Bus Knoxville, TN to San Antonio, TX

Compare all timetables for the bus from Knoxville, TN to San Antonio, TX

Here is a selection of the cheapest bus trips from the schedule from Knoxville, TN to San Antonio, TX from various bus operators like Greyhound US for the next days.

today

$126

tomorrow

$109

Monday

Tuesday

$128

Wednesday

$119

Thursday

$105

Friday

$105

Cheapest bus trips today
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	25h 0m	6:10 PM	Knoxville, TN	Greyhound Bus Station	6:10 PM	San Antonio, TX	Bus Station		Economy	$126	A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 6/20/2026 6:10:00 PM to Bus Station, San Antonio, TX (USA) arriving at 6/21/2026 6:10:00 PM. 50 Economy ticket for $126 per person are available. Travel duration is 25h 0m
	Greyhound US	28h 5m	7:40 PM	Knoxville, TN	Greyhound Bus Station	10:45 PM	San Antonio, TX	Bus Station		Economy	$127	A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 6/20/2026 7:40:00 PM to Bus Station, San Antonio, TX (USA) arriving at 6/21/2026 10:45:00 PM. 50 Economy ticket for $127 per person are available. Travel duration is 28h 5m

Cheapest bus trips tomorrow
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	28h 5m	7:40 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	10:45 PM	San Antonio, TX	Bus Station		Economy	$109	A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 6/21/2026 7:40:00 PM to Bus Station, San Antonio, TX (USA) arriving at 6/22/2026 10:45:00 PM. 50 Economy ticket for $109 per person are available. Travel duration is 28h 5m
	Greyhound US	25h 0m	6:10 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	6:10 PM	San Antonio, TX	Bus Station		Economy	$111	A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 6/21/2026 6:10:00 PM to Bus Station, San Antonio, TX (USA) arriving at 6/22/2026 6:10:00 PM. 50 Economy ticket for $111 per person are available. Travel duration is 25h 0m

Cheapest bus trips Tuesday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	29h 15m	7:40 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	11:55 PM	San Antonio, TX	Bus Station		Economy	$128	A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 6/23/2026 7:40:00 PM to Bus Station, San Antonio, TX (USA) arriving at 6/24/2026 11:55:00 PM. 50 Economy ticket for $128 per person are available. Travel duration is 29h 15m
	Greyhound US	25h 0m	6:10 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	6:10 PM	San Antonio, TX	Bus Station		Economy	$134	A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 6/23/2026 6:10:00 PM to Bus Station, San Antonio, TX (USA) arriving at 6/24/2026 6:10:00 PM. 50 Economy ticket for $134 per person are available. Travel duration is 25h 0m

Cheapest bus trips Wednesday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	25h 0m	6:10 PM	Knoxville, TN	Greyhound Bus Station	6:10 PM	San Antonio, TX	Bus Station		Economy	$119	A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 6/24/2026 6:10:00 PM to Bus Station, San Antonio, TX (USA) arriving at 6/25/2026 6:10:00 PM. 50 Economy ticket for $119 per person are available. Travel duration is 25h 0m
	Greyhound US	29h 15m	7:40 PM	Knoxville, TN	Greyhound Bus Station	11:55 PM	San Antonio, TX	Bus Station		Economy	$119	A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 6/24/2026 7:40:00 PM to Bus Station, San Antonio, TX (USA) arriving at 6/25/2026 11:55:00 PM. 50 Economy ticket for $119 per person are available. Travel duration is 29h 15m

Cheapest bus trips Thursday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	25h 0m	6:10 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	6:10 PM	San Antonio, TX	Bus Station		Economy	$105	A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 6/25/2026 6:10:00 PM to Bus Station, San Antonio, TX (USA) arriving at 6/26/2026 6:10:00 PM. 50 Economy ticket for $105 per person are available. Travel duration is 25h 0m
	Greyhound US	28h 5m	7:40 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	10:45 PM	San Antonio, TX	Bus Station		Economy	$107	A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 6/25/2026 7:40:00 PM to Bus Station, San Antonio, TX (USA) arriving at 6/26/2026 10:45:00 PM. 50 Economy ticket for $107 per person are available. Travel duration is 28h 5m

Cheapest bus trips Friday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	25h 0m	6:10 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	6:10 PM	San Antonio, TX	Bus Station		Economy	$105	A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 6/26/2026 6:10:00 PM to Bus Station, San Antonio, TX (USA) arriving at 6/27/2026 6:10:00 PM. 50 Economy ticket for $105 per person are available. Travel duration is 25h 0m
	Greyhound US	28h 5m	7:40 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	10:45 PM	San Antonio, TX	Bus Station		Economy	$107	A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 6/26/2026 7:40:00 PM to Bus Station, San Antonio, TX (USA) arriving at 6/27/2026 10:45:00 PM. 50 Economy ticket for $107 per person are available. Travel duration is 28h 5m

Best Price Offer: The price for the cheapest bus from Knoxville, TN to San Antonio, TX is $105 on 6/25/2026. Flexible travelers save on ticket prices.

Facts about the bus from Knoxville, TN to San Antonio, TX

Compare all providers like Greyhound US that travel 2 times every day by bus from Knoxville, TN to San Antonio, TX in one click! Book your bus ticket from Knoxville, TN to San Antonio, TX starting from $105!

Cheapest Bus	$105
Fastest Bus	24h 0m
Earliest Bus	6:10 PM
Latest Bus	7:40 PM
Daily Bus Routes	2 Ø
Distance	958.9 miles
Bus Companies	Greyhound US

Cheapest bus connections from Knoxville, TN to San Antonio, TX

Every day, 2 buses from 1 bus companies leave Knoxville, TN for San Antonio, TX: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 06/20/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 06/14

Monday 06/15

Tuesday 06/16

Wednesday 06/17

Thursday 06/18

Friday 06/19

Saturday 06/20

$126

Sunday 06/21

$109

Monday 06/22

Tuesday 06/23

$128

Wednesday 06/24

$119

Thursday 06/25

$105

Friday 06/26

$105

Saturday 06/27

Sunday 06/28

$106

Monday 06/29

Tuesday 06/30

Wednesday 07/01

Thursday 07/02

Friday 07/03

Saturday 07/04

Sunday 07/05

Monday 07/06

Tuesday 07/07

Wednesday 07/08

Thursday 07/09

Friday 07/10

$133

Saturday 07/11

How to save money travelling from Knoxville, TN to San Antonio, TX

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Knoxville, TN to San Antonio, TX in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Knoxville, TN to San Antonio, TX, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Knoxville, TN to San Antonio, TX are also emptier.

All bus stations and stops in Knoxville, TN and San Antonio, TX

In the map below, you can see where to find all bus stations in Knoxville, TN and San Antonio, TX.

Kingston Pike

Kingston Pike 6927

Walker Springs Plaza Shopping Center

Kingston Pike 8509

Greyhound Bus Station

E Magnolia Ave 100

Knoxville Area Transit Bus Stop

Knoxville Area Transit Bus Stop Knoxville Area Transit Bus Stop

Transit Center

E Church Ave 301

Bus Station

N St Mary's St 500

San Antonio

Pearl District

Avenue A 699-599

Commerce & Bowie Bus Stop

W. Southcross & Buffalo Bus Stop

Service and Comfort on the bus from Knoxville, TN to San Antonio, TX

Want to know which seat classes are available on the buses from Knoxville, TN to San Antonio, TX? Or which bus companies serve the route Knoxville, TN to San Antonio, TX? Below you will find answers to your questions.

FAQs about the Knoxville, TN to San Antonio, TX bus

How much does a Knoxville, TN San Antonio, TX bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $105 and takes 24h 0m to reach San Antonio, TX. Compare offers to save money!

How much could I save by comparing buses from Knoxville, TN to San Antonio, TX?

This route is offered by 1 companies with a range of ticket prices between $105 and $138. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to San Antonio, TX.

On average, how many connections are available from Knoxville, TN to San Antonio, TX each day?

Every day, the Knoxville, TN to San Antonio, TX bus route is served by approximately 2 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Knoxville, TN to San Antonio, TX take?

The fastest bus from Knoxville, TN to San Antonio, TX is offered by Greyhound US and takes 24h 0m. Bus tickets for this connection cost $126. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Knoxville, TN to San Antonio, TX?

The earliest bus arriving in San Antonio, TX from Knoxville, TN starts at 6:10 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Knoxville, TN to San Antonio, TX?

The latest bus trip departing from Knoxville, TN for San Antonio, TX starts at 7:40 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Knoxville, TN San Antonio, TX route?

When traveling by bus from Knoxville, TN to San Antonio, TX, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Knoxville, TN and San Antonio, TX?

You can check all the direct connections between Knoxville, TN and San Antonio, TX by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Knoxville, TN to San Antonio, TX bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Knoxville, TN San Antonio, TX bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Knoxville, TN San Antonio, TX bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Knoxville, TN to San Antonio, TX on your planned travel date.

How does CheckMyBus find the best bus deals from Knoxville, TN to San Antonio, TX?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 2 daily trips between Knoxville, TN and San Antonio, TX. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Knoxville, TN to San Antonio, TX?

Prices and availability for 2 trips between Knoxville, TN and San Antonio, TX change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Knoxville, TN to San Antonio, TX

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Knoxville, TN and to San Antonio, TX

Here’s an overview of the most popular bus routes to Knoxville, TN and to San Antonio, TX. Simply click on the connection of your choice, and you will find all the details about your bus route!