting from $100!

Cheapest Bus	$100
Fastest Bus	13h 50m
Earliest Bus	6:10 PM
Latest Bus	10:00 PM
Daily Bus Routes	7 Ø
Distance	455.0 miles
Bus Companies	Greyhound US

Cheapest bus connections from Knoxville, TN to Chicago

Every day, 7 buses from 1 bus companies leave Knoxville, TN for Chicago: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/19/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 12/14

Monday 12/15

Tuesday 12/16

Wednesday 12/17

Thursday 12/18

Friday 12/19

Saturday 12/20

Sunday 12/21

$177

Monday 12/22

Tuesday 12/23

$189

Wednesday 12/24

$144

Thursday 12/25

Friday 12/26

$175

Saturday 12/27

$150

Sunday 12/28

$143

Monday 12/29

Tuesday 12/30

Wednesday 12/31

Thursday 01/01

Friday 01/02

Saturday 01/03

Sunday 01/04

Monday 01/05

Tuesday 01/06

Wednesday 01/07

Thursday 01/08

$100

Friday 01/09

Saturday 01/10

How to save money travelling from Knoxville, TN to Chicago

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Knoxville, TN to Chicago in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Knoxville, TN to Chicago, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Knoxville, TN to Chicago are also emptier.

Beloved bus companies from Knoxville, TN to Chicago

These are the most booked bus companies between Knoxville, TN to Chicago from our users.

Greyhound US from Knoxville, TN to Chicago

Here you will find the key facts about the Greyhound US bus route Knoxville, TN to Chicago:

Cheapest Price	$144
Fastest Bus	13h 50m
Earliest Bus	6:10 PM
Last Bus	10:00 PM
Daily Connections	7 Ø
Found on	12/17/2025

All bus stations and stops in Knoxville, TN and Chicago

In the map below, you can see where to find all bus stations in Knoxville, TN and Chicago.

Kingston Pike

Kingston Pike 6927

Knoxville Area Transit Bus Stop

Knoxville Area Transit Bus Stop Knoxville Area Transit Bus Stop

Walker Springs Plaza Shopping Center

Kingston Pike 8509

Greyhound Bus Station

E Magnolia Ave 100

Transit Center

E Church Ave 301

95th Red Line Station

W. 95th St 14

Downtown Bus Station

West Harrison Street 630-670

Union Station

S Canal St 225

Cumberland CTA

N Cumberland Ave 5800

Canal & Van Buren

S Canal St 310-320

Service and Comfort on the bus from Knoxville, TN to Chicago

Want to know which seat classes are available on the buses from Knoxville, TN to Chicago? Or which bus companies serve the route Knoxville, TN to Chicago? Below you will find answers to your questions.

FAQs about the Knoxville, TN to Chicago bus

How much does a Knoxville, TN Chicago bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $100 and takes 19h 0m to reach Chicago. Compare offers to save money!

How much could I save by comparing buses from Knoxville, TN to Chicago?

This route is offered by 1 companies with a range of ticket prices between $100 and $214. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Chicago.

On average, how many connections are available from Knoxville, TN to Chicago each day?

Every day, the Knoxville, TN to Chicago bus route is served by approximately 7 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Knoxville, TN to Chicago take?

The fastest bus from Knoxville, TN to Chicago is offered by Greyhound US and takes 13h 50m. Bus tickets for this connection cost $177. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Knoxville, TN to Chicago?

The earliest bus arriving in Chicago from Knoxville, TN starts at 6:10 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Knoxville, TN to Chicago?

The latest bus trip departing from Knoxville, TN for Chicago starts at 10:00 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Knoxville, TN Chicago route?

When traveling by bus from Knoxville, TN to Chicago, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Knoxville, TN and Chicago?

You can check all the direct connections between Knoxville, TN and Chicago by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Knoxville, TN to Chicago bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Knoxville, TN Chicago bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Knoxville, TN Chicago bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Knoxville, TN to Chicago on your planned travel date.

How does CheckMyBus find the best bus deals from Knoxville, TN to Chicago?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 7 daily trips between Knoxville, TN and Chicago. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Knoxville, TN to Chicago?

Prices and availability for 7 trips between Knoxville, TN and Chicago change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Knoxville, TN to Chicago

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Knoxville, TN and to Chicago

Here’s an overview of the most popular bus routes to Knoxville, TN and to Chicago. Simply click on the connection of your choice, and you will find all the details about your bus route!