Bus St. Louis, MO to Jacksonville, FL: Compare prices and save money

Compare all timetables for the bus from St. Louis, MO to Jacksonville, FL

Here is a selection of the cheapest bus trips from the schedule from St. Louis, MO to Jacksonville, FL from various bus operators like FlixBus or Greyhound US for the next days.

today

tomorrow

Saturday

$109

Sunday

Monday

$102

Tuesday

$107

Wednesday

$115

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	28h 0m	2:00 AM	St. Louis, MO	Gateway Station	7:00 AM	Jacksonville, FL	Amtrak Train Station	Economy	$109	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 5/9/2026 2:00:00 AM to Amtrak Train Station, Jacksonville, FL (USA) arriving at 5/10/2026 7:00:00 AM. 50 Economy ticket for $109 per person are available. Travel duration is 28h 0m
FlixBus	20h 35m	4:00 PM	St. Louis, MO	Gateway Station	1:35 PM	Jacksonville, FL	Amtrak Train Station	Economy	$110	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 5/9/2026 4:00:00 PM to Amtrak Train Station, Jacksonville, FL (USA) arriving at 5/10/2026 1:35:00 PM. 50 Economy ticket for $110 per person are available. Travel duration is 20h 35m
FlixBus	22h 20m	11:45 PM	St. Louis, MO	Gateway Station	11:05 PM	Jacksonville, FL	Amtrak Train Station	Economy	$111	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 5/9/2026 11:45:00 PM to Amtrak Train Station, Jacksonville, FL (USA) arriving at 5/10/2026 11:05:00 PM. 50 Economy ticket for $111 per person are available. Travel duration is 22h 20m

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	28h 0m	2:00 AM	St. Louis, MO	Gateway Station	7:00 AM	Jacksonville, FL	Amtrak Train Station	Economy	$102	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 5/11/2026 2:00:00 AM to Amtrak Train Station, Jacksonville, FL (USA) arriving at 5/12/2026 7:00:00 AM. 50 Economy ticket for $102 per person are available. Travel duration is 28h 0m
FlixBus	20h 35m	4:00 PM	St. Louis, MO	Gateway Station	1:35 PM	Jacksonville, FL	Amtrak Train Station	Economy	$102	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 5/11/2026 4:00:00 PM to Amtrak Train Station, Jacksonville, FL (USA) arriving at 5/12/2026 1:35:00 PM. 50 Economy ticket for $102 per person are available. Travel duration is 20h 35m
FlixBus	22h 20m	11:45 PM	St. Louis, MO	Gateway Station	11:05 PM	Jacksonville, FL	Amtrak Train Station	Economy	$102	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 5/11/2026 11:45:00 PM to Amtrak Train Station, Jacksonville, FL (USA) arriving at 5/12/2026 11:05:00 PM. 50 Economy ticket for $102 per person are available. Travel duration is 22h 20m

Cheapest bus trips Tuesday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	FlixBus	20h 35m	4:00 PM	St. Louis, MO	Gateway Station	1:35 PM	Jacksonville, FL	Amtrak Train Station		Economy	$107	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 5/12/2026 4:00:00 PM to Amtrak Train Station, Jacksonville, FL (USA) arriving at 5/13/2026 1:35:00 PM. 50 Economy ticket for $107 per person are available. Travel duration is 20h 35m
	Greyhound US	28h 0m	2:00 AM	St. Louis, MO	Gateway Station	7:00 AM	Jacksonville, FL	Amtrak Train Station		Economy	$108	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 5/12/2026 2:00:00 AM to Amtrak Train Station, Jacksonville, FL (USA) arriving at 5/13/2026 7:00:00 AM. 50 Economy ticket for $108 per person are available. Travel duration is 28h 0m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	28h 0m	2:00 AM	St. Louis, MO	Gateway Station	7:00 AM	Jacksonville, FL	Amtrak Train Station	Economy	$115	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 5/13/2026 2:00:00 AM to Amtrak Train Station, Jacksonville, FL (USA) arriving at 5/14/2026 7:00:00 AM. 50 Economy ticket for $115 per person are available. Travel duration is 28h 0m
FlixBus	22h 20m	11:45 PM	St. Louis, MO	Gateway Station	11:05 PM	Jacksonville, FL	Amtrak Train Station	Economy	$116	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 5/13/2026 11:45:00 PM to Amtrak Train Station, Jacksonville, FL (USA) arriving at 5/14/2026 11:05:00 PM. 50 Economy ticket for $116 per person are available. Travel duration is 22h 20m
FlixBus	20h 35m	4:00 PM	St. Louis, MO	Gateway Station	1:35 PM	Jacksonville, FL	Amtrak Train Station	Economy	$118	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 5/13/2026 4:00:00 PM to Amtrak Train Station, Jacksonville, FL (USA) arriving at 5/14/2026 1:35:00 PM. 50 Economy ticket for $118 per person are available. Travel duration is 20h 35m

Did you know that if you travel from St. Louis, MO to Jacksonville, FL via Atlanta, GA, you can save more than $17? You can find the corresponding connections below.
- FlixBus
  
  30h 15m
  
  0
  
  11:45 PM
  
  St. Louis, MO
  Gateway Station
  
  11:00 AM
  
  Atlanta, GA
  Garnett Transit Station
  
  0
  
  Economy
  
  $52
  
  A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 5/12/2026 11:45:00 PM to Garnett Transit Station, Atlanta, GA (USA) arriving at 5/13/2026 11:00:00 AM. 50 Economy ticket for $52 per person are available. Travel duration is 10h 15m
- FlixBus
  
  6h 35m
  
  0
  
  12:25 AM
  
  Atlanta, GA
  Garnett Transit Station
  
  7:00 AM
  
  Jacksonville, FL
  Downtown Bus Stop
  
  0
  
  Economy
  
  $46
  
  A Bus from FlixBus goes from Garnett Transit Station, Atlanta, GA (USA) at 5/14/2026 12:25:00 AM to Downtown Bus Stop, Jacksonville, FL (USA) arriving at 5/14/2026 7:00:00 AM. 50 Economy ticket for $46 per person are available. Travel duration is 6h 35m
Travel time is 8h 40m longer, but you will save $17

Best Price Offer: The price for the cheapest bus from St. Louis, MO to Jacksonville, FL is $102 on 5/11/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between St. Louis, MO and Jacksonville, FL

See here how frequent the connections between St. Louis, MO and Jacksonville, FL are, during different times and days of the week.

Monday is the busiest day, with more than 3 daily buses from St. Louis, MO to Jacksonville, FL. Tuesday has instead the fewest connections, with only 2 daily coaches between St. Louis, MO and Jacksonville, FL.

The busiest time of the day is the Afternoon, with 4 buses from St. Louis, MO to Jacksonville, FL, while Evening sees the fewest connections between St. Louis, MO and Jacksonville, FL, with 3 offers.

Facts about the bus from St. Louis, MO to Jacksonville, FL

Compare all providers like FlixBus and Greyhound US that travel 2 times every day by bus from St. Louis, MO to Jacksonville, FL in one click! Book your bus ticket from St. Louis, MO to Jacksonville, FL starting from $102!

Cheapest Bus	$102
Fastest Bus	21h 35m
Earliest Bus	2:00 AM
Latest Bus	11:45 PM
Daily Bus Routes	2 Ø
Distance	750.9 miles
Bus Companies	FlixBus and Greyhound US

Cheapest bus connections from St. Louis, MO to Jacksonville, FL

Every day, 2 buses from 2 bus companies leave St. Louis, MO for Jacksonville, FL: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 05/07/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 05/03

Monday 05/04

Tuesday 05/05

Wednesday 05/06

Thursday 05/07

Friday 05/08

Saturday 05/09

$109

Sunday 05/10

Monday 05/11

$102

Tuesday 05/12

$107

Wednesday 05/13

$115

Thursday 05/14

Friday 05/15

$109

Saturday 05/16

Sunday 05/17

$103

Monday 05/18

Tuesday 05/19

$107

Wednesday 05/20

Thursday 05/21

$108

Friday 05/22

Saturday 05/23

Sunday 05/24

$113

Monday 05/25

Tuesday 05/26

$108

Wednesday 05/27

Thursday 05/28

$104

Friday 05/29

Saturday 05/30

The cheapest time to travel from St. Louis, MO to Jacksonville, FL

See here on which day and which time of the day you can find the cheapest bus ticket from St. Louis, MO to Jacksonville, FL, for the next 30 days.

With a price starting from $93, Monday is the cheapest day for a bus from St. Louis, MO to Jacksonville, FL. Wednesday instead is the most expensive day with prices starting from $115.

Night is the cheapest day time for bus tickets from St. Louis, MO to Jacksonville, FL, with $93. Afternoon is the most expensive time of the day with prices starting from $102.

How to save money travelling from St. Louis, MO to Jacksonville, FL

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from St. Louis, MO to Jacksonville, FL in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from St. Louis, MO to Jacksonville, FL, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from St. Louis, MO to Jacksonville, FL are also emptier.

All bus stations and stops in St. Louis, MO and Jacksonville, FL

In the map below, you can see where to find all bus stations in St. Louis, MO and Jacksonville, FL.

Gateway Station

S 15th St 430

Skinker Boulevard

Boulevard between Lindell Blvd. and Lagoon Drive

Lindbergh @ Hackberry NB Bus Stop

Downtown Bus Stop

West Forsyth Street 1111

Beaver St. & Ocean St. Bus Stop

Central Bus Station

Old St. Augustine Rd

Old St. Augustine Rd 10584-13

Southpoint Bus Stop

Service and Comfort on the bus from St. Louis, MO to Jacksonville, FL

Want to know which seat classes are available on the buses from St. Louis, MO to Jacksonville, FL? Or which bus companies serve the route St. Louis, MO to Jacksonville, FL? Below you will find answers to your questions.

FAQs about the St. Louis, MO to Jacksonville, FL bus

How much does a St. Louis, MO Jacksonville, FL bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $102 and takes 23h 20m to reach Jacksonville, FL. Compare offers to save money!

How much could I save by comparing buses from St. Louis, MO to Jacksonville, FL?

This route is offered by 2 companies with a range of ticket prices between $102 and $118. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Jacksonville, FL.

On average, how many connections are available from St. Louis, MO to Jacksonville, FL each day?

Every day, the St. Louis, MO to Jacksonville, FL bus route is served by approximately 2 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from St. Louis, MO to Jacksonville, FL take?

The fastest bus from St. Louis, MO to Jacksonville, FL is offered by FlixBus and takes 21h 35m. Bus tickets for this connection cost $110. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from St. Louis, MO to Jacksonville, FL?

The earliest bus arriving in Jacksonville, FL from St. Louis, MO starts at 2:00 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from St. Louis, MO to Jacksonville, FL?

The latest bus trip departing from St. Louis, MO for Jacksonville, FL starts at 11:45 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the St. Louis, MO Jacksonville, FL route?

When traveling by bus from St. Louis, MO to Jacksonville, FL, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between St. Louis, MO and Jacksonville, FL?

You can check all the direct connections between St. Louis, MO and Jacksonville, FL by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the St. Louis, MO to Jacksonville, FL bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the St. Louis, MO Jacksonville, FL bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the St. Louis, MO Jacksonville, FL bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from St. Louis, MO to Jacksonville, FL on your planned travel date.

How does CheckMyBus find the best bus deals from St. Louis, MO to Jacksonville, FL?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 2 daily trips between St. Louis, MO and Jacksonville, FL. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from St. Louis, MO to Jacksonville, FL?

Prices and availability for 2 trips between St. Louis, MO and Jacksonville, FL change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route St. Louis, MO to Jacksonville, FL

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to St. Louis, MO and to Jacksonville, FL

Here’s an overview of the most popular bus routes to St. Louis, MO and to Jacksonville, FL. Simply click on the connection of your choice, and you will find all the details about your bus route!