Bus from St. Louis, MO to Jacksonville, FL from $116

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Compare all timetables for the bus from St. Louis, MO to Jacksonville, FL

Here is a selection of the cheapest bus trips from the schedule from St. Louis, MO to Jacksonville, FL from various bus operators like Greyhound US or FlixBus for the next days.

today
tomorrow
Monday
Tuesday
$221
Wednesday
Thursday
Friday
$116

Cheapest bus trips Tuesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 28h 0m 2:00 AM St. Louis, MO Gateway Station 7:00 AM Jacksonville, FL Amtrak Train Station  Economy $221
Greyhound US 22h 50m 1:45 PM St. Louis, MO Gateway Station 1:35 PM Jacksonville, FL Amtrak Train Station  Economy $221
Greyhound US 29h 0m 1:55 PM St. Louis, MO Gateway Station 7:55 PM Jacksonville, FL Amtrak Train Station  Economy $221
  • Did you know that if you travel from St. Louis, MO to Jacksonville, FL via Atlanta, GA, you can save more than $111? You can find the corresponding connections below.
    • Busbud
      22h 35m
      0
      11:30 PM
      St. Louis, MO
      Gateway Station
      11:00 AM
      Atlanta, GA
      Garnett Transit Station
      0
      Busbud
      Economy
      $56
      • Waiting Time 5h 35m
    • FlixBus
      6h 30m
      0
      4:35 PM
      Atlanta, GA
      Garnett Transit Station
      11:05 PM
      Jacksonville, FL
      Amtrak Train Station
      0
      FlixBus
      Economy
      $54
    Travel Time is 1h 15m shorter, and you will save $111

Cheapest bus trips Friday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 20h 35m 4:00 PM St. Louis, MO Gateway Station 1:35 PM Jacksonville, FL Amtrak Train Station  Economy $116
FlixBus 22h 35m 11:30 PM St. Louis, MO Gateway Station 11:05 PM Jacksonville, FL Amtrak Train Station  Economy $116
Greyhound US 28h 0m 2:00 AM St. Louis, MO Gateway Station 7:00 AM Jacksonville, FL Amtrak Train Station  Economy $122

Best Price Offer: The price for the cheapest bus from St. Louis, MO to Jacksonville, FL is $116 on 2/13/2026. Flexible travelers save on ticket prices.


Frequency of bus connections between St. Louis, MO and Jacksonville, FL

See here how frequent the connections between St. Louis, MO and Jacksonville, FL are, during different times and days of the week.
Tuesday is the busiest day, with more than 3 daily buses from St. Louis, MO to Jacksonville, FL. Tuesday has instead the fewest connections, with only 3 daily coaches between St. Louis, MO and Jacksonville, FL.
The busiest time of the day is the Afternoon, with 3 buses from St. Louis, MO to Jacksonville, FL, while Evening sees the fewest connections between St. Louis, MO and Jacksonville, FL, with 1 offers.

Facts about the bus from St. Louis, MO to Jacksonville, FL

Compare all providers like Greyhound US and FlixBus that travel 3 times every day by bus from St. Louis, MO to Jacksonville, FL in one click! Book your bus ticket from St. Louis, MO to Jacksonville, FL starting from $116!

Cheapest Bus $116
Fastest Bus 21h 35m
Earliest Bus 2:00 AM
Latest Bus 11:30 PM
Daily Bus Routes 3 Ø
Distance 750.9 miles
Bus Companies Greyhound US and FlixBus

Cheapest bus connections from St. Louis, MO to Jacksonville, FL

Every day, 3 buses from 2 bus companies leave St. Louis, MO for Jacksonville, FL: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 02/07/2026 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 02/01
Monday 02/02
Tuesday 02/03
Wednesday 02/04
Thursday 02/05
Friday 02/06
Saturday 02/07
Sunday 02/08
Monday 02/09
Tuesday 02/10
$221
Wednesday 02/11
Thursday 02/12
Friday 02/13
$116
Saturday 02/14
$231
Sunday 02/15
Monday 02/16
Tuesday 02/17
Wednesday 02/18
Thursday 02/19
Friday 02/20
Saturday 02/21
Sunday 02/22
Monday 02/23
Tuesday 02/24
Wednesday 02/25
Thursday 02/26
Friday 02/27
Saturday 02/28

The cheapest time to travel from St. Louis, MO to Jacksonville, FL

See here on which day and which time of the day you can find the cheapest bus ticket from St. Louis, MO to Jacksonville, FL, for the next 30 days.
With a price starting from $116, Friday is the cheapest day for a bus from St. Louis, MO to Jacksonville, FL. Tuesday instead is the most expensive day with prices starting from $219.
Evening is the cheapest day time for bus tickets from St. Louis, MO to Jacksonville, FL, with $115. Afternoon is the most expensive time of the day with prices starting from $116.

How to save money travelling from St. Louis, MO to Jacksonville, FL

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from St. Louis, MO to Jacksonville, FL in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from St. Louis, MO to Jacksonville, FL, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from St. Louis, MO to Jacksonville, FL are also emptier.

Beloved bus companies from St. Louis, MO to Jacksonville, FL

These are the most booked bus companies between St. Louis, MO to Jacksonville, FL from our users.

FlixBus from St. Louis, MO to Jacksonville, FL

FlixBus

Here you will find the key facts about the FlixBus bus route St. Louis, MO to Jacksonville, FL:

Cheapest Price $116
Fastest Bus 21h 35m
Earliest Bus 4:00 PM
Last Bus 11:30 PM
Daily Connections 2 Ø
Found on 2/4/2026

All bus stations and stops in St. Louis, MO and Jacksonville, FL

In the map below, you can see where to find all bus stations in St. Louis, MO and Jacksonville, FL.

Service and Comfort on the bus from St. Louis, MO to Jacksonville, FL

Want to know which seat classes are available on the buses from St. Louis, MO to Jacksonville, FL? Or which bus companies serve the route St. Louis, MO to Jacksonville, FL? Below you will find answers to your questions.

FAQs about the St. Louis, MO to Jacksonville, FL bus

How much does a St. Louis, MO Jacksonville, FL bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $116 and takes 21h 35m to reach Jacksonville, FL. Compare offers to save money!

How much could I save by comparing buses from St. Louis, MO to Jacksonville, FL?

This route is offered by 2 companies with a range of ticket prices between $116 and $221. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Jacksonville, FL.

On average, how many connections are available from St. Louis, MO to Jacksonville, FL each day?

Every day, the St. Louis, MO to Jacksonville, FL bus route is served by approximately 3 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from St. Louis, MO to Jacksonville, FL take?

The fastest bus from St. Louis, MO to Jacksonville, FL is offered by FlixBus and takes 21h 35m. Bus tickets for this connection cost $116. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from St. Louis, MO to Jacksonville, FL?

The earliest bus arriving in Jacksonville, FL from St. Louis, MO starts at 2:00 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from St. Louis, MO to Jacksonville, FL?

The latest bus trip departing from St. Louis, MO for Jacksonville, FL starts at 11:30 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the St. Louis, MO Jacksonville, FL route?

When traveling by bus from St. Louis, MO to Jacksonville, FL, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between St. Louis, MO and Jacksonville, FL?

You can check all the direct connections between St. Louis, MO and Jacksonville, FL by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the St. Louis, MO to Jacksonville, FL bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the St. Louis, MO Jacksonville, FL bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the St. Louis, MO Jacksonville, FL bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from St. Louis, MO to Jacksonville, FL on your planned travel date.

How does CheckMyBus find the best bus deals from St. Louis, MO to Jacksonville, FL?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 3 daily trips between St. Louis, MO and Jacksonville, FL. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from St. Louis, MO to Jacksonville, FL?

Prices and availability for 3 trips between St. Louis, MO and Jacksonville, FL change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route St. Louis, MO to Jacksonville, FL

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to St. Louis, MO and to Jacksonville, FL

Here’s an overview of the most popular bus routes to St. Louis, MO and to Jacksonville, FL. Simply click on the connection of your choice, and you will find all the details about your bus route!
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Popular Airport Shuttles to St. Louis, MO and to Jacksonville, FL
CheckMyBus › Buses in USA › Bus to St. Louis, MO › Bus to Jacksonville, FL

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